FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APW4_LEIMU

TriTrypDb:

LmxM.14.1170

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APW4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	647	651	PF00656	0.429
CLV_NRD_NRD_1	130	132	PF00675	0.483
CLV_NRD_NRD_1	222	224	PF00675	0.704
CLV_NRD_NRD_1	361	363	PF00675	0.597
CLV_NRD_NRD_1	423	425	PF00675	0.432
CLV_NRD_NRD_1	455	457	PF00675	0.351
CLV_NRD_NRD_1	472	474	PF00675	0.351
CLV_NRD_NRD_1	52	54	PF00675	0.352
CLV_NRD_NRD_1	739	741	PF00675	0.715
CLV_NRD_NRD_1	766	768	PF00675	0.657
CLV_PCSK_KEX2_1	130	132	PF00082	0.483
CLV_PCSK_KEX2_1	221	223	PF00082	0.702
CLV_PCSK_KEX2_1	342	344	PF00082	0.598
CLV_PCSK_KEX2_1	361	363	PF00082	0.597
CLV_PCSK_KEX2_1	423	425	PF00082	0.432
CLV_PCSK_KEX2_1	455	457	PF00082	0.331
CLV_PCSK_KEX2_1	543	545	PF00082	0.714
CLV_PCSK_KEX2_1	738	740	PF00082	0.727
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.598
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.603
CLV_PCSK_SKI1_1	14	18	PF00082	0.636
CLV_PCSK_SKI1_1	233	237	PF00082	0.567
CLV_PCSK_SKI1_1	379	383	PF00082	0.496
CLV_PCSK_SKI1_1	387	391	PF00082	0.378
CLV_PCSK_SKI1_1	424	428	PF00082	0.407
CLV_PCSK_SKI1_1	473	477	PF00082	0.379
CLV_Separin_Metazoa	281	285	PF03568	0.581
DEG_APCC_DBOX_1	224	232	PF00400	0.636
DEG_SCF_FBW7_2	667	674	PF00400	0.551
DEG_SPOP_SBC_1	146	150	PF00917	0.203
DEG_SPOP_SBC_1	689	693	PF00917	0.620
DEG_SPOP_SBC_1	7	11	PF00917	0.679
DEG_SPOP_SBC_1	83	87	PF00917	0.483
DOC_CYCLIN_RxL_1	376	384	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	382	388	PF00134	0.467
DOC_MAPK_gen_1	423	430	PF00069	0.432
DOC_MAPK_MEF2A_6	246	253	PF00069	0.348
DOC_MAPK_MEF2A_6	423	430	PF00069	0.483
DOC_PP4_FxxP_1	152	155	PF00568	0.273
DOC_USP7_MATH_1	117	121	PF00917	0.430
DOC_USP7_MATH_1	141	145	PF00917	0.392
DOC_USP7_MATH_1	201	205	PF00917	0.337
DOC_USP7_MATH_1	292	296	PF00917	0.713
DOC_USP7_MATH_1	314	318	PF00917	0.698
DOC_USP7_MATH_1	42	46	PF00917	0.390
DOC_USP7_MATH_1	528	532	PF00917	0.685
DOC_USP7_MATH_1	546	550	PF00917	0.459
DOC_USP7_MATH_1	568	572	PF00917	0.573
DOC_USP7_MATH_1	639	643	PF00917	0.561
DOC_USP7_MATH_1	690	694	PF00917	0.605
DOC_USP7_MATH_1	741	745	PF00917	0.640
DOC_USP7_MATH_1	83	87	PF00917	0.473
DOC_USP7_MATH_1	91	95	PF00917	0.485
DOC_USP7_MATH_1	99	103	PF00917	0.325
DOC_WW_Pin1_4	105	110	PF00397	0.350
DOC_WW_Pin1_4	170	175	PF00397	0.397
DOC_WW_Pin1_4	185	190	PF00397	0.365
DOC_WW_Pin1_4	381	386	PF00397	0.454
DOC_WW_Pin1_4	538	543	PF00397	0.500
DOC_WW_Pin1_4	621	626	PF00397	0.743
DOC_WW_Pin1_4	635	640	PF00397	0.546
DOC_WW_Pin1_4	667	672	PF00397	0.554
DOC_WW_Pin1_4	724	729	PF00397	0.737
LIG_14-3-3_CanoR_1	198	207	PF00244	0.351
LIG_14-3-3_CanoR_1	284	289	PF00244	0.642
LIG_14-3-3_CanoR_1	315	319	PF00244	0.702
LIG_14-3-3_CanoR_1	343	348	PF00244	0.612
LIG_14-3-3_CanoR_1	350	359	PF00244	0.536
LIG_14-3-3_CanoR_1	379	385	PF00244	0.488
LIG_14-3-3_CanoR_1	423	429	PF00244	0.422
LIG_14-3-3_CanoR_1	432	440	PF00244	0.446
LIG_14-3-3_CanoR_1	473	478	PF00244	0.379
LIG_14-3-3_CanoR_1	548	553	PF00244	0.635
LIG_14-3-3_CanoR_1	62	72	PF00244	0.467
LIG_14-3-3_CanoR_1	657	666	PF00244	0.505
LIG_14-3-3_CanoR_1	733	741	PF00244	0.688
LIG_14-3-3_CanoR_1	82	90	PF00244	0.157
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BIR_III_4	650	654	PF00653	0.528
LIG_BRCT_BRCA1_1	254	258	PF00533	0.517
LIG_BRCT_BRCA1_1	44	48	PF00533	0.390
LIG_FHA_1	2	8	PF00498	0.667
LIG_FHA_1	272	278	PF00498	0.572
LIG_FHA_1	352	358	PF00498	0.525
LIG_FHA_1	425	431	PF00498	0.347
LIG_FHA_1	690	696	PF00498	0.590
LIG_FHA_2	211	217	PF00498	0.698
LIG_FHA_2	242	248	PF00498	0.617
LIG_FHA_2	692	698	PF00498	0.654
LIG_LIR_Apic_2	149	155	PF02991	0.432
LIG_LIR_Gen_1	241	249	PF02991	0.481
LIG_LIR_Gen_1	354	360	PF02991	0.509
LIG_LIR_Gen_1	670	681	PF02991	0.506
LIG_LIR_LC3C_4	206	211	PF02991	0.575
LIG_LIR_Nem_3	241	245	PF02991	0.521
LIG_LIR_Nem_3	304	308	PF02991	0.664
LIG_LIR_Nem_3	354	359	PF02991	0.492
LIG_LIR_Nem_3	449	454	PF02991	0.338
LIG_LIR_Nem_3	45	51	PF02991	0.351
LIG_LIR_Nem_3	670	676	PF02991	0.507
LIG_MYND_1	665	669	PF01753	0.557
LIG_NRBOX	760	766	PF00104	0.538
LIG_PCNA_yPIPBox_3	263	277	PF02747	0.550
LIG_PTAP_UEV_1	323	328	PF05743	0.452
LIG_RPA_C_Fungi	427	439	PF08784	0.413
LIG_SH2_SRC	469	472	PF00017	0.432
LIG_SH2_SRC	74	77	PF00017	0.483
LIG_SH2_STAP1	205	209	PF00017	0.351
LIG_SH2_STAP1	353	357	PF00017	0.606
LIG_SH2_STAT3	205	208	PF00017	0.351
LIG_SH2_STAT5	259	262	PF00017	0.576
LIG_SH2_STAT5	306	309	PF00017	0.643
LIG_SH2_STAT5	353	356	PF00017	0.612
LIG_SH2_STAT5	74	77	PF00017	0.432
LIG_SH2_STAT5	95	98	PF00017	0.273
LIG_SH3_3	321	327	PF00018	0.457
LIG_SH3_3	411	417	PF00018	0.483
LIG_SH3_3	623	629	PF00018	0.687
LIG_SH3_3	70	76	PF00018	0.483
LIG_SUMO_SIM_anti_2	679	686	PF11976	0.497
LIG_SUMO_SIM_par_1	15	20	PF11976	0.667
LIG_TRAF2_1	213	216	PF00917	0.704
LIG_WRC_WIRS_1	239	244	PF05994	0.593
LIG_WRC_WIRS_1	371	376	PF05994	0.538
MOD_CDC14_SPxK_1	384	387	PF00782	0.422
MOD_CDC14_SPxK_1	541	544	PF00782	0.503
MOD_CDK_SPK_2	538	543	PF00069	0.500
MOD_CDK_SPxK_1	381	387	PF00069	0.445
MOD_CDK_SPxK_1	538	544	PF00069	0.501
MOD_CK1_1	102	108	PF00069	0.390
MOD_CK1_1	120	126	PF00069	0.440
MOD_CK1_1	144	150	PF00069	0.434
MOD_CK1_1	173	179	PF00069	0.479
MOD_CK1_1	185	191	PF00069	0.373
MOD_CK1_1	241	247	PF00069	0.527
MOD_CK1_1	252	258	PF00069	0.533
MOD_CK1_1	287	293	PF00069	0.645
MOD_CK1_1	304	310	PF00069	0.755
MOD_CK1_1	372	378	PF00069	0.550
MOD_CK1_1	510	516	PF00069	0.779
MOD_CK1_1	531	537	PF00069	0.696
MOD_CK1_1	556	562	PF00069	0.731
MOD_CK1_1	638	644	PF00069	0.704
MOD_CK1_1	691	697	PF00069	0.608
MOD_CK1_1	713	719	PF00069	0.775
MOD_CK1_1	720	726	PF00069	0.748
MOD_CK1_1	727	733	PF00069	0.730
MOD_CK2_1	210	216	PF00069	0.689
MOD_CK2_1	221	227	PF00069	0.680
MOD_CK2_1	333	339	PF00069	0.593
MOD_CK2_1	639	645	PF00069	0.507
MOD_CK2_1	82	88	PF00069	0.477
MOD_GlcNHglycan	1	4	PF01048	0.640
MOD_GlcNHglycan	104	107	PF01048	0.473
MOD_GlcNHglycan	121	125	PF01048	0.477
MOD_GlcNHglycan	144	147	PF01048	0.464
MOD_GlcNHglycan	254	257	PF01048	0.561
MOD_GlcNHglycan	309	312	PF01048	0.741
MOD_GlcNHglycan	324	327	PF01048	0.489
MOD_GlcNHglycan	398	401	PF01048	0.376
MOD_GlcNHglycan	434	437	PF01048	0.365
MOD_GlcNHglycan	444	448	PF01048	0.330
MOD_GlcNHglycan	488	491	PF01048	0.390
MOD_GlcNHglycan	510	513	PF01048	0.776
MOD_GlcNHglycan	530	533	PF01048	0.758
MOD_GlcNHglycan	538	541	PF01048	0.694
MOD_GlcNHglycan	595	598	PF01048	0.684
MOD_GlcNHglycan	641	644	PF01048	0.629
MOD_GlcNHglycan	697	701	PF01048	0.668
MOD_GlcNHglycan	706	709	PF01048	0.699
MOD_GlcNHglycan	722	725	PF01048	0.588
MOD_GlcNHglycan	729	732	PF01048	0.666
MOD_GSK3_1	101	108	PF00069	0.326
MOD_GSK3_1	141	148	PF00069	0.415
MOD_GSK3_1	165	172	PF00069	0.410
MOD_GSK3_1	175	182	PF00069	0.347
MOD_GSK3_1	183	190	PF00069	0.241
MOD_GSK3_1	283	290	PF00069	0.586
MOD_GSK3_1	42	49	PF00069	0.411
MOD_GSK3_1	469	476	PF00069	0.432
MOD_GSK3_1	506	513	PF00069	0.722
MOD_GSK3_1	534	541	PF00069	0.648
MOD_GSK3_1	584	591	PF00069	0.706
MOD_GSK3_1	621	628	PF00069	0.689
MOD_GSK3_1	635	642	PF00069	0.568
MOD_GSK3_1	685	692	PF00069	0.534
MOD_GSK3_1	696	703	PF00069	0.586
MOD_GSK3_1	706	713	PF00069	0.639
MOD_GSK3_1	714	721	PF00069	0.647
MOD_GSK3_1	723	730	PF00069	0.733
MOD_GSK3_1	91	98	PF00069	0.348
MOD_N-GLC_1	249	254	PF02516	0.639
MOD_N-GLC_1	271	276	PF02516	0.536
MOD_N-GLC_1	351	356	PF02516	0.512
MOD_N-GLC_1	584	589	PF02516	0.721
MOD_N-GLC_1	752	757	PF02516	0.544
MOD_N-GLC_1	83	88	PF02516	0.404
MOD_N-GLC_1	99	104	PF02516	0.273
MOD_N-GLC_2	582	584	PF02516	0.660
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	17	22	PF00069	0.547
MOD_NEK2_1	209	214	PF00069	0.669
MOD_NEK2_1	536	541	PF00069	0.734
MOD_NEK2_1	573	578	PF00069	0.494
MOD_NEK2_1	588	593	PF00069	0.674
MOD_NEK2_1	64	69	PF00069	0.393
MOD_NEK2_1	644	649	PF00069	0.462
MOD_NEK2_1	676	681	PF00069	0.446
MOD_NEK2_1	704	709	PF00069	0.471
MOD_NEK2_1	752	757	PF00069	0.462
MOD_NEK2_2	658	663	PF00069	0.529
MOD_NEK2_2	700	705	PF00069	0.455
MOD_OFUCOSY	197	203	PF10250	0.432
MOD_OFUCOSY	609	614	PF10250	0.480
MOD_PIKK_1	130	136	PF00454	0.444
MOD_PIKK_1	17	23	PF00454	0.586
MOD_PIKK_1	188	194	PF00454	0.483
MOD_PIKK_1	351	357	PF00454	0.536
MOD_PIKK_1	408	414	PF00454	0.390
MOD_PK_1	548	554	PF00069	0.509
MOD_PKA_1	130	136	PF00069	0.297
MOD_PKA_1	221	227	PF00069	0.724
MOD_PKA_1	473	479	PF00069	0.379
MOD_PKA_2	130	136	PF00069	0.376
MOD_PKA_2	221	227	PF00069	0.724
MOD_PKA_2	283	289	PF00069	0.705
MOD_PKA_2	314	320	PF00069	0.733
MOD_PKA_2	415	421	PF00069	0.414
MOD_Plk_1	17	23	PF00069	0.538
MOD_Plk_1	249	255	PF00069	0.540
MOD_Plk_1	271	277	PF00069	0.586
MOD_Plk_1	330	336	PF00069	0.649
MOD_Plk_1	351	357	PF00069	0.507
MOD_Plk_1	568	574	PF00069	0.666
MOD_Plk_1	584	590	PF00069	0.443
MOD_Plk_1	644	650	PF00069	0.565
MOD_Plk_1	685	691	PF00069	0.590
MOD_Plk_1	700	706	PF00069	0.681
MOD_Plk_1	752	758	PF00069	0.550
MOD_Plk_1	99	105	PF00069	0.390
MOD_Plk_4	147	153	PF00069	0.491
MOD_Plk_4	238	244	PF00069	0.463
MOD_Plk_4	249	255	PF00069	0.506
MOD_Plk_4	301	307	PF00069	0.633
MOD_Plk_4	314	320	PF00069	0.674
MOD_Plk_4	473	479	PF00069	0.351
MOD_Plk_4	492	498	PF00069	0.351
MOD_Plk_4	548	554	PF00069	0.579
MOD_Plk_4	568	574	PF00069	0.545
MOD_Plk_4	676	682	PF00069	0.465
MOD_Plk_4	91	97	PF00069	0.372
MOD_ProDKin_1	105	111	PF00069	0.350
MOD_ProDKin_1	170	176	PF00069	0.397
MOD_ProDKin_1	185	191	PF00069	0.409
MOD_ProDKin_1	381	387	PF00069	0.445
MOD_ProDKin_1	538	544	PF00069	0.501
MOD_ProDKin_1	621	627	PF00069	0.743
MOD_ProDKin_1	635	641	PF00069	0.541
MOD_ProDKin_1	667	673	PF00069	0.547
MOD_ProDKin_1	724	730	PF00069	0.739
MOD_SUMO_for_1	542	545	PF00179	0.669
MOD_SUMO_rev_2	224	231	PF00179	0.694
TRG_DiLeu_BaEn_2	452	458	PF01217	0.483
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.552
TRG_ENDOCYTIC_2	353	356	PF00928	0.612
TRG_ENDOCYTIC_2	451	454	PF00928	0.432
TRG_ER_diArg_1	129	131	PF00400	0.483
TRG_ER_diArg_1	220	223	PF00400	0.697
TRG_ER_diArg_1	454	456	PF00400	0.333
TRG_ER_diArg_1	518	521	PF00400	0.491
TRG_ER_diArg_1	738	740	PF00400	0.729
TRG_NES_CRM1_1	674	686	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	745	749	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I177	Leptomonas seymouri	63%	88%
A0A1X0NPZ6	Trypanosomatidae	41%	100%
A0A3R7LJV9	Trypanosoma rangeli	43%	100%
A0A3S7WT46	Leishmania donovani	88%	100%
A4H7T7	Leishmania braziliensis	72%	100%
Q4QFL7	Leishmania major	87%	100%