Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APV4_LEIMU

TriTrypDb:

LmxM.14.1080

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.455
CLV_NRD_NRD_1	159	161	PF00675	0.616
CLV_NRD_NRD_1	202	204	PF00675	0.594
CLV_NRD_NRD_1	24	26	PF00675	0.588
CLV_NRD_NRD_1	325	327	PF00675	0.732
CLV_PCSK_KEX2_1	139	141	PF00082	0.809
CLV_PCSK_KEX2_1	159	161	PF00082	0.655
CLV_PCSK_KEX2_1	24	26	PF00082	0.588
CLV_PCSK_KEX2_1	325	327	PF00082	0.732
CLV_PCSK_KEX2_1	348	350	PF00082	0.714
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.809
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.714
CLV_PCSK_PC7_1	20	26	PF00082	0.414
CLV_PCSK_SKI1_1	159	163	PF00082	0.651
CLV_PCSK_SKI1_1	326	330	PF00082	0.794
CLV_PCSK_SKI1_1	345	349	PF00082	0.597
CLV_PCSK_SKI1_1	360	364	PF00082	0.595
CLV_Separin_Metazoa	253	257	PF03568	0.586
DEG_APCC_DBOX_1	202	210	PF00400	0.496
DEG_Nend_UBRbox_2	1	3	PF02207	0.604
DEG_SCF_FBW7_2	150	157	PF00400	0.551
DEG_SPOP_SBC_1	116	120	PF00917	0.438
DEG_SPOP_SBC_1	192	196	PF00917	0.562
DEG_SPOP_SBC_1	294	298	PF00917	0.504
DOC_CKS1_1	151	156	PF01111	0.477
DOC_CYCLIN_RxL_1	201	210	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.594
DOC_MAPK_FxFP_2	363	366	PF00069	0.439
DOC_MAPK_gen_1	203	209	PF00069	0.309
DOC_MAPK_MEF2A_6	38	46	PF00069	0.224
DOC_PP1_RVXF_1	358	364	PF00149	0.405
DOC_PP2B_LxvP_1	171	174	PF13499	0.567
DOC_PP2B_LxvP_1	176	179	PF13499	0.548
DOC_PP2B_LxvP_1	4	7	PF13499	0.591
DOC_PP4_FxxP_1	151	154	PF00568	0.557
DOC_PP4_FxxP_1	363	366	PF00568	0.439
DOC_USP7_MATH_1	116	120	PF00917	0.513
DOC_USP7_MATH_1	16	20	PF00917	0.613
DOC_USP7_MATH_1	185	189	PF00917	0.480
DOC_USP7_MATH_1	192	196	PF00917	0.561
DOC_USP7_MATH_1	217	221	PF00917	0.530
DOC_USP7_MATH_1	292	296	PF00917	0.597
DOC_USP7_MATH_1	352	356	PF00917	0.505
DOC_USP7_MATH_1	57	61	PF00917	0.568
DOC_USP7_MATH_2	265	271	PF00917	0.369
DOC_WW_Pin1_4	150	155	PF00397	0.479
DOC_WW_Pin1_4	181	186	PF00397	0.568
DOC_WW_Pin1_4	188	193	PF00397	0.552
DOC_WW_Pin1_4	33	38	PF00397	0.488
DOC_WW_Pin1_4	331	336	PF00397	0.598
LIG_14-3-3_CanoR_1	17	26	PF00244	0.604
LIG_14-3-3_CanoR_1	175	179	PF00244	0.574
LIG_14-3-3_CanoR_1	186	192	PF00244	0.555
LIG_14-3-3_CanoR_1	238	244	PF00244	0.516
LIG_14-3-3_CanoR_1	325	331	PF00244	0.383
LIG_BIR_III_2	189	193	PF00653	0.504
LIG_BIR_III_4	131	135	PF00653	0.483
LIG_deltaCOP1_diTrp_1	29	32	PF00928	0.737
LIG_FHA_1	168	174	PF00498	0.484
LIG_FHA_1	249	255	PF00498	0.564
LIG_FHA_1	327	333	PF00498	0.427
LIG_FHA_2	240	246	PF00498	0.433
LIG_HP1_1	205	209	PF01393	0.489
LIG_IBAR_NPY_1	257	259	PF08397	0.574
LIG_LIR_Gen_1	233	241	PF02991	0.487
LIG_LIR_Gen_1	273	280	PF02991	0.452
LIG_LIR_Gen_1	29	40	PF02991	0.559
LIG_LIR_Gen_1	340	351	PF02991	0.525
LIG_LIR_Nem_3	130	136	PF02991	0.612
LIG_LIR_Nem_3	153	158	PF02991	0.465
LIG_LIR_Nem_3	233	237	PF02991	0.419
LIG_LIR_Nem_3	273	277	PF02991	0.451
LIG_LIR_Nem_3	29	35	PF02991	0.559
LIG_LIR_Nem_3	340	346	PF02991	0.535
LIG_MYND_1	37	41	PF01753	0.492
LIG_Pex14_1	412	416	PF04695	0.431
LIG_Pex14_2	151	155	PF04695	0.548
LIG_REV1ctd_RIR_1	390	397	PF16727	0.494
LIG_SH2_NCK_1	263	267	PF00017	0.516
LIG_SH2_STAT5	236	239	PF00017	0.514
LIG_SH2_STAT5	357	360	PF00017	0.431
LIG_SH3_3	252	258	PF00018	0.584
LIG_SH3_3	94	100	PF00018	0.463
LIG_SUMO_SIM_par_1	204	210	PF11976	0.421
MOD_CDK_SPK_2	181	186	PF00069	0.722
MOD_CDK_SPK_2	33	38	PF00069	0.224
MOD_CDK_SPxK_1	150	156	PF00069	0.598
MOD_CK1_1	188	194	PF00069	0.567
MOD_CK1_1	218	224	PF00069	0.593
MOD_CK1_1	270	276	PF00069	0.551
MOD_CK1_1	295	301	PF00069	0.773
MOD_CK1_1	55	61	PF00069	0.592
MOD_CK1_1	91	97	PF00069	0.623
MOD_CK2_1	309	315	PF00069	0.681
MOD_CMANNOS	271	274	PF00535	0.474
MOD_GlcNHglycan	145	148	PF01048	0.700
MOD_GlcNHglycan	209	212	PF01048	0.550
MOD_GlcNHglycan	297	300	PF01048	0.720
MOD_GlcNHglycan	54	57	PF01048	0.499
MOD_GlcNHglycan	64	67	PF01048	0.564
MOD_GlcNHglycan	80	83	PF01048	0.551
MOD_GSK3_1	112	119	PF00069	0.739
MOD_GSK3_1	177	184	PF00069	0.718
MOD_GSK3_1	188	195	PF00069	0.602
MOD_GSK3_1	217	224	PF00069	0.662
MOD_GSK3_1	295	302	PF00069	0.714
MOD_GSK3_1	333	340	PF00069	0.688
MOD_GSK3_1	378	385	PF00069	0.713
MOD_N-GLC_1	275	280	PF02516	0.517
MOD_N-GLC_1	367	372	PF02516	0.510
MOD_NEK2_1	272	277	PF00069	0.691
MOD_NEK2_1	52	57	PF00069	0.474
MOD_NEK2_1	62	67	PF00069	0.523
MOD_NEK2_1	78	83	PF00069	0.558
MOD_PIKK_1	382	388	PF00454	0.726
MOD_PIKK_1	9	15	PF00454	0.546
MOD_PKA_2	16	22	PF00069	0.499
MOD_PKA_2	174	180	PF00069	0.670
MOD_PKA_2	185	191	PF00069	0.717
MOD_PKA_2	309	315	PF00069	0.475
MOD_PKA_2	62	68	PF00069	0.688
MOD_PKA_2	70	76	PF00069	0.625
MOD_Plk_1	378	384	PF00069	0.667
MOD_Plk_2-3	248	254	PF00069	0.668
MOD_Plk_4	239	245	PF00069	0.496
MOD_Plk_4	267	273	PF00069	0.448
MOD_Plk_4	326	332	PF00069	0.513
MOD_Plk_4	367	373	PF00069	0.521
MOD_ProDKin_1	150	156	PF00069	0.598
MOD_ProDKin_1	181	187	PF00069	0.723
MOD_ProDKin_1	188	194	PF00069	0.698
MOD_ProDKin_1	33	39	PF00069	0.488
MOD_ProDKin_1	331	337	PF00069	0.764
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.469
TRG_ER_diArg_1	158	160	PF00400	0.548
TRG_ER_diArg_1	24	26	PF00400	0.751
TRG_ER_diArg_1	324	326	PF00400	0.665
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.735
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P428	Leptomonas seymouri	48%	100%
A0A3S7WT47	Leishmania donovani	84%	100%
A4H7R2	Leishmania braziliensis	70%	100%
A4HW50	Leishmania infantum	84%	100%
Q4QFM7	Leishmania major	84%	100%