Inositol-3-phosphate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myo-inositol-1-phosphate synthase

Species:

Leishmania mexicana

UniProt:

E9APY4_LEIMU

TriTrypDb:

LmxM.14.1360

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APY4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006020	inositol metabolic process	4	11
GO:0006021	inositol biosynthetic process	5	11
GO:0006066	alcohol metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016051	carbohydrate biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0034637	obsolete cellular carbohydrate biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044262	obsolete cellular carbohydrate metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004512	inositol-3-phosphate synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016872	intramolecular lyase activity	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.536
CLV_NRD_NRD_1	150	152	PF00675	0.318
CLV_NRD_NRD_1	206	208	PF00675	0.319
CLV_NRD_NRD_1	30	32	PF00675	0.459
CLV_NRD_NRD_1	375	377	PF00675	0.319
CLV_PCSK_FUR_1	28	32	PF00082	0.456
CLV_PCSK_KEX2_1	150	152	PF00082	0.318
CLV_PCSK_KEX2_1	252	254	PF00082	0.318
CLV_PCSK_KEX2_1	30	32	PF00082	0.459
CLV_PCSK_KEX2_1	394	396	PF00082	0.304
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.318
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.304
CLV_PCSK_SKI1_1	211	215	PF00082	0.318
CLV_PCSK_SKI1_1	293	297	PF00082	0.441
CLV_PCSK_SKI1_1	312	316	PF00082	0.249
CLV_PCSK_SKI1_1	352	356	PF00082	0.304
CLV_PCSK_SKI1_1	394	398	PF00082	0.385
CLV_PCSK_SKI1_1	45	49	PF00082	0.534
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.560
DOC_MAPK_DCC_7	49	59	PF00069	0.523
DOC_MAPK_gen_1	150	157	PF00069	0.518
DOC_MAPK_gen_1	310	318	PF00069	0.548
DOC_MAPK_gen_1	376	384	PF00069	0.519
DOC_MAPK_gen_1	49	59	PF00069	0.414
DOC_MAPK_MEF2A_6	112	121	PF00069	0.585
DOC_MAPK_MEF2A_6	150	159	PF00069	0.505
DOC_MAPK_MEF2A_6	52	61	PF00069	0.515
DOC_PP1_RVXF_1	43	49	PF00149	0.501
DOC_PP2B_LxvP_1	423	426	PF13499	0.535
DOC_PP2B_LxvP_1	449	452	PF13499	0.480
DOC_PP2B_LxvP_1	471	474	PF13499	0.504
DOC_USP7_MATH_1	17	21	PF00917	0.345
DOC_USP7_MATH_1	504	508	PF00917	0.391
DOC_USP7_UBL2_3	214	218	PF12436	0.480
DOC_USP7_UBL2_3	352	356	PF12436	0.504
DOC_USP7_UBL2_3	80	84	PF12436	0.496
DOC_WW_Pin1_4	126	131	PF00397	0.599
DOC_WW_Pin1_4	450	455	PF00397	0.635
DOC_WW_Pin1_4	477	482	PF00397	0.504
LIG_14-3-3_CanoR_1	232	240	PF00244	0.518
LIG_14-3-3_CanoR_1	30	39	PF00244	0.635
LIG_Actin_WH2_2	107	124	PF00022	0.439
LIG_BIR_III_4	201	205	PF00653	0.433
LIG_BRCT_BRCA1_1	367	371	PF00533	0.539
LIG_FHA_1	103	109	PF00498	0.519
LIG_FHA_1	24	30	PF00498	0.494
LIG_FHA_1	34	40	PF00498	0.559
LIG_FHA_1	399	405	PF00498	0.518
LIG_FHA_1	409	415	PF00498	0.487
LIG_FHA_1	478	484	PF00498	0.508
LIG_FHA_1	71	77	PF00498	0.494
LIG_FHA_2	415	421	PF00498	0.504
LIG_LIR_Gen_1	161	172	PF02991	0.553
LIG_LIR_Gen_1	198	206	PF02991	0.551
LIG_LIR_Gen_1	331	339	PF02991	0.504
LIG_LIR_Gen_1	399	406	PF02991	0.504
LIG_LIR_Gen_1	456	464	PF02991	0.522
LIG_LIR_Nem_3	115	121	PF02991	0.567
LIG_LIR_Nem_3	198	203	PF02991	0.586
LIG_LIR_Nem_3	331	335	PF02991	0.504
LIG_LIR_Nem_3	399	405	PF02991	0.504
LIG_NRBOX	466	472	PF00104	0.504
LIG_Pex14_2	177	181	PF04695	0.504
LIG_Rb_pABgroove_1	16	24	PF01858	0.402
LIG_SH2_NCK_1	264	268	PF00017	0.504
LIG_SH2_SRC	22	25	PF00017	0.489
LIG_SH2_STAP1	13	17	PF00017	0.362
LIG_SH2_STAP1	264	268	PF00017	0.518
LIG_SH2_STAP1	400	404	PF00017	0.509
LIG_SH2_STAT5	13	16	PF00017	0.442
LIG_SH2_STAT5	164	167	PF00017	0.433
LIG_SH2_STAT5	386	389	PF00017	0.531
LIG_SH2_STAT5	400	403	PF00017	0.547
LIG_SH2_STAT5	469	472	PF00017	0.534
LIG_SH2_STAT5	96	99	PF00017	0.496
LIG_SH3_3	114	120	PF00018	0.526
LIG_SH3_3	366	372	PF00018	0.599
LIG_SH3_3	471	477	PF00018	0.504
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.504
LIG_SUMO_SIM_anti_2	430	436	PF11976	0.504
LIG_SUMO_SIM_anti_2	461	468	PF11976	0.504
LIG_SUMO_SIM_par_1	220	227	PF11976	0.504
LIG_SUMO_SIM_par_1	33	40	PF11976	0.466
LIG_SUMO_SIM_par_1	425	430	PF11976	0.504
LIG_SUMO_SIM_par_1	461	468	PF11976	0.522
LIG_UBA3_1	466	472	PF00899	0.339
MOD_CK1_1	306	312	PF00069	0.339
MOD_CK1_1	33	39	PF00069	0.524
MOD_CK1_1	453	459	PF00069	0.452
MOD_CK1_1	465	471	PF00069	0.346
MOD_GlcNHglycan	305	308	PF01048	0.311
MOD_GlcNHglycan	312	315	PF01048	0.347
MOD_GlcNHglycan	92	95	PF01048	0.488
MOD_GSK3_1	227	234	PF00069	0.379
MOD_GSK3_1	306	313	PF00069	0.342
MOD_GSK3_1	348	355	PF00069	0.370
MOD_GSK3_1	414	421	PF00069	0.339
MOD_GSK3_1	439	446	PF00069	0.439
MOD_GSK3_1	98	105	PF00069	0.324
MOD_N-GLC_1	253	258	PF02516	0.472
MOD_N-GLC_1	341	346	PF02516	0.417
MOD_N-GLC_1	67	72	PF02516	0.324
MOD_N-GLC_2	416	418	PF02516	0.339
MOD_NEK2_1	363	368	PF00069	0.382
MOD_NEK2_2	17	22	PF00069	0.323
MOD_NEK2_2	400	405	PF00069	0.339
MOD_PIKK_1	193	199	PF00454	0.240
MOD_PIKK_1	98	104	PF00454	0.324
MOD_PK_1	365	371	PF00069	0.283
MOD_PKA_1	30	36	PF00069	0.575
MOD_PKA_2	231	237	PF00069	0.358
MOD_PKA_2	30	36	PF00069	0.560
MOD_PKA_2	439	445	PF00069	0.382
MOD_PKB_1	28	36	PF00069	0.467
MOD_Plk_1	398	404	PF00069	0.339
MOD_Plk_1	418	424	PF00069	0.444
MOD_Plk_4	17	23	PF00069	0.416
MOD_Plk_4	259	265	PF00069	0.392
MOD_Plk_4	271	277	PF00069	0.300
MOD_Plk_4	365	371	PF00069	0.330
MOD_Plk_4	408	414	PF00069	0.339
MOD_Plk_4	418	424	PF00069	0.339
MOD_Plk_4	459	465	PF00069	0.369
MOD_ProDKin_1	126	132	PF00069	0.472
MOD_ProDKin_1	450	456	PF00069	0.522
MOD_ProDKin_1	477	483	PF00069	0.339
MOD_SUMO_for_1	324	327	PF00179	0.339
MOD_SUMO_rev_2	209	216	PF00179	0.551
MOD_SUMO_rev_2	290	298	PF00179	0.400
MOD_SUMO_rev_2	302	306	PF00179	0.297
MOD_SUMO_rev_2	446	452	PF00179	0.240
TRG_DiLeu_BaEn_2	270	276	PF01217	0.472
TRG_DiLeu_BaEn_2	293	299	PF01217	0.360
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.357
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.339
TRG_ENDOCYTIC_2	164	167	PF00928	0.407
TRG_ENDOCYTIC_2	332	335	PF00928	0.364
TRG_ER_diArg_1	149	151	PF00400	0.358
TRG_ER_diArg_1	28	31	PF00400	0.464
TRG_ER_diArg_1	85	88	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I042	Leptomonas seymouri	82%	100%
A0A0S4JLI5	Bodo saltans	67%	100%
A0A1X0P7U4	Trypanosomatidae	72%	99%
A0A3R7LTQ6	Trypanosoma rangeli	68%	100%
A0A3S5H6T1	Leishmania donovani	93%	100%
A4H7V6	Leishmania braziliensis	83%	100%
A4HW82	Leishmania infantum	94%	100%
O64437	Oryza sativa subsp. japonica	57%	100%
O65195	Hordeum vulgare	57%	100%
O97477	Drosophila melanogaster	57%	93%
P11986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	99%
P42800	Candida albicans (strain SC5314 / ATCC MYA-2876)	50%	100%
P42801	Arabidopsis thaliana	56%	100%
P42802	Citrus paradisi	55%	100%
P42803	Spirodela polyrhiza	57%	100%
Q2NL29	Bos taurus	58%	94%
Q38862	Arabidopsis thaliana	57%	100%
Q40271	Mesembryanthemum crystallinum	56%	100%
Q41107	Phaseolus vulgaris	56%	100%
Q4QFJ8	Leishmania major	93%	100%
Q4R6E3	Macaca fascicularis	58%	94%
Q54N49	Dictyostelium discoideum	57%	100%
Q6AYK3	Rattus norvegicus	57%	94%
Q6DDT1	Xenopus laevis	56%	93%
Q6FQI1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	51%	98%
Q7ZXY0	Xenopus laevis	56%	93%
Q8A7J8	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	32%	100%
Q8I3Y8	Plasmodium falciparum (isolate 3D7)	36%	87%
Q8S5N2	Oryza sativa subsp. japonica	57%	100%
Q96348	Brassica napus	57%	100%
Q9FPK7	Zea mays	57%	100%
Q9FYV1	Sesamum indicum	58%	100%
Q9JHU9	Mus musculus	58%	94%
Q9LW96	Nicotiana tabacum	57%	100%
Q9LX12	Arabidopsis thaliana	56%	100%
Q9NPH2	Homo sapiens	58%	94%
Q9S7U0	Triticum aestivum	58%	100%
Q9SSV4	Nicotiana paniculata	57%	100%
V5B836	Trypanosoma cruzi	71%	99%