Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APX0_LEIMU

TriTrypDb:

LmxM.14.1230

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.466
CLV_NRD_NRD_1	567	569	PF00675	0.572
CLV_PCSK_KEX2_1	567	569	PF00082	0.572
CLV_PCSK_SKI1_1	152	156	PF00082	0.567
CLV_PCSK_SKI1_1	240	244	PF00082	0.588
CLV_PCSK_SKI1_1	34	38	PF00082	0.546
CLV_PCSK_SKI1_1	387	391	PF00082	0.625
CLV_PCSK_SKI1_1	477	481	PF00082	0.593
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DOC_CKS1_1	299	304	PF01111	0.674
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.590
DOC_PP2B_LxvP_1	196	199	PF13499	0.555
DOC_PP2B_LxvP_1	312	315	PF13499	0.577
DOC_PP4_FxxP_1	422	425	PF00568	0.756
DOC_USP7_MATH_1	154	158	PF00917	0.708
DOC_USP7_MATH_1	191	195	PF00917	0.653
DOC_USP7_MATH_1	238	242	PF00917	0.609
DOC_USP7_MATH_1	333	337	PF00917	0.668
DOC_USP7_MATH_1	431	435	PF00917	0.691
DOC_USP7_MATH_1	45	49	PF00917	0.679
DOC_USP7_MATH_1	535	539	PF00917	0.683
DOC_WW_Pin1_4	127	132	PF00397	0.376
DOC_WW_Pin1_4	157	162	PF00397	0.648
DOC_WW_Pin1_4	298	303	PF00397	0.788
DOC_WW_Pin1_4	304	309	PF00397	0.755
DOC_WW_Pin1_4	318	323	PF00397	0.512
DOC_WW_Pin1_4	392	397	PF00397	0.642
DOC_WW_Pin1_4	421	426	PF00397	0.755
DOC_WW_Pin1_4	429	434	PF00397	0.552
DOC_WW_Pin1_4	485	490	PF00397	0.732
LIG_14-3-3_CanoR_1	112	120	PF00244	0.744
LIG_14-3-3_CanoR_1	387	397	PF00244	0.465
LIG_14-3-3_CanoR_1	477	487	PF00244	0.469
LIG_14-3-3_CanoR_1	520	529	PF00244	0.520
LIG_14-3-3_CanoR_1	7	16	PF00244	0.511
LIG_14-3-3_CanoR_1	79	89	PF00244	0.507
LIG_BRCT_BRCA1_1	186	190	PF00533	0.750
LIG_CtBP_PxDLS_1	315	319	PF00389	0.543
LIG_EH1_1	267	275	PF00400	0.391
LIG_FAT_LD_1	25	33	PF03623	0.597
LIG_FHA_1	162	168	PF00498	0.676
LIG_FHA_1	171	177	PF00498	0.496
LIG_FHA_1	274	280	PF00498	0.563
LIG_FHA_1	293	299	PF00498	0.531
LIG_FHA_1	384	390	PF00498	0.320
LIG_FHA_1	406	412	PF00498	0.650
LIG_FHA_1	541	547	PF00498	0.543
LIG_FHA_2	79	85	PF00498	0.534
LIG_GBD_Chelix_1	377	385	PF00786	0.533
LIG_LIR_Nem_3	144	150	PF02991	0.576
LIG_LIR_Nem_3	352	357	PF02991	0.620
LIG_LIR_Nem_3	550	556	PF02991	0.411
LIG_NRBOX	238	244	PF00104	0.656
LIG_Pex14_1	206	210	PF04695	0.503
LIG_Pex14_2	134	138	PF04695	0.626
LIG_PTAP_UEV_1	302	307	PF05743	0.744
LIG_SH2_CRK	210	214	PF00017	0.611
LIG_SH2_PTP2	359	362	PF00017	0.417
LIG_SH2_STAP1	135	139	PF00017	0.500
LIG_SH2_STAT5	203	206	PF00017	0.497
LIG_SH2_STAT5	359	362	PF00017	0.654
LIG_SH2_STAT5	368	371	PF00017	0.514
LIG_SH3_2	425	430	PF14604	0.525
LIG_SH3_3	125	131	PF00018	0.405
LIG_SH3_3	180	186	PF00018	0.522
LIG_SH3_3	300	306	PF00018	0.727
LIG_SH3_3	35	41	PF00018	0.624
LIG_SH3_3	422	428	PF00018	0.596
LIG_SH3_3	90	96	PF00018	0.597
LIG_TRAF2_1	504	507	PF00917	0.729
LIG_TYR_ITIM	357	362	PF00017	0.419
LIG_WW_1	396	399	PF00397	0.486
MOD_CDC14_SPxK_1	160	163	PF00782	0.567
MOD_CDK_SPxK_1	157	163	PF00069	0.552
MOD_CK1_1	115	121	PF00069	0.711
MOD_CK1_1	122	128	PF00069	0.620
MOD_CK1_1	157	163	PF00069	0.576
MOD_CK1_1	211	217	PF00069	0.541
MOD_CK1_1	287	293	PF00069	0.464
MOD_CK1_1	304	310	PF00069	0.771
MOD_CK1_1	317	323	PF00069	0.632
MOD_CK1_1	336	342	PF00069	0.517
MOD_CK1_1	434	440	PF00069	0.759
MOD_CK1_1	48	54	PF00069	0.650
MOD_CK1_1	502	508	PF00069	0.518
MOD_CK1_1	524	530	PF00069	0.731
MOD_CK1_1	538	544	PF00069	0.425
MOD_CK1_1	80	86	PF00069	0.537
MOD_CK2_1	501	507	PF00069	0.718
MOD_CK2_1	78	84	PF00069	0.497
MOD_CMANNOS	67	70	PF00535	0.662
MOD_GlcNHglycan	114	117	PF01048	0.697
MOD_GlcNHglycan	121	124	PF01048	0.647
MOD_GlcNHglycan	167	170	PF01048	0.713
MOD_GlcNHglycan	180	183	PF01048	0.471
MOD_GlcNHglycan	21	24	PF01048	0.546
MOD_GlcNHglycan	235	238	PF01048	0.532
MOD_GlcNHglycan	252	256	PF01048	0.655
MOD_GlcNHglycan	303	306	PF01048	0.723
MOD_GlcNHglycan	335	338	PF01048	0.782
MOD_GlcNHglycan	390	393	PF01048	0.547
MOD_GlcNHglycan	433	436	PF01048	0.800
MOD_GlcNHglycan	47	50	PF01048	0.699
MOD_GlcNHglycan	59	62	PF01048	0.544
MOD_GSK3_1	111	118	PF00069	0.793
MOD_GSK3_1	150	157	PF00069	0.504
MOD_GSK3_1	161	168	PF00069	0.663
MOD_GSK3_1	208	215	PF00069	0.508
MOD_GSK3_1	247	254	PF00069	0.443
MOD_GSK3_1	297	304	PF00069	0.750
MOD_GSK3_1	314	321	PF00069	0.611
MOD_GSK3_1	324	331	PF00069	0.576
MOD_GSK3_1	336	343	PF00069	0.545
MOD_GSK3_1	369	376	PF00069	0.577
MOD_GSK3_1	388	395	PF00069	0.473
MOD_GSK3_1	429	436	PF00069	0.780
MOD_GSK3_1	48	55	PF00069	0.747
MOD_GSK3_1	516	523	PF00069	0.786
MOD_GSK3_1	558	565	PF00069	0.484
MOD_N-GLC_1	502	507	PF02516	0.517
MOD_N-GLC_1	52	57	PF02516	0.565
MOD_NEK2_1	212	217	PF00069	0.531
MOD_NEK2_1	232	237	PF00069	0.393
MOD_NEK2_1	273	278	PF00069	0.619
MOD_NEK2_1	28	33	PF00069	0.469
MOD_NEK2_1	344	349	PF00069	0.786
MOD_NEK2_1	369	374	PF00069	0.604
MOD_NEK2_1	380	385	PF00069	0.588
MOD_NEK2_1	388	393	PF00069	0.301
MOD_NEK2_2	340	345	PF00069	0.637
MOD_OFUCOSY	245	251	PF10250	0.413
MOD_PIKK_1	535	541	PF00454	0.436
MOD_PK_1	483	489	PF00069	0.489
MOD_PK_1	558	564	PF00069	0.578
MOD_PKA_1	19	25	PF00069	0.371
MOD_PKA_2	111	117	PF00069	0.742
MOD_PKA_2	78	84	PF00069	0.580
MOD_Plk_4	154	160	PF00069	0.651
MOD_Plk_4	172	178	PF00069	0.690
MOD_Plk_4	185	191	PF00069	0.658
MOD_Plk_4	208	214	PF00069	0.585
MOD_Plk_4	284	290	PF00069	0.703
MOD_Plk_4	558	564	PF00069	0.520
MOD_ProDKin_1	127	133	PF00069	0.378
MOD_ProDKin_1	157	163	PF00069	0.649
MOD_ProDKin_1	298	304	PF00069	0.790
MOD_ProDKin_1	318	324	PF00069	0.511
MOD_ProDKin_1	392	398	PF00069	0.649
MOD_ProDKin_1	421	427	PF00069	0.763
MOD_ProDKin_1	429	435	PF00069	0.551
MOD_ProDKin_1	485	491	PF00069	0.733
MOD_SUMO_rev_2	12	22	PF00179	0.481
TRG_DiLeu_BaEn_1	552	557	PF01217	0.444
TRG_DiLeu_BaEn_1	84	89	PF01217	0.520
TRG_DiLeu_BaEn_4	86	92	PF01217	0.355
TRG_ENDOCYTIC_2	135	138	PF00928	0.444
TRG_ENDOCYTIC_2	210	213	PF00928	0.599
TRG_ENDOCYTIC_2	354	357	PF00928	0.718
TRG_ENDOCYTIC_2	359	362	PF00928	0.626
TRG_ER_diArg_1	1	4	PF00400	0.591
TRG_ER_diArg_1	566	568	PF00400	0.540
TRG_ER_diArg_1	94	97	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAA7	Leptomonas seymouri	28%	98%
A0A3S7WTC0	Leishmania donovani	78%	100%
A4H7U3	Leishmania braziliensis	63%	99%
A4HW69	Leishmania infantum	78%	100%
Q4QFL1	Leishmania major	78%	100%