LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania mexicana
UniProt:
E9APW2_LEIMU
TriTrypDb:
LmxM.14.1155
Length:
343

Annotations

LeishMANIAdb annotations

Very putatively an organellar or non-TM protein

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APW2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APW2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 44 48 PF00656 0.687
CLV_NRD_NRD_1 102 104 PF00675 0.554
CLV_NRD_NRD_1 191 193 PF00675 0.575
CLV_NRD_NRD_1 2 4 PF00675 0.541
CLV_NRD_NRD_1 63 65 PF00675 0.335
CLV_PCSK_KEX2_1 102 104 PF00082 0.554
CLV_PCSK_KEX2_1 181 183 PF00082 0.594
CLV_PCSK_KEX2_1 193 195 PF00082 0.561
CLV_PCSK_KEX2_1 2 4 PF00082 0.541
CLV_PCSK_KEX2_1 63 65 PF00082 0.344
CLV_PCSK_PC1ET2_1 181 183 PF00082 0.674
CLV_PCSK_PC1ET2_1 193 195 PF00082 0.643
CLV_PCSK_PC7_1 177 183 PF00082 0.644
CLV_PCSK_PC7_1 189 195 PF00082 0.543
CLV_PCSK_SKI1_1 193 197 PF00082 0.604
CLV_PCSK_SKI1_1 30 34 PF00082 0.462
CLV_PCSK_SKI1_1 308 312 PF00082 0.624
DEG_Nend_UBRbox_1 1 4 PF02207 0.645
DEG_SPOP_SBC_1 137 141 PF00917 0.410
DEG_SPOP_SBC_1 38 42 PF00917 0.672
DOC_CYCLIN_RxL_1 189 200 PF00134 0.399
DOC_MAPK_gen_1 189 197 PF00069 0.392
DOC_MAPK_gen_1 321 331 PF00069 0.375
DOC_MAPK_gen_1 63 69 PF00069 0.579
DOC_MAPK_MEF2A_6 271 280 PF00069 0.356
DOC_PP1_RVXF_1 191 198 PF00149 0.398
DOC_PP2B_LxvP_1 75 78 PF13499 0.300
DOC_USP7_MATH_1 130 134 PF00917 0.490
DOC_USP7_MATH_1 20 24 PF00917 0.734
DOC_USP7_MATH_1 243 247 PF00917 0.449
DOC_USP7_MATH_1 255 259 PF00917 0.327
DOC_USP7_MATH_1 293 297 PF00917 0.479
DOC_USP7_MATH_1 36 40 PF00917 0.584
DOC_WW_Pin1_4 117 122 PF00397 0.495
DOC_WW_Pin1_4 131 136 PF00397 0.614
DOC_WW_Pin1_4 139 144 PF00397 0.612
DOC_WW_Pin1_4 212 217 PF00397 0.461
DOC_WW_Pin1_4 263 268 PF00397 0.484
LIG_14-3-3_CanoR_1 201 210 PF00244 0.458
LIG_14-3-3_CanoR_1 248 254 PF00244 0.341
LIG_14-3-3_CanoR_1 5 14 PF00244 0.668
LIG_Actin_WH2_2 81 99 PF00022 0.534
LIG_APCC_ABBA_1 315 320 PF00400 0.216
LIG_CSL_BTD_1 111 114 PF09270 0.439
LIG_deltaCOP1_diTrp_1 170 178 PF00928 0.440
LIG_FHA_1 275 281 PF00498 0.472
LIG_FHA_1 311 317 PF00498 0.302
LIG_FHA_2 206 212 PF00498 0.531
LIG_FHA_2 239 245 PF00498 0.467
LIG_LIR_Nem_3 66 72 PF02991 0.557
LIG_LIR_Nem_3 81 86 PF02991 0.331
LIG_LIR_Nem_3 92 98 PF02991 0.319
LIG_PCNA_yPIPBox_3 58 72 PF02747 0.447
LIG_PDZ_Class_3 338 343 PF00595 0.402
LIG_Pex14_2 109 113 PF04695 0.354
LIG_SH2_STAP1 249 253 PF00017 0.432
LIG_SH2_STAT3 13 16 PF00017 0.551
LIG_SH2_STAT5 98 101 PF00017 0.340
LIG_SH3_3 115 121 PF00018 0.416
LIG_SH3_3 261 267 PF00018 0.454
LIG_SH3_3 280 286 PF00018 0.567
LIG_SH3_3 292 298 PF00018 0.443
LIG_SUMO_SIM_par_1 114 120 PF11976 0.479
LIG_SUMO_SIM_par_1 276 281 PF11976 0.358
LIG_TRFH_1 86 90 PF08558 0.500
MOD_CK1_1 131 137 PF00069 0.559
MOD_CK1_1 139 145 PF00069 0.554
MOD_CK1_1 205 211 PF00069 0.403
MOD_CK1_1 266 272 PF00069 0.505
MOD_CK1_1 39 45 PF00069 0.704
MOD_CK1_1 8 14 PF00069 0.610
MOD_CK2_1 117 123 PF00069 0.502
MOD_CK2_1 181 187 PF00069 0.452
MOD_CK2_1 205 211 PF00069 0.496
MOD_CK2_1 212 218 PF00069 0.474
MOD_CK2_1 238 244 PF00069 0.467
MOD_GlcNHglycan 22 25 PF01048 0.492
MOD_GlcNHglycan 257 260 PF01048 0.664
MOD_GlcNHglycan 43 46 PF01048 0.485
MOD_GlcNHglycan 51 54 PF01048 0.422
MOD_GSK3_1 119 126 PF00069 0.540
MOD_GSK3_1 131 138 PF00069 0.611
MOD_GSK3_1 160 167 PF00069 0.513
MOD_GSK3_1 205 212 PF00069 0.510
MOD_GSK3_1 26 33 PF00069 0.724
MOD_GSK3_1 306 313 PF00069 0.471
MOD_GSK3_1 34 41 PF00069 0.697
MOD_GSK3_1 4 11 PF00069 0.716
MOD_NEK2_1 105 110 PF00069 0.342
MOD_NEK2_1 310 315 PF00069 0.318
MOD_NEK2_1 4 9 PF00069 0.686
MOD_NEK2_2 78 83 PF00069 0.403
MOD_PKA_1 181 187 PF00069 0.442
MOD_PKA_2 181 187 PF00069 0.286
MOD_PKA_2 20 26 PF00069 0.709
MOD_PKA_2 4 10 PF00069 0.714
MOD_PKA_2 88 94 PF00069 0.435
MOD_PKB_1 3 11 PF00069 0.534
MOD_Plk_1 105 111 PF00069 0.347
MOD_Plk_1 205 211 PF00069 0.539
MOD_Plk_1 306 312 PF00069 0.424
MOD_Plk_4 160 166 PF00069 0.454
MOD_Plk_4 205 211 PF00069 0.528
MOD_ProDKin_1 117 123 PF00069 0.499
MOD_ProDKin_1 131 137 PF00069 0.611
MOD_ProDKin_1 139 145 PF00069 0.612
MOD_ProDKin_1 212 218 PF00069 0.458
MOD_ProDKin_1 263 269 PF00069 0.484
MOD_SUMO_rev_2 258 264 PF00179 0.336
TRG_DiLeu_BaEn_4 221 227 PF01217 0.503
TRG_DiLeu_BaLyEn_6 191 196 PF01217 0.377
TRG_ENDOCYTIC_2 83 86 PF00928 0.411
TRG_ER_diArg_1 1 3 PF00400 0.781
TRG_ER_diArg_1 192 195 PF00400 0.381
TRG_ER_diArg_1 62 64 PF00400 0.550
TRG_NLS_Bipartite_1 181 196 PF00514 0.402
TRG_NLS_MonoExtN_4 189 196 PF00514 0.439
TRG_Pf-PMV_PEXEL_1 224 228 PF00026 0.710

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P306 Leptomonas seymouri 52% 97%
A0A1X0NQ49 Trypanosomatidae 35% 100%
A0A3R7M3H5 Trypanosoma rangeli 35% 100%
A0A3S5H6S8 Leishmania donovani 83% 98%
A4H7R9 Leishmania braziliensis 68% 91%
C9ZSW2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9ACR5 Leishmania major 86% 100%
E9AGL5 Leishmania infantum 84% 99%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS