Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APX6_LEIMU

TriTrypDb:

LmxM.14.1290

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.565
CLV_C14_Caspase3-7	501	505	PF00656	0.559
CLV_C14_Caspase3-7	658	662	PF00656	0.579
CLV_NRD_NRD_1	131	133	PF00675	0.601
CLV_NRD_NRD_1	148	150	PF00675	0.359
CLV_NRD_NRD_1	191	193	PF00675	0.558
CLV_NRD_NRD_1	261	263	PF00675	0.611
CLV_NRD_NRD_1	336	338	PF00675	0.614
CLV_NRD_NRD_1	36	38	PF00675	0.454
CLV_NRD_NRD_1	410	412	PF00675	0.521
CLV_NRD_NRD_1	454	456	PF00675	0.691
CLV_NRD_NRD_1	475	477	PF00675	0.809
CLV_NRD_NRD_1	494	496	PF00675	0.420
CLV_NRD_NRD_1	52	54	PF00675	0.466
CLV_NRD_NRD_1	599	601	PF00675	0.774
CLV_NRD_NRD_1	61	63	PF00675	0.465
CLV_NRD_NRD_1	648	650	PF00675	0.760
CLV_NRD_NRD_1	779	781	PF00675	0.606
CLV_PCSK_FUR_1	34	38	PF00082	0.462
CLV_PCSK_FUR_1	452	456	PF00082	0.671
CLV_PCSK_FUR_1	475	479	PF00082	0.688
CLV_PCSK_KEX2_1	131	133	PF00082	0.601
CLV_PCSK_KEX2_1	147	149	PF00082	0.375
CLV_PCSK_KEX2_1	191	193	PF00082	0.558
CLV_PCSK_KEX2_1	261	263	PF00082	0.611
CLV_PCSK_KEX2_1	275	277	PF00082	0.443
CLV_PCSK_KEX2_1	336	338	PF00082	0.614
CLV_PCSK_KEX2_1	36	38	PF00082	0.463
CLV_PCSK_KEX2_1	454	456	PF00082	0.664
CLV_PCSK_KEX2_1	475	477	PF00082	0.640
CLV_PCSK_KEX2_1	494	496	PF00082	0.503
CLV_PCSK_KEX2_1	51	53	PF00082	0.516
CLV_PCSK_KEX2_1	599	601	PF00082	0.774
CLV_PCSK_KEX2_1	61	63	PF00082	0.459
CLV_PCSK_KEX2_1	779	781	PF00082	0.607
CLV_PCSK_KEX2_1	90	92	PF00082	0.636
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.587
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.633
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.526
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.774
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.636
CLV_PCSK_PC7_1	775	781	PF00082	0.662
CLV_PCSK_SKI1_1	112	116	PF00082	0.679
CLV_PCSK_SKI1_1	148	152	PF00082	0.607
CLV_PCSK_SKI1_1	213	217	PF00082	0.510
CLV_PCSK_SKI1_1	27	31	PF00082	0.460
CLV_PCSK_SKI1_1	400	404	PF00082	0.493
CLV_PCSK_SKI1_1	411	415	PF00082	0.483
CLV_PCSK_SKI1_1	497	501	PF00082	0.609
DEG_APCC_DBOX_1	147	155	PF00400	0.593
DEG_APCC_DBOX_1	496	504	PF00400	0.524
DEG_COP1_1	463	471	PF00400	0.519
DEG_SCF_TRCP1_1	657	663	PF00400	0.518
DOC_ANK_TNKS_1	477	484	PF00023	0.676
DOC_ANK_TNKS_1	728	735	PF00023	0.749
DOC_CDC14_PxL_1	778	786	PF14671	0.477
DOC_CKS1_1	614	619	PF01111	0.727
DOC_CYCLIN_RxL_1	146	157	PF00134	0.535
DOC_CYCLIN_RxL_1	21	33	PF00134	0.461
DOC_CYCLIN_RxL_1	210	217	PF00134	0.618
DOC_MAPK_gen_1	147	154	PF00069	0.535
DOC_MAPK_gen_1	336	343	PF00069	0.608
DOC_MAPK_gen_1	34	43	PF00069	0.450
DOC_MAPK_gen_1	366	373	PF00069	0.591
DOC_MAPK_gen_1	411	417	PF00069	0.541
DOC_MAPK_gen_1	472	481	PF00069	0.503
DOC_MAPK_gen_1	51	60	PF00069	0.468
DOC_MAPK_MEF2A_6	770	778	PF00069	0.503
DOC_PP1_RVXF_1	147	154	PF00149	0.522
DOC_USP7_MATH_1	16	20	PF00917	0.467
DOC_USP7_MATH_1	274	278	PF00917	0.633
DOC_USP7_MATH_1	286	290	PF00917	0.456
DOC_USP7_MATH_1	312	316	PF00917	0.559
DOC_USP7_MATH_1	438	442	PF00917	0.621
DOC_USP7_MATH_1	450	454	PF00917	0.493
DOC_USP7_MATH_1	622	626	PF00917	0.786
DOC_USP7_MATH_1	629	633	PF00917	0.707
DOC_USP7_MATH_1	718	722	PF00917	0.609
DOC_USP7_MATH_1	768	772	PF00917	0.709
DOC_USP7_UBL2_3	51	55	PF12436	0.525
DOC_WW_Pin1_4	549	554	PF00397	0.693
DOC_WW_Pin1_4	613	618	PF00397	0.704
DOC_WW_Pin1_4	625	630	PF00397	0.558
DOC_WW_Pin1_4	666	671	PF00397	0.649
DOC_WW_Pin1_4	724	729	PF00397	0.604
LIG_14-3-3_CanoR_1	159	167	PF00244	0.540
LIG_14-3-3_CanoR_1	170	179	PF00244	0.438
LIG_14-3-3_CanoR_1	213	219	PF00244	0.555
LIG_14-3-3_CanoR_1	261	265	PF00244	0.563
LIG_14-3-3_CanoR_1	411	416	PF00244	0.456
LIG_14-3-3_CanoR_1	454	459	PF00244	0.621
LIG_14-3-3_CanoR_1	519	525	PF00244	0.654
LIG_14-3-3_CanoR_1	568	573	PF00244	0.647
LIG_14-3-3_CanoR_1	6	12	PF00244	0.445
LIG_14-3-3_CanoR_1	739	744	PF00244	0.683
LIG_Actin_WH2_2	338	356	PF00022	0.591
LIG_AP2alpha_1	796	800	PF02296	0.560
LIG_APCC_ABBA_1	225	230	PF00400	0.494
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_eIF4E_1	339	345	PF01652	0.598
LIG_FHA_1	156	162	PF00498	0.562
LIG_FHA_1	170	176	PF00498	0.376
LIG_FHA_1	298	304	PF00498	0.452
LIG_FHA_1	329	335	PF00498	0.692
LIG_FHA_1	412	418	PF00498	0.452
LIG_FHA_1	444	450	PF00498	0.432
LIG_FHA_1	6	12	PF00498	0.467
LIG_FHA_1	629	635	PF00498	0.599
LIG_FHA_2	246	252	PF00498	0.500
LIG_FHA_2	261	267	PF00498	0.646
LIG_FHA_2	288	294	PF00498	0.613
LIG_FHA_2	305	311	PF00498	0.457
LIG_FHA_2	325	331	PF00498	0.446
LIG_FHA_2	376	382	PF00498	0.601
LIG_Integrin_isoDGR_2	603	605	PF01839	0.537
LIG_LIR_Gen_1	19	30	PF02991	0.467
LIG_LIR_Gen_1	752	761	PF02991	0.734
LIG_LIR_Gen_1	793	801	PF02991	0.562
LIG_LIR_Nem_3	19	25	PF02991	0.468
LIG_LIR_Nem_3	420	425	PF02991	0.456
LIG_LIR_Nem_3	641	646	PF02991	0.740
LIG_LIR_Nem_3	752	758	PF02991	0.792
LIG_NRBOX	139	145	PF00104	0.502
LIG_NRBOX	340	346	PF00104	0.528
LIG_Pex14_1	422	426	PF04695	0.576
LIG_Pex14_2	747	751	PF04695	0.718
LIG_Pex14_2	796	800	PF04695	0.560
LIG_RPA_C_Fungi	432	444	PF08784	0.608
LIG_SH2_CRK	426	430	PF00017	0.570
LIG_SH2_NCK_1	339	343	PF00017	0.604
LIG_SH2_SRC	228	231	PF00017	0.502
LIG_SH2_STAP1	228	232	PF00017	0.684
LIG_SH2_STAP1	339	343	PF00017	0.604
LIG_SH2_STAP1	426	430	PF00017	0.570
LIG_SH2_STAT5	486	489	PF00017	0.471
LIG_SH3_1	583	589	PF00018	0.703
LIG_SH3_3	583	589	PF00018	0.719
LIG_SH3_3	671	677	PF00018	0.678
LIG_SH3_3	742	748	PF00018	0.611
LIG_SH3_3	771	777	PF00018	0.741
LIG_SH3_CIN85_PxpxPR_1	670	675	PF14604	0.626
LIG_SH3_CIN85_PxpxPR_1	695	700	PF14604	0.569
LIG_SUMO_SIM_par_1	343	349	PF11976	0.499
LIG_SUMO_SIM_par_1	413	418	PF11976	0.450
LIG_TRAF2_1	239	242	PF00917	0.511
LIG_TRAF2_1	263	266	PF00917	0.663
LIG_TRAF2_1	299	302	PF00917	0.610
LIG_TRAF2_1	308	311	PF00917	0.509
LIG_TRAF2_2	699	704	PF00917	0.505
LIG_TYR_ITIM	424	429	PF00017	0.572
LIG_WW_3	472	476	PF00397	0.675
LIG_WW_3	743	747	PF00397	0.513
MOD_CDK_SPK_2	670	675	PF00069	0.626
MOD_CDK_SPK_2	724	729	PF00069	0.604
MOD_CDK_SPxxK_3	668	675	PF00069	0.631
MOD_CK1_1	304	310	PF00069	0.469
MOD_CK1_1	485	491	PF00069	0.600
MOD_CK1_1	511	517	PF00069	0.677
MOD_CK1_1	557	563	PF00069	0.808
MOD_CK1_1	625	631	PF00069	0.642
MOD_CK1_1	632	638	PF00069	0.618
MOD_CK1_1	639	645	PF00069	0.650
MOD_CK1_1	660	666	PF00069	0.700
MOD_CK1_1	749	755	PF00069	0.588
MOD_CK2_1	17	23	PF00069	0.467
MOD_CK2_1	260	266	PF00069	0.670
MOD_CK2_1	287	293	PF00069	0.613
MOD_CK2_1	304	310	PF00069	0.453
MOD_CK2_1	375	381	PF00069	0.605
MOD_Cter_Amidation	129	132	PF01082	0.601
MOD_GlcNHglycan	106	109	PF01048	0.483
MOD_GlcNHglycan	161	164	PF01048	0.428
MOD_GlcNHglycan	172	175	PF01048	0.490
MOD_GlcNHglycan	257	260	PF01048	0.620
MOD_GlcNHglycan	301	306	PF01048	0.628
MOD_GlcNHglycan	322	325	PF01048	0.480
MOD_GlcNHglycan	440	443	PF01048	0.619
MOD_GlcNHglycan	469	472	PF01048	0.747
MOD_GlcNHglycan	522	525	PF01048	0.533
MOD_GlcNHglycan	539	542	PF01048	0.727
MOD_GlcNHglycan	624	627	PF01048	0.781
MOD_GlcNHglycan	631	634	PF01048	0.703
MOD_GlcNHglycan	650	653	PF01048	0.490
MOD_GlcNHglycan	657	660	PF01048	0.543
MOD_GlcNHglycan	714	717	PF01048	0.606
MOD_GlcNHglycan	720	723	PF01048	0.604
MOD_GlcNHglycan	92	95	PF01048	0.598
MOD_GSK3_1	155	162	PF00069	0.581
MOD_GSK3_1	190	197	PF00069	0.621
MOD_GSK3_1	203	210	PF00069	0.442
MOD_GSK3_1	297	304	PF00069	0.451
MOD_GSK3_1	320	327	PF00069	0.529
MOD_GSK3_1	450	457	PF00069	0.639
MOD_GSK3_1	507	514	PF00069	0.612
MOD_GSK3_1	554	561	PF00069	0.670
MOD_GSK3_1	563	570	PF00069	0.602
MOD_GSK3_1	625	632	PF00069	0.636
MOD_GSK3_1	635	642	PF00069	0.601
MOD_GSK3_1	655	662	PF00069	0.679
MOD_GSK3_1	666	673	PF00069	0.621
MOD_GSK3_1	714	721	PF00069	0.602
MOD_GSK3_1	724	731	PF00069	0.610
MOD_LATS_1	168	174	PF00433	0.580
MOD_LATS_1	409	415	PF00433	0.541
MOD_N-GLC_1	506	511	PF02516	0.461
MOD_N-GLC_1	737	742	PF02516	0.634
MOD_NEK2_1	214	219	PF00069	0.564
MOD_NEK2_1	260	265	PF00069	0.536
MOD_NEK2_1	320	325	PF00069	0.646
MOD_NEK2_1	353	358	PF00069	0.597
MOD_NEK2_1	387	392	PF00069	0.554
MOD_NEK2_1	506	511	PF00069	0.574
MOD_NEK2_2	223	228	PF00069	0.543
MOD_NEK2_2	559	564	PF00069	0.753
MOD_PIKK_1	508	514	PF00454	0.598
MOD_PK_1	454	460	PF00069	0.589
MOD_PK_1	568	574	PF00069	0.753
MOD_PKA_1	131	137	PF00069	0.507
MOD_PKA_1	411	417	PF00069	0.486
MOD_PKA_1	454	460	PF00069	0.589
MOD_PKA_1	579	585	PF00069	0.586
MOD_PKA_1	90	96	PF00069	0.569
MOD_PKA_2	131	137	PF00069	0.587
MOD_PKA_2	169	175	PF00069	0.554
MOD_PKA_2	177	183	PF00069	0.522
MOD_PKA_2	185	191	PF00069	0.420
MOD_PKA_2	260	266	PF00069	0.563
MOD_PKA_2	297	303	PF00069	0.577
MOD_PKA_2	353	359	PF00069	0.560
MOD_PKA_2	387	393	PF00069	0.597
MOD_PKA_2	454	460	PF00069	0.653
MOD_PKA_2	5	11	PF00069	0.446
MOD_PKA_2	518	524	PF00069	0.627
MOD_PKA_2	563	569	PF00069	0.626
MOD_PKA_2	648	654	PF00069	0.724
MOD_PKA_2	728	734	PF00069	0.558
MOD_PKA_2	738	744	PF00069	0.661
MOD_PKA_2	83	89	PF00069	0.467
MOD_PKA_2	90	96	PF00069	0.541
MOD_PKB_1	452	460	PF00069	0.582
MOD_Plk_1	286	292	PF00069	0.510
MOD_Plk_2-3	287	293	PF00069	0.576
MOD_Plk_4	223	229	PF00069	0.515
MOD_Plk_4	482	488	PF00069	0.481
MOD_ProDKin_1	549	555	PF00069	0.691
MOD_ProDKin_1	613	619	PF00069	0.705
MOD_ProDKin_1	625	631	PF00069	0.558
MOD_ProDKin_1	666	672	PF00069	0.646
MOD_ProDKin_1	724	730	PF00069	0.607
MOD_SUMO_for_1	239	242	PF00179	0.418
MOD_SUMO_for_1	367	370	PF00179	0.529
MOD_SUMO_rev_2	267	277	PF00179	0.626
MOD_SUMO_rev_2	405	414	PF00179	0.462
TRG_DiLeu_BaEn_4	241	247	PF01217	0.518
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.457
TRG_DiLeu_BaLyEn_6	683	688	PF01217	0.503
TRG_ENDOCYTIC_2	22	25	PF00928	0.467
TRG_ENDOCYTIC_2	426	429	PF00928	0.636
TRG_ER_diArg_1	131	133	PF00400	0.601
TRG_ER_diArg_1	146	149	PF00400	0.383
TRG_ER_diArg_1	260	262	PF00400	0.616
TRG_ER_diArg_1	336	338	PF00400	0.672
TRG_ER_diArg_1	34	37	PF00400	0.455
TRG_ER_diArg_1	43	46	PF00400	0.466
TRG_ER_diArg_1	452	455	PF00400	0.665
TRG_ER_diArg_1	474	476	PF00400	0.679
TRG_ER_diArg_1	478	481	PF00400	0.725
TRG_ER_diArg_1	494	497	PF00400	0.457
TRG_ER_diArg_1	60	62	PF00400	0.354
TRG_ER_diArg_1	646	649	PF00400	0.691
TRG_ER_diArg_1	778	780	PF00400	0.605
TRG_NLS_Bipartite_1	36	55	PF00514	0.512
TRG_NLS_MonoExtC_3	475	480	PF00514	0.748
TRG_NLS_MonoExtC_3	50	55	PF00514	0.524
TRG_NLS_MonoExtN_4	473	480	PF00514	0.621
TRG_NLS_MonoExtN_4	598	603	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P321	Leptomonas seymouri	40%	100%
A0A3S5H6T0	Leishmania donovani	88%	100%
A4H7U9	Leishmania braziliensis	71%	100%
A4HW75	Leishmania infantum	88%	100%
Q4QFK5	Leishmania major	86%	100%