COMM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APY6_LEIMU

TriTrypDb:

LmxM.14.1380

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.632
CLV_NRD_NRD_1	167	169	PF00675	0.555
CLV_NRD_NRD_1	188	190	PF00675	0.509
CLV_NRD_NRD_1	310	312	PF00675	0.550
CLV_PCSK_KEX2_1	105	107	PF00082	0.509
CLV_PCSK_KEX2_1	167	169	PF00082	0.497
CLV_PCSK_KEX2_1	188	190	PF00082	0.509
CLV_PCSK_KEX2_1	310	312	PF00082	0.550
CLV_PCSK_PC7_1	163	169	PF00082	0.480
CLV_PCSK_SKI1_1	125	129	PF00082	0.629
CLV_PCSK_SKI1_1	311	315	PF00082	0.432
CLV_PCSK_SKI1_1	84	88	PF00082	0.490
CLV_PCSK_SKI1_1	99	103	PF00082	0.474
CLV_Separin_Metazoa	205	209	PF03568	0.561
DEG_APCC_DBOX_1	292	300	PF00400	0.415
DEG_Nend_UBRbox_2	1	3	PF02207	0.515
DOC_CYCLIN_RxL_1	78	91	PF00134	0.465
DOC_CYCLIN_RxL_1	96	104	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.509
DOC_MAPK_RevD_3	155	168	PF00069	0.513
DOC_PP1_RVXF_1	176	183	PF00149	0.557
DOC_PP4_FxxP_1	155	158	PF00568	0.546
DOC_SPAK_OSR1_1	154	158	PF12202	0.502
DOC_USP7_MATH_1	172	176	PF00917	0.533
DOC_USP7_MATH_1	25	29	PF00917	0.397
DOC_WW_Pin1_4	277	282	PF00397	0.559
LIG_14-3-3_CanoR_1	167	173	PF00244	0.631
LIG_14-3-3_CanoR_1	216	221	PF00244	0.504
LIG_14-3-3_CanoR_1	232	240	PF00244	0.439
LIG_14-3-3_CanoR_1	247	251	PF00244	0.392
LIG_14-3-3_CanoR_1	274	279	PF00244	0.517
LIG_14-3-3_CanoR_1	82	87	PF00244	0.445
LIG_Actin_WH2_2	141	156	PF00022	0.409
LIG_Actin_WH2_2	158	176	PF00022	0.446
LIG_FHA_1	102	108	PF00498	0.486
LIG_FHA_1	159	165	PF00498	0.473
LIG_FHA_1	215	221	PF00498	0.520
LIG_FHA_1	232	238	PF00498	0.464
LIG_FHA_1	75	81	PF00498	0.379
LIG_FHA_2	217	223	PF00498	0.773
LIG_FHA_2	83	89	PF00498	0.504
LIG_LIR_Gen_1	108	117	PF02991	0.693
LIG_LIR_Gen_1	295	304	PF02991	0.457
LIG_LIR_Gen_1	38	48	PF02991	0.413
LIG_LIR_Gen_1	58	69	PF02991	0.450
LIG_LIR_Nem_3	108	112	PF02991	0.642
LIG_LIR_Nem_3	161	165	PF02991	0.520
LIG_LIR_Nem_3	20	26	PF02991	0.461
LIG_LIR_Nem_3	295	300	PF02991	0.457
LIG_LIR_Nem_3	38	43	PF02991	0.436
LIG_LIR_Nem_3	58	64	PF02991	0.434
LIG_LIR_Nem_3	85	90	PF02991	0.578
LIG_NRBOX	123	129	PF00104	0.531
LIG_NRBOX	97	103	PF00104	0.511
LIG_SH2_CRK	109	113	PF00017	0.534
LIG_SH2_STAT5	109	112	PF00017	0.707
LIG_SH2_STAT5	42	45	PF00017	0.327
LIG_SH3_3	126	132	PF00018	0.507
LIG_SH3_3	154	160	PF00018	0.546
LIG_SH3_3	200	206	PF00018	0.603
LIG_SH3_3	298	304	PF00018	0.558
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.513
LIG_SUMO_SIM_par_1	130	136	PF11976	0.575
LIG_TYR_ITIM	107	112	PF00017	0.527
LIG_WRC_WIRS_1	159	164	PF05994	0.482
MOD_CDK_SPK_2	277	282	PF00069	0.464
MOD_CK1_1	273	279	PF00069	0.543
MOD_CK1_1	28	34	PF00069	0.505
MOD_CK1_1	280	286	PF00069	0.511
MOD_CK2_1	110	116	PF00069	0.472
MOD_CK2_1	216	222	PF00069	0.555
MOD_CK2_1	82	88	PF00069	0.497
MOD_GlcNHglycan	168	171	PF01048	0.585
MOD_GlcNHglycan	174	177	PF01048	0.618
MOD_GlcNHglycan	237	240	PF01048	0.469
MOD_GlcNHglycan	282	285	PF01048	0.569
MOD_GlcNHglycan	69	72	PF01048	0.483
MOD_GSK3_1	231	238	PF00069	0.577
MOD_GSK3_1	270	277	PF00069	0.532
MOD_N-GLC_1	110	115	PF02516	0.504
MOD_NEK2_1	101	106	PF00069	0.482
MOD_NEK2_1	26	31	PF00069	0.486
MOD_NEK2_1	265	270	PF00069	0.518
MOD_NEK2_1	74	79	PF00069	0.374
MOD_PKA_2	166	172	PF00069	0.534
MOD_PKA_2	231	237	PF00069	0.547
MOD_PKA_2	246	252	PF00069	0.400
MOD_PKA_2	273	279	PF00069	0.515
MOD_PKA_2	67	73	PF00069	0.475
MOD_Plk_1	110	116	PF00069	0.479
MOD_Plk_1	38	44	PF00069	0.447
MOD_ProDKin_1	277	283	PF00069	0.550
MOD_SUMO_rev_2	113	120	PF00179	0.386
TRG_AP2beta_CARGO_1	58	68	PF09066	0.449
TRG_DiLeu_BaEn_4	38	44	PF01217	0.425
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.504
TRG_ENDOCYTIC_2	109	112	PF00928	0.707
TRG_ENDOCYTIC_2	297	300	PF00928	0.454
TRG_ER_diArg_1	105	107	PF00400	0.514
TRG_ER_diArg_1	166	168	PF00400	0.495
TRG_ER_diArg_1	188	190	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	178	183	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q5	Leptomonas seymouri	41%	76%
A0A3Q8I8Y2	Leishmania donovani	85%	100%
A4H7V8	Leishmania braziliensis	69%	100%
A4HW84	Leishmania infantum	86%	100%
Q4QFJ6	Leishmania major	88%	100%