Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APV9_LEIMU

TriTrypDb:

LmxM.14.1130

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9APV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APV9

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	637	641	PF00656	0.341
CLV_C14_Caspase3-7	685	689	PF00656	0.626
CLV_C14_Caspase3-7	883	887	PF00656	0.588
CLV_NRD_NRD_1	219	221	PF00675	0.569
CLV_NRD_NRD_1	260	262	PF00675	0.501
CLV_NRD_NRD_1	437	439	PF00675	0.571
CLV_NRD_NRD_1	518	520	PF00675	0.520
CLV_NRD_NRD_1	6	8	PF00675	0.466
CLV_NRD_NRD_1	737	739	PF00675	0.683
CLV_PCSK_KEX2_1	259	261	PF00082	0.516
CLV_PCSK_KEX2_1	518	520	PF00082	0.520
CLV_PCSK_KEX2_1	6	8	PF00082	0.462
CLV_PCSK_KEX2_1	737	739	PF00082	0.683
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.462
CLV_PCSK_SKI1_1	17	21	PF00082	0.452
CLV_PCSK_SKI1_1	228	232	PF00082	0.593
CLV_PCSK_SKI1_1	261	265	PF00082	0.485
CLV_PCSK_SKI1_1	368	372	PF00082	0.610
CLV_PCSK_SKI1_1	414	418	PF00082	0.505
CLV_PCSK_SKI1_1	47	51	PF00082	0.587
CLV_PCSK_SKI1_1	518	522	PF00082	0.486
CLV_PCSK_SKI1_1	639	643	PF00082	0.557
DEG_APCC_DBOX_1	6	14	PF00400	0.459
DEG_Nend_UBRbox_2	1	3	PF02207	0.500
DEG_SCF_FBW7_1	827	833	PF00400	0.406
DEG_SPOP_SBC_1	39	43	PF00917	0.652
DEG_SPOP_SBC_1	405	409	PF00917	0.534
DEG_SPOP_SBC_1	656	660	PF00917	0.555
DEG_SPOP_SBC_1	680	684	PF00917	0.499
DOC_CKS1_1	119	124	PF01111	0.684
DOC_CKS1_1	129	134	PF01111	0.597
DOC_CKS1_1	827	832	PF01111	0.409
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	535	538	PF00134	0.446
DOC_MAPK_gen_1	414	424	PF00069	0.410
DOC_MAPK_gen_1	748	756	PF00069	0.490
DOC_MAPK_MEF2A_6	417	424	PF00069	0.413
DOC_PP1_RVXF_1	500	507	PF00149	0.367
DOC_PP2B_LxvP_1	52	55	PF13499	0.629
DOC_PP2B_LxvP_1	534	537	PF13499	0.440
DOC_PP4_FxxP_1	427	430	PF00568	0.381
DOC_PP4_FxxP_1	546	549	PF00568	0.468
DOC_USP7_MATH_1	105	109	PF00917	0.691
DOC_USP7_MATH_1	113	117	PF00917	0.618
DOC_USP7_MATH_1	195	199	PF00917	0.601
DOC_USP7_MATH_1	301	305	PF00917	0.510
DOC_USP7_MATH_1	39	43	PF00917	0.603
DOC_USP7_MATH_1	393	397	PF00917	0.616
DOC_USP7_MATH_1	399	403	PF00917	0.586
DOC_USP7_MATH_1	541	545	PF00917	0.434
DOC_USP7_MATH_1	590	594	PF00917	0.388
DOC_USP7_MATH_1	60	64	PF00917	0.608
DOC_USP7_MATH_1	656	660	PF00917	0.559
DOC_USP7_MATH_1	672	676	PF00917	0.595
DOC_USP7_MATH_1	679	683	PF00917	0.625
DOC_USP7_MATH_1	695	699	PF00917	0.563
DOC_USP7_MATH_1	708	712	PF00917	0.577
DOC_USP7_MATH_1	714	718	PF00917	0.564
DOC_USP7_MATH_1	724	728	PF00917	0.669
DOC_USP7_MATH_1	795	799	PF00917	0.386
DOC_USP7_MATH_1	906	910	PF00917	0.457
DOC_USP7_MATH_2	788	794	PF00917	0.419
DOC_WW_Pin1_4	109	114	PF00397	0.621
DOC_WW_Pin1_4	115	120	PF00397	0.627
DOC_WW_Pin1_4	128	133	PF00397	0.548
DOC_WW_Pin1_4	175	180	PF00397	0.632
DOC_WW_Pin1_4	287	292	PF00397	0.541
DOC_WW_Pin1_4	304	309	PF00397	0.517
DOC_WW_Pin1_4	35	40	PF00397	0.649
DOC_WW_Pin1_4	351	356	PF00397	0.552
DOC_WW_Pin1_4	416	421	PF00397	0.436
DOC_WW_Pin1_4	462	467	PF00397	0.460
DOC_WW_Pin1_4	545	550	PF00397	0.456
DOC_WW_Pin1_4	667	672	PF00397	0.484
DOC_WW_Pin1_4	69	74	PF00397	0.613
DOC_WW_Pin1_4	698	703	PF00397	0.567
DOC_WW_Pin1_4	799	804	PF00397	0.379
DOC_WW_Pin1_4	826	831	PF00397	0.410
LIG_14-3-3_CanoR_1	134	138	PF00244	0.635
LIG_14-3-3_CanoR_1	156	161	PF00244	0.515
LIG_14-3-3_CanoR_1	337	347	PF00244	0.676
LIG_14-3-3_CanoR_1	383	389	PF00244	0.560
LIG_14-3-3_CanoR_1	47	53	PF00244	0.613
LIG_14-3-3_CanoR_1	540	549	PF00244	0.479
LIG_14-3-3_CanoR_1	750	755	PF00244	0.406
LIG_14-3-3_CanoR_1	844	854	PF00244	0.525
LIG_14-3-3_CanoR_1	89	98	PF00244	0.648
LIG_APCC_ABBA_1	559	564	PF00400	0.384
LIG_APCC_ABBAyCdc20_2	558	564	PF00400	0.383
LIG_BIR_III_4	229	233	PF00653	0.586
LIG_BIR_III_4	813	817	PF00653	0.456
LIG_BRCT_BRCA1_1	907	911	PF00533	0.374
LIG_CtBP_PxDLS_1	78	82	PF00389	0.583
LIG_deltaCOP1_diTrp_1	915	920	PF00928	0.384
LIG_FHA_1	234	240	PF00498	0.556
LIG_FHA_1	265	271	PF00498	0.475
LIG_FHA_1	529	535	PF00498	0.483
LIG_FHA_1	65	71	PF00498	0.630
LIG_FHA_1	662	668	PF00498	0.554
LIG_FHA_1	730	736	PF00498	0.550
LIG_FHA_1	758	764	PF00498	0.517
LIG_FHA_1	823	829	PF00498	0.460
LIG_FHA_1	831	837	PF00498	0.367
LIG_FHA_1	928	934	PF00498	0.474
LIG_FHA_2	405	411	PF00498	0.578
LIG_FHA_2	635	641	PF00498	0.321
LIG_FHA_2	704	710	PF00498	0.530
LIG_LIR_Apic_2	544	549	PF02991	0.450
LIG_LIR_Apic_2	645	651	PF02991	0.422
LIG_LIR_Gen_1	465	476	PF02991	0.329
LIG_LIR_Nem_3	465	471	PF02991	0.355
LIG_LIR_Nem_3	596	600	PF02991	0.422
LIG_MLH1_MIPbox_1	908	912	PF16413	0.375
LIG_PCNA_yPIPBox_3	14	28	PF02747	0.464
LIG_PDZ_Class_1	933	938	PF00595	0.457
LIG_REV1ctd_RIR_1	909	918	PF16727	0.366
LIG_SH2_CRK	649	653	PF00017	0.449
LIG_SH2_PTP2	468	471	PF00017	0.329
LIG_SH2_STAT5	27	30	PF00017	0.563
LIG_SH2_STAT5	468	471	PF00017	0.329
LIG_SH2_STAT5	597	600	PF00017	0.405
LIG_SH2_STAT5	927	930	PF00017	0.399
LIG_SH3_1	126	132	PF00018	0.671
LIG_SH3_2	129	134	PF14604	0.662
LIG_SH3_3	116	122	PF00018	0.637
LIG_SH3_3	126	132	PF00018	0.584
LIG_SH3_3	232	238	PF00018	0.558
LIG_SH3_3	328	334	PF00018	0.568
LIG_SH3_3	426	432	PF00018	0.415
LIG_SH3_3	485	491	PF00018	0.556
LIG_SH3_3	535	541	PF00018	0.447
LIG_SH3_3	584	590	PF00018	0.407
LIG_SH3_3	668	674	PF00018	0.483
LIG_SH3_3	699	705	PF00018	0.545
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.403
LIG_SUMO_SIM_par_1	344	351	PF11976	0.486
LIG_SUMO_SIM_par_1	663	668	PF11976	0.558
LIG_SUMO_SIM_par_1	829	835	PF11976	0.411
LIG_TRAF2_1	205	208	PF00917	0.639
LIG_TYR_ITIM	595	600	PF00017	0.398
LIG_WW_3	650	654	PF00397	0.478
MOD_CDC14_SPxK_1	802	805	PF00782	0.417
MOD_CDK_SPK_2	69	74	PF00069	0.593
MOD_CDK_SPxK_1	128	134	PF00069	0.666
MOD_CDK_SPxK_1	799	805	PF00069	0.394
MOD_CK1_1	108	114	PF00069	0.640
MOD_CK1_1	118	124	PF00069	0.723
MOD_CK1_1	133	139	PF00069	0.578
MOD_CK1_1	164	170	PF00069	0.550
MOD_CK1_1	175	181	PF00069	0.598
MOD_CK1_1	254	260	PF00069	0.584
MOD_CK1_1	29	35	PF00069	0.579
MOD_CK1_1	304	310	PF00069	0.602
MOD_CK1_1	38	44	PF00069	0.588
MOD_CK1_1	456	462	PF00069	0.532
MOD_CK1_1	48	54	PF00069	0.514
MOD_CK1_1	545	551	PF00069	0.445
MOD_CK1_1	593	599	PF00069	0.478
MOD_CK1_1	682	688	PF00069	0.665
MOD_CK1_1	689	695	PF00069	0.776
MOD_CK1_1	698	704	PF00069	0.523
MOD_CK1_1	72	78	PF00069	0.681
MOD_CK1_1	726	732	PF00069	0.699
MOD_CK1_1	771	777	PF00069	0.502
MOD_CK1_1	794	800	PF00069	0.389
MOD_CK1_1	80	86	PF00069	0.634
MOD_CK1_1	826	832	PF00069	0.407
MOD_CK1_1	857	863	PF00069	0.649
MOD_CK1_1	905	911	PF00069	0.346
MOD_CK1_1	91	97	PF00069	0.722
MOD_CK2_1	404	410	PF00069	0.586
MOD_CK2_1	703	709	PF00069	0.529
MOD_CK2_1	832	838	PF00069	0.413
MOD_CK2_1	893	899	PF00069	0.619
MOD_DYRK1A_RPxSP_1	128	132	PF00069	0.662
MOD_GlcNHglycan	107	110	PF01048	0.687
MOD_GlcNHglycan	115	118	PF01048	0.626
MOD_GlcNHglycan	174	177	PF01048	0.598
MOD_GlcNHglycan	190	193	PF01048	0.633
MOD_GlcNHglycan	28	31	PF01048	0.583
MOD_GlcNHglycan	340	343	PF01048	0.755
MOD_GlcNHglycan	395	398	PF01048	0.635
MOD_GlcNHglycan	401	404	PF01048	0.603
MOD_GlcNHglycan	410	413	PF01048	0.571
MOD_GlcNHglycan	451	454	PF01048	0.538
MOD_GlcNHglycan	458	461	PF01048	0.592
MOD_GlcNHglycan	47	50	PF01048	0.506
MOD_GlcNHglycan	629	632	PF01048	0.392
MOD_GlcNHglycan	674	677	PF01048	0.549
MOD_GlcNHglycan	688	691	PF01048	0.504
MOD_GlcNHglycan	709	713	PF01048	0.694
MOD_GlcNHglycan	715	719	PF01048	0.733
MOD_GlcNHglycan	728	731	PF01048	0.545
MOD_GlcNHglycan	74	77	PF01048	0.800
MOD_GlcNHglycan	770	773	PF01048	0.356
MOD_GlcNHglycan	793	796	PF01048	0.465
MOD_GlcNHglycan	813	817	PF01048	0.251
MOD_GlcNHglycan	84	87	PF01048	0.668
MOD_GlcNHglycan	856	859	PF01048	0.572
MOD_GlcNHglycan	904	907	PF01048	0.355
MOD_GSK3_1	105	112	PF00069	0.641
MOD_GSK3_1	113	120	PF00069	0.662
MOD_GSK3_1	251	258	PF00069	0.574
MOD_GSK3_1	26	33	PF00069	0.531
MOD_GSK3_1	304	311	PF00069	0.690
MOD_GSK3_1	347	354	PF00069	0.601
MOD_GSK3_1	35	42	PF00069	0.607
MOD_GSK3_1	395	402	PF00069	0.635
MOD_GSK3_1	404	411	PF00069	0.597
MOD_GSK3_1	439	446	PF00069	0.515
MOD_GSK3_1	449	456	PF00069	0.539
MOD_GSK3_1	476	483	PF00069	0.369
MOD_GSK3_1	524	531	PF00069	0.470
MOD_GSK3_1	541	548	PF00069	0.597
MOD_GSK3_1	578	585	PF00069	0.418
MOD_GSK3_1	60	67	PF00069	0.590
MOD_GSK3_1	615	622	PF00069	0.476
MOD_GSK3_1	657	664	PF00069	0.556
MOD_GSK3_1	682	689	PF00069	0.586
MOD_GSK3_1	720	727	PF00069	0.647
MOD_GSK3_1	790	797	PF00069	0.417
MOD_GSK3_1	812	819	PF00069	0.370
MOD_GSK3_1	822	829	PF00069	0.411
MOD_GSK3_1	88	95	PF00069	0.702
MOD_GSK3_1	902	909	PF00069	0.433
MOD_N-GLC_1	35	40	PF02516	0.517
MOD_N-GLC_1	823	828	PF02516	0.387
MOD_N-GLC_1	845	850	PF02516	0.638
MOD_N-GLC_2	180	182	PF02516	0.491
MOD_NEK2_1	188	193	PF00069	0.692
MOD_NEK2_1	264	269	PF00069	0.469
MOD_NEK2_1	338	343	PF00069	0.536
MOD_NEK2_1	347	352	PF00069	0.566
MOD_NEK2_1	443	448	PF00069	0.482
MOD_NEK2_1	45	50	PF00069	0.667
MOD_NEK2_1	495	500	PF00069	0.378
MOD_NEK2_1	525	530	PF00069	0.474
MOD_NEK2_1	625	630	PF00069	0.394
MOD_NEK2_1	634	639	PF00069	0.405
MOD_NEK2_1	665	670	PF00069	0.565
MOD_NEK2_1	686	691	PF00069	0.520
MOD_NEK2_1	722	727	PF00069	0.536
MOD_NEK2_1	782	787	PF00069	0.413
MOD_NEK2_1	90	95	PF00069	0.690
MOD_NEK2_1	919	924	PF00069	0.378
MOD_NEK2_1	933	938	PF00069	0.457
MOD_NEK2_2	563	568	PF00069	0.423
MOD_NEK2_2	906	911	PF00069	0.468
MOD_NEK2_2	927	932	PF00069	0.401
MOD_PIKK_1	136	142	PF00454	0.626
MOD_PIKK_1	233	239	PF00454	0.638
MOD_PIKK_1	356	362	PF00454	0.648
MOD_PIKK_1	571	577	PF00454	0.357
MOD_PIKK_1	582	588	PF00454	0.411
MOD_PIKK_1	724	730	PF00454	0.498
MOD_PK_1	156	162	PF00069	0.513
MOD_PKA_2	127	133	PF00069	0.717
MOD_PKA_2	30	36	PF00069	0.653
MOD_PKA_2	384	390	PF00069	0.554
MOD_PKA_2	686	692	PF00069	0.499
MOD_PKA_2	720	726	PF00069	0.517
MOD_PKA_2	88	94	PF00069	0.659
MOD_PKB_1	748	756	PF00069	0.490
MOD_Plk_1	162	168	PF00069	0.538
MOD_Plk_1	317	323	PF00069	0.695
MOD_Plk_1	782	788	PF00069	0.490
MOD_Plk_1	823	829	PF00069	0.389
MOD_Plk_2-3	640	646	PF00069	0.420
MOD_Plk_4	242	248	PF00069	0.604
MOD_Plk_4	289	295	PF00069	0.521
MOD_Plk_4	480	486	PF00069	0.405
MOD_Plk_4	490	496	PF00069	0.443
MOD_Plk_4	530	536	PF00069	0.445
MOD_Plk_4	593	599	PF00069	0.421
MOD_Plk_4	657	663	PF00069	0.555
MOD_Plk_4	816	822	PF00069	0.360
MOD_Plk_4	823	829	PF00069	0.416
MOD_Plk_4	906	912	PF00069	0.376
MOD_ProDKin_1	109	115	PF00069	0.622
MOD_ProDKin_1	118	124	PF00069	0.629
MOD_ProDKin_1	128	134	PF00069	0.664
MOD_ProDKin_1	175	181	PF00069	0.634
MOD_ProDKin_1	287	293	PF00069	0.534
MOD_ProDKin_1	304	310	PF00069	0.520
MOD_ProDKin_1	35	41	PF00069	0.649
MOD_ProDKin_1	351	357	PF00069	0.551
MOD_ProDKin_1	416	422	PF00069	0.427
MOD_ProDKin_1	462	468	PF00069	0.453
MOD_ProDKin_1	545	551	PF00069	0.445
MOD_ProDKin_1	667	673	PF00069	0.487
MOD_ProDKin_1	69	75	PF00069	0.613
MOD_ProDKin_1	698	704	PF00069	0.568
MOD_ProDKin_1	799	805	PF00069	0.379
MOD_ProDKin_1	826	832	PF00069	0.407
MOD_SUMO_rev_2	572	579	PF00179	0.357
TRG_DiLeu_BaEn_1	418	423	PF01217	0.408
TRG_DiLeu_BaEn_1	480	485	PF01217	0.369
TRG_DiLeu_BaEn_1	516	521	PF01217	0.443
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.485
TRG_DiLeu_LyEn_5	516	521	PF01217	0.443
TRG_ENDOCYTIC_2	468	471	PF00928	0.329
TRG_ENDOCYTIC_2	597	600	PF00928	0.408
TRG_ER_diArg_1	126	129	PF00400	0.543
TRG_ER_diArg_1	259	261	PF00400	0.514
TRG_ER_diArg_1	517	519	PF00400	0.530
TRG_ER_diArg_1	737	739	PF00400	0.683
TRG_ER_diArg_1	748	751	PF00400	0.393
TRG_ER_diArg_1	763	766	PF00400	0.420
TRG_ER_diArg_1	81	84	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHJ0	Leptomonas seymouri	51%	93%
A0A3S7WT61	Leishmania donovani	89%	100%
A4H7R6	Leishmania braziliensis	75%	99%
A4HW59	Leishmania infantum	89%	100%
Q4QFM1	Leishmania major	87%	99%