Mannose-P-dolichol utilization defect 1 protein homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PQ loop repeat, putative

Species:

Leishmania mexicana

UniProt:

E9APV5_LEIMU

TriTrypDb:

LmxM.14.1090

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9APV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	215	217	PF00082	0.421
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.476
CLV_PCSK_SKI1_1	169	173	PF00082	0.300
CLV_PCSK_SKI1_1	183	187	PF00082	0.448
CLV_PCSK_SKI1_1	225	229	PF00082	0.474
DEG_APCC_DBOX_1	150	158	PF00400	0.553
DEG_SPOP_SBC_1	170	174	PF00917	0.369
DOC_MAPK_gen_1	147	156	PF00069	0.507
DOC_MAPK_gen_1	181	190	PF00069	0.308
DOC_MAPK_MEF2A_6	181	190	PF00069	0.323
DOC_PP1_SILK_1	23	28	PF00149	0.420
DOC_PP2B_LxvP_1	26	29	PF13499	0.316
DOC_USP7_MATH_1	210	214	PF00917	0.565
DOC_WW_Pin1_4	217	222	PF00397	0.577
LIG_14-3-3_CanoR_1	151	157	PF00244	0.494
LIG_14-3-3_CanoR_1	169	179	PF00244	0.151
LIG_14-3-3_CanoR_1	98	102	PF00244	0.587
LIG_APCC_ABBA_1	46	51	PF00400	0.233
LIG_BIR_II_1	1	5	PF00653	0.419
LIG_FHA_1	103	109	PF00498	0.543
LIG_FHA_1	156	162	PF00498	0.329
LIG_FHA_1	170	176	PF00498	0.300
LIG_FHA_2	119	125	PF00498	0.581
LIG_GBD_Chelix_1	167	175	PF00786	0.419
LIG_GBD_Chelix_1	78	86	PF00786	0.156
LIG_LIR_Gen_1	155	163	PF02991	0.307
LIG_LIR_Gen_1	16	25	PF02991	0.420
LIG_LIR_Gen_1	47	57	PF02991	0.362
LIG_LIR_Gen_1	74	85	PF02991	0.420
LIG_LIR_Nem_3	12	17	PF02991	0.385
LIG_LIR_Nem_3	155	159	PF02991	0.315
LIG_LIR_Nem_3	47	52	PF02991	0.366
LIG_LIR_Nem_3	58	64	PF02991	0.329
LIG_LIR_Nem_3	74	80	PF02991	0.214
LIG_NRBOX	81	87	PF00104	0.420
LIG_Pex14_2	132	136	PF04695	0.553
LIG_Pex14_2	156	160	PF04695	0.357
LIG_Pex14_2	49	53	PF04695	0.156
LIG_SH2_CRK	17	21	PF00017	0.300
LIG_SH2_GRB2like	143	146	PF00017	0.512
LIG_SH2_STAP1	17	21	PF00017	0.357
LIG_SH2_STAT5	111	114	PF00017	0.541
LIG_SH2_STAT5	125	128	PF00017	0.514
LIG_SH2_STAT5	14	17	PF00017	0.353
LIG_SH2_STAT5	55	58	PF00017	0.376
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.535
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.496
LIG_TYR_ITIM	15	20	PF00017	0.300
LIG_TYR_ITIM	204	209	PF00017	0.414
LIG_UBA3_1	84	91	PF00899	0.412
LIG_WRC_WIRS_1	156	161	PF05994	0.325
MOD_CDC14_SPxK_1	220	223	PF00782	0.487
MOD_CDK_SPxK_1	217	223	PF00069	0.483
MOD_CK1_1	155	161	PF00069	0.316
MOD_CK1_1	2	8	PF00069	0.429
MOD_CK1_1	44	50	PF00069	0.306
MOD_CK2_1	118	124	PF00069	0.550
MOD_CK2_1	211	217	PF00069	0.508
MOD_GlcNHglycan	114	117	PF01048	0.326
MOD_GlcNHglycan	127	130	PF01048	0.320
MOD_GSK3_1	171	178	PF00069	0.371
MOD_GSK3_1	188	195	PF00069	0.154
MOD_GSK3_1	51	58	PF00069	0.357
MOD_GSK3_1	9	16	PF00069	0.322
MOD_GSK3_1	93	100	PF00069	0.575
MOD_N-GLC_1	175	180	PF02516	0.456
MOD_NEK2_1	171	176	PF00069	0.306
MOD_NEK2_1	92	97	PF00069	0.529
MOD_PKA_2	211	217	PF00069	0.578
MOD_PKA_2	97	103	PF00069	0.602
MOD_Plk_1	175	181	PF00069	0.273
MOD_Plk_4	152	158	PF00069	0.451
MOD_Plk_4	2	8	PF00069	0.362
MOD_Plk_4	21	27	PF00069	0.230
MOD_Plk_4	44	50	PF00069	0.385
MOD_ProDKin_1	217	223	PF00069	0.578
TRG_ENDOCYTIC_2	17	20	PF00928	0.300
TRG_ENDOCYTIC_2	206	209	PF00928	0.573
TRG_ER_diArg_1	146	149	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I8	Leptomonas seymouri	70%	100%
A0A0S4JQ57	Bodo saltans	48%	82%
A0A1X0NQ59	Trypanosomatidae	47%	91%
A0A3S7WT35	Leishmania donovani	88%	100%
A0A422MWP8	Trypanosoma rangeli	48%	94%
A4H7R3	Leishmania braziliensis	77%	100%
A4HW51	Leishmania infantum	87%	100%
C9ZSW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	96%
O75352	Homo sapiens	30%	93%
Q20157	Caenorhabditis elegans	31%	95%
Q4QFM6	Leishmania major	87%	100%
Q60441	Cricetulus griseus	29%	93%
Q8VY63	Arabidopsis thaliana	34%	98%
Q9LTI3	Arabidopsis thaliana	30%	96%
Q9R0Q9	Mus musculus	28%	93%
Q9VMW8	Drosophila melanogaster	28%	91%
V5BJ03	Trypanosoma cruzi	49%	91%