WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cilia and flagella associated protein 44, putative

Species:

Leishmania mexicana

UniProt:

E9APZ1_LEIMU

TriTrypDb:

LmxM.14.1430

Length:

1754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

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Expansion

Sequence features

E9APZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0048870	cell motility	2	1
GO:0060271	cilium assembly	6	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1032	1036	PF00656	0.695
CLV_C14_Caspase3-7	1252	1256	PF00656	0.546
CLV_C14_Caspase3-7	1472	1476	PF00656	0.506
CLV_C14_Caspase3-7	1729	1733	PF00656	0.394
CLV_C14_Caspase3-7	70	74	PF00656	0.532
CLV_C14_Caspase3-7	868	872	PF00656	0.652
CLV_C14_Caspase3-7	963	967	PF00656	0.776
CLV_NRD_NRD_1	1027	1029	PF00675	0.575
CLV_NRD_NRD_1	1033	1035	PF00675	0.554
CLV_NRD_NRD_1	1042	1044	PF00675	0.526

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC4	Leptomonas seymouri	63%	99%
A0A0S4IVP0	Bodo saltans	33%	100%
A0A1X0NNE2	Trypanosomatidae	39%	99%
A0A3S7WT85	Leishmania donovani	92%	100%
A0A422NFQ5	Trypanosoma rangeli	40%	100%
A4H7W3	Leishmania braziliensis	83%	100%
A4HW90	Leishmania infantum	92%	100%
C9ZSS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9Q5M6	Mus musculus	21%	95%
Q4QFJ0	Leishmania major	93%	100%

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