Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APW9_LEIMU

TriTrypDb:

LmxM.14.1220

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.641
CLV_C14_Caspase3-7	267	271	PF00656	0.768
CLV_C14_Caspase3-7	440	444	PF00656	0.677
CLV_C14_Caspase3-7	455	459	PF00656	0.535
CLV_C14_Caspase3-7	490	494	PF00656	0.667
CLV_C14_Caspase3-7	536	540	PF00656	0.674
CLV_C14_Caspase3-7	741	745	PF00656	0.449
CLV_C14_Caspase3-7	80	84	PF00656	0.628
CLV_C14_Caspase3-7	803	807	PF00656	0.505
CLV_NRD_NRD_1	122	124	PF00675	0.538
CLV_NRD_NRD_1	263	265	PF00675	0.780
CLV_NRD_NRD_1	343	345	PF00675	0.656
CLV_NRD_NRD_1	359	361	PF00675	0.587
CLV_NRD_NRD_1	389	391	PF00675	0.597
CLV_NRD_NRD_1	447	449	PF00675	0.484
CLV_NRD_NRD_1	510	512	PF00675	0.427
CLV_NRD_NRD_1	580	582	PF00675	0.523
CLV_PCSK_FUR_1	261	265	PF00082	0.711
CLV_PCSK_KEX2_1	263	265	PF00082	0.780
CLV_PCSK_KEX2_1	343	345	PF00082	0.656
CLV_PCSK_KEX2_1	351	353	PF00082	0.599
CLV_PCSK_KEX2_1	359	361	PF00082	0.587
CLV_PCSK_KEX2_1	389	391	PF00082	0.481
CLV_PCSK_KEX2_1	447	449	PF00082	0.487
CLV_PCSK_KEX2_1	478	480	PF00082	0.541
CLV_PCSK_KEX2_1	510	512	PF00082	0.510
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.721
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.524
CLV_PCSK_SKI1_1	32	36	PF00082	0.456
CLV_PCSK_SKI1_1	351	355	PF00082	0.643
CLV_PCSK_SKI1_1	364	368	PF00082	0.559
CLV_PCSK_SKI1_1	485	489	PF00082	0.524
CLV_PCSK_SKI1_1	668	672	PF00082	0.504
DEG_APCC_DBOX_1	667	675	PF00400	0.507
DEG_APCC_KENBOX_2	42	46	PF00400	0.581
DEG_APCC_KENBOX_2	78	82	PF00400	0.500
DEG_SPOP_SBC_1	905	909	PF00917	0.648
DOC_MAPK_gen_1	261	268	PF00069	0.700
DOC_MAPK_HePTP_8	201	213	PF00069	0.613
DOC_MAPK_MEF2A_6	16	24	PF00069	0.614
DOC_MAPK_MEF2A_6	204	213	PF00069	0.617
DOC_MIT_MIM_1	500	508	PF04212	0.359
DOC_PIKK_1	93	101	PF02985	0.622
DOC_USP7_MATH_1	134	138	PF00917	0.548
DOC_USP7_MATH_1	161	165	PF00917	0.719
DOC_USP7_MATH_1	173	177	PF00917	0.591
DOC_USP7_MATH_1	178	182	PF00917	0.536
DOC_USP7_MATH_1	277	281	PF00917	0.619
DOC_USP7_MATH_1	334	338	PF00917	0.662
DOC_USP7_MATH_1	494	498	PF00917	0.560
DOC_USP7_MATH_1	622	626	PF00917	0.611
DOC_USP7_MATH_1	642	646	PF00917	0.578
DOC_USP7_MATH_1	68	72	PF00917	0.453
DOC_USP7_MATH_1	916	920	PF00917	0.657
DOC_USP7_UBL2_3	557	561	PF12436	0.467
DOC_WW_Pin1_4	148	153	PF00397	0.824
DOC_WW_Pin1_4	247	252	PF00397	0.699
DOC_WW_Pin1_4	297	302	PF00397	0.714
DOC_WW_Pin1_4	374	379	PF00397	0.753
DOC_WW_Pin1_4	861	866	PF00397	0.740
DOC_WW_Pin1_4	912	917	PF00397	0.770
LIG_14-3-3_CanoR_1	123	133	PF00244	0.648
LIG_14-3-3_CanoR_1	278	284	PF00244	0.655
LIG_14-3-3_CanoR_1	287	292	PF00244	0.647
LIG_14-3-3_CanoR_1	485	492	PF00244	0.490
LIG_14-3-3_CanoR_1	702	710	PF00244	0.511
LIG_14-3-3_CanoR_1	855	860	PF00244	0.661
LIG_14-3-3_CanoR_1	922	928	PF00244	0.663
LIG_Actin_WH2_2	467	484	PF00022	0.486
LIG_Actin_WH2_2	707	724	PF00022	0.504
LIG_APCC_ABBAyCdc20_2	344	350	PF00400	0.547
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	279	283	PF00533	0.772
LIG_Clathr_ClatBox_1	505	509	PF01394	0.356
LIG_FAT_LD_1	442	450	PF03623	0.530
LIG_FHA_1	243	249	PF00498	0.548
LIG_FHA_1	3	9	PF00498	0.641
LIG_FHA_1	326	332	PF00498	0.784
LIG_FHA_1	428	434	PF00498	0.505
LIG_FHA_1	54	60	PF00498	0.521
LIG_FHA_1	575	581	PF00498	0.615
LIG_FHA_1	862	868	PF00498	0.737
LIG_FHA_1	878	884	PF00498	0.607
LIG_FHA_2	113	119	PF00498	0.563
LIG_FHA_2	28	34	PF00498	0.474
LIG_FHA_2	302	308	PF00498	0.611
LIG_FHA_2	314	320	PF00498	0.758
LIG_FHA_2	486	492	PF00498	0.466
LIG_FHA_2	534	540	PF00498	0.669
LIG_FHA_2	641	647	PF00498	0.410
LIG_FHA_2	808	814	PF00498	0.527
LIG_FHA_2	922	928	PF00498	0.663
LIG_GBD_Chelix_1	401	409	PF00786	0.469
LIG_LIR_Gen_1	383	391	PF02991	0.519
LIG_LIR_Gen_1	524	532	PF02991	0.553
LIG_LIR_LC3C_4	210	213	PF02991	0.469
LIG_LIR_Nem_3	23	27	PF02991	0.614
LIG_LIR_Nem_3	280	286	PF02991	0.703
LIG_LIR_Nem_3	383	388	PF02991	0.537
LIG_LIR_Nem_3	524	529	PF02991	0.541
LIG_LIR_Nem_3	837	842	PF02991	0.566
LIG_NRBOX	441	447	PF00104	0.535
LIG_NRBOX	562	568	PF00104	0.501
LIG_NRBOX	683	689	PF00104	0.541
LIG_NRBOX	97	103	PF00104	0.511
LIG_Rb_LxCxE_1	33	56	PF01857	0.350
LIG_RPA_C_Fungi	354	366	PF08784	0.651
LIG_SH2_GRB2like	397	400	PF00017	0.479
LIG_SH2_STAT3	273	276	PF00017	0.576
LIG_SH2_STAT5	397	400	PF00017	0.479
LIG_SH2_STAT5	767	770	PF00017	0.470
LIG_SH3_3	210	216	PF00018	0.478
LIG_SH3_3	266	272	PF00018	0.762
LIG_SH3_3	925	931	PF00018	0.647
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.696
LIG_SUMO_SIM_anti_2	414	421	PF11976	0.505
LIG_SUMO_SIM_anti_2	683	689	PF11976	0.374
LIG_SUMO_SIM_par_1	528	534	PF11976	0.526
LIG_TRAF2_1	568	571	PF00917	0.571
LIG_UBA3_1	34	43	PF00899	0.576
LIG_UBA3_1	405	410	PF00899	0.479
LIG_UBA3_1	790	796	PF00899	0.461
LIG_UBA3_1	800	808	PF00899	0.501
LIG_WW_3	888	892	PF00397	0.787
MOD_CK1_1	138	144	PF00069	0.782
MOD_CK1_1	148	154	PF00069	0.678
MOD_CK1_1	156	162	PF00069	0.544
MOD_CK1_1	174	180	PF00069	0.750
MOD_CK1_1	191	197	PF00069	0.485
MOD_CK1_1	2	8	PF00069	0.644
MOD_CK1_1	252	258	PF00069	0.750
MOD_CK1_1	279	285	PF00069	0.809
MOD_CK1_1	377	383	PF00069	0.720
MOD_CK1_1	649	655	PF00069	0.561
MOD_CK1_1	909	915	PF00069	0.749
MOD_CK1_1	923	929	PF00069	0.543
MOD_CK2_1	112	118	PF00069	0.566
MOD_CK2_1	313	319	PF00069	0.737
MOD_CK2_1	622	628	PF00069	0.628
MOD_CK2_1	649	655	PF00069	0.604
MOD_CK2_1	921	927	PF00069	0.667
MOD_GlcNHglycan	127	130	PF01048	0.544
MOD_GlcNHglycan	147	150	PF01048	0.743
MOD_GlcNHglycan	158	161	PF01048	0.640
MOD_GlcNHglycan	163	166	PF01048	0.567
MOD_GlcNHglycan	168	171	PF01048	0.787
MOD_GlcNHglycan	173	176	PF01048	0.615
MOD_GlcNHglycan	189	193	PF01048	0.581
MOD_GlcNHglycan	217	220	PF01048	0.725
MOD_GlcNHglycan	254	257	PF01048	0.727
MOD_GlcNHglycan	279	282	PF01048	0.536
MOD_GlcNHglycan	307	311	PF01048	0.621
MOD_GlcNHglycan	361	364	PF01048	0.733
MOD_GlcNHglycan	496	499	PF01048	0.386
MOD_GlcNHglycan	595	598	PF01048	0.525
MOD_GlcNHglycan	70	73	PF01048	0.539
MOD_GlcNHglycan	703	706	PF01048	0.580
MOD_GlcNHglycan	717	721	PF01048	0.421
MOD_GlcNHglycan	734	737	PF01048	0.372
MOD_GlcNHglycan	911	914	PF01048	0.634
MOD_GSK3_1	134	141	PF00069	0.649
MOD_GSK3_1	173	180	PF00069	0.635
MOD_GSK3_1	187	194	PF00069	0.615
MOD_GSK3_1	220	227	PF00069	0.670
MOD_GSK3_1	247	254	PF00069	0.686
MOD_GSK3_1	297	304	PF00069	0.642
MOD_GSK3_1	370	377	PF00069	0.716
MOD_GSK3_1	423	430	PF00069	0.664
MOD_GSK3_1	460	467	PF00069	0.397
MOD_GSK3_1	632	639	PF00069	0.574
MOD_GSK3_1	642	649	PF00069	0.537
MOD_GSK3_1	790	797	PF00069	0.459
MOD_GSK3_1	855	862	PF00069	0.663
MOD_GSK3_1	905	912	PF00069	0.760
MOD_GSK3_1	916	923	PF00069	0.615
MOD_LATS_1	262	268	PF00433	0.542
MOD_N-GLC_1	616	621	PF02516	0.554
MOD_N-GLC_1	783	788	PF02516	0.464
MOD_N-GLC_1	877	882	PF02516	0.593
MOD_NEK2_1	27	32	PF00069	0.481
MOD_NEK2_1	286	291	PF00069	0.591
MOD_NEK2_1	418	423	PF00069	0.693
MOD_NEK2_1	783	788	PF00069	0.464
MOD_NEK2_1	794	799	PF00069	0.455
MOD_NEK2_1	920	925	PF00069	0.670
MOD_NEK2_2	916	921	PF00069	0.774
MOD_PIKK_1	178	184	PF00454	0.773
MOD_PIKK_1	2	8	PF00454	0.644
MOD_PIKK_1	224	230	PF00454	0.698
MOD_PIKK_1	242	248	PF00454	0.608
MOD_PIKK_1	460	466	PF00454	0.548
MOD_PK_1	264	270	PF00069	0.707
MOD_PK_1	287	293	PF00069	0.534
MOD_PKA_1	343	349	PF00069	0.753
MOD_PKA_1	351	357	PF00069	0.587
MOD_PKA_1	359	365	PF00069	0.512
MOD_PKA_2	112	118	PF00069	0.583
MOD_PKA_2	277	283	PF00069	0.770
MOD_PKA_2	286	292	PF00069	0.649
MOD_PKA_2	324	330	PF00069	0.688
MOD_PKA_2	343	349	PF00069	0.709
MOD_PKA_2	351	357	PF00069	0.587
MOD_PKA_2	359	365	PF00069	0.617
MOD_PKA_2	649	655	PF00069	0.601
MOD_PKA_2	659	665	PF00069	0.527
MOD_PKA_2	701	707	PF00069	0.601
MOD_PKA_2	742	748	PF00069	0.361
MOD_PKA_2	921	927	PF00069	0.767
MOD_Plk_1	306	312	PF00069	0.653
MOD_Plk_1	622	628	PF00069	0.706
MOD_Plk_1	716	722	PF00069	0.605
MOD_Plk_1	754	760	PF00069	0.468
MOD_Plk_1	794	800	PF00069	0.459
MOD_Plk_1	93	99	PF00069	0.651
MOD_Plk_2-3	640	646	PF00069	0.419
MOD_Plk_4	20	26	PF00069	0.692
MOD_Plk_4	264	270	PF00069	0.784
MOD_Plk_4	287	293	PF00069	0.574
MOD_Plk_4	343	349	PF00069	0.576
MOD_Plk_4	380	386	PF00069	0.576
MOD_Plk_4	622	628	PF00069	0.695
MOD_Plk_4	754	760	PF00069	0.468
MOD_ProDKin_1	148	154	PF00069	0.822
MOD_ProDKin_1	247	253	PF00069	0.695
MOD_ProDKin_1	297	303	PF00069	0.716
MOD_ProDKin_1	374	380	PF00069	0.752
MOD_ProDKin_1	861	867	PF00069	0.743
MOD_ProDKin_1	912	918	PF00069	0.773
MOD_SUMO_rev_2	404	412	PF00179	0.479
MOD_SUMO_rev_2	607	616	PF00179	0.495
MOD_SUMO_rev_2	659	666	PF00179	0.656
MOD_SUMO_rev_2	735	742	PF00179	0.545
MOD_SUMO_rev_2	74	84	PF00179	0.723
MOD_SUMO_rev_2	803	810	PF00179	0.510
TRG_DiLeu_BaEn_1	207	212	PF01217	0.689
TRG_DiLeu_BaEn_1	414	419	PF01217	0.476
TRG_DiLeu_BaEn_1	683	688	PF01217	0.374
TRG_DiLeu_BaEn_4	472	478	PF01217	0.446
TRG_DiLeu_BaEn_4	93	99	PF01217	0.621
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.359
TRG_ER_diArg_1	261	264	PF00400	0.768
TRG_ER_diArg_1	342	344	PF00400	0.798
TRG_ER_diArg_1	388	390	PF00400	0.617
TRG_ER_diArg_1	446	448	PF00400	0.487
TRG_ER_diArg_1	510	513	PF00400	0.426
TRG_ER_diArg_1	854	857	PF00400	0.597
TRG_NES_CRM1_1	676	691	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	504	509	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	682	686	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	712	717	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	881	885	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B0	Leptomonas seymouri	50%	100%
A0A3Q8I8X0	Leishmania donovani	88%	100%
A4H7U2	Leishmania braziliensis	75%	99%
A4HW68	Leishmania infantum	88%	100%
Q4QFL2	Leishmania major	88%	100%