CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APW0_LEIMU

TriTrypDb:

LmxM.14.1140

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APW0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.660
CLV_NRD_NRD_1	149	151	PF00675	0.707
CLV_NRD_NRD_1	154	156	PF00675	0.718
CLV_NRD_NRD_1	163	165	PF00675	0.743
CLV_NRD_NRD_1	252	254	PF00675	0.636
CLV_NRD_NRD_1	336	338	PF00675	0.565
CLV_NRD_NRD_1	455	457	PF00675	0.749
CLV_NRD_NRD_1	68	70	PF00675	0.482
CLV_PCSK_KEX2_1	149	151	PF00082	0.663
CLV_PCSK_KEX2_1	154	156	PF00082	0.686
CLV_PCSK_KEX2_1	252	254	PF00082	0.636
CLV_PCSK_KEX2_1	336	338	PF00082	0.561
CLV_PCSK_KEX2_1	455	457	PF00082	0.794
CLV_PCSK_KEX2_1	68	70	PF00082	0.497
CLV_PCSK_PC7_1	150	156	PF00082	0.452
CLV_PCSK_SKI1_1	118	122	PF00082	0.556
CLV_PCSK_SKI1_1	124	128	PF00082	0.557
CLV_PCSK_SKI1_1	338	342	PF00082	0.601
DEG_SCF_FBW7_1	289	295	PF00400	0.521
DOC_CKS1_1	289	294	PF01111	0.511
DOC_CYCLIN_RxL_1	337	349	PF00134	0.673
DOC_MAPK_DCC_7	221	230	PF00069	0.463
DOC_MAPK_gen_1	417	425	PF00069	0.468
DOC_PP1_RVXF_1	136	142	PF00149	0.521
DOC_PP1_RVXF_1	231	238	PF00149	0.496
DOC_PP1_RVXF_1	279	286	PF00149	0.444
DOC_PP4_FxxP_1	341	344	PF00568	0.629
DOC_PP4_FxxP_1	40	43	PF00568	0.678
DOC_USP7_MATH_1	196	200	PF00917	0.743
DOC_USP7_MATH_1	292	296	PF00917	0.747
DOC_USP7_MATH_1	6	10	PF00917	0.671
DOC_USP7_UBL2_3	413	417	PF12436	0.497
DOC_WW_Pin1_4	144	149	PF00397	0.560
DOC_WW_Pin1_4	157	162	PF00397	0.728
DOC_WW_Pin1_4	16	21	PF00397	0.708
DOC_WW_Pin1_4	220	225	PF00397	0.458
DOC_WW_Pin1_4	288	293	PF00397	0.484
DOC_WW_Pin1_4	303	308	PF00397	0.687
LIG_14-3-3_CanoR_1	138	142	PF00244	0.474
LIG_14-3-3_CanoR_1	207	213	PF00244	0.552
LIG_14-3-3_CanoR_1	22	30	PF00244	0.723
LIG_14-3-3_CanoR_1	261	267	PF00244	0.497
LIG_14-3-3_CanoR_1	401	405	PF00244	0.534
LIG_14-3-3_CanoR_1	47	56	PF00244	0.561
LIG_Actin_WH2_2	262	280	PF00022	0.488
LIG_BIR_III_2	349	353	PF00653	0.706
LIG_BRCT_BRCA1_1	118	122	PF00533	0.435
LIG_BRCT_BRCA1_1	383	387	PF00533	0.424
LIG_FHA_1	401	407	PF00498	0.579
LIG_FHA_1	6	12	PF00498	0.682
LIG_FHA_2	132	138	PF00498	0.542
LIG_FHA_2	217	223	PF00498	0.513
LIG_FHA_2	457	463	PF00498	0.690
LIG_LIR_Apic_2	211	217	PF02991	0.303
LIG_LIR_Gen_1	140	148	PF02991	0.561
LIG_LIR_Gen_1	465	471	PF02991	0.590
LIG_LIR_Nem_3	140	144	PF02991	0.523
LIG_LIR_Nem_3	358	364	PF02991	0.502
LIG_LIR_Nem_3	371	376	PF02991	0.371
LIG_LIR_Nem_3	383	389	PF02991	0.542
LIG_LIR_Nem_3	465	471	PF02991	0.582
LIG_MLH1_MIPbox_1	118	122	PF16413	0.435
LIG_MLH1_MIPbox_1	383	387	PF16413	0.424
LIG_PDZ_Class_3	466	471	PF00595	0.655
LIG_REV1ctd_RIR_1	118	128	PF16727	0.526
LIG_SH2_CRK	231	235	PF00017	0.512
LIG_SH2_CRK	421	425	PF00017	0.497
LIG_SH2_CRK	71	75	PF00017	0.401
LIG_SH2_PTP2	90	93	PF00017	0.749
LIG_SH2_STAP1	421	425	PF00017	0.497
LIG_SH2_STAT5	132	135	PF00017	0.412
LIG_SH2_STAT5	282	285	PF00017	0.453
LIG_SH2_STAT5	404	407	PF00017	0.543
LIG_SH2_STAT5	90	93	PF00017	0.716
LIG_SH3_1	221	227	PF00018	0.483
LIG_SH3_2	145	150	PF14604	0.580
LIG_SH3_3	142	148	PF00018	0.548
LIG_SH3_3	221	227	PF00018	0.480
LIG_SH3_3	257	263	PF00018	0.561
LIG_SH3_3	286	292	PF00018	0.581
LIG_SUMO_SIM_anti_2	318	325	PF11976	0.549
LIG_SUMO_SIM_par_1	299	306	PF11976	0.475
LIG_SUMO_SIM_par_1	343	349	PF11976	0.680
LIG_TRAF2_1	108	111	PF00917	0.624
LIG_TRFH_1	285	289	PF08558	0.547
MOD_CDC14_SPxK_1	147	150	PF00782	0.411
MOD_CDK_SPK_2	144	149	PF00069	0.361
MOD_CDK_SPxK_1	144	150	PF00069	0.443
MOD_CDK_SPxK_1	16	22	PF00069	0.719
MOD_CDK_SPxxK_3	157	164	PF00069	0.589
MOD_CK1_1	160	166	PF00069	0.678
MOD_CK1_1	182	188	PF00069	0.720
MOD_CK1_1	195	201	PF00069	0.661
MOD_CK1_1	265	271	PF00069	0.562
MOD_CK1_1	359	365	PF00069	0.505
MOD_CK1_1	381	387	PF00069	0.532
MOD_CK1_1	390	396	PF00069	0.503
MOD_CK1_1	9	15	PF00069	0.681
MOD_CK2_1	131	137	PF00069	0.536
MOD_CK2_1	216	222	PF00069	0.513
MOD_CK2_1	306	312	PF00069	0.773
MOD_CK2_1	329	335	PF00069	0.498
MOD_Cter_Amidation	415	418	PF01082	0.490
MOD_GlcNHglycan	124	127	PF01048	0.541
MOD_GlcNHglycan	184	187	PF01048	0.689
MOD_GlcNHglycan	191	197	PF01048	0.721
MOD_GlcNHglycan	308	311	PF01048	0.722
MOD_GlcNHglycan	361	364	PF01048	0.534
MOD_GlcNHglycan	378	383	PF01048	0.487
MOD_GlcNHglycan	49	52	PF01048	0.612
MOD_GlcNHglycan	8	11	PF01048	0.690
MOD_GlcNHglycan	81	84	PF01048	0.659
MOD_GSK3_1	1	8	PF00069	0.663
MOD_GSK3_1	116	123	PF00069	0.474
MOD_GSK3_1	175	182	PF00069	0.649
MOD_GSK3_1	192	199	PF00069	0.673
MOD_GSK3_1	216	223	PF00069	0.511
MOD_GSK3_1	265	272	PF00069	0.459
MOD_GSK3_1	288	295	PF00069	0.507
MOD_GSK3_1	387	394	PF00069	0.558
MOD_N-GLC_1	390	395	PF02516	0.580
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	116	121	PF00069	0.552
MOD_NEK2_1	122	127	PF00069	0.515
MOD_NEK2_1	30	35	PF00069	0.648
MOD_NEK2_1	387	392	PF00069	0.452
MOD_NEK2_1	58	63	PF00069	0.502
MOD_NMyristoyl	1	7	PF02799	0.631
MOD_PIKK_1	198	204	PF00454	0.742
MOD_PKA_2	137	143	PF00069	0.486
MOD_PKA_2	21	27	PF00069	0.673
MOD_PKA_2	359	365	PF00069	0.505
MOD_PKA_2	400	406	PF00069	0.569
MOD_PKA_2	454	460	PF00069	0.785
MOD_Plk_1	179	185	PF00069	0.711
MOD_Plk_1	269	275	PF00069	0.491
MOD_Plk_1	298	304	PF00069	0.476
MOD_Plk_1	330	336	PF00069	0.551
MOD_Plk_4	298	304	PF00069	0.476
MOD_Plk_4	381	387	PF00069	0.435
MOD_Plk_4	400	406	PF00069	0.467
MOD_ProDKin_1	144	150	PF00069	0.576
MOD_ProDKin_1	157	163	PF00069	0.729
MOD_ProDKin_1	16	22	PF00069	0.710
MOD_ProDKin_1	220	226	PF00069	0.466
MOD_ProDKin_1	288	294	PF00069	0.497
MOD_ProDKin_1	303	309	PF00069	0.686
TRG_DiLeu_BaEn_1	319	324	PF01217	0.551
TRG_ENDOCYTIC_2	231	234	PF00928	0.506
TRG_ENDOCYTIC_2	282	285	PF00928	0.453
TRG_ENDOCYTIC_2	421	424	PF00928	0.498
TRG_ENDOCYTIC_2	71	74	PF00928	0.396
TRG_ENDOCYTIC_2	90	93	PF00928	0.716
TRG_ER_diArg_1	148	150	PF00400	0.680
TRG_ER_diArg_1	154	156	PF00400	0.725
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L8	Leptomonas seymouri	51%	86%
A0A1X0NNT6	Trypanosomatidae	36%	100%
A0A3R7R786	Trypanosoma rangeli	36%	100%
A0A3S7WTB0	Leishmania donovani	87%	99%
A4H7R7	Leishmania braziliensis	72%	100%
A4HW60	Leishmania infantum	87%	99%
C9ZSW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QFM0	Leishmania major	86%	100%
V5DC73	Trypanosoma cruzi	37%	100%