LeishMANIAdb
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Bifunctional NAD(P)H-hydrate repair enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Bifunctional NAD(P)H-hydrate repair enzyme
Gene product:
Bifunctional NAD(P)H-hydrate repair enzyme
Species:
Leishmania mexicana
UniProt:
E9APW6_LEIMU
TriTrypDb:
LmxM.14.1190
Length:
556

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APW6

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006753 nucleoside phosphate metabolic process 4 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009117 nucleotide metabolic process 5 7
GO:0009987 cellular process 1 7
GO:0019362 pyridine nucleotide metabolic process 5 7
GO:0019637 organophosphate metabolic process 3 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044281 small molecule metabolic process 2 7
GO:0046483 heterocycle metabolic process 3 7
GO:0046496 nicotinamide nucleotide metabolic process 6 7
GO:0055086 nucleobase-containing small molecule metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:0072524 pyridine-containing compound metabolic process 4 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0110051 metabolite repair 3 1
GO:0016310 phosphorylation 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016829 lyase activity 2 7
GO:0016835 carbon-oxygen lyase activity 3 7
GO:0016836 hydro-lyase activity 4 7
GO:0016853 isomerase activity 2 7
GO:0016854 racemase and epimerase activity 3 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity 5 7
GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity 5 7
GO:0052856 NADHX epimerase activity 4 7
GO:0052857 NADPHX epimerase activity 4 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 20 22 PF00675 0.267
CLV_NRD_NRD_1 245 247 PF00675 0.307
CLV_NRD_NRD_1 259 261 PF00675 0.395
CLV_NRD_NRD_1 442 444 PF00675 0.245
CLV_PCSK_KEX2_1 20 22 PF00082 0.267
CLV_PCSK_KEX2_1 245 247 PF00082 0.307
CLV_PCSK_KEX2_1 259 261 PF00082 0.395
CLV_PCSK_KEX2_1 442 444 PF00082 0.245
CLV_PCSK_SKI1_1 240 244 PF00082 0.401
CLV_PCSK_SKI1_1 246 250 PF00082 0.338
CLV_PCSK_SKI1_1 260 264 PF00082 0.276
CLV_PCSK_SKI1_1 271 275 PF00082 0.279
CLV_PCSK_SKI1_1 301 305 PF00082 0.245
CLV_PCSK_SKI1_1 94 98 PF00082 0.279
DEG_APCC_DBOX_1 245 253 PF00400 0.383
DEG_APCC_DBOX_1 66 74 PF00400 0.213
DEG_Kelch_Keap1_1 184 189 PF01344 0.344
DEG_Nend_Nbox_1 1 3 PF02207 0.448
DOC_CKS1_1 414 419 PF01111 0.445
DOC_CYCLIN_RxL_1 222 231 PF00134 0.329
DOC_CYCLIN_yCln2_LP_2 134 140 PF00134 0.300
DOC_PP2B_LxvP_1 134 137 PF13499 0.344
DOC_PP2B_LxvP_1 170 173 PF13499 0.279
DOC_PP2B_LxvP_1 99 102 PF13499 0.279
DOC_USP7_MATH_1 36 40 PF00917 0.358
DOC_WW_Pin1_4 413 418 PF00397 0.459
DOC_WW_Pin1_4 548 553 PF00397 0.528
LIG_14-3-3_CanoR_1 21 29 PF00244 0.354
LIG_14-3-3_CanoR_1 4 12 PF00244 0.369
LIG_14-3-3_CanoR_1 499 505 PF00244 0.374
LIG_14-3-3_CanoR_1 533 541 PF00244 0.491
LIG_Actin_WH2_2 16 32 PF00022 0.329
LIG_BIR_III_2 31 35 PF00653 0.432
LIG_BRCT_BRCA1_1 103 107 PF00533 0.180
LIG_FHA_1 298 304 PF00498 0.445
LIG_FHA_1 343 349 PF00498 0.445
LIG_FHA_1 361 367 PF00498 0.445
LIG_FHA_1 374 380 PF00498 0.411
LIG_FHA_1 449 455 PF00498 0.445
LIG_FHA_1 467 473 PF00498 0.445
LIG_FHA_1 487 493 PF00498 0.445
LIG_FHA_1 527 533 PF00498 0.445
LIG_FHA_2 11 17 PF00498 0.358
LIG_FHA_2 302 308 PF00498 0.445
LIG_FHA_2 320 326 PF00498 0.445
LIG_GBD_Chelix_1 11 19 PF00786 0.331
LIG_LIR_Apic_2 307 311 PF02991 0.445
LIG_LIR_Gen_1 158 167 PF02991 0.279
LIG_LIR_Gen_1 200 211 PF02991 0.279
LIG_LIR_Gen_1 250 258 PF02991 0.429
LIG_LIR_Gen_1 57 63 PF02991 0.279
LIG_LIR_Nem_3 158 163 PF02991 0.279
LIG_LIR_Nem_3 200 206 PF02991 0.279
LIG_LIR_Nem_3 250 256 PF02991 0.454
LIG_LIR_Nem_3 57 62 PF02991 0.279
LIG_NRBOX 487 493 PF00104 0.445
LIG_SH2_CRK 224 228 PF00017 0.324
LIG_SH2_PTP2 308 311 PF00017 0.405
LIG_SH2_SRC 160 163 PF00017 0.295
LIG_SH2_SRC 83 86 PF00017 0.279
LIG_SH2_STAP1 160 164 PF00017 0.279
LIG_SH2_STAP1 56 60 PF00017 0.248
LIG_SH2_STAT3 218 221 PF00017 0.337
LIG_SH2_STAT3 63 66 PF00017 0.279
LIG_SH2_STAT5 218 221 PF00017 0.337
LIG_SH2_STAT5 22 25 PF00017 0.265
LIG_SH2_STAT5 255 258 PF00017 0.420
LIG_SH2_STAT5 308 311 PF00017 0.405
LIG_SH2_STAT5 63 66 PF00017 0.300
LIG_SH2_STAT5 83 86 PF00017 0.197
LIG_SH3_1 405 411 PF00018 0.491
LIG_SH3_3 127 133 PF00018 0.276
LIG_SH3_3 405 411 PF00018 0.491
LIG_SUMO_SIM_anti_2 139 145 PF11976 0.279
LIG_SUMO_SIM_par_1 374 380 PF11976 0.445
LIG_TYR_ITIM 222 227 PF00017 0.312
LIG_WW_3 154 158 PF00397 0.344
MOD_CDK_SPxxK_3 548 555 PF00069 0.545
MOD_CK1_1 3 9 PF00069 0.442
MOD_CK1_1 413 419 PF00069 0.279
MOD_CK1_1 466 472 PF00069 0.344
MOD_CK1_1 548 554 PF00069 0.579
MOD_CK2_1 10 16 PF00069 0.355
MOD_CK2_1 301 307 PF00069 0.279
MOD_CK2_1 319 325 PF00069 0.279
MOD_GlcNHglycan 180 183 PF01048 0.279
MOD_GlcNHglycan 24 27 PF01048 0.322
MOD_GlcNHglycan 260 263 PF01048 0.401
MOD_GlcNHglycan 287 290 PF01048 0.322
MOD_GlcNHglycan 465 468 PF01048 0.288
MOD_GlcNHglycan 480 483 PF01048 0.279
MOD_GlcNHglycan 547 550 PF01048 0.507
MOD_GSK3_1 297 304 PF00069 0.272
MOD_GSK3_1 3 10 PF00069 0.437
MOD_GSK3_1 319 326 PF00069 0.344
MOD_GSK3_1 38 45 PF00069 0.326
MOD_GSK3_1 500 507 PF00069 0.396
MOD_N-GLC_1 545 550 PF02516 0.431
MOD_NEK2_1 147 152 PF00069 0.326
MOD_NEK2_1 448 453 PF00069 0.279
MOD_NEK2_1 504 509 PF00069 0.331
MOD_NEK2_1 62 67 PF00069 0.344
MOD_PIKK_1 36 42 PF00454 0.340
MOD_PIKK_1 62 68 PF00454 0.344
MOD_PKA_2 258 264 PF00069 0.483
MOD_PKA_2 3 9 PF00069 0.442
MOD_PKA_2 526 532 PF00069 0.279
MOD_Plk_1 124 130 PF00069 0.259
MOD_Plk_1 373 379 PF00069 0.265
MOD_Plk_1 42 48 PF00069 0.321
MOD_Plk_4 199 205 PF00069 0.279
MOD_Plk_4 282 288 PF00069 0.296
MOD_Plk_4 373 379 PF00069 0.265
MOD_Plk_4 410 416 PF00069 0.279
MOD_Plk_4 456 462 PF00069 0.279
MOD_Plk_4 7 13 PF00069 0.254
MOD_Plk_4 94 100 PF00069 0.279
MOD_ProDKin_1 413 419 PF00069 0.299
MOD_ProDKin_1 548 554 PF00069 0.536
TRG_DiLeu_BaEn_1 421 426 PF01217 0.279
TRG_DiLeu_BaLyEn_6 308 313 PF01217 0.279
TRG_DiLeu_LyEn_5 421 426 PF01217 0.279
TRG_ENDOCYTIC_2 160 163 PF00928 0.279
TRG_ENDOCYTIC_2 224 227 PF00928 0.314
TRG_ENDOCYTIC_2 253 256 PF00928 0.401
TRG_ENDOCYTIC_2 56 59 PF00928 0.279
TRG_ER_diArg_1 19 21 PF00400 0.256
TRG_ER_diArg_1 245 247 PF00400 0.298
TRG_ER_diArg_1 258 260 PF00400 0.381
TRG_ER_diArg_1 442 444 PF00400 0.279
TRG_NES_CRM1_1 237 251 PF08389 0.399
TRG_Pf-PMV_PEXEL_1 225 230 PF00026 0.394

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3B5 Leptomonas seymouri 69% 96%
A0A1X0NNH9 Trypanosomatidae 44% 90%
A0A3R7M9Q9 Trypanosoma rangeli 44% 96%
A0A3S7WT52 Leishmania donovani 94% 99%
A1S0R2 Thermofilum pendens (strain DSM 2475 / Hrk 5) 30% 100%
A2BLC0 Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) 33% 100%
A4H7T9 Leishmania braziliensis 87% 100%
A4HW65 Leishmania infantum 94% 99%
B1L3W1 Korarchaeum cryptofilum (strain OPF8) 28% 100%
B5YIM0 Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) 29% 100%
B8E2P6 Dictyoglomus turgidum (strain DSM 6724 / Z-1310) 27% 100%
C9ZSV9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 97%
D1BAA5 Thermanaerovibrio acidaminovorans (strain ATCC 49978 / DSM 6589 / Su883) 32% 100%
O27324 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 28% 100%
O29407 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 29% 100%
O67377 Aquifex aeolicus (strain VF5) 28% 100%
P31806 Escherichia coli (strain K12) 47% 100%
P37391 Mycobacterium leprae (strain TN) 29% 100%
P56176 Helicobacter pylori (strain ATCC 700392 / 26695) 24% 100%
P74217 Synechocystis sp. (strain PCC 6803 / Kazusa) 29% 100%
P9WF10 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 28% 100%
P9WF11 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 28% 100%
Q2RGI2 Moorella thermoacetica (strain ATCC 39073 / JCM 9320) 33% 100%
Q2S580 Salinibacter ruber (strain DSM 13855 / M31) 32% 100%
Q4QFL5 Leishmania major 92% 100%
Q58981 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 26% 100%
Q7NIE6 Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) 34% 100%
Q83CM5 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 37% 100%
Q8DGC3 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) 33% 100%
Q8NSS3 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 25% 97%
Q8TX67 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 28% 100%
Q8ZV04 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 33% 100%
Q9KMX5 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 39% 100%
Q9X024 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 30% 100%
Q9ZJM4 Helicobacter pylori (strain J99 / ATCC 700824) 25% 100%
V5BG46 Trypanosoma cruzi 46% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS