Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APY8_LEIMU

TriTrypDb:

LmxM.14.1395

Length:

148


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

E9APY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APY8


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.402
CLV_PCSK_KEX2_1	3	5	PF00082	0.402
CLV_PCSK_SKI1_1	3	7	PF00082	0.408
CLV_PCSK_SKI1_1	47	51	PF00082	0.391
DEG_MDM2_SWIB_1	119	126	PF02201	0.204
DEG_Nend_Nbox_1	1	3	PF02207	0.601
DEG_ODPH_VHL_1	133	145	PF01847	0.335
DOC_MAPK_gen_1	3	9	PF00069	0.677
DOC_USP7_MATH_1	11	15	PF00917	0.538
DOC_USP7_MATH_1	74	78	PF00917	0.535
LIG_14-3-3_CanoR_1	3	8	PF00244	0.637
LIG_14-3-3_CanoR_1	56	63	PF00244	0.587
LIG_BRCT_BRCA1_1	34	38	PF00533	0.506
LIG_deltaCOP1_diTrp_1	33	38	PF00928	0.553
LIG_FHA_1	4	10	PF00498	0.655
LIG_FHA_1	76	82	PF00498	0.526
LIG_FHA_2	28	34	PF00498	0.588
LIG_LIR_Gen_1	31	42	PF02991	0.660
LIG_LIR_Nem_3	31	37	PF02991	0.651
LIG_Pex14_1	34	38	PF04695	0.551
LIG_Pex14_1	97	101	PF04695	0.271
LIG_Pex14_2	119	123	PF04695	0.271
LIG_Pex14_2	67	71	PF04695	0.548
LIG_Pex14_2	93	97	PF04695	0.404
LIG_SH2_CRK	101	105	PF00017	0.314
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.533
LIG_SUMO_SIM_par_1	87	94	PF11976	0.404
LIG_TYR_ITIM	120	125	PF00017	0.349
MOD_CK1_1	54	60	PF00069	0.671
MOD_CK1_1	77	83	PF00069	0.533
MOD_GlcNHglycan	11	14	PF01048	0.452
MOD_GlcNHglycan	110	113	PF01048	0.594
MOD_GlcNHglycan	15	18	PF01048	0.404
MOD_GlcNHglycan	58	61	PF01048	0.380
MOD_GlcNHglycan	86	89	PF01048	0.317
MOD_GSK3_1	23	30	PF00069	0.656
MOD_GSK3_1	9	16	PF00069	0.642
MOD_PIKK_1	32	38	PF00454	0.631
MOD_PKA_1	3	9	PF00069	0.677
MOD_PKA_2	3	9	PF00069	0.677
MOD_Plk_1	32	38	PF00069	0.597
MOD_Plk_1	74	80	PF00069	0.542
MOD_Plk_4	133	139	PF00069	0.377
MOD_Plk_4	77	83	PF00069	0.519
TRG_ENDOCYTIC_2	101	104	PF00928	0.289
TRG_ENDOCYTIC_2	122	125	PF00928	0.314
TRG_ER_diArg_1	2	4	PF00400	0.611


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B8	Leptomonas seymouri	78%	100%
A0A1X0NP05	Trypanosomatidae	63%	97%
A0A3R7KDD1	Trypanosoma rangeli	55%	98%
A0A3S7WT76	Leishmania donovani	92%	100%
A4H7W0	Leishmania braziliensis	92%	100%
A4HW86	Leishmania infantum	92%	100%
C9ZSS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
Q4QFJ4	Leishmania major	93%	100%
V5BG05	Trypanosoma cruzi	58%	98%