J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APY1_LEIMU

TriTrypDb:

LmxM.14.1330

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.293
CLV_NRD_NRD_1	200	202	PF00675	0.443
CLV_NRD_NRD_1	227	229	PF00675	0.356
CLV_NRD_NRD_1	280	282	PF00675	0.309
CLV_NRD_NRD_1	429	431	PF00675	0.443
CLV_NRD_NRD_1	449	451	PF00675	0.123
CLV_NRD_NRD_1	452	454	PF00675	0.241
CLV_PCSK_FUR_1	225	229	PF00082	0.378
CLV_PCSK_KEX2_1	167	169	PF00082	0.287
CLV_PCSK_KEX2_1	227	229	PF00082	0.382
CLV_PCSK_KEX2_1	280	282	PF00082	0.292
CLV_PCSK_KEX2_1	311	313	PF00082	0.509
CLV_PCSK_KEX2_1	425	427	PF00082	0.447
CLV_PCSK_KEX2_1	449	451	PF00082	0.241
CLV_PCSK_KEX2_1	496	498	PF00082	0.272
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.483
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.410
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.272
CLV_PCSK_SKI1_1	212	216	PF00082	0.461
CLV_PCSK_SKI1_1	246	250	PF00082	0.484
CLV_PCSK_SKI1_1	304	308	PF00082	0.368
CLV_PCSK_SKI1_1	454	458	PF00082	0.390
CLV_PCSK_SKI1_1	467	471	PF00082	0.396
CLV_PCSK_SKI1_1	488	492	PF00082	0.241
CLV_PCSK_SKI1_1	51	55	PF00082	0.328
DEG_APCC_DBOX_1	91	99	PF00400	0.315
DOC_CYCLIN_RxL_1	278	288	PF00134	0.346
DOC_CYCLIN_RxL_1	430	442	PF00134	0.303
DOC_CYCLIN_RxL_1	48	58	PF00134	0.397
DOC_MAPK_gen_1	141	149	PF00069	0.513
DOC_MAPK_gen_1	201	209	PF00069	0.481
DOC_MAPK_gen_1	316	324	PF00069	0.457
DOC_MAPK_MEF2A_6	413	421	PF00069	0.351
DOC_USP7_MATH_1	156	160	PF00917	0.405
DOC_USP7_MATH_1	291	295	PF00917	0.259
DOC_USP7_MATH_1	456	460	PF00917	0.408
DOC_USP7_UBL2_3	151	155	PF12436	0.416
DOC_USP7_UBL2_3	307	311	PF12436	0.461
DOC_USP7_UBL2_3	431	435	PF12436	0.241
DOC_WW_Pin1_4	249	254	PF00397	0.463
DOC_WW_Pin1_4	371	376	PF00397	0.430
LIG_14-3-3_CanoR_1	102	109	PF00244	0.282
LIG_14-3-3_CanoR_1	126	130	PF00244	0.346
LIG_14-3-3_CanoR_1	175	183	PF00244	0.433
LIG_14-3-3_CanoR_1	18	28	PF00244	0.430
LIG_14-3-3_CanoR_1	353	361	PF00244	0.487
LIG_14-3-3_CanoR_1	8	17	PF00244	0.597
LIG_14-3-3_CanoR_1	81	90	PF00244	0.418
LIG_Actin_WH2_2	212	229	PF00022	0.202
LIG_Actin_WH2_2	410	427	PF00022	0.467
LIG_APCC_ABBA_1	113	118	PF00400	0.237
LIG_FHA_1	20	26	PF00498	0.467
LIG_FHA_1	240	246	PF00498	0.382
LIG_FHA_1	47	53	PF00498	0.340
LIG_FHA_1	74	80	PF00498	0.307
LIG_FHA_2	102	108	PF00498	0.214
LIG_FHA_2	374	380	PF00498	0.366
LIG_FHA_2	427	433	PF00498	0.373
LIG_FHA_2	468	474	PF00498	0.303
LIG_LIR_Apic_2	180	186	PF02991	0.412
LIG_LIR_Gen_1	173	182	PF02991	0.422
LIG_LIR_Gen_1	315	326	PF02991	0.413
LIG_LIR_Gen_1	379	389	PF02991	0.184
LIG_LIR_Gen_1	73	83	PF02991	0.335
LIG_LIR_Gen_1	94	103	PF02991	0.468
LIG_LIR_LC3C_4	27	31	PF02991	0.627
LIG_LIR_Nem_3	11	17	PF02991	0.518
LIG_LIR_Nem_3	173	179	PF02991	0.325
LIG_LIR_Nem_3	315	321	PF02991	0.374
LIG_LIR_Nem_3	376	381	PF02991	0.195
LIG_LIR_Nem_3	432	437	PF02991	0.256
LIG_LIR_Nem_3	478	484	PF02991	0.241
LIG_LIR_Nem_3	73	78	PF02991	0.373
LIG_NRBOX	108	114	PF00104	0.293
LIG_NRBOX	24	30	PF00104	0.521
LIG_NRBOX	49	55	PF00104	0.225
LIG_PCNA_yPIPBox_3	126	137	PF02747	0.370
LIG_Pex14_2	518	522	PF04695	0.643
LIG_Pex14_2	526	530	PF04695	0.607
LIG_Pex14_2	534	538	PF04695	0.606
LIG_Pex14_2	542	546	PF04695	0.440
LIG_REV1ctd_RIR_1	561	569	PF16727	0.554
LIG_SH2_CRK	150	154	PF00017	0.510
LIG_SH2_CRK	434	438	PF00017	0.241
LIG_SH2_CRK	452	456	PF00017	0.242
LIG_SH2_CRK	75	79	PF00017	0.370
LIG_SH2_GRB2like	500	503	PF00017	0.413
LIG_SH2_NCK_1	190	194	PF00017	0.498
LIG_SH2_NCK_1	90	94	PF00017	0.291
LIG_SH2_PTP2	381	384	PF00017	0.183
LIG_SH2_SRC	500	503	PF00017	0.413
LIG_SH2_STAP1	172	176	PF00017	0.372
LIG_SH2_STAP1	337	341	PF00017	0.462
LIG_SH2_STAP1	75	79	PF00017	0.275
LIG_SH2_STAT3	247	250	PF00017	0.359
LIG_SH2_STAT3	337	340	PF00017	0.358
LIG_SH2_STAT5	16	19	PF00017	0.530
LIG_SH2_STAT5	172	175	PF00017	0.350
LIG_SH2_STAT5	247	250	PF00017	0.387
LIG_SH2_STAT5	381	384	PF00017	0.232
LIG_SH2_STAT5	75	78	PF00017	0.297
LIG_SH3_3	330	336	PF00018	0.428
LIG_SH3_3	503	509	PF00018	0.474
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.315
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.500
LIG_TRAF2_1	241	244	PF00917	0.332
LIG_TRAF2_1	336	339	PF00917	0.497
LIG_UBA3_1	112	117	PF00899	0.312
LIG_UBA3_1	305	311	PF00899	0.334
LIG_UBA3_1	436	441	PF00899	0.387
MOD_CK1_1	128	134	PF00069	0.337
MOD_CK1_1	218	224	PF00069	0.408
MOD_CK1_1	73	79	PF00069	0.365
MOD_CK2_1	272	278	PF00069	0.441
MOD_CK2_1	467	473	PF00069	0.256
MOD_CK2_1	88	94	PF00069	0.285
MOD_GlcNHglycan	37	40	PF01048	0.502
MOD_GlcNHglycan	443	446	PF01048	0.316
MOD_GSK3_1	156	163	PF00069	0.561
MOD_GSK3_1	170	177	PF00069	0.510
MOD_GSK3_1	463	470	PF00069	0.241
MOD_GSK3_1	73	80	PF00069	0.315
MOD_NEK2_1	125	130	PF00069	0.322
MOD_NEK2_1	2	7	PF00069	0.582
MOD_NEK2_1	24	29	PF00069	0.551
MOD_NEK2_1	272	277	PF00069	0.373
MOD_NEK2_1	424	429	PF00069	0.542
MOD_NEK2_1	439	444	PF00069	0.313
MOD_NEK2_1	455	460	PF00069	0.182
MOD_NEK2_1	517	522	PF00069	0.602
MOD_NEK2_2	291	296	PF00069	0.214
MOD_PIKK_1	128	134	PF00454	0.389
MOD_PIKK_1	181	187	PF00454	0.527
MOD_PIKK_1	239	245	PF00454	0.456
MOD_PIKK_1	246	252	PF00454	0.485
MOD_PKA_2	101	107	PF00069	0.293
MOD_PKA_2	125	131	PF00069	0.326
MOD_PKA_2	174	180	PF00069	0.396
MOD_PKA_2	3	9	PF00069	0.536
MOD_PKA_2	352	358	PF00069	0.357
MOD_Plk_1	215	221	PF00069	0.335
MOD_Plk_1	272	278	PF00069	0.459
MOD_Plk_1	46	52	PF00069	0.355
MOD_Plk_4	108	114	PF00069	0.215
MOD_Plk_4	24	30	PF00069	0.542
MOD_Plk_4	373	379	PF00069	0.446
MOD_Plk_4	94	100	PF00069	0.341
MOD_ProDKin_1	249	255	PF00069	0.460
MOD_ProDKin_1	371	377	PF00069	0.421
MOD_SUMO_for_1	419	422	PF00179	0.417
MOD_SUMO_for_1	83	86	PF00179	0.389
MOD_SUMO_rev_2	138	146	PF00179	0.508
MOD_SUMO_rev_2	310	318	PF00179	0.459
MOD_SUMO_rev_2	406	414	PF00179	0.545
MOD_SUMO_rev_2	483	490	PF00179	0.261
MOD_SUMO_rev_2	493	498	PF00179	0.247
TRG_DiLeu_BaEn_1	205	210	PF01217	0.394
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.345
TRG_ENDOCYTIC_2	150	153	PF00928	0.418
TRG_ENDOCYTIC_2	381	384	PF00928	0.183
TRG_ENDOCYTIC_2	433	436	PF00928	0.241
TRG_ENDOCYTIC_2	452	455	PF00928	0.241
TRG_ENDOCYTIC_2	75	78	PF00928	0.396
TRG_ENDOCYTIC_2	96	99	PF00928	0.487
TRG_ER_diArg_1	166	168	PF00400	0.396
TRG_ER_diArg_1	224	227	PF00400	0.376
TRG_ER_diArg_1	279	281	PF00400	0.304
TRG_ER_diArg_1	448	450	PF00400	0.241
TRG_ER_diArg_1	497	500	PF00400	0.300
TRG_NES_CRM1_1	208	223	PF08389	0.320
TRG_NES_CRM1_1	274	288	PF08389	0.337
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1E2P6	Ustilago maydis (strain 521 / FGSC 9021)	26%	98%
A0A0D2XVZ5	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	28%	100%
A0A0N1PCC0	Leptomonas seymouri	65%	100%
A0A0N1PF59	Leptomonas seymouri	26%	100%
A0A0S4JQ76	Bodo saltans	46%	100%
A0A1X0NP19	Trypanosomatidae	44%	100%
A0A3S7WTD0	Leishmania donovani	93%	100%
A0A422NFP3	Trypanosoma rangeli	46%	100%
A4H7V3	Leishmania braziliensis	85%	100%
A4HW79	Leishmania infantum	93%	99%
C9ZST7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
J9VKM5	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	26%	100%
Q13217	Homo sapiens	28%	100%
Q27968	Bos taurus	27%	100%
Q4QFK1	Leishmania major	91%	99%
Q54M21	Dictyostelium discoideum	26%	100%
Q5R8D8	Pongo abelii	22%	100%
Q5ZI13	Gallus gallus	28%	100%
Q91YW3	Mus musculus	27%	100%
Q99615	Homo sapiens	23%	100%
Q9QYI3	Mus musculus	22%	100%
Q9R0T3	Rattus norvegicus	27%	100%
V5BKH0	Trypanosoma cruzi	48%	100%