5_nucleotid_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APX2_LEIMU

TriTrypDb:

LmxM.14.1250

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.505
CLV_PCSK_KEX2_1	10	12	PF00082	0.505
CLV_PCSK_SKI1_1	141	145	PF00082	0.601
CLV_PCSK_SKI1_1	198	202	PF00082	0.645
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.373
DOC_MAPK_gen_1	10	17	PF00069	0.529
DOC_MAPK_MEF2A_6	10	19	PF00069	0.481
DOC_USP7_MATH_1	5	9	PF00917	0.590
DOC_USP7_MATH_1	79	83	PF00917	0.538
DOC_USP7_UBL2_3	44	48	PF12436	0.397
DOC_WW_Pin1_4	65	70	PF00397	0.463
DOC_WW_Pin1_4	93	98	PF00397	0.400
LIG_14-3-3_CanoR_1	194	198	PF00244	0.386
LIG_APCC_ABBA_1	107	112	PF00400	0.338
LIG_FHA_1	132	138	PF00498	0.450
LIG_FHA_1	147	153	PF00498	0.303
LIG_FHA_1	154	160	PF00498	0.318
LIG_FHA_1	75	81	PF00498	0.412
LIG_FHA_2	37	43	PF00498	0.447
LIG_LIR_Gen_1	172	181	PF02991	0.310
LIG_LIR_Gen_1	59	69	PF02991	0.401
LIG_LIR_Nem_3	103	108	PF02991	0.452
LIG_LIR_Nem_3	172	177	PF02991	0.274
LIG_LIR_Nem_3	196	200	PF02991	0.358
LIG_LIR_Nem_3	59	65	PF02991	0.412
LIG_LIR_Nem_3	95	101	PF02991	0.360
LIG_PDZ_Class_3	200	205	PF00595	0.454
LIG_Pex14_2	197	201	PF04695	0.435
LIG_PTB_Apo_2	46	53	PF02174	0.353
LIG_PTB_Phospho_1	46	52	PF10480	0.349
LIG_SH2_CRK	105	109	PF00017	0.400
LIG_SH2_CRK	62	66	PF00017	0.405
LIG_SH2_CRK	98	102	PF00017	0.338
LIG_SH2_STAT5	114	117	PF00017	0.327
LIG_SH2_STAT5	147	150	PF00017	0.351
LIG_SH2_STAT5	180	183	PF00017	0.428
LIG_SH2_STAT5	75	78	PF00017	0.405
LIG_SH3_3	112	118	PF00018	0.393
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.340
LIG_SUMO_SIM_par_1	24	29	PF11976	0.255
MOD_CK1_1	126	132	PF00069	0.295
MOD_CK1_1	3	9	PF00069	0.672
MOD_CK1_1	63	69	PF00069	0.437
MOD_CK1_1	93	99	PF00069	0.378
MOD_GlcNHglycan	125	128	PF01048	0.570
MOD_GSK3_1	32	39	PF00069	0.491
MOD_GSK3_1	56	63	PF00069	0.434
MOD_GSK3_1	75	82	PF00069	0.400
MOD_N-GLC_1	129	134	PF02516	0.622
MOD_NEK2_1	148	153	PF00069	0.417
MOD_NEK2_1	176	181	PF00069	0.456
MOD_NEK2_1	61	66	PF00069	0.487
MOD_NEK2_2	193	198	PF00069	0.439
MOD_PIKK_1	32	38	PF00454	0.412
MOD_PIKK_1	79	85	PF00454	0.353
MOD_PKA_2	193	199	PF00069	0.385
MOD_Plk_4	148	154	PF00069	0.382
MOD_Plk_4	176	182	PF00069	0.429
MOD_ProDKin_1	65	71	PF00069	0.461
MOD_ProDKin_1	93	99	PF00069	0.393
MOD_SUMO_for_1	47	50	PF00179	0.397
TRG_DiLeu_BaEn_1	104	109	PF01217	0.409
TRG_ENDOCYTIC_2	105	108	PF00928	0.409
TRG_ENDOCYTIC_2	184	187	PF00928	0.437
TRG_ENDOCYTIC_2	62	65	PF00928	0.403
TRG_ENDOCYTIC_2	98	101	PF00928	0.336
TRG_ER_diArg_1	10	12	PF00400	0.705
TRG_NES_CRM1_1	166	178	PF08389	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ7	Leptomonas seymouri	41%	100%
A0A3S7WT67	Leishmania donovani	87%	100%
A4H7U5	Leishmania braziliensis	71%	100%
A4HW71	Leishmania infantum	86%	100%
Q4QFK9	Leishmania major	86%	100%