Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APY3_LEIMU

TriTrypDb:

LmxM.14.1350

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005868	cytoplasmic dynein complex	4	4
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	4
GO:0030286	dynein complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4
GO:1902494	catalytic complex	2	4

Expansion

Sequence features

E9APY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APY3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.763
CLV_C14_Caspase3-7	212	216	PF00656	0.717
CLV_C14_Caspase3-7	565	569	PF00656	0.703
CLV_MEL_PAP_1	469	475	PF00089	0.617
CLV_NRD_NRD_1	102	104	PF00675	0.453
CLV_NRD_NRD_1	237	239	PF00675	0.502
CLV_NRD_NRD_1	308	310	PF00675	0.498
CLV_NRD_NRD_1	85	87	PF00675	0.470
CLV_PCSK_KEX2_1	102	104	PF00082	0.460
CLV_PCSK_KEX2_1	237	239	PF00082	0.502
CLV_PCSK_KEX2_1	308	310	PF00082	0.498
CLV_PCSK_KEX2_1	85	87	PF00082	0.471
CLV_PCSK_KEX2_1	97	99	PF00082	0.445
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.457
CLV_PCSK_PC7_1	98	104	PF00082	0.535
CLV_PCSK_SKI1_1	39	43	PF00082	0.507
CLV_PCSK_SKI1_1	463	467	PF00082	0.507
CLV_PCSK_SKI1_1	86	90	PF00082	0.538
DEG_APCC_DBOX_1	443	451	PF00400	0.501
DEG_APCC_DBOX_1	462	470	PF00400	0.275
DEG_SPOP_SBC_1	10	14	PF00917	0.515
DEG_SPOP_SBC_1	351	355	PF00917	0.567
DEG_SPOP_SBC_1	547	551	PF00917	0.353
DOC_CKS1_1	228	233	PF01111	0.670
DOC_CKS1_1	578	583	PF01111	0.674
DOC_CYCLIN_RxL_1	408	418	PF00134	0.548
DOC_CYCLIN_RxL_1	97	109	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.503
DOC_MAPK_gen_1	39	47	PF00069	0.712
DOC_MAPK_gen_1	441	450	PF00069	0.520
DOC_MAPK_gen_1	82	90	PF00069	0.428
DOC_MAPK_HePTP_8	426	438	PF00069	0.507
DOC_MAPK_MEF2A_6	359	367	PF00069	0.686
DOC_MAPK_MEF2A_6	429	438	PF00069	0.507
DOC_PP1_RVXF_1	100	107	PF00149	0.532
DOC_PP2B_LxvP_1	430	433	PF13499	0.574
DOC_PP2B_LxvP_1	70	73	PF13499	0.674
DOC_PP4_FxxP_1	367	370	PF00568	0.624
DOC_PP4_FxxP_1	382	385	PF00568	0.606
DOC_PP4_FxxP_1	41	44	PF00568	0.502
DOC_USP7_MATH_1	118	122	PF00917	0.570
DOC_USP7_MATH_1	164	168	PF00917	0.678
DOC_USP7_MATH_1	2	6	PF00917	0.782
DOC_USP7_MATH_1	335	339	PF00917	0.629
DOC_USP7_MATH_1	350	354	PF00917	0.571
DOC_USP7_MATH_1	46	50	PF00917	0.705
DOC_USP7_MATH_1	468	472	PF00917	0.452
DOC_USP7_MATH_1	511	515	PF00917	0.592
DOC_USP7_MATH_1	9	13	PF00917	0.745
DOC_WW_Pin1_4	227	232	PF00397	0.669
DOC_WW_Pin1_4	31	36	PF00397	0.764
DOC_WW_Pin1_4	559	564	PF00397	0.789
DOC_WW_Pin1_4	577	582	PF00397	0.612
LIG_14-3-3_CanoR_1	173	179	PF00244	0.776
LIG_14-3-3_CanoR_1	222	229	PF00244	0.752
LIG_14-3-3_CanoR_1	237	243	PF00244	0.363
LIG_14-3-3_CanoR_1	383	391	PF00244	0.630
LIG_14-3-3_CanoR_1	444	448	PF00244	0.531
LIG_14-3-3_CanoR_1	472	476	PF00244	0.616
LIG_14-3-3_CanoR_1	521	529	PF00244	0.533
LIG_14-3-3_CanoR_1	572	581	PF00244	0.681
LIG_Actin_WH2_2	423	439	PF00022	0.584
LIG_BRCT_BRCA1_1	223	227	PF00533	0.751
LIG_BRCT_BRCA1_1	353	357	PF00533	0.670
LIG_BRCT_BRCA1_1	378	382	PF00533	0.571
LIG_BRCT_BRCA1_2	353	359	PF00533	0.580
LIG_Clathr_ClatBox_1	267	271	PF01394	0.392
LIG_EH_1	490	494	PF12763	0.521
LIG_eIF4E_1	260	266	PF01652	0.360
LIG_eIF4E_1	484	490	PF01652	0.641
LIG_EVH1_2	37	41	PF00568	0.499
LIG_FHA_1	223	229	PF00498	0.658
LIG_FHA_1	343	349	PF00498	0.567
LIG_FHA_2	399	405	PF00498	0.408
LIG_FHA_2	559	565	PF00498	0.772
LIG_FHA_2	571	577	PF00498	0.692
LIG_LIR_Apic_2	364	370	PF02991	0.636
LIG_LIR_Apic_2	379	385	PF02991	0.613
LIG_LIR_Apic_2	40	44	PF02991	0.504
LIG_LIR_Gen_1	283	294	PF02991	0.511
LIG_LIR_Nem_3	283	289	PF02991	0.508
LIG_PTB_Apo_2	488	495	PF02174	0.547
LIG_PTB_Phospho_1	488	494	PF10480	0.549
LIG_SH2_CRK	194	198	PF00017	0.589
LIG_SH2_GRB2like	484	487	PF00017	0.711
LIG_SH2_SRC	194	197	PF00017	0.598
LIG_SH2_SRC	260	263	PF00017	0.376
LIG_SH2_SRC	484	487	PF00017	0.711
LIG_SH2_STAP1	194	198	PF00017	0.589
LIG_SH2_STAP1	484	488	PF00017	0.671
LIG_SH2_STAT3	196	199	PF00017	0.603
LIG_SH2_STAT3	591	594	PF00017	0.567
LIG_SH2_STAT5	196	199	PF00017	0.588
LIG_SH2_STAT5	260	263	PF00017	0.472
LIG_SH2_STAT5	284	287	PF00017	0.418
LIG_SH2_STAT5	292	295	PF00017	0.384
LIG_SH2_STAT5	500	503	PF00017	0.365
LIG_SH2_STAT5	591	594	PF00017	0.541
LIG_SH3_3	32	38	PF00018	0.755
LIG_SH3_3	552	558	PF00018	0.666
LIG_SH3_3	575	581	PF00018	0.687
LIG_SH3_5	256	260	PF00018	0.395
LIG_SUMO_SIM_anti_2	262	269	PF11976	0.381
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.433
LIG_SUMO_SIM_par_1	265	271	PF11976	0.390
LIG_TRAF2_1	315	318	PF00917	0.536
LIG_TRAF2_1	608	611	PF00917	0.702
LIG_TYR_ITIM	192	197	PF00017	0.598
LIG_WW_3	36	40	PF00397	0.730
MOD_CK1_1	187	193	PF00069	0.657
MOD_CK1_1	273	279	PF00069	0.516
MOD_CK1_1	31	37	PF00069	0.761
MOD_CK1_1	336	342	PF00069	0.660
MOD_CK1_1	353	359	PF00069	0.622
MOD_CK1_1	387	393	PF00069	0.564
MOD_CK1_1	443	449	PF00069	0.468
MOD_CK1_1	471	477	PF00069	0.584
MOD_CK1_1	514	520	PF00069	0.582
MOD_CK1_1	559	565	PF00069	0.790
MOD_CK1_1	577	583	PF00069	0.486
MOD_CK1_1	77	83	PF00069	0.650
MOD_CK2_1	118	124	PF00069	0.506
MOD_CK2_1	284	290	PF00069	0.523
MOD_CK2_1	398	404	PF00069	0.479
MOD_CK2_1	547	553	PF00069	0.570
MOD_CK2_1	558	564	PF00069	0.777
MOD_CK2_1	570	576	PF00069	0.681
MOD_CK2_1	605	611	PF00069	0.741
MOD_Cter_Amidation	95	98	PF01082	0.427
MOD_GlcNHglycan	120	123	PF01048	0.775
MOD_GlcNHglycan	166	169	PF01048	0.702
MOD_GlcNHglycan	189	192	PF01048	0.656
MOD_GlcNHglycan	20	25	PF01048	0.720
MOD_GlcNHglycan	211	214	PF01048	0.666
MOD_GlcNHglycan	215	218	PF01048	0.662
MOD_GlcNHglycan	262	265	PF01048	0.545
MOD_GlcNHglycan	335	338	PF01048	0.659
MOD_GlcNHglycan	340	343	PF01048	0.687
MOD_GlcNHglycan	386	389	PF01048	0.602
MOD_GlcNHglycan	417	420	PF01048	0.576
MOD_GlcNHglycan	486	489	PF01048	0.629
MOD_GlcNHglycan	523	526	PF01048	0.441
MOD_GlcNHglycan	550	553	PF01048	0.520
MOD_GlcNHglycan	601	604	PF01048	0.685
MOD_GlcNHglycan	94	97	PF01048	0.467
MOD_GSK3_1	209	216	PF00069	0.663
MOD_GSK3_1	217	224	PF00069	0.683
MOD_GSK3_1	232	239	PF00069	0.509
MOD_GSK3_1	25	32	PF00069	0.805
MOD_GSK3_1	270	277	PF00069	0.497
MOD_GSK3_1	284	291	PF00069	0.475
MOD_GSK3_1	329	336	PF00069	0.595
MOD_GSK3_1	338	345	PF00069	0.692
MOD_GSK3_1	346	353	PF00069	0.708
MOD_GSK3_1	413	420	PF00069	0.551
MOD_GSK3_1	559	566	PF00069	0.726
MOD_GSK3_1	570	577	PF00069	0.656
MOD_GSK3_1	77	84	PF00069	0.675
MOD_GSK3_1	92	99	PF00069	0.375
MOD_N-GLC_1	377	382	PF02516	0.641
MOD_N-GLC_1	511	516	PF02516	0.616
MOD_NEK2_1	232	237	PF00069	0.608
MOD_NEK2_1	296	301	PF00069	0.553
MOD_NEK2_1	415	420	PF00069	0.612
MOD_NEK2_1	440	445	PF00069	0.489
MOD_NEK2_1	546	551	PF00069	0.649
MOD_NEK2_1	599	604	PF00069	0.661
MOD_NEK2_2	583	588	PF00069	0.592
MOD_PIKK_1	217	223	PF00454	0.696
MOD_PIKK_1	3	9	PF00454	0.659
MOD_PIKK_1	377	383	PF00454	0.466
MOD_PIKK_1	449	455	PF00454	0.489
MOD_PIKK_1	46	52	PF00454	0.763
MOD_PIKK_1	77	83	PF00454	0.682
MOD_PKA_1	237	243	PF00069	0.534
MOD_PKA_2	172	178	PF00069	0.686
MOD_PKA_2	221	227	PF00069	0.757
MOD_PKA_2	236	242	PF00069	0.374
MOD_PKA_2	407	413	PF00069	0.510
MOD_PKA_2	440	446	PF00069	0.453
MOD_PKA_2	471	477	PF00069	0.617
MOD_PKA_2	571	577	PF00069	0.698
MOD_PKA_2	81	87	PF00069	0.357
MOD_Plk_1	273	279	PF00069	0.493
MOD_Plk_1	377	383	PF00069	0.593
MOD_Plk_1	511	517	PF00069	0.620
MOD_Plk_4	288	294	PF00069	0.449
MOD_Plk_4	443	449	PF00069	0.419
MOD_Plk_4	566	572	PF00069	0.701
MOD_Plk_4	574	580	PF00069	0.558
MOD_ProDKin_1	227	233	PF00069	0.669
MOD_ProDKin_1	31	37	PF00069	0.761
MOD_ProDKin_1	559	565	PF00069	0.791
MOD_ProDKin_1	577	583	PF00069	0.603
MOD_SUMO_rev_2	318	327	PF00179	0.545
TRG_DiLeu_BaEn_1	422	427	PF01217	0.591
TRG_ENDOCYTIC_2	194	197	PF00928	0.665
TRG_ENDOCYTIC_2	286	289	PF00928	0.373
TRG_ENDOCYTIC_2	494	497	PF00928	0.376
TRG_ER_diArg_1	102	104	PF00400	0.453
TRG_ER_diArg_1	236	238	PF00400	0.510
TRG_ER_diArg_1	307	309	PF00400	0.496
TRG_ER_diArg_1	85	87	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	590	594	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ5	Leptomonas seymouri	56%	100%
A0A1X0NMR8	Trypanosomatidae	27%	100%
A0A3Q8I9X0	Leishmania donovani	92%	100%
A0A422NDE3	Trypanosoma rangeli	28%	87%
A4H7V5	Leishmania braziliensis	75%	100%
A4HW81	Leishmania infantum	92%	100%
D0A9A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QFJ9	Leishmania major	92%	100%
V5BID0	Trypanosoma cruzi	28%	100%