CUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APX3_LEIMU

TriTrypDb:

LmxM.14.1260

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	84	86	PF00082	0.412
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.412
CLV_PCSK_SKI1_1	13	17	PF00082	0.524
DEG_APCC_DBOX_1	93	101	PF00400	0.383
DEG_Nend_UBRbox_2	1	3	PF02207	0.613
DEG_SPOP_SBC_1	59	63	PF00917	0.340
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.580
DOC_MAPK_gen_1	84	91	PF00069	0.400
DOC_MAPK_MEF2A_6	94	101	PF00069	0.384
DOC_USP7_MATH_1	37	41	PF00917	0.438
DOC_USP7_MATH_1	60	64	PF00917	0.475
LIG_14-3-3_CanoR_1	123	132	PF00244	0.380
LIG_14-3-3_CanoR_1	137	142	PF00244	0.574
LIG_14-3-3_CanoR_1	58	67	PF00244	0.411
LIG_14-3-3_CanoR_1	85	90	PF00244	0.296
LIG_BRCT_BRCA1_1	87	91	PF00533	0.428
LIG_DLG_GKlike_1	85	93	PF00625	0.287
LIG_FHA_1	100	106	PF00498	0.384
LIG_FHA_1	109	115	PF00498	0.423
LIG_FHA_1	44	50	PF00498	0.412
LIG_FHA_1	60	66	PF00498	0.380
LIG_FHA_1	88	94	PF00498	0.461
LIG_LIR_Gen_1	21	32	PF02991	0.564
LIG_LIR_Gen_1	35	45	PF02991	0.312
LIG_LIR_Gen_1	66	73	PF02991	0.422
LIG_LIR_Nem_3	111	116	PF02991	0.468
LIG_LIR_Nem_3	117	121	PF02991	0.369
LIG_LIR_Nem_3	144	150	PF02991	0.568
LIG_LIR_Nem_3	35	41	PF02991	0.421
LIG_LIR_Nem_3	66	70	PF02991	0.393
LIG_SH2_CRK	38	42	PF00017	0.551
LIG_SH2_CRK	67	71	PF00017	0.454
LIG_SH2_NCK_1	34	38	PF00017	0.434
LIG_SH2_NCK_1	67	71	PF00017	0.419
LIG_SH2_STAP1	34	38	PF00017	0.434
LIG_SH2_STAP1	45	49	PF00017	0.345
LIG_SH2_STAT3	119	122	PF00017	0.410
LIG_SH2_STAT5	119	122	PF00017	0.384
LIG_SH2_STAT5	45	48	PF00017	0.450
LIG_SH3_3	132	138	PF00018	0.541
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.415
LIG_SUMO_SIM_par_1	52	57	PF11976	0.384
LIG_SUMO_SIM_par_1	95	102	PF11976	0.291
LIG_TYR_ITIM	116	121	PF00017	0.351
LIG_TYR_ITIM	36	41	PF00017	0.432
LIG_TYR_ITIM	65	70	PF00017	0.434
MOD_CK1_1	104	110	PF00069	0.322
MOD_CK1_1	125	131	PF00069	0.473
MOD_CK1_1	52	58	PF00069	0.453
MOD_CK1_1	63	69	PF00069	0.346
MOD_CK1_1	87	93	PF00069	0.374
MOD_CK2_1	37	43	PF00069	0.473
MOD_CK2_1	89	95	PF00069	0.362
MOD_GlcNHglycan	128	131	PF01048	0.446
MOD_GlcNHglycan	2	5	PF01048	0.693
MOD_GlcNHglycan	62	65	PF01048	0.377
MOD_GSK3_1	104	111	PF00069	0.519
MOD_GSK3_1	122	129	PF00069	0.297
MOD_GSK3_1	13	20	PF00069	0.609
MOD_GSK3_1	133	140	PF00069	0.395
MOD_GSK3_1	28	35	PF00069	0.552
MOD_GSK3_1	39	46	PF00069	0.396
MOD_GSK3_1	54	61	PF00069	0.324
MOD_GSK3_1	72	79	PF00069	0.452
MOD_GSK3_1	85	92	PF00069	0.369
MOD_N-GLC_1	133	138	PF02516	0.522
MOD_NEK2_1	106	111	PF00069	0.373
MOD_NEK2_1	32	37	PF00069	0.495
MOD_NEK2_1	89	94	PF00069	0.504
MOD_OFUCOSY	74	80	PF10250	0.327
MOD_PK_1	137	143	PF00069	0.476
MOD_PKA_1	84	90	PF00069	0.379
MOD_PKA_2	122	128	PF00069	0.327
MOD_PKA_2	84	90	PF00069	0.379
MOD_Plk_1	28	34	PF00069	0.374
MOD_Plk_4	101	107	PF00069	0.401
MOD_Plk_4	114	120	PF00069	0.435
MOD_Plk_4	142	148	PF00069	0.496
MOD_Plk_4	49	55	PF00069	0.510
MOD_Plk_4	65	71	PF00069	0.334
TRG_ENDOCYTIC_2	118	121	PF00928	0.361
TRG_ENDOCYTIC_2	12	15	PF00928	0.615
TRG_ENDOCYTIC_2	38	41	PF00928	0.547
TRG_ENDOCYTIC_2	67	70	PF00928	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA15	Leptomonas seymouri	42%	80%
A0A3S5H6S9	Leishmania donovani	89%	100%
A4H7U6	Leishmania braziliensis	68%	100%
A4HW72	Leishmania infantum	89%	100%
Q4QFK8	Leishmania major	88%	100%