LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9APY9_LEIMU
TriTrypDb:
LmxM.14.1410
Length:
555

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 15
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 45
NetGPI no yes: 0, no: 45
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 7
GO:0005737 cytoplasm 2 6
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

E9APY9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APY9

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 46
GO:0006793 phosphorus metabolic process 3 46
GO:0006796 phosphate-containing compound metabolic process 4 46
GO:0006807 nitrogen compound metabolic process 2 46
GO:0008152 metabolic process 1 46
GO:0009987 cellular process 1 46
GO:0016310 phosphorylation 5 46
GO:0019538 protein metabolic process 3 46
GO:0036211 protein modification process 4 46
GO:0043170 macromolecule metabolic process 3 46
GO:0043412 macromolecule modification 4 46
GO:0044237 cellular metabolic process 2 46
GO:0044238 primary metabolic process 2 46
GO:0071704 organic substance metabolic process 2 46
GO:1901564 organonitrogen compound metabolic process 3 46
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
GO:0007165 signal transduction 2 3
GO:0035556 intracellular signal transduction 3 3
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0065007 biological regulation 1 3
GO:0046777 protein autophosphorylation 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 46
GO:0003824 catalytic activity 1 46
GO:0004672 protein kinase activity 3 46
GO:0005488 binding 1 46
GO:0005524 ATP binding 5 46
GO:0016301 kinase activity 4 46
GO:0016740 transferase activity 2 46
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 46
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 46
GO:0017076 purine nucleotide binding 4 46
GO:0030554 adenyl nucleotide binding 5 46
GO:0032553 ribonucleotide binding 3 46
GO:0032555 purine ribonucleotide binding 4 46
GO:0032559 adenyl ribonucleotide binding 5 46
GO:0035639 purine ribonucleoside triphosphate binding 4 46
GO:0036094 small molecule binding 2 46
GO:0043167 ion binding 2 46
GO:0043168 anion binding 3 46
GO:0097159 organic cyclic compound binding 2 46
GO:0097367 carbohydrate derivative binding 2 46
GO:0140096 catalytic activity, acting on a protein 2 46
GO:1901265 nucleoside phosphate binding 3 46
GO:1901363 heterocyclic compound binding 2 46
GO:0004674 protein serine/threonine kinase activity 4 31
GO:0004707 MAP kinase activity 5 4
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1
GO:0004140 dephospho-CoA kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 365 369 PF00656 0.574
CLV_NRD_NRD_1 123 125 PF00675 0.297
CLV_NRD_NRD_1 494 496 PF00675 0.566
CLV_NRD_NRD_1 502 504 PF00675 0.579
CLV_NRD_NRD_1 72 74 PF00675 0.263
CLV_PCSK_KEX2_1 502 504 PF00082 0.574
CLV_PCSK_SKI1_1 105 109 PF00082 0.304
CLV_PCSK_SKI1_1 124 128 PF00082 0.287
CLV_PCSK_SKI1_1 129 133 PF00082 0.399
CLV_PCSK_SKI1_1 208 212 PF00082 0.353
CLV_PCSK_SKI1_1 542 546 PF00082 0.476
DEG_APCC_DBOX_1 104 112 PF00400 0.236
DEG_APCC_DBOX_1 247 255 PF00400 0.289
DEG_Nend_UBRbox_2 1 3 PF02207 0.460
DOC_CKS1_1 166 171 PF01111 0.319
DOC_CKS1_1 427 432 PF01111 0.505
DOC_CYCLIN_yCln2_LP_2 178 184 PF00134 0.250
DOC_CYCLIN_yCln2_LP_2 201 207 PF00134 0.259
DOC_CYCLIN_yCln2_LP_2 531 537 PF00134 0.491
DOC_MAPK_gen_1 129 138 PF00069 0.403
DOC_MAPK_gen_1 248 257 PF00069 0.306
DOC_MAPK_gen_1 73 80 PF00069 0.301
DOC_MAPK_gen_1 93 102 PF00069 0.291
DOC_MAPK_MEF2A_6 250 259 PF00069 0.234
DOC_MAPK_MEF2A_6 73 82 PF00069 0.350
DOC_MAPK_RevD_3 112 125 PF00069 0.250
DOC_PP2B_LxvP_1 255 258 PF13499 0.250
DOC_PP2B_LxvP_1 398 401 PF13499 0.743
DOC_PP2B_LxvP_1 531 534 PF13499 0.503
DOC_PP4_FxxP_1 268 271 PF00568 0.327
DOC_PP4_FxxP_1 349 352 PF00568 0.600
DOC_PP4_FxxP_1 423 426 PF00568 0.514
DOC_PP4_FxxP_1 427 430 PF00568 0.492
DOC_PP4_FxxP_1 518 521 PF00568 0.537
DOC_PP4_FxxP_1 535 538 PF00568 0.447
DOC_USP7_MATH_1 297 301 PF00917 0.505
DOC_USP7_MATH_1 362 366 PF00917 0.576
DOC_USP7_MATH_1 72 76 PF00917 0.225
DOC_USP7_UBL2_3 265 269 PF12436 0.290
DOC_USP7_UBL2_3 8 12 PF12436 0.253
DOC_WW_Pin1_4 165 170 PF00397 0.315
DOC_WW_Pin1_4 341 346 PF00397 0.604
DOC_WW_Pin1_4 392 397 PF00397 0.547
DOC_WW_Pin1_4 415 420 PF00397 0.541
DOC_WW_Pin1_4 422 427 PF00397 0.505
DOC_WW_Pin1_4 480 485 PF00397 0.528
DOC_WW_Pin1_4 516 521 PF00397 0.517
LIG_14-3-3_CanoR_1 415 419 PF00244 0.531
LIG_14-3-3_CanoR_1 424 430 PF00244 0.492
LIG_14-3-3_CanoR_1 45 50 PF00244 0.324
LIG_14-3-3_CanoR_1 508 512 PF00244 0.510
LIG_14-3-3_CanoR_1 53 59 PF00244 0.321
LIG_14-3-3_CanoR_1 73 81 PF00244 0.250
LIG_Actin_RPEL_3 236 255 PF02755 0.239
LIG_APCC_ABBA_1 218 223 PF00400 0.220
LIG_APCC_ABBAyCdc20_2 124 130 PF00400 0.324
LIG_BRCT_BRCA1_1 299 303 PF00533 0.459
LIG_BRCT_BRCA1_1 419 423 PF00533 0.522
LIG_eIF4E_1 171 177 PF01652 0.282
LIG_EVH1_1 535 539 PF00568 0.460
LIG_FHA_1 131 137 PF00498 0.290
LIG_FHA_1 15 21 PF00498 0.359
LIG_FHA_1 335 341 PF00498 0.495
LIG_FHA_1 427 433 PF00498 0.519
LIG_FHA_2 316 322 PF00498 0.486
LIG_FHA_2 325 331 PF00498 0.510
LIG_LIR_Apic_2 168 174 PF02991 0.359
LIG_LIR_Apic_2 420 426 PF02991 0.518
LIG_LIR_Apic_2 469 475 PF02991 0.531
LIG_LIR_Apic_2 510 516 PF02991 0.551
LIG_LIR_Gen_1 2 10 PF02991 0.370
LIG_LIR_Nem_3 2 7 PF02991 0.372
LIG_LIR_Nem_3 26 32 PF02991 0.300
LIG_MAD2 216 224 PF02301 0.255
LIG_MAD2 53 61 PF02301 0.228
LIG_MYND_1 380 384 PF01753 0.523
LIG_MYND_1 480 484 PF01753 0.501
LIG_MYND_1 512 516 PF01753 0.524
LIG_NRP_CendR_1 552 555 PF00754 0.494
LIG_Pex14_2 423 427 PF04695 0.509
LIG_PTB_Apo_2 512 519 PF02174 0.549
LIG_SH2_CRK 222 226 PF00017 0.229
LIG_SH2_CRK 385 389 PF00017 0.547
LIG_SH2_CRK 4 8 PF00017 0.267
LIG_SH2_CRK 472 476 PF00017 0.530
LIG_SH2_CRK 528 532 PF00017 0.548
LIG_SH2_GRB2like 385 388 PF00017 0.526
LIG_SH2_GRB2like 513 516 PF00017 0.534
LIG_SH2_NCK_1 159 163 PF00017 0.237
LIG_SH2_NCK_1 472 476 PF00017 0.530
LIG_SH2_SRC 513 516 PF00017 0.534
LIG_SH2_SRC 66 69 PF00017 0.278
LIG_SH2_SRC 84 87 PF00017 0.257
LIG_SH2_STAP1 229 233 PF00017 0.316
LIG_SH2_STAT3 120 123 PF00017 0.228
LIG_SH2_STAT3 399 402 PF00017 0.606
LIG_SH2_STAT3 476 479 PF00017 0.548
LIG_SH2_STAT5 120 123 PF00017 0.291
LIG_SH2_STAT5 171 174 PF00017 0.321
LIG_SH2_STAT5 278 281 PF00017 0.343
LIG_SH2_STAT5 30 33 PF00017 0.320
LIG_SH2_STAT5 4 7 PF00017 0.355
LIG_SH2_STAT5 488 491 PF00017 0.631
LIG_SH2_STAT5 513 516 PF00017 0.534
LIG_SH2_STAT5 66 69 PF00017 0.343
LIG_SH3_3 163 169 PF00018 0.342
LIG_SH3_3 239 245 PF00018 0.304
LIG_SH3_3 342 348 PF00018 0.564
LIG_SH3_3 374 380 PF00018 0.559
LIG_SH3_3 398 404 PF00018 0.568
LIG_SH3_3 413 419 PF00018 0.661
LIG_SH3_3 451 457 PF00018 0.746
LIG_SH3_3 527 533 PF00018 0.578
LIG_SH3_3 97 103 PF00018 0.279
LIG_SUMO_SIM_par_1 114 119 PF11976 0.233
LIG_TRAF2_1 312 315 PF00917 0.462
LIG_TRFH_1 170 174 PF08558 0.286
LIG_TYR_ITIM 194 199 PF00017 0.336
LIG_TYR_ITIM 220 225 PF00017 0.285
LIG_UBA3_1 198 202 PF00899 0.223
LIG_WRC_WIRS_1 67 72 PF05994 0.268
LIG_WW_3 519 523 PF00397 0.484
MOD_CDC14_SPxK_1 418 421 PF00782 0.520
MOD_CDC14_SPxK_1 519 522 PF00782 0.481
MOD_CDK_SPxK_1 415 421 PF00069 0.532
MOD_CDK_SPxK_1 516 522 PF00069 0.485
MOD_CK1_1 320 326 PF00069 0.554
MOD_CK1_1 350 356 PF00069 0.529
MOD_CK1_1 417 423 PF00069 0.530
MOD_CK1_1 425 431 PF00069 0.522
MOD_CK1_1 449 455 PF00069 0.580
MOD_CK1_1 507 513 PF00069 0.533
MOD_CK2_1 315 321 PF00069 0.494
MOD_CK2_1 45 51 PF00069 0.296
MOD_DYRK1A_RPxSP_1 415 419 PF00069 0.536
MOD_GlcNHglycan 229 232 PF01048 0.342
MOD_GlcNHglycan 323 326 PF01048 0.571
MOD_GlcNHglycan 434 437 PF01048 0.582
MOD_GlcNHglycan 86 89 PF01048 0.240
MOD_GSK3_1 151 158 PF00069 0.305
MOD_GSK3_1 161 168 PF00069 0.324
MOD_GSK3_1 293 300 PF00069 0.659
MOD_GSK3_1 316 323 PF00069 0.548
MOD_GSK3_1 347 354 PF00069 0.525
MOD_GSK3_1 422 429 PF00069 0.598
MOD_LATS_1 407 413 PF00433 0.548
MOD_N-GLC_1 334 339 PF02516 0.514
MOD_N-GLC_1 368 373 PF02516 0.537
MOD_N-GLC_2 77 79 PF02516 0.228
MOD_PIKK_1 130 136 PF00454 0.250
MOD_PIKK_1 446 452 PF00454 0.552
MOD_PKA_2 316 322 PF00069 0.530
MOD_PKA_2 375 381 PF00069 0.558
MOD_PKA_2 38 44 PF00069 0.301
MOD_PKA_2 414 420 PF00069 0.523
MOD_PKA_2 459 465 PF00069 0.653
MOD_PKA_2 507 513 PF00069 0.525
MOD_PKA_2 72 78 PF00069 0.253
MOD_Plk_1 293 299 PF00069 0.476
MOD_Plk_1 35 41 PF00069 0.268
MOD_Plk_4 161 167 PF00069 0.328
MOD_Plk_4 224 230 PF00069 0.272
MOD_Plk_4 66 72 PF00069 0.266
MOD_ProDKin_1 165 171 PF00069 0.315
MOD_ProDKin_1 341 347 PF00069 0.607
MOD_ProDKin_1 392 398 PF00069 0.550
MOD_ProDKin_1 415 421 PF00069 0.539
MOD_ProDKin_1 422 428 PF00069 0.503
MOD_ProDKin_1 480 486 PF00069 0.529
MOD_ProDKin_1 516 522 PF00069 0.518
MOD_SUMO_for_1 249 252 PF00179 0.207
TRG_ENDOCYTIC_2 196 199 PF00928 0.304
TRG_ENDOCYTIC_2 222 225 PF00928 0.273
TRG_ENDOCYTIC_2 29 32 PF00928 0.257
TRG_ENDOCYTIC_2 385 388 PF00928 0.526
TRG_ENDOCYTIC_2 4 7 PF00928 0.344
TRG_ENDOCYTIC_2 528 531 PF00928 0.534
TRG_ER_diArg_1 260 263 PF00400 0.261
TRG_ER_diArg_1 501 503 PF00400 0.565
TRG_ER_diArg_1 552 555 PF00400 0.523
TRG_NES_CRM1_1 106 119 PF08389 0.249
TRG_NES_CRM1_1 209 223 PF08389 0.228
TRG_NES_CRM1_1 232 244 PF08389 0.253

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHM7 Leptomonas seymouri 53% 94%
A0A0S4JIJ6 Bodo saltans 30% 98%
A0A3Q8IB74 Leishmania donovani 25% 100%
A0A3Q8IC87 Leishmania donovani 29% 100%
A0A3Q8IFK8 Leishmania donovani 36% 100%
A0A3Q8IIG1 Leishmania donovani 30% 100%
A0A3Q8IIH5 Leishmania donovani 91% 100%
A0A3Q8INQ4 Leishmania donovani 28% 100%
A0A3S5H789 Leishmania donovani 23% 100%
A0A3S7X2W3 Leishmania donovani 28% 100%
A0A3S7X7Y2 Leishmania donovani 28% 100%
A4H7W1 Leishmania braziliensis 77% 100%
A4H9X5 Leishmania braziliensis 23% 100%
A4HAS1 Leishmania braziliensis 29% 100%
A4HCD7 Leishmania braziliensis 28% 100%
A4HED7 Leishmania braziliensis 28% 100%
A4HH03 Leishmania braziliensis 32% 100%
A4HHN1 Leishmania braziliensis 27% 100%
A4HW88 Leishmania infantum 91% 100%
A4HYX6 Leishmania infantum 23% 100%
A4HZV1 Leishmania infantum 29% 100%
A4I1T4 Leishmania infantum 28% 100%
A4I435 Leishmania infantum 30% 100%
A4I4U6 Leishmania infantum 28% 100%
A4I7A1 Leishmania infantum 36% 100%
A4I9Y5 Leishmania infantum 28% 100%
E9AGS0 Leishmania infantum 25% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ARW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q2Z2 Leishmania major 28% 100%
Q4Q3K6 Leishmania major 25% 100%
Q4Q5W2 Leishmania major 37% 100%
Q4Q7W2 Leishmania major 31% 100%
Q4Q9K2 Leishmania major 28% 100%
Q4QBR6 Leishmania major 29% 100%
Q4QCR3 Leishmania major 23% 100%
Q4QDK3 Leishmania major 25% 100%
Q4QFJ2 Leishmania major 91% 100%
Q9Y077 Leishmania major 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS