DEK_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APX1_LEIMU

TriTrypDb:

LmxM.14.1240

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX1

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	4
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	4
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.564
CLV_NRD_NRD_1	198	200	PF00675	0.517
CLV_NRD_NRD_1	61	63	PF00675	0.436
CLV_PCSK_KEX2_1	145	147	PF00082	0.637
CLV_PCSK_KEX2_1	159	161	PF00082	0.523
CLV_PCSK_KEX2_1	198	200	PF00082	0.430
CLV_PCSK_KEX2_1	60	62	PF00082	0.428
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.637
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.529
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.579
CLV_PCSK_SKI1_1	198	202	PF00082	0.417
CLV_PCSK_SKI1_1	208	212	PF00082	0.435
CLV_PCSK_SKI1_1	247	251	PF00082	0.547
CLV_PCSK_SKI1_1	62	66	PF00082	0.497
CLV_PCSK_SKI1_1	82	86	PF00082	0.261
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.483
DOC_MAPK_MEF2A_6	96	104	PF00069	0.512
DOC_PP2B_LxvP_1	119	122	PF13499	0.499
DOC_USP7_MATH_1	135	139	PF00917	0.764
DOC_USP7_MATH_1	175	179	PF00917	0.629
DOC_USP7_MATH_1	185	189	PF00917	0.443
DOC_USP7_MATH_1	260	264	PF00917	0.486
DOC_USP7_MATH_1	267	271	PF00917	0.713
DOC_USP7_MATH_1	282	286	PF00917	0.757
DOC_USP7_MATH_2	165	171	PF00917	0.469
DOC_WW_Pin1_4	129	134	PF00397	0.577
DOC_WW_Pin1_4	139	144	PF00397	0.625
DOC_WW_Pin1_4	201	206	PF00397	0.534
DOC_WW_Pin1_4	269	274	PF00397	0.765
DOC_WW_Pin1_4	297	302	PF00397	0.642
LIG_14-3-3_CanoR_1	217	221	PF00244	0.510
LIG_Actin_WH2_2	76	94	PF00022	0.526
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BIR_III_2	266	270	PF00653	0.441
LIG_BRCT_BRCA1_1	177	181	PF00533	0.439
LIG_CtBP_PxDLS_1	165	169	PF00389	0.469
LIG_FHA_1	114	120	PF00498	0.426
LIG_FHA_2	202	208	PF00498	0.524
LIG_FHA_2	216	222	PF00498	0.360
LIG_FHA_2	272	278	PF00498	0.644
LIG_LIR_Nem_3	195	200	PF02991	0.511
LIG_PTAP_UEV_1	283	288	PF05743	0.546
LIG_SH2_CRK	197	201	PF00017	0.437
LIG_SH3_1	146	152	PF00018	0.658
LIG_SH3_1	160	166	PF00018	0.665
LIG_SH3_3	146	152	PF00018	0.548
LIG_SH3_3	160	166	PF00018	0.710
LIG_SH3_3	281	287	PF00018	0.624
LIG_SH3_3	295	301	PF00018	0.592
LIG_SUMO_SIM_par_1	300	305	PF11976	0.457
LIG_TRAF2_1	2	5	PF00917	0.688
MOD_CDC14_SPxK_1	142	145	PF00782	0.707
MOD_CDK_SPxK_1	139	145	PF00069	0.682
MOD_CDK_SPxxK_3	139	146	PF00069	0.712
MOD_CDK_SPxxK_3	201	208	PF00069	0.540
MOD_CK1_1	271	277	PF00069	0.655
MOD_CK1_1	300	306	PF00069	0.519
MOD_CK2_1	104	110	PF00069	0.523
MOD_CK2_1	158	164	PF00069	0.651
MOD_CK2_1	215	221	PF00069	0.485
MOD_CK2_1	271	277	PF00069	0.696
MOD_CK2_1	282	288	PF00069	0.642
MOD_Cter_Amidation	58	61	PF01082	0.548
MOD_GlcNHglycan	169	172	PF01048	0.702
MOD_GlcNHglycan	183	186	PF01048	0.404
MOD_GlcNHglycan	274	277	PF01048	0.684
MOD_GlcNHglycan	284	287	PF01048	0.665
MOD_GSK3_1	135	142	PF00069	0.594
MOD_GSK3_1	176	183	PF00069	0.693
MOD_GSK3_1	236	243	PF00069	0.482
MOD_GSK3_1	25	32	PF00069	0.551
MOD_GSK3_1	267	274	PF00069	0.607
MOD_NEK2_1	128	133	PF00069	0.668
MOD_NEK2_1	181	186	PF00069	0.412
MOD_PKA_2	216	222	PF00069	0.508
MOD_Plk_4	176	182	PF00069	0.484
MOD_ProDKin_1	129	135	PF00069	0.578
MOD_ProDKin_1	139	145	PF00069	0.628
MOD_ProDKin_1	201	207	PF00069	0.536
MOD_ProDKin_1	269	275	PF00069	0.691
MOD_ProDKin_1	297	303	PF00069	0.643
MOD_SUMO_rev_2	124	128	PF00179	0.528
MOD_SUMO_rev_2	151	161	PF00179	0.609
TRG_ENDOCYTIC_2	197	200	PF00928	0.433
TRG_ER_diArg_1	160	163	PF00400	0.535
TRG_ER_diArg_1	197	199	PF00400	0.537
TRG_NLS_Bipartite_1	145	163	PF00514	0.706
TRG_NLS_MonoExtC_3	158	163	PF00514	0.680
TRG_NLS_MonoExtN_4	156	163	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C3	Leptomonas seymouri	60%	90%
A0A3Q8IC32	Leishmania donovani	92%	100%
A0A422MT09	Trypanosoma rangeli	44%	83%
A4H7U4	Leishmania braziliensis	77%	96%
A4HW70	Leishmania infantum	92%	100%
C9ZSU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QFL0	Leishmania major	92%	100%
V5AW13	Trypanosoma cruzi	39%	85%