F420_oxidored domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADP oxidoreductase coenzyme F420-dependent, putative

Species:

Leishmania mexicana

UniProt:

E9APX5_LEIMU

TriTrypDb:

LmxM.14.1280

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006560	proline metabolic process	6	7
GO:0006561	proline biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008652	amino acid biosynthetic process	4	7
GO:0009058	biosynthetic process	2	7
GO:0009064	glutamine family amino acid metabolic process	5	7
GO:0009084	glutamine family amino acid biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0016053	organic acid biosynthetic process	4	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044283	small molecule biosynthetic process	3	7
GO:0046394	carboxylic acid biosynthetic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1901605	alpha-amino acid metabolic process	4	7
GO:1901607	alpha-amino acid biosynthetic process	5	7
GO:0018130	heterocycle biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055129	L-proline biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004735	pyrroline-5-carboxylate reductase activity	5	7
GO:0016491	oxidoreductase activity	2	7
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	7
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.463
CLV_NRD_NRD_1	489	491	PF00675	0.538
CLV_PCSK_KEX2_1	487	489	PF00082	0.681
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.681
CLV_PCSK_SKI1_1	204	208	PF00082	0.346
CLV_PCSK_SKI1_1	224	228	PF00082	0.494
CLV_PCSK_SKI1_1	432	436	PF00082	0.666
CLV_PCSK_SKI1_1	52	56	PF00082	0.461
CLV_PCSK_SKI1_1	570	574	PF00082	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.597
DEG_ODPH_VHL_1	98	110	PF01847	0.463
DEG_SPOP_SBC_1	482	486	PF00917	0.651
DOC_CKS1_1	320	325	PF01111	0.509
DOC_CKS1_1	80	85	PF01111	0.697
DOC_CYCLIN_RxL_1	49	59	PF00134	0.470
DOC_CYCLIN_RxL_1	567	577	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	501	507	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.645
DOC_MAPK_gen_1	163	172	PF00069	0.508
DOC_PP1_RVXF_1	512	518	PF00149	0.598
DOC_PP4_FxxP_1	363	366	PF00568	0.684
DOC_USP7_MATH_1	100	104	PF00917	0.543
DOC_USP7_MATH_1	19	23	PF00917	0.485
DOC_USP7_MATH_1	218	222	PF00917	0.593
DOC_USP7_MATH_1	289	293	PF00917	0.595
DOC_USP7_MATH_1	348	352	PF00917	0.630
DOC_USP7_MATH_1	372	376	PF00917	0.664
DOC_USP7_MATH_1	386	390	PF00917	0.574
DOC_USP7_MATH_1	452	456	PF00917	0.656
DOC_WW_Pin1_4	228	233	PF00397	0.674
DOC_WW_Pin1_4	238	243	PF00397	0.416
DOC_WW_Pin1_4	283	288	PF00397	0.684
DOC_WW_Pin1_4	305	310	PF00397	0.668
DOC_WW_Pin1_4	319	324	PF00397	0.593
DOC_WW_Pin1_4	79	84	PF00397	0.629
DOC_WW_Pin1_4	90	95	PF00397	0.622
LIG_14-3-3_CanoR_1	416	422	PF00244	0.713
LIG_14-3-3_CanoR_1	451	460	PF00244	0.673
LIG_14-3-3_CanoR_1	553	561	PF00244	0.611
LIG_14-3-3_CanoR_1	88	94	PF00244	0.557
LIG_Actin_WH2_2	547	564	PF00022	0.611
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.564
LIG_BRCT_BRCA1_1	359	363	PF00533	0.578
LIG_eIF4E_1	2	8	PF01652	0.569
LIG_FHA_1	134	140	PF00498	0.402
LIG_FHA_1	239	245	PF00498	0.531
LIG_FHA_1	27	33	PF00498	0.608
LIG_FHA_1	308	314	PF00498	0.504
LIG_FHA_1	359	365	PF00498	0.621
LIG_FHA_1	511	517	PF00498	0.599
LIG_FHA_2	113	119	PF00498	0.531
LIG_FHA_2	34	40	PF00498	0.558
LIG_FHA_2	380	386	PF00498	0.513
LIG_FHA_2	421	427	PF00498	0.720
LIG_FHA_2	439	445	PF00498	0.424
LIG_FHA_2	561	567	PF00498	0.405
LIG_HCF-1_HBM_1	39	42	PF13415	0.528
LIG_LIR_Apic_2	360	366	PF02991	0.676
LIG_LIR_Gen_1	281	290	PF02991	0.479
LIG_LIR_Gen_1	3	13	PF02991	0.530
LIG_LIR_Gen_1	426	434	PF02991	0.534
LIG_LIR_Gen_1	59	70	PF02991	0.435
LIG_LIR_Nem_3	281	285	PF02991	0.465
LIG_LIR_Nem_3	3	8	PF02991	0.536
LIG_LIR_Nem_3	39	45	PF02991	0.441
LIG_LIR_Nem_3	426	430	PF02991	0.529
LIG_LIR_Nem_3	471	476	PF02991	0.707
LIG_LIR_Nem_3	566	572	PF02991	0.516
LIG_LIR_Nem_3	59	65	PF02991	0.367
LIG_MYND_1	537	541	PF01753	0.632
LIG_MYND_1	96	100	PF01753	0.621
LIG_SH2_CRK	34	38	PF00017	0.546
LIG_SH2_CRK	473	477	PF00017	0.654
LIG_SH2_CRK	5	9	PF00017	0.525
LIG_SH2_NCK_1	555	559	PF00017	0.617
LIG_SH2_STAP1	2	6	PF00017	0.624
LIG_SH2_STAP1	555	559	PF00017	0.617
LIG_SH2_STAT5	2	5	PF00017	0.582
LIG_SH2_STAT5	427	430	PF00017	0.604
LIG_SH2_STAT5	43	46	PF00017	0.449
LIG_SH2_STAT5	437	440	PF00017	0.481
LIG_SH2_STAT5	555	558	PF00017	0.615
LIG_SH3_3	229	235	PF00018	0.707
LIG_SH3_3	310	316	PF00018	0.609
LIG_SH3_3	317	323	PF00018	0.561
LIG_SH3_3	389	395	PF00018	0.723
LIG_SH3_3	476	482	PF00018	0.614
LIG_SH3_3	503	509	PF00018	0.630
LIG_SH3_3	534	540	PF00018	0.635
LIG_SH3_3	91	97	PF00018	0.696
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.482
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.482
LIG_SxIP_EBH_1	88	101	PF03271	0.498
LIG_TRAF2_1	329	332	PF00917	0.654
LIG_TYR_ITIM	32	37	PF00017	0.573
LIG_WRC_WIRS_1	279	284	PF05994	0.576
LIG_WW_2	392	395	PF00397	0.659
LIG_WW_2	537	540	PF00397	0.636
LIG_WW_3	405	409	PF00397	0.706
MOD_CDC14_SPxK_1	308	311	PF00782	0.647
MOD_CDK_SPxK_1	305	311	PF00069	0.670
MOD_CDK_SPxxK_3	238	245	PF00069	0.545
MOD_CK1_1	152	158	PF00069	0.473
MOD_CK1_1	217	223	PF00069	0.659
MOD_CK1_1	230	236	PF00069	0.621
MOD_CK1_1	278	284	PF00069	0.656
MOD_CK1_1	305	311	PF00069	0.660
MOD_CK1_1	359	365	PF00069	0.674
MOD_CK1_1	557	563	PF00069	0.500
MOD_CK1_1	89	95	PF00069	0.555
MOD_CK2_1	112	118	PF00069	0.396
MOD_CK2_1	326	332	PF00069	0.656
MOD_CK2_1	33	39	PF00069	0.506
MOD_CK2_1	379	385	PF00069	0.511
MOD_CK2_1	420	426	PF00069	0.727
MOD_CK2_1	438	444	PF00069	0.420
MOD_CMANNOS	517	520	PF00535	0.518
MOD_GlcNHglycan	208	211	PF01048	0.535
MOD_GlcNHglycan	216	219	PF01048	0.553
MOD_GlcNHglycan	235	238	PF01048	0.677
MOD_GlcNHglycan	304	307	PF01048	0.569
MOD_GlcNHglycan	350	353	PF01048	0.663
MOD_GlcNHglycan	374	377	PF01048	0.634
MOD_GlcNHglycan	454	457	PF01048	0.630
MOD_GlcNHglycan	523	526	PF01048	0.592
MOD_GlcNHglycan	556	559	PF01048	0.630
MOD_GSK3_1	19	26	PF00069	0.538
MOD_GSK3_1	214	221	PF00069	0.636
MOD_GSK3_1	224	231	PF00069	0.793
MOD_GSK3_1	296	303	PF00069	0.773
MOD_GSK3_1	348	355	PF00069	0.535
MOD_GSK3_1	395	402	PF00069	0.583
MOD_GSK3_1	416	423	PF00069	0.698
MOD_GSK3_1	462	469	PF00069	0.528
MOD_GSK3_1	553	560	PF00069	0.518
MOD_GSK3_1	86	93	PF00069	0.643
MOD_LATS_1	86	92	PF00433	0.509
MOD_NEK2_1	106	111	PF00069	0.382
MOD_NEK2_1	139	144	PF00069	0.528
MOD_NEK2_1	206	211	PF00069	0.653
MOD_NEK2_1	243	248	PF00069	0.496
MOD_NEK2_1	266	271	PF00069	0.537
MOD_NEK2_1	357	362	PF00069	0.571
MOD_NEK2_1	8	13	PF00069	0.509
MOD_NEK2_2	395	400	PF00069	0.529
MOD_OFUCOSY	288	293	PF10250	0.566
MOD_PIKK_1	218	224	PF00454	0.686
MOD_PKA_1	489	495	PF00069	0.522
MOD_PKA_2	133	139	PF00069	0.405
MOD_PKA_2	352	358	PF00069	0.549
MOD_PKA_2	407	413	PF00069	0.701
MOD_PKA_2	452	458	PF00069	0.694
MOD_PKA_2	462	468	PF00069	0.691
MOD_PKA_2	489	495	PF00069	0.657
MOD_Plk_1	326	332	PF00069	0.653
MOD_Plk_2-3	331	337	PF00069	0.610
MOD_Plk_4	106	112	PF00069	0.382
MOD_Plk_4	359	365	PF00069	0.674
MOD_Plk_4	395	401	PF00069	0.604
MOD_Plk_4	46	52	PF00069	0.380
MOD_Plk_4	475	481	PF00069	0.768
MOD_Plk_4	8	14	PF00069	0.511
MOD_ProDKin_1	228	234	PF00069	0.672
MOD_ProDKin_1	238	244	PF00069	0.401
MOD_ProDKin_1	283	289	PF00069	0.687
MOD_ProDKin_1	305	311	PF00069	0.670
MOD_ProDKin_1	319	325	PF00069	0.591
MOD_ProDKin_1	79	85	PF00069	0.629
MOD_ProDKin_1	90	96	PF00069	0.620
TRG_DiLeu_BaEn_4	444	450	PF01217	0.627
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.406
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.477
TRG_ENDOCYTIC_2	167	170	PF00928	0.546
TRG_ENDOCYTIC_2	34	37	PF00928	0.467
TRG_ENDOCYTIC_2	42	45	PF00928	0.442
TRG_ENDOCYTIC_2	427	430	PF00928	0.640
TRG_ENDOCYTIC_2	473	476	PF00928	0.691
TRG_ENDOCYTIC_2	5	8	PF00928	0.529
TRG_ER_diArg_1	388	391	PF00400	0.537
TRG_ER_diArg_1	488	490	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F8	Leptomonas seymouri	40%	100%
A0A3S7WT63	Leishmania donovani	86%	100%
A4H7U8	Leishmania braziliensis	72%	98%
A4HW74	Leishmania infantum	86%	100%
Q4QFK6	Leishmania major	87%	100%