HEAT repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APZ0_LEIMU

TriTrypDb:

LmxM.14.1420

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.436
CLV_NRD_NRD_1	348	350	PF00675	0.569
CLV_NRD_NRD_1	427	429	PF00675	0.513
CLV_NRD_NRD_1	473	475	PF00675	0.523
CLV_NRD_NRD_1	525	527	PF00675	0.526
CLV_NRD_NRD_1	564	566	PF00675	0.548
CLV_NRD_NRD_1	60	62	PF00675	0.569
CLV_NRD_NRD_1	665	667	PF00675	0.540
CLV_PCSK_FUR_1	58	62	PF00082	0.670
CLV_PCSK_KEX2_1	348	350	PF00082	0.569
CLV_PCSK_KEX2_1	427	429	PF00082	0.476
CLV_PCSK_KEX2_1	473	475	PF00082	0.523
CLV_PCSK_KEX2_1	525	527	PF00082	0.526
CLV_PCSK_KEX2_1	58	60	PF00082	0.587
CLV_PCSK_KEX2_1	665	667	PF00082	0.502
CLV_PCSK_SKI1_1	181	185	PF00082	0.466
CLV_PCSK_SKI1_1	250	254	PF00082	0.478
CLV_PCSK_SKI1_1	325	329	PF00082	0.533
CLV_PCSK_SKI1_1	451	455	PF00082	0.584
CLV_PCSK_SKI1_1	484	488	PF00082	0.479
CLV_PCSK_SKI1_1	525	529	PF00082	0.523
CLV_PCSK_SKI1_1	635	639	PF00082	0.378
CLV_PCSK_SKI1_1	665	669	PF00082	0.503
DEG_APCC_DBOX_1	386	394	PF00400	0.533
DEG_Nend_UBRbox_2	1	3	PF02207	0.646
DEG_SCF_FBW7_1	304	310	PF00400	0.400
DEG_SCF_FBW7_1	386	392	PF00400	0.269
DOC_CDC14_PxL_1	121	129	PF14671	0.531
DOC_CDC14_PxL_1	406	414	PF14671	0.563
DOC_CKS1_1	304	309	PF01111	0.479
DOC_CKS1_1	365	370	PF01111	0.403
DOC_CKS1_1	386	391	PF01111	0.518
DOC_CYCLIN_RxL_1	247	256	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.303
DOC_MAPK_DCC_7	650	659	PF00069	0.566
DOC_MAPK_gen_1	178	186	PF00069	0.524
DOC_MAPK_gen_1	348	357	PF00069	0.544
DOC_MAPK_gen_1	565	572	PF00069	0.512
DOC_MAPK_MEF2A_6	178	186	PF00069	0.524
DOC_MAPK_MEF2A_6	23	31	PF00069	0.673
DOC_MAPK_MEF2A_6	239	248	PF00069	0.539
DOC_MAPK_MEF2A_6	325	334	PF00069	0.550
DOC_MAPK_MEF2A_6	350	359	PF00069	0.447
DOC_PP1_RVXF_1	632	639	PF00149	0.373
DOC_PP2B_LxvP_1	212	215	PF13499	0.578
DOC_PP4_FxxP_1	36	39	PF00568	0.665
DOC_PP4_FxxP_1	582	585	PF00568	0.547
DOC_SPAK_OSR1_1	114	118	PF12202	0.527
DOC_USP7_MATH_1	171	175	PF00917	0.560
DOC_USP7_MATH_1	208	212	PF00917	0.556
DOC_USP7_MATH_1	22	26	PF00917	0.635
DOC_USP7_MATH_1	231	235	PF00917	0.557
DOC_USP7_MATH_1	307	311	PF00917	0.390
DOC_USP7_MATH_1	389	393	PF00917	0.278
DOC_USP7_MATH_1	416	420	PF00917	0.636
DOC_USP7_MATH_1	47	51	PF00917	0.637
DOC_USP7_MATH_1	511	515	PF00917	0.690
DOC_USP7_MATH_1	529	533	PF00917	0.422
DOC_USP7_MATH_1	545	549	PF00917	0.338
DOC_WW_Pin1_4	303	308	PF00397	0.481
DOC_WW_Pin1_4	364	369	PF00397	0.413
DOC_WW_Pin1_4	385	390	PF00397	0.522
DOC_WW_Pin1_4	412	417	PF00397	0.579
LIG_14-3-3_CanoR_1	105	112	PF00244	0.550
LIG_14-3-3_CanoR_1	132	137	PF00244	0.487
LIG_14-3-3_CanoR_1	181	187	PF00244	0.445
LIG_14-3-3_CanoR_1	23	31	PF00244	0.637
LIG_14-3-3_CanoR_1	239	246	PF00244	0.523
LIG_14-3-3_CanoR_1	308	317	PF00244	0.517
LIG_14-3-3_CanoR_1	32	37	PF00244	0.595
LIG_14-3-3_CanoR_1	46	52	PF00244	0.680
LIG_14-3-3_CanoR_1	510	516	PF00244	0.638
LIG_14-3-3_CanoR_1	590	596	PF00244	0.457
LIG_14-3-3_CanoR_1	94	100	PF00244	0.521
LIG_Clathr_ClatBox_1	572	576	PF01394	0.421
LIG_Clathr_ClatBox_1	657	661	PF01394	0.455
LIG_eIF4E_1	353	359	PF01652	0.523
LIG_FHA_1	155	161	PF00498	0.540
LIG_FHA_1	235	241	PF00498	0.545
LIG_FHA_1	312	318	PF00498	0.546
LIG_FHA_1	365	371	PF00498	0.395
LIG_FHA_1	517	523	PF00498	0.608
LIG_FHA_1	627	633	PF00498	0.539
LIG_FHA_2	105	111	PF00498	0.585
LIG_FHA_2	615	621	PF00498	0.530
LIG_FHA_2	650	656	PF00498	0.487
LIG_LIR_Apic_2	35	39	PF02991	0.736
LIG_LIR_Apic_2	581	585	PF02991	0.518
LIG_LIR_Gen_1	219	230	PF02991	0.514
LIG_LIR_Gen_1	531	542	PF02991	0.508
LIG_LIR_Gen_1	553	563	PF02991	0.424
LIG_LIR_Gen_1	598	609	PF02991	0.454
LIG_LIR_Gen_1	98	103	PF02991	0.543
LIG_LIR_LC3C_4	241	246	PF02991	0.494
LIG_LIR_Nem_3	198	203	PF02991	0.419
LIG_LIR_Nem_3	219	225	PF02991	0.431
LIG_LIR_Nem_3	30	36	PF02991	0.597
LIG_LIR_Nem_3	53	57	PF02991	0.656
LIG_LIR_Nem_3	531	537	PF02991	0.530
LIG_LIR_Nem_3	598	604	PF02991	0.468
LIG_LIR_Nem_3	98	102	PF02991	0.535
LIG_LYPXL_yS_3	409	412	PF13949	0.553
LIG_NRBOX	289	295	PF00104	0.474
LIG_NRBOX	369	375	PF00104	0.524
LIG_Pex14_1	595	599	PF04695	0.418
LIG_Pex14_2	222	226	PF04695	0.432
LIG_SH2_CRK	413	417	PF00017	0.601
LIG_SH2_CRK	534	538	PF00017	0.372
LIG_SH2_STAP1	326	330	PF00017	0.479
LIG_SH2_STAP1	599	603	PF00017	0.484
LIG_SH2_STAT5	16	19	PF00017	0.756
LIG_SH2_STAT5	534	537	PF00017	0.450
LIG_SH2_STAT5	55	58	PF00017	0.685
LIG_SH2_STAT5	599	602	PF00017	0.440
LIG_SH3_1	170	176	PF00018	0.535
LIG_SH3_2	173	178	PF14604	0.539
LIG_SH3_3	170	176	PF00018	0.535
LIG_SH3_3	505	511	PF00018	0.665
LIG_SH3_3	74	80	PF00018	0.544
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.547
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.524
LIG_SUMO_SIM_anti_2	600	606	PF11976	0.530
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.548
LIG_SUMO_SIM_par_1	144	152	PF11976	0.499
LIG_SUMO_SIM_par_1	340	347	PF11976	0.488
LIG_SUMO_SIM_par_1	375	381	PF11976	0.475
LIG_SUMO_SIM_par_1	518	523	PF11976	0.538
LIG_SUMO_SIM_par_1	655	661	PF11976	0.427
LIG_TRAF2_1	437	440	PF00917	0.515
LIG_UBA3_1	165	170	PF00899	0.441
LIG_UBA3_1	449	457	PF00899	0.390
LIG_WRC_WIRS_1	33	38	PF05994	0.732
MOD_CDK_SPK_2	303	308	PF00069	0.481
MOD_CK1_1	189	195	PF00069	0.510
MOD_CK1_1	234	240	PF00069	0.576
MOD_CK1_1	272	278	PF00069	0.605
MOD_CK1_1	311	317	PF00069	0.579
MOD_CK1_1	366	372	PF00069	0.388
MOD_CK1_1	466	472	PF00069	0.339
MOD_CK1_1	506	512	PF00069	0.656
MOD_CK2_1	104	110	PF00069	0.565
MOD_CK2_1	438	444	PF00069	0.467
MOD_CK2_1	61	67	PF00069	0.475
MOD_CK2_1	614	620	PF00069	0.543
MOD_CK2_1	639	645	PF00069	0.482
MOD_CK2_1	649	655	PF00069	0.440
MOD_GlcNHglycan	233	236	PF01048	0.546
MOD_GlcNHglycan	24	27	PF01048	0.608
MOD_GlcNHglycan	259	262	PF01048	0.460
MOD_GlcNHglycan	271	274	PF01048	0.430
MOD_GlcNHglycan	310	313	PF01048	0.548
MOD_GlcNHglycan	465	468	PF01048	0.479
MOD_GlcNHglycan	513	516	PF01048	0.595
MOD_GlcNHglycan	538	541	PF01048	0.351
MOD_GlcNHglycan	63	66	PF01048	0.550
MOD_GSK3_1	182	189	PF00069	0.472
MOD_GSK3_1	191	198	PF00069	0.464
MOD_GSK3_1	234	241	PF00069	0.543
MOD_GSK3_1	253	260	PF00069	0.293
MOD_GSK3_1	303	310	PF00069	0.670
MOD_GSK3_1	311	318	PF00069	0.533
MOD_GSK3_1	385	392	PF00069	0.452
MOD_GSK3_1	412	419	PF00069	0.569
MOD_GSK3_1	529	536	PF00069	0.514
MOD_N-GLC_1	130	135	PF02516	0.538
MOD_NEK2_1	154	159	PF00069	0.557
MOD_NEK2_1	186	191	PF00069	0.496
MOD_NEK2_1	240	245	PF00069	0.445
MOD_NEK2_1	252	257	PF00069	0.352
MOD_NEK2_1	358	363	PF00069	0.447
MOD_NEK2_1	463	468	PF00069	0.414
MOD_NEK2_1	559	564	PF00069	0.496
MOD_NEK2_1	591	596	PF00069	0.431
MOD_NEK2_1	607	612	PF00069	0.271
MOD_NEK2_1	626	631	PF00069	0.510
MOD_NEK2_1	85	90	PF00069	0.557
MOD_NEK2_2	47	52	PF00069	0.710
MOD_NEK2_2	529	534	PF00069	0.614
MOD_PIKK_1	189	195	PF00454	0.588
MOD_PIKK_1	378	384	PF00454	0.539
MOD_PIKK_1	416	422	PF00454	0.636
MOD_PIKK_1	626	632	PF00454	0.532
MOD_PK_1	132	138	PF00069	0.550
MOD_PKA_2	104	110	PF00069	0.598
MOD_PKA_2	186	192	PF00069	0.302
MOD_PKA_2	22	28	PF00069	0.671
MOD_PKA_2	238	244	PF00069	0.540
MOD_PKA_2	307	313	PF00069	0.481
MOD_PKA_2	506	512	PF00069	0.669
MOD_PKB_1	59	67	PF00069	0.642
MOD_Plk_1	130	136	PF00069	0.546
MOD_Plk_1	597	603	PF00069	0.548
MOD_Plk_4	132	138	PF00069	0.550
MOD_Plk_4	161	167	PF00069	0.421
MOD_Plk_4	195	201	PF00069	0.480
MOD_Plk_4	240	246	PF00069	0.433
MOD_Plk_4	366	372	PF00069	0.454
MOD_Plk_4	389	395	PF00069	0.322
MOD_Plk_4	529	535	PF00069	0.479
MOD_Plk_4	597	603	PF00069	0.529
MOD_Plk_4	73	79	PF00069	0.658
MOD_ProDKin_1	303	309	PF00069	0.481
MOD_ProDKin_1	364	370	PF00069	0.411
MOD_ProDKin_1	385	391	PF00069	0.524
MOD_ProDKin_1	412	418	PF00069	0.592
MOD_SUMO_rev_2	300	304	PF00179	0.578
TRG_DiLeu_BaEn_1	523	528	PF01217	0.542
TRG_DiLeu_BaLyEn_6	653	658	PF01217	0.484
TRG_DiLeu_BaLyEn_6	663	668	PF01217	0.348
TRG_DiLeu_LyEn_5	523	528	PF01217	0.529
TRG_ENDOCYTIC_2	33	36	PF00928	0.690
TRG_ENDOCYTIC_2	352	355	PF00928	0.393
TRG_ENDOCYTIC_2	409	412	PF00928	0.473
TRG_ENDOCYTIC_2	534	537	PF00928	0.377
TRG_ENDOCYTIC_2	599	602	PF00928	0.440
TRG_ENDOCYTIC_2	99	102	PF00928	0.543
TRG_ER_diArg_1	472	474	PF00400	0.522
TRG_ER_diArg_1	524	526	PF00400	0.509
TRG_ER_diArg_1	57	60	PF00400	0.592
TRG_ER_diArg_1	664	666	PF00400	0.488
TRG_NES_CRM1_1	333	347	PF08389	0.237
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	665	670	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI6	Leptomonas seymouri	64%	100%
A0A1X0NND4	Trypanosomatidae	31%	85%
A0A3R7NL73	Trypanosoma rangeli	31%	95%
A0A3S7WT73	Leishmania donovani	94%	100%
A4H7W2	Leishmania braziliensis	85%	100%
A4HW89	Leishmania infantum	94%	100%
C9ZSS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QFJ1	Leishmania major	92%	100%
V5AW01	Trypanosoma cruzi	32%	95%