Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9APX7_LEIMU

TriTrypDb:

LmxM.14.1300

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016310	phosphorylation	5	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:0000165	MAPK cascade	4	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0001934	positive regulation of protein phosphorylation	8	1
GO:0007165	signal transduction	2	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009966	regulation of signal transduction	4	1
GO:0009967	positive regulation of signal transduction	5	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010647	positive regulation of cell communication	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0023051	regulation of signaling	3	1
GO:0023056	positive regulation of signaling	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0033674	positive regulation of kinase activity	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0042325	regulation of phosphorylation	7	1
GO:0042327	positive regulation of phosphorylation	8	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043405	regulation of MAP kinase activity	8	1
GO:0043406	positive regulation of MAP kinase activity	8	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043410	positive regulation of MAPK cascade	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0045860	positive regulation of protein kinase activity	7	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0046777	protein autophosphorylation	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048584	positive regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0071902	positive regulation of protein serine/threonine kinase activity	8	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902533	positive regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0004708	MAP kinase kinase activity	5	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0051019	mitogen-activated protein kinase binding	6	1
GO:0004674	protein serine/threonine kinase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.303
CLV_C14_Caspase3-7	652	656	PF00656	0.555
CLV_NRD_NRD_1	227	229	PF00675	0.264
CLV_NRD_NRD_1	456	458	PF00675	0.604
CLV_NRD_NRD_1	46	48	PF00675	0.539
CLV_NRD_NRD_1	468	470	PF00675	0.593
CLV_NRD_NRD_1	529	531	PF00675	0.593
CLV_PCSK_FUR_1	461	465	PF00082	0.610
CLV_PCSK_KEX2_1	157	159	PF00082	0.361
CLV_PCSK_KEX2_1	227	229	PF00082	0.264
CLV_PCSK_KEX2_1	46	48	PF00082	0.539
CLV_PCSK_KEX2_1	460	462	PF00082	0.603
CLV_PCSK_KEX2_1	463	465	PF00082	0.614
CLV_PCSK_KEX2_1	468	470	PF00082	0.607
CLV_PCSK_KEX2_1	529	531	PF00082	0.596
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.264
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.584
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.597
CLV_PCSK_PC7_1	464	470	PF00082	0.598
CLV_PCSK_SKI1_1	158	162	PF00082	0.264
CLV_PCSK_SKI1_1	233	237	PF00082	0.277
CLV_PCSK_SKI1_1	404	408	PF00082	0.553
CLV_PCSK_SKI1_1	578	582	PF00082	0.583
CLV_PCSK_SKI1_1	633	637	PF00082	0.442
DOC_CKS1_1	385	390	PF01111	0.547
DOC_CKS1_1	394	399	PF01111	0.549
DOC_CYCLIN_yClb5_NLxxxL_5	418	427	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.551
DOC_MAPK_gen_1	233	242	PF00069	0.258
DOC_MAPK_gen_1	631	638	PF00069	0.436
DOC_PP1_RVXF_1	17	23	PF00149	0.509
DOC_PP4_FxxP_1	206	209	PF00568	0.245
DOC_PP4_FxxP_1	275	278	PF00568	0.264
DOC_PP4_FxxP_1	394	397	PF00568	0.524
DOC_USP7_MATH_1	129	133	PF00917	0.504
DOC_USP7_MATH_1	139	143	PF00917	0.545
DOC_USP7_MATH_1	199	203	PF00917	0.264
DOC_USP7_MATH_1	383	387	PF00917	0.582
DOC_USP7_MATH_1	40	44	PF00917	0.530
DOC_USP7_MATH_1	58	62	PF00917	0.530
DOC_USP7_MATH_1	64	68	PF00917	0.508
DOC_USP7_MATH_1	654	658	PF00917	0.522
DOC_USP7_MATH_1	700	704	PF00917	0.541
DOC_WW_Pin1_4	131	136	PF00397	0.575
DOC_WW_Pin1_4	36	41	PF00397	0.560
DOC_WW_Pin1_4	384	389	PF00397	0.602
DOC_WW_Pin1_4	393	398	PF00397	0.664
DOC_WW_Pin1_4	413	418	PF00397	0.494
DOC_WW_Pin1_4	425	430	PF00397	0.509
DOC_WW_Pin1_4	471	476	PF00397	0.544
DOC_WW_Pin1_4	491	496	PF00397	0.585
DOC_WW_Pin1_4	591	596	PF00397	0.543
DOC_WW_Pin1_4	7	12	PF00397	0.554
LIG_14-3-3_CanoR_1	404	409	PF00244	0.566
LIG_14-3-3_CanoR_1	46	51	PF00244	0.526
LIG_14-3-3_CanoR_1	515	520	PF00244	0.586
LIG_14-3-3_CanoR_1	547	556	PF00244	0.581
LIG_14-3-3_CanoR_1	604	610	PF00244	0.651
LIG_14-3-3_CterR_2	710	713	PF00244	0.521
LIG_Actin_WH2_2	596	612	PF00022	0.549
LIG_APCC_ABBA_1	184	189	PF00400	0.264
LIG_APCC_ABBAyCdc20_2	228	234	PF00400	0.439
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_BIR_III_1	1	5	PF00653	0.492
LIG_BIR_III_3	1	5	PF00653	0.492
LIG_deltaCOP1_diTrp_1	339	349	PF00928	0.264
LIG_FHA_1	122	128	PF00498	0.475
LIG_FHA_1	181	187	PF00498	0.284
LIG_FHA_1	195	201	PF00498	0.235
LIG_FHA_1	264	270	PF00498	0.286
LIG_FHA_1	327	333	PF00498	0.264
LIG_FHA_1	390	396	PF00498	0.625
LIG_FHA_1	422	428	PF00498	0.525
LIG_FHA_2	288	294	PF00498	0.264
LIG_FHA_2	30	36	PF00498	0.593
LIG_FHA_2	361	367	PF00498	0.361
LIG_FHA_2	451	457	PF00498	0.639
LIG_FHA_2	624	630	PF00498	0.513
LIG_LIR_Apic_2	205	209	PF02991	0.245
LIG_LIR_Apic_2	272	278	PF02991	0.530
LIG_LIR_Apic_2	392	397	PF02991	0.540
LIG_LIR_Gen_1	371	379	PF02991	0.355
LIG_LIR_Nem_3	202	206	PF02991	0.445
LIG_LIR_Nem_3	371	376	PF02991	0.335
LIG_LIR_Nem_3	428	434	PF02991	0.503
LIG_LIR_Nem_3	657	663	PF02991	0.510
LIG_LIR_Nem_3	84	88	PF02991	0.379
LIG_PALB2_WD40_1	368	376	PF16756	0.212
LIG_PTAP_UEV_1	396	401	PF05743	0.511
LIG_SH2_CRK	431	435	PF00017	0.552
LIG_SH2_CRK	533	537	PF00017	0.531
LIG_SH2_CRK	660	664	PF00017	0.509
LIG_SH2_CRK	85	89	PF00017	0.436
LIG_SH2_GRB2like	174	177	PF00017	0.264
LIG_SH2_NCK_1	533	537	PF00017	0.531
LIG_SH2_SRC	335	338	PF00017	0.264
LIG_SH2_STAP1	598	602	PF00017	0.527
LIG_SH2_STAP1	624	628	PF00017	0.486
LIG_SH2_STAT3	554	557	PF00017	0.548
LIG_SH2_STAT5	174	177	PF00017	0.330
LIG_SH2_STAT5	190	193	PF00017	0.407
LIG_SH2_STAT5	274	277	PF00017	0.305
LIG_SH2_STAT5	335	338	PF00017	0.264
LIG_SH2_STAT5	554	557	PF00017	0.548
LIG_SH2_STAT5	624	627	PF00017	0.504
LIG_SH3_3	132	138	PF00018	0.580
LIG_SH3_3	277	283	PF00018	0.264
LIG_SH3_3	394	400	PF00018	0.659
LIG_SH3_3	8	14	PF00018	0.528
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.282
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.264
LIG_SUMO_SIM_anti_2	599	605	PF11976	0.495
LIG_TRAF2_1	205	208	PF00917	0.264
LIG_TYR_ITIM	658	663	PF00017	0.510
LIG_UBA3_1	99	103	PF00899	0.331
LIG_WRC_WIRS_1	203	208	PF05994	0.264
LIG_WRC_WIRS_1	391	396	PF05994	0.527
MOD_CK1_1	192	198	PF00069	0.264
MOD_CK1_1	202	208	PF00069	0.232
MOD_CK1_1	23	29	PF00069	0.516
MOD_CK1_1	258	264	PF00069	0.270
MOD_CK1_1	284	290	PF00069	0.256
MOD_CK1_1	384	390	PF00069	0.626
MOD_CK1_1	393	399	PF00069	0.586
MOD_CK1_1	443	449	PF00069	0.650
MOD_CK1_1	450	456	PF00069	0.592
MOD_CK1_1	476	482	PF00069	0.592
MOD_CK1_1	483	489	PF00069	0.571
MOD_CK1_1	490	496	PF00069	0.579
MOD_CK1_1	498	504	PF00069	0.622
MOD_CK1_1	507	513	PF00069	0.566
MOD_CK1_1	546	552	PF00069	0.603
MOD_CK1_1	605	611	PF00069	0.562
MOD_CK1_1	612	618	PF00069	0.558
MOD_CK1_1	623	629	PF00069	0.499
MOD_CK1_1	67	73	PF00069	0.456
MOD_CK1_1	670	676	PF00069	0.533
MOD_CK2_1	202	208	PF00069	0.426
MOD_CK2_1	360	366	PF00069	0.342
MOD_CK2_1	450	456	PF00069	0.638
MOD_CK2_1	547	553	PF00069	0.568
MOD_CK2_1	611	617	PF00069	0.648
MOD_CK2_1	623	629	PF00069	0.528
MOD_Cter_Amidation	458	461	PF01082	0.597
MOD_GlcNHglycan	141	144	PF01048	0.572
MOD_GlcNHglycan	146	149	PF01048	0.458
MOD_GlcNHglycan	191	194	PF01048	0.293
MOD_GlcNHglycan	22	25	PF01048	0.576
MOD_GlcNHglycan	261	264	PF01048	0.304
MOD_GlcNHglycan	284	287	PF01048	0.244
MOD_GlcNHglycan	326	329	PF01048	0.268
MOD_GlcNHglycan	42	45	PF01048	0.610
MOD_GlcNHglycan	436	439	PF01048	0.620
MOD_GlcNHglycan	465	468	PF01048	0.582
MOD_GlcNHglycan	475	478	PF01048	0.552
MOD_GlcNHglycan	505	509	PF01048	0.604
MOD_GlcNHglycan	52	57	PF01048	0.564
MOD_GlcNHglycan	564	567	PF01048	0.601
MOD_GlcNHglycan	578	581	PF01048	0.533
MOD_GlcNHglycan	611	614	PF01048	0.589
MOD_GlcNHglycan	62	65	PF01048	0.524
MOD_GlcNHglycan	669	672	PF01048	0.539
MOD_GlcNHglycan	687	691	PF01048	0.511
MOD_GlcNHglycan	698	701	PF01048	0.531
MOD_GSK3_1	23	30	PF00069	0.568
MOD_GSK3_1	255	262	PF00069	0.384
MOD_GSK3_1	36	43	PF00069	0.554
MOD_GSK3_1	377	384	PF00069	0.573
MOD_GSK3_1	389	396	PF00069	0.702
MOD_GSK3_1	413	420	PF00069	0.597
MOD_GSK3_1	421	428	PF00069	0.580
MOD_GSK3_1	440	447	PF00069	0.617
MOD_GSK3_1	473	480	PF00069	0.569
MOD_GSK3_1	483	490	PF00069	0.541
MOD_GSK3_1	491	498	PF00069	0.571
MOD_GSK3_1	500	507	PF00069	0.592
MOD_GSK3_1	509	516	PF00069	0.565
MOD_GSK3_1	543	550	PF00069	0.585
MOD_GSK3_1	60	67	PF00069	0.644
MOD_GSK3_1	605	612	PF00069	0.639
MOD_GSK3_1	616	623	PF00069	0.603
MOD_GSK3_1	686	693	PF00069	0.517
MOD_GSK3_1	696	703	PF00069	0.520
MOD_N-GLC_1	377	382	PF02516	0.422
MOD_N-GLC_1	421	426	PF02516	0.515
MOD_N-GLC_1	444	449	PF02516	0.546
MOD_N-GLC_1	576	581	PF02516	0.568
MOD_N-GLC_1	605	610	PF02516	0.527
MOD_N-GLC_1	696	701	PF02516	0.506
MOD_NEK2_1	121	126	PF00069	0.482
MOD_NEK2_1	20	25	PF00069	0.614
MOD_NEK2_1	241	246	PF00069	0.368
MOD_NEK2_1	29	34	PF00069	0.555
MOD_NEK2_1	368	373	PF00069	0.306
MOD_NEK2_1	377	382	PF00069	0.495
MOD_NEK2_1	434	439	PF00069	0.609
MOD_NEK2_1	513	518	PF00069	0.568
MOD_NEK2_1	609	614	PF00069	0.637
MOD_NEK2_1	653	658	PF00069	0.552
MOD_NEK2_1	686	691	PF00069	0.538
MOD_NEK2_1	92	97	PF00069	0.353
MOD_NEK2_2	702	707	PF00069	0.531
MOD_PIKK_1	243	249	PF00454	0.266
MOD_PIKK_1	348	354	PF00454	0.299
MOD_PIKK_1	483	489	PF00454	0.586
MOD_PKA_1	46	52	PF00069	0.524
MOD_PKA_1	463	469	PF00069	0.594
MOD_PKA_2	115	121	PF00069	0.490
MOD_PKA_2	360	366	PF00069	0.530
MOD_PKA_2	443	449	PF00069	0.607
MOD_PKA_2	451	457	PF00069	0.575
MOD_PKA_2	46	52	PF00069	0.538
MOD_PKA_2	463	469	PF00069	0.575
MOD_PKA_2	483	489	PF00069	0.568
MOD_PKA_2	546	552	PF00069	0.632
MOD_PKA_2	609	615	PF00069	0.661
MOD_PKA_2	67	73	PF00069	0.412
MOD_PKB_1	502	510	PF00069	0.567
MOD_Plk_1	158	164	PF00069	0.284
MOD_Plk_1	338	344	PF00069	0.247
MOD_Plk_1	377	383	PF00069	0.476
MOD_Plk_1	552	558	PF00069	0.544
MOD_Plk_1	576	582	PF00069	0.539
MOD_Plk_1	605	611	PF00069	0.537
MOD_Plk_1	654	660	PF00069	0.552
MOD_Plk_1	696	702	PF00069	0.501
MOD_Plk_4	158	164	PF00069	0.284
MOD_Plk_4	368	374	PF00069	0.254
MOD_Plk_4	390	396	PF00069	0.587
MOD_Plk_4	404	410	PF00069	0.577
MOD_Plk_4	678	684	PF00069	0.546
MOD_ProDKin_1	131	137	PF00069	0.577
MOD_ProDKin_1	36	42	PF00069	0.561
MOD_ProDKin_1	384	390	PF00069	0.603
MOD_ProDKin_1	393	399	PF00069	0.662
MOD_ProDKin_1	413	419	PF00069	0.496
MOD_ProDKin_1	425	431	PF00069	0.514
MOD_ProDKin_1	471	477	PF00069	0.546
MOD_ProDKin_1	491	497	PF00069	0.587
MOD_ProDKin_1	591	597	PF00069	0.544
MOD_ProDKin_1	7	13	PF00069	0.553
MOD_SUMO_for_1	143	146	PF00179	0.516
MOD_SUMO_for_1	156	159	PF00179	0.222
MOD_SUMO_for_1	75	78	PF00179	0.379
TRG_DiLeu_BaEn_2	344	350	PF01217	0.264
TRG_ENDOCYTIC_2	203	206	PF00928	0.361
TRG_ENDOCYTIC_2	431	434	PF00928	0.520
TRG_ENDOCYTIC_2	533	536	PF00928	0.537
TRG_ENDOCYTIC_2	660	663	PF00928	0.512
TRG_ENDOCYTIC_2	85	88	PF00928	0.439
TRG_ENDOCYTIC_2	89	92	PF00928	0.399
TRG_ER_diArg_1	46	48	PF00400	0.520
TRG_NES_CRM1_1	345	360	PF08389	0.212
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	233	238	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	651	655	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAX0	Leishmania donovani	25%	100%
A4H7V0	Leishmania braziliensis	76%	100%
A4HNU6	Leishmania braziliensis	26%	100%
A4HW76	Leishmania infantum	86%	89%
A4IDK3	Leishmania infantum	25%	100%
E9AH34	Leishmania infantum	22%	100%
E9ASK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AT06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
Q4Q1J2	Leishmania major	25%	100%
Q4Q1Z0	Leishmania major	26%	100%
Q4QFK4	Leishmania major	86%	99%