LeishMANIAdb
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Tub family protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tub family protein-like protein
Gene product:
tub family protein-like protein
Species:
Leishmania mexicana
UniProt:
E9APW1_LEIMU
TriTrypDb:
LmxM.14.1150
Length:
361

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APW1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APW1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 6 10 PF00656 0.602
CLV_NRD_NRD_1 133 135 PF00675 0.352
CLV_NRD_NRD_1 148 150 PF00675 0.235
CLV_NRD_NRD_1 269 271 PF00675 0.453
CLV_NRD_NRD_1 3 5 PF00675 0.770
CLV_NRD_NRD_1 34 36 PF00675 0.286
CLV_NRD_NRD_1 44 46 PF00675 0.497
CLV_PCSK_FUR_1 131 135 PF00082 0.214
CLV_PCSK_FUR_1 32 36 PF00082 0.258
CLV_PCSK_KEX2_1 131 133 PF00082 0.341
CLV_PCSK_KEX2_1 269 271 PF00082 0.322
CLV_PCSK_KEX2_1 34 36 PF00082 0.286
CLV_PCSK_KEX2_1 44 46 PF00082 0.497
CLV_PCSK_SKI1_1 150 154 PF00082 0.453
CLV_PCSK_SKI1_1 18 22 PF00082 0.464
CLV_PCSK_SKI1_1 332 336 PF00082 0.335
CLV_PCSK_SKI1_1 35 39 PF00082 0.306
CLV_PCSK_SKI1_1 45 49 PF00082 0.306
CLV_PCSK_SKI1_1 80 84 PF00082 0.389
DEG_APCC_DBOX_1 132 140 PF00400 0.214
DEG_APCC_DBOX_1 337 345 PF00400 0.335
DEG_APCC_DBOX_1 43 51 PF00400 0.278
DOC_CYCLIN_yCln2_LP_2 171 177 PF00134 0.453
DOC_MAPK_FxFP_2 337 340 PF00069 0.335
DOC_MAPK_gen_1 131 141 PF00069 0.483
DOC_MAPK_gen_1 146 155 PF00069 0.251
DOC_MAPK_gen_1 307 315 PF00069 0.214
DOC_MAPK_gen_1 44 52 PF00069 0.335
DOC_MAPK_MEF2A_6 149 157 PF00069 0.335
DOC_MAPK_MEF2A_6 270 279 PF00069 0.335
DOC_PP1_RVXF_1 293 299 PF00149 0.335
DOC_PP2B_PxIxI_1 274 280 PF00149 0.335
DOC_PP4_FxxP_1 337 340 PF00568 0.335
DOC_USP7_MATH_1 209 213 PF00917 0.310
DOC_USP7_MATH_1 244 248 PF00917 0.369
DOC_USP7_UBL2_3 146 150 PF12436 0.335
DOC_USP7_UBL2_3 304 308 PF12436 0.453
DOC_WW_Pin1_4 225 230 PF00397 0.389
DOC_WW_Pin1_4 271 276 PF00397 0.332
LIG_14-3-3_CanoR_1 165 171 PF00244 0.389
LIG_14-3-3_CanoR_1 197 204 PF00244 0.325
LIG_14-3-3_CanoR_1 59 64 PF00244 0.485
LIG_Actin_RPEL_3 37 56 PF02755 0.335
LIG_APCC_ABBA_1 138 143 PF00400 0.335
LIG_BRCT_BRCA1_1 61 65 PF00533 0.344
LIG_FHA_1 167 173 PF00498 0.335
LIG_FHA_1 51 57 PF00498 0.278
LIG_FHA_2 1 7 PF00498 0.637
LIG_FHA_2 200 206 PF00498 0.223
LIG_FHA_2 84 90 PF00498 0.389
LIG_LIR_Apic_2 178 184 PF02991 0.334
LIG_LIR_Apic_2 27 33 PF02991 0.416
LIG_LIR_Apic_2 336 340 PF02991 0.335
LIG_LIR_Gen_1 166 175 PF02991 0.313
LIG_LIR_Gen_1 228 236 PF02991 0.244
LIG_LIR_Gen_1 62 70 PF02991 0.344
LIG_LIR_Nem_3 166 171 PF02991 0.334
LIG_LIR_Nem_3 228 234 PF02991 0.321
LIG_LIR_Nem_3 284 290 PF02991 0.453
LIG_LIR_Nem_3 62 66 PF02991 0.344
LIG_NRBOX 152 158 PF00104 0.453
LIG_NRP_CendR_1 358 361 PF00754 0.458
LIG_Pex14_2 333 337 PF04695 0.335
LIG_SH2_PTP2 181 184 PF00017 0.335
LIG_SH2_STAT5 181 184 PF00017 0.335
LIG_SH2_STAT5 41 44 PF00017 0.335
LIG_SH3_1 269 275 PF00018 0.335
LIG_SH3_3 167 173 PF00018 0.335
LIG_SH3_3 19 25 PF00018 0.471
LIG_SH3_3 269 275 PF00018 0.335
LIG_SH3_3 312 318 PF00018 0.313
LIG_SUMO_SIM_anti_2 151 157 PF11976 0.453
LIG_SUMO_SIM_par_1 276 282 PF11976 0.453
LIG_SUMO_SIM_par_1 311 317 PF11976 0.313
LIG_UBA3_1 277 283 PF00899 0.313
MOD_CDK_SPK_2 225 230 PF00069 0.214
MOD_CK1_1 12 18 PF00069 0.727
MOD_CK1_1 142 148 PF00069 0.335
MOD_CK1_1 166 172 PF00069 0.342
MOD_CK1_1 199 205 PF00069 0.236
MOD_CK1_1 222 228 PF00069 0.389
MOD_CK1_1 248 254 PF00069 0.374
MOD_CK1_1 81 87 PF00069 0.453
MOD_CK2_1 145 151 PF00069 0.258
MOD_CK2_1 244 250 PF00069 0.389
MOD_CK2_1 83 89 PF00069 0.389
MOD_GlcNHglycan 178 181 PF01048 0.348
MOD_GlcNHglycan 9 12 PF01048 0.650
MOD_GlcNHglycan 92 95 PF01048 0.482
MOD_GSK3_1 117 124 PF00069 0.406
MOD_GSK3_1 160 167 PF00069 0.335
MOD_GSK3_1 218 225 PF00069 0.300
MOD_GSK3_1 244 251 PF00069 0.370
MOD_GSK3_1 299 306 PF00069 0.389
MOD_GSK3_1 348 355 PF00069 0.335
MOD_GSK3_1 5 12 PF00069 0.603
MOD_N-GLC_1 209 214 PF02516 0.389
MOD_NEK2_1 16 21 PF00069 0.520
MOD_NEK2_1 50 55 PF00069 0.278
MOD_PIKK_1 100 106 PF00454 0.358
MOD_PKA_2 164 170 PF00069 0.389
MOD_PKA_2 196 202 PF00069 0.485
MOD_PKA_2 248 254 PF00069 0.249
MOD_PKA_2 300 306 PF00069 0.348
MOD_Plk_1 163 169 PF00069 0.389
MOD_Plk_4 349 355 PF00069 0.335
MOD_Plk_4 51 57 PF00069 0.337
MOD_Plk_4 9 15 PF00069 0.569
MOD_ProDKin_1 225 231 PF00069 0.389
MOD_ProDKin_1 271 277 PF00069 0.332
TRG_ER_diArg_1 131 134 PF00400 0.214
TRG_ER_diArg_1 268 270 PF00400 0.453
TRG_ER_diArg_1 31 34 PF00400 0.413
TRG_NLS_Bipartite_1 34 49 PF00514 0.326
TRG_NLS_MonoExtN_4 44 49 PF00514 0.453
TRG_Pf-PMV_PEXEL_1 35 39 PF00026 0.306

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC07 Leptomonas seymouri 71% 74%
A0A3Q8I9W0 Leishmania donovani 89% 100%
A4H7R8 Leishmania braziliensis 78% 100%
A4HW61 Leishmania infantum 89% 70%
Q4QFL9 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS