FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9APW8_LEIMU

TriTrypDb:

LmxM.14.1210

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APW8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.671
CLV_NRD_NRD_1	167	169	PF00675	0.326
CLV_NRD_NRD_1	257	259	PF00675	0.449
CLV_PCSK_KEX2_1	123	125	PF00082	0.681
CLV_PCSK_KEX2_1	167	169	PF00082	0.327
CLV_PCSK_KEX2_1	257	259	PF00082	0.449
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.681
CLV_PCSK_PC7_1	119	125	PF00082	0.672
CLV_PCSK_SKI1_1	252	256	PF00082	0.426
CLV_PCSK_SKI1_1	5	9	PF00082	0.345
DEG_SCF_SKP2-CKS1_1	202	209	PF00560	0.314
DOC_ANK_TNKS_1	22	29	PF00023	0.535
DOC_PP1_RVXF_1	147	153	PF00149	0.406
DOC_USP7_MATH_1	102	106	PF00917	0.806
DOC_USP7_MATH_1	108	112	PF00917	0.705
DOC_USP7_MATH_1	171	175	PF00917	0.346
DOC_USP7_MATH_1	94	98	PF00917	0.527
DOC_WW_Pin1_4	203	208	PF00397	0.330
LIG_14-3-3_CanoR_1	69	73	PF00244	0.465
LIG_APCC_ABBAyCdc20_2	209	215	PF00400	0.237
LIG_BRCT_BRCA1_1	184	188	PF00533	0.406
LIG_EH1_1	239	247	PF00400	0.344
LIG_FHA_1	198	204	PF00498	0.314
LIG_FHA_1	33	39	PF00498	0.468
LIG_FHA_1	69	75	PF00498	0.430
LIG_FHA_2	13	19	PF00498	0.354
LIG_FHA_2	159	165	PF00498	0.329
LIG_FHA_2	178	184	PF00498	0.389
LIG_GBD_Chelix_1	8	16	PF00786	0.375
LIG_Integrin_isoDGR_2	114	116	PF01839	0.669
LIG_LIR_Gen_1	185	195	PF02991	0.363
LIG_LIR_Gen_1	215	221	PF02991	0.386
LIG_LIR_Nem_3	164	169	PF02991	0.389
LIG_LIR_Nem_3	185	191	PF02991	0.341
LIG_LIR_Nem_3	215	220	PF02991	0.386
LIG_MYND_1	2	6	PF01753	0.535
LIG_Pex14_2	152	156	PF04695	0.314
LIG_PTB_Apo_2	73	80	PF02174	0.466
LIG_SH2_PTP2	217	220	PF00017	0.257
LIG_SH2_STAT5	217	220	PF00017	0.416
LIG_SH3_3	141	147	PF00018	0.314
LIG_SUMO_SIM_par_1	199	206	PF11976	0.316
LIG_TRAF2_1	132	135	PF00917	0.369
MOD_CDK_SPxK_1	203	209	PF00069	0.314
MOD_CK1_1	64	70	PF00069	0.399
MOD_CK1_1	81	87	PF00069	0.629
MOD_CK2_1	12	18	PF00069	0.348
MOD_GlcNHglycan	102	105	PF01048	0.786
MOD_GlcNHglycan	110	113	PF01048	0.706
MOD_GSK3_1	154	161	PF00069	0.297
MOD_GSK3_1	64	71	PF00069	0.390
MOD_GSK3_1	90	97	PF00069	0.584
MOD_N-GLC_1	142	147	PF02516	0.193
MOD_N-GLC_1	81	86	PF02516	0.616
MOD_NEK2_1	12	17	PF00069	0.361
MOD_PIKK_1	142	148	PF00454	0.311
MOD_PIKK_1	182	188	PF00454	0.374
MOD_PIKK_1	95	101	PF00454	0.490
MOD_PKA_2	12	18	PF00069	0.348
MOD_PKA_2	68	74	PF00069	0.431
MOD_Plk_1	158	164	PF00069	0.455
MOD_Plk_1	182	188	PF00069	0.455
MOD_Plk_1	32	38	PF00069	0.465
MOD_Plk_1	81	87	PF00069	0.619
MOD_Plk_4	12	18	PF00069	0.348
MOD_Plk_4	197	203	PF00069	0.411
MOD_ProDKin_1	203	209	PF00069	0.330
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.411
TRG_ENDOCYTIC_2	217	220	PF00928	0.406
TRG_ER_diArg_1	124	126	PF00400	0.671
TRG_ER_diArg_1	166	168	PF00400	0.327
TRG_ER_diArg_1	235	238	PF00400	0.346
TRG_ER_diArg_1	256	258	PF00400	0.469
TRG_NLS_MonoExtC_3	122	127	PF00514	0.641
TRG_NLS_MonoExtN_4	122	127	PF00514	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q2	Leptomonas seymouri	61%	94%
A0A0S4IS02	Bodo saltans	42%	100%
A0A3R7R775	Trypanosoma rangeli	39%	100%
A0A3S7WT65	Leishmania donovani	88%	100%
A4H7U1	Leishmania braziliensis	73%	100%
A4HW67	Leishmania infantum	88%	100%
Q4QFL3	Leishmania major	86%	100%