GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania mexicana

UniProt:

E9APY7_LEIMU

TriTrypDb:

LmxM.14.1390

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9APY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APY7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.308
CLV_NRD_NRD_1	140	142	PF00675	0.544
CLV_NRD_NRD_1	206	208	PF00675	0.389
CLV_PCSK_KEX2_1	131	133	PF00082	0.482
CLV_PCSK_KEX2_1	206	208	PF00082	0.394
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.482
CLV_PCSK_SKI1_1	119	123	PF00082	0.490
CLV_PCSK_SKI1_1	142	146	PF00082	0.459
CLV_PCSK_SKI1_1	174	178	PF00082	0.472
DEG_Nend_UBRbox_1	1	4	PF02207	0.557
DOC_MAPK_gen_1	119	127	PF00069	0.273
DOC_MAPK_MEF2A_6	119	127	PF00069	0.257
DOC_MAPK_MEF2A_6	174	183	PF00069	0.308
DOC_PP1_RVXF_1	92	98	PF00149	0.244
LIG_14-3-3_CanoR_1	206	211	PF00244	0.626
LIG_APCC_ABBA_1	152	157	PF00400	0.255
LIG_deltaCOP1_diTrp_1	170	176	PF00928	0.344
LIG_FHA_1	178	184	PF00498	0.279
LIG_FHA_1	33	39	PF00498	0.291
LIG_FHA_2	143	149	PF00498	0.308
LIG_HCF-1_HBM_1	104	107	PF13415	0.344
LIG_LIR_Gen_1	173	184	PF02991	0.344
LIG_LIR_Gen_1	57	66	PF02991	0.327
LIG_LIR_Gen_1	68	76	PF02991	0.353
LIG_LIR_Nem_3	173	179	PF02991	0.346
LIG_LIR_Nem_3	51	56	PF02991	0.313
LIG_LIR_Nem_3	66	72	PF02991	0.221
LIG_NRP_CendR_1	220	221	PF00754	0.480
LIG_Pex14_2	9	13	PF04695	0.384
LIG_PTB_Apo_2	108	115	PF02174	0.255
LIG_PTB_Phospho_1	108	114	PF10480	0.255
LIG_SH2_STAP1	82	86	PF00017	0.344
LIG_SH2_STAT5	107	110	PF00017	0.286
LIG_SH2_STAT5	203	206	PF00017	0.496
LIG_SH2_STAT5	96	99	PF00017	0.312
LIG_SUMO_SIM_par_1	197	202	PF11976	0.299
LIG_UBA3_1	159	164	PF00899	0.344
MOD_GlcNHglycan	113	117	PF01048	0.484
MOD_NEK2_1	199	204	PF00069	0.352
MOD_NEK2_1	214	219	PF00069	0.658
MOD_NEK2_2	126	131	PF00069	0.281
MOD_PKA_1	206	212	PF00069	0.664
MOD_PKA_2	206	212	PF00069	0.632
MOD_SUMO_for_1	101	104	PF00179	0.164
MOD_SUMO_for_1	121	124	PF00179	0.344
MOD_SUMO_rev_2	113	121	PF00179	0.317
TRG_ENDOCYTIC_2	53	56	PF00928	0.275
TRG_ENDOCYTIC_2	60	63	PF00928	0.233
TRG_ER_diArg_1	205	207	PF00400	0.552
TRG_NES_CRM1_1	173	186	PF08389	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ0	Leptomonas seymouri	78%	100%
A0A0S4JYK0	Bodo saltans	25%	100%
A0A1X0NPX7	Trypanosomatidae	50%	100%
A0A3Q8IC43	Leishmania donovani	94%	100%
A0A422NFM3	Trypanosoma rangeli	49%	98%
A4H7V9	Leishmania braziliensis	89%	100%
A4HW85	Leishmania infantum	94%	100%
C9ZST1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
Q4QFJ5	Leishmania major	94%	100%
V5BKG3	Trypanosoma cruzi	48%	98%