Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APX8_LEIMU

TriTrypDb:

LmxM.14.1310 , LmxM.14.1311

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.641
CLV_C14_Caspase3-7	135	139	PF00656	0.685
CLV_MEL_PAP_1	254	260	PF00089	0.441
CLV_NRD_NRD_1	21	23	PF00675	0.552
CLV_NRD_NRD_1	256	258	PF00675	0.479
CLV_NRD_NRD_1	298	300	PF00675	0.582
CLV_NRD_NRD_1	98	100	PF00675	0.549
CLV_PCSK_KEX2_1	20	22	PF00082	0.468
CLV_PCSK_KEX2_1	256	258	PF00082	0.581
CLV_PCSK_KEX2_1	298	300	PF00082	0.587
CLV_PCSK_KEX2_1	98	100	PF00082	0.552
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.439
CLV_PCSK_SKI1_1	125	129	PF00082	0.701
CLV_PCSK_SKI1_1	333	337	PF00082	0.411
CLV_PCSK_SKI1_1	89	93	PF00082	0.531
DEG_COP1_1	285	294	PF00400	0.610
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_CKS1_1	327	332	PF01111	0.541
DOC_MAPK_gen_1	123	132	PF00069	0.415
DOC_MAPK_gen_1	298	306	PF00069	0.403
DOC_MAPK_gen_1	72	81	PF00069	0.434
DOC_MAPK_HePTP_8	204	216	PF00069	0.527
DOC_MAPK_MEF2A_6	207	216	PF00069	0.398
DOC_MAPK_MEF2A_6	298	306	PF00069	0.402
DOC_PP1_MyPhoNE_1	298	305	PF00149	0.461
DOC_PP1_RVXF_1	9	16	PF00149	0.586
DOC_PP2B_LxvP_1	243	246	PF13499	0.465
DOC_PP2B_LxvP_1	358	361	PF13499	0.495
DOC_USP7_MATH_1	121	125	PF00917	0.539
DOC_USP7_MATH_1	149	153	PF00917	0.650
DOC_USP7_MATH_1	164	168	PF00917	0.516
DOC_USP7_MATH_1	187	191	PF00917	0.634
DOC_USP7_MATH_1	231	235	PF00917	0.580
DOC_USP7_MATH_1	239	243	PF00917	0.469
DOC_USP7_MATH_1	317	321	PF00917	0.503
DOC_USP7_MATH_1	38	42	PF00917	0.630
DOC_USP7_MATH_1	52	56	PF00917	0.587
DOC_WW_Pin1_4	145	150	PF00397	0.644
DOC_WW_Pin1_4	217	222	PF00397	0.566
DOC_WW_Pin1_4	323	328	PF00397	0.504
LIG_14-3-3_CanoR_1	107	117	PF00244	0.604
LIG_14-3-3_CanoR_1	174	178	PF00244	0.520
LIG_14-3-3_CanoR_1	197	204	PF00244	0.596
LIG_14-3-3_CanoR_1	280	287	PF00244	0.686
LIG_BRCT_BRCA1_1	156	160	PF00533	0.597
LIG_CaM_IQ_9	248	264	PF13499	0.428
LIG_FHA_1	14	20	PF00498	0.491
LIG_FHA_1	209	215	PF00498	0.394
LIG_FHA_1	273	279	PF00498	0.594
LIG_FHA_2	283	289	PF00498	0.679
LIG_LIR_Nem_3	12	18	PF02991	0.554
LIG_Pex14_2	336	340	PF04695	0.529
LIG_PTAP_UEV_1	165	170	PF05743	0.531
LIG_SH2_STAP1	269	273	PF00017	0.484
LIG_SH2_STAP1	346	350	PF00017	0.441
LIG_SH2_STAT5	18	21	PF00017	0.555
LIG_SH2_STAT5	182	185	PF00017	0.473
LIG_SH3_3	1	7	PF00018	0.536
LIG_SH3_3	137	143	PF00018	0.689
LIG_SH3_3	163	169	PF00018	0.684
LIG_SH3_3	186	192	PF00018	0.567
LIG_SH3_3	324	330	PF00018	0.565
LIG_SH3_3	46	52	PF00018	0.481
LIG_TRAF2_1	293	296	PF00917	0.519
LIG_TRAF2_1	64	67	PF00917	0.457
MOD_CDK_SPxxK_3	326	333	PF00069	0.463
MOD_CK1_1	108	114	PF00069	0.610
MOD_CK1_1	148	154	PF00069	0.634
MOD_CK1_1	156	162	PF00069	0.600
MOD_CK1_1	199	205	PF00069	0.635
MOD_CK1_1	234	240	PF00069	0.514
MOD_CK1_1	283	289	PF00069	0.689
MOD_CK1_1	326	332	PF00069	0.468
MOD_CK1_1	41	47	PF00069	0.601
MOD_CK2_1	234	240	PF00069	0.629
MOD_CK2_1	282	288	PF00069	0.639
MOD_CK2_1	290	296	PF00069	0.708
MOD_CK2_1	307	313	PF00069	0.416
MOD_CK2_1	61	67	PF00069	0.486
MOD_GlcNHglycan	132	135	PF01048	0.645
MOD_GlcNHglycan	166	169	PF01048	0.515
MOD_GlcNHglycan	201	204	PF01048	0.606
MOD_GlcNHglycan	237	240	PF01048	0.463
MOD_GlcNHglycan	292	295	PF01048	0.567
MOD_GlcNHglycan	40	43	PF01048	0.653
MOD_GlcNHglycan	54	57	PF01048	0.595
MOD_GlcNHglycan	63	66	PF01048	0.510
MOD_GlcNHglycan	75	78	PF01048	0.438
MOD_GSK3_1	101	108	PF00069	0.631
MOD_GSK3_1	121	128	PF00069	0.545
MOD_GSK3_1	144	151	PF00069	0.657
MOD_GSK3_1	152	159	PF00069	0.601
MOD_GSK3_1	195	202	PF00069	0.693
MOD_GSK3_1	231	238	PF00069	0.576
MOD_GSK3_1	278	285	PF00069	0.587
MOD_GSK3_1	286	293	PF00069	0.637
MOD_NEK2_1	172	177	PF00069	0.521
MOD_NEK2_1	195	200	PF00069	0.714
MOD_NEK2_1	260	265	PF00069	0.542
MOD_NEK2_1	278	283	PF00069	0.431
MOD_NEK2_1	43	48	PF00069	0.627
MOD_PIKK_1	149	155	PF00454	0.710
MOD_PIKK_1	246	252	PF00454	0.377
MOD_PIKK_1	280	286	PF00454	0.584
MOD_PK_1	307	313	PF00069	0.438
MOD_PKA_2	108	114	PF00069	0.603
MOD_PKA_2	173	179	PF00069	0.519
MOD_PKA_2	196	202	PF00069	0.614
MOD_PKB_1	107	115	PF00069	0.591
MOD_PKB_1	280	288	PF00069	0.597
MOD_Plk_1	231	237	PF00069	0.476
MOD_Plk_1	239	245	PF00069	0.413
MOD_Plk_4	14	20	PF00069	0.337
MOD_Plk_4	208	214	PF00069	0.369
MOD_ProDKin_1	145	151	PF00069	0.644
MOD_ProDKin_1	217	223	PF00069	0.563
MOD_ProDKin_1	323	329	PF00069	0.502
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.604
TRG_ENDOCYTIC_2	10	13	PF00928	0.484
TRG_ER_diArg_1	107	110	PF00400	0.604
TRG_ER_diArg_1	19	22	PF00400	0.578
TRG_ER_diArg_1	256	258	PF00400	0.477
TRG_ER_diArg_1	297	299	PF00400	0.552
TRG_NLS_MonoCore_2	96	101	PF00514	0.544
TRG_NLS_MonoExtC_3	96	102	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHA6	Leptomonas seymouri	57%	100%
A0A1X0NNF4	Trypanosomatidae	28%	90%
A0A3S7WT74	Leishmania donovani	90%	100%
A0A422NFP0	Trypanosoma rangeli	34%	100%
A4H7V1	Leishmania braziliensis	81%	100%
A4HW77	Leishmania infantum	91%	100%
C9ZST9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QFK3	Leishmania major	92%	100%
V5AW09	Trypanosoma cruzi	36%	100%