Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9APV3_LEIMU

TriTrypDb:

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APV3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.775
CLV_C14_Caspase3-7	43	47	PF00656	0.788
CLV_C14_Caspase3-7	517	521	PF00656	0.755
CLV_NRD_NRD_1	10	12	PF00675	0.653
CLV_NRD_NRD_1	114	116	PF00675	0.637
CLV_NRD_NRD_1	199	201	PF00675	0.813
CLV_NRD_NRD_1	253	255	PF00675	0.769
CLV_NRD_NRD_1	412	414	PF00675	0.563
CLV_NRD_NRD_1	568	570	PF00675	0.552
CLV_NRD_NRD_1	659	661	PF00675	0.312
CLV_NRD_NRD_1	777	779	PF00675	0.355
CLV_PCSK_FUR_1	421	425	PF00082	0.660
CLV_PCSK_FUR_1	657	661	PF00082	0.312
CLV_PCSK_KEX2_1	199	201	PF00082	0.817
CLV_PCSK_KEX2_1	253	255	PF00082	0.769
CLV_PCSK_KEX2_1	362	364	PF00082	0.729
CLV_PCSK_KEX2_1	412	414	PF00082	0.560
CLV_PCSK_KEX2_1	423	425	PF00082	0.553
CLV_PCSK_KEX2_1	568	570	PF00082	0.518
CLV_PCSK_KEX2_1	659	661	PF00082	0.312
CLV_PCSK_KEX2_1	777	779	PF00082	0.355
CLV_PCSK_KEX2_1	890	892	PF00082	0.355
CLV_PCSK_KEX2_1	9	11	PF00082	0.651
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.719
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.668
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.518
CLV_PCSK_PC1ET2_1	890	892	PF00082	0.355
CLV_PCSK_PC7_1	564	570	PF00082	0.599
CLV_PCSK_SKI1_1	45	49	PF00082	0.671
CLV_PCSK_SKI1_1	569	573	PF00082	0.539
CLV_PCSK_SKI1_1	586	590	PF00082	0.209
CLV_PCSK_SKI1_1	597	601	PF00082	0.324
CLV_PCSK_SKI1_1	659	663	PF00082	0.389
CLV_PCSK_SKI1_1	777	781	PF00082	0.335
CLV_Separin_Metazoa	631	635	PF03568	0.447
DEG_COP1_1	756	763	PF00400	0.335
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SCF_FBW7_1	824	830	PF00400	0.447
DEG_SPOP_SBC_1	852	856	PF00917	0.457
DOC_CDC14_PxL_1	652	660	PF14671	0.355
DOC_CKS1_1	824	829	PF01111	0.335
DOC_MAPK_gen_1	719	728	PF00069	0.335
DOC_MAPK_HePTP_8	716	728	PF00069	0.335
DOC_MAPK_MEF2A_6	719	728	PF00069	0.335
DOC_PP1_RVXF_1	397	404	PF00149	0.594
DOC_PP1_RVXF_1	696	703	PF00149	0.335
DOC_PP2B_LxvP_1	849	852	PF13499	0.188
DOC_PP4_FxxP_1	317	320	PF00568	0.620
DOC_PP4_FxxP_1	653	656	PF00568	0.355
DOC_USP7_MATH_1	142	146	PF00917	0.702
DOC_USP7_MATH_1	190	194	PF00917	0.779
DOC_USP7_MATH_1	371	375	PF00917	0.727
DOC_USP7_MATH_1	47	51	PF00917	0.791
DOC_USP7_MATH_1	514	518	PF00917	0.477
DOC_USP7_MATH_1	547	551	PF00917	0.729
DOC_USP7_MATH_1	560	564	PF00917	0.711
DOC_USP7_MATH_1	844	848	PF00917	0.393
DOC_USP7_UBL2_3	116	120	PF12436	0.724
DOC_USP7_UBL2_3	562	566	PF12436	0.584
DOC_WW_Pin1_4	277	282	PF00397	0.798
DOC_WW_Pin1_4	386	391	PF00397	0.588
DOC_WW_Pin1_4	770	775	PF00397	0.447
DOC_WW_Pin1_4	823	828	PF00397	0.335
DOC_WW_Pin1_4	95	100	PF00397	0.757
LIG_14-3-3_CanoR_1	104	112	PF00244	0.816
LIG_14-3-3_CanoR_1	136	144	PF00244	0.717
LIG_14-3-3_CanoR_1	18	22	PF00244	0.664
LIG_14-3-3_CanoR_1	199	207	PF00244	0.667
LIG_14-3-3_CanoR_1	424	430	PF00244	0.671
LIG_14-3-3_CanoR_1	597	602	PF00244	0.355
LIG_14-3-3_CanoR_1	784	793	PF00244	0.335
LIG_14-3-3_CanoR_1	843	852	PF00244	0.295
LIG_14-3-3_CanoR_1	853	858	PF00244	0.383
LIG_14-3-3_CanoR_1	891	898	PF00244	0.447
LIG_AP2alpha_2	439	441	PF02296	0.648
LIG_BRCT_BRCA1_1	703	707	PF00533	0.335
LIG_EH1_1	462	470	PF00400	0.410
LIG_FHA_1	10	16	PF00498	0.627
LIG_FHA_1	202	208	PF00498	0.823
LIG_FHA_1	224	230	PF00498	0.609
LIG_FHA_1	250	256	PF00498	0.739
LIG_FHA_1	37	43	PF00498	0.693
LIG_FHA_1	429	435	PF00498	0.621
LIG_FHA_1	58	64	PF00498	0.752
LIG_FHA_1	628	634	PF00498	0.333
LIG_FHA_1	660	666	PF00498	0.381
LIG_FHA_1	71	77	PF00498	0.720
LIG_FHA_1	748	754	PF00498	0.335
LIG_FHA_1	85	91	PF00498	0.630
LIG_FHA_2	217	223	PF00498	0.724
LIG_FHA_2	359	365	PF00498	0.597
LIG_FHA_2	38	44	PF00498	0.795
LIG_FHA_2	441	447	PF00498	0.524
LIG_FHA_2	546	552	PF00498	0.488
LIG_FHA_2	634	640	PF00498	0.447
LIG_FHA_2	757	763	PF00498	0.335
LIG_FHA_2	876	882	PF00498	0.261
LIG_FHA_2	891	897	PF00498	0.451
LIG_LIR_Apic_2	650	656	PF02991	0.355
LIG_LIR_Apic_2	718	724	PF02991	0.335
LIG_LIR_Gen_1	20	28	PF02991	0.608
LIG_LIR_Gen_1	367	378	PF02991	0.720
LIG_LIR_Gen_1	388	397	PF02991	0.581
LIG_LIR_Gen_1	400	408	PF02991	0.574
LIG_LIR_Gen_1	856	867	PF02991	0.370
LIG_LIR_Gen_1	873	884	PF02991	0.239
LIG_LIR_Nem_3	20	24	PF02991	0.598
LIG_LIR_Nem_3	219	224	PF02991	0.619
LIG_LIR_Nem_3	367	373	PF02991	0.624
LIG_LIR_Nem_3	388	394	PF02991	0.595
LIG_LIR_Nem_3	400	406	PF02991	0.594
LIG_LIR_Nem_3	448	454	PF02991	0.529
LIG_LIR_Nem_3	639	643	PF02991	0.335
LIG_LIR_Nem_3	650	655	PF02991	0.335
LIG_LIR_Nem_3	819	825	PF02991	0.338
LIG_LIR_Nem_3	856	862	PF02991	0.351
LIG_LIR_Nem_3	873	879	PF02991	0.271
LIG_MAD2	766	774	PF02301	0.335
LIG_NRBOX	597	603	PF00104	0.447
LIG_PDZ_Class_2	903	908	PF00595	0.617
LIG_Pex14_2	441	445	PF04695	0.638
LIG_SH2_CRK	221	225	PF00017	0.627
LIG_SH2_CRK	574	578	PF00017	0.447
LIG_SH2_CRK	825	829	PF00017	0.335
LIG_SH2_CRK	859	863	PF00017	0.335
LIG_SH2_GRB2like	789	792	PF00017	0.447
LIG_SH2_NCK_1	370	374	PF00017	0.714
LIG_SH2_NCK_1	463	467	PF00017	0.511
LIG_SH2_NCK_1	54	58	PF00017	0.700
LIG_SH2_NCK_1	825	829	PF00017	0.331
LIG_SH2_SRC	370	373	PF00017	0.685
LIG_SH2_SRC	463	466	PF00017	0.391
LIG_SH2_SRC	638	641	PF00017	0.335
LIG_SH2_SRC	671	674	PF00017	0.335
LIG_SH2_SRC	797	800	PF00017	0.447
LIG_SH2_STAP1	21	25	PF00017	0.633
LIG_SH2_STAP1	391	395	PF00017	0.661
LIG_SH2_STAP1	499	503	PF00017	0.770
LIG_SH2_STAP1	692	696	PF00017	0.447
LIG_SH2_STAT3	481	484	PF00017	0.538
LIG_SH2_STAT5	652	655	PF00017	0.335
LIG_SH2_STAT5	671	674	PF00017	0.335
LIG_SH2_STAT5	715	718	PF00017	0.335
LIG_SH2_STAT5	769	772	PF00017	0.335
LIG_SH2_STAT5	789	792	PF00017	0.422
LIG_SH2_STAT5	822	825	PF00017	0.339
LIG_SH3_1	278	284	PF00018	0.792
LIG_SH3_1	449	455	PF00018	0.606
LIG_SH3_3	278	284	PF00018	0.792
LIG_SH3_3	317	323	PF00018	0.595
LIG_SH3_3	384	390	PF00018	0.580
LIG_SH3_3	449	455	PF00018	0.606
LIG_SH3_4	566	573	PF00018	0.438
LIG_SUMO_SIM_anti_2	624	631	PF11976	0.447
LIG_SUMO_SIM_par_1	392	398	PF11976	0.546
LIG_TRAF2_1	408	411	PF00917	0.555
LIG_TYR_ITIM	572	577	PF00017	0.476
LIG_TYR_ITSM	217	224	PF00017	0.728
LIG_UBA3_1	465	471	PF00899	0.442
LIG_UBA3_1	598	606	PF00899	0.324
LIG_WRC_WIRS_1	429	434	PF05994	0.523
LIG_WRC_WIRS_1	876	881	PF05994	0.190
LIG_WW_3	850	854	PF00397	0.480
MOD_CDK_SPxxK_3	770	777	PF00069	0.447
MOD_CK1_1	268	274	PF00069	0.773
MOD_CK1_1	374	380	PF00069	0.664
MOD_CK1_1	556	562	PF00069	0.714
MOD_CK1_1	839	845	PF00069	0.405
MOD_CK1_1	98	104	PF00069	0.757
MOD_CK2_1	10	16	PF00069	0.669
MOD_CK2_1	270	276	PF00069	0.712
MOD_CK2_1	37	43	PF00069	0.783
MOD_CK2_1	386	392	PF00069	0.622
MOD_CK2_1	440	446	PF00069	0.519
MOD_CK2_1	545	551	PF00069	0.522
MOD_CK2_1	589	595	PF00069	0.335
MOD_CK2_1	756	762	PF00069	0.321
MOD_CK2_1	875	881	PF00069	0.246
MOD_CK2_1	890	896	PF00069	0.431
MOD_GlcNHglycan	272	275	PF01048	0.605
MOD_GlcNHglycan	285	288	PF01048	0.578
MOD_GlcNHglycan	366	369	PF01048	0.741
MOD_GlcNHglycan	372	376	PF01048	0.669
MOD_GlcNHglycan	82	85	PF01048	0.670
MOD_GlcNHglycan	846	849	PF01048	0.188
MOD_GlcNHglycan	893	896	PF01048	0.480
MOD_GSK3_1	138	145	PF00069	0.507
MOD_GSK3_1	265	272	PF00069	0.675
MOD_GSK3_1	33	40	PF00069	0.701
MOD_GSK3_1	381	388	PF00069	0.561
MOD_GSK3_1	534	541	PF00069	0.744
MOD_GSK3_1	543	550	PF00069	0.784
MOD_GSK3_1	552	559	PF00069	0.734
MOD_GSK3_1	667	674	PF00069	0.447
MOD_GSK3_1	702	709	PF00069	0.335
MOD_GSK3_1	711	718	PF00069	0.335
MOD_GSK3_1	76	83	PF00069	0.702
MOD_GSK3_1	823	830	PF00069	0.442
MOD_GSK3_1	835	842	PF00069	0.447
MOD_GSK3_1	84	91	PF00069	0.644
MOD_GSK3_1	853	860	PF00069	0.426
MOD_LATS_1	888	894	PF00433	0.447
MOD_N-GLC_1	268	273	PF02516	0.776
MOD_N-GLC_1	37	42	PF02516	0.755
MOD_N-GLC_1	582	587	PF02516	0.335
MOD_NEK2_1	2	7	PF00069	0.662
MOD_NEK2_1	380	385	PF00069	0.655
MOD_NEK2_1	633	638	PF00069	0.410
MOD_NEK2_1	651	656	PF00069	0.150
MOD_NEK2_1	688	693	PF00069	0.335
MOD_NEK2_1	702	707	PF00069	0.335
MOD_PIKK_1	104	110	PF00454	0.790
MOD_PIKK_1	142	148	PF00454	0.716
MOD_PIKK_1	190	196	PF00454	0.801
MOD_PIKK_1	223	229	PF00454	0.630
MOD_PK_1	11	17	PF00069	0.683
MOD_PKA_1	659	665	PF00069	0.434
MOD_PKA_1	890	896	PF00069	0.447
MOD_PKA_1	9	15	PF00069	0.637
MOD_PKA_2	135	141	PF00069	0.674
MOD_PKA_2	17	23	PF00069	0.614
MOD_PKA_2	265	271	PF00069	0.679
MOD_PKA_2	633	639	PF00069	0.447
MOD_PKA_2	659	665	PF00069	0.434
MOD_PKA_2	783	789	PF00069	0.335
MOD_PKA_2	852	858	PF00069	0.279
MOD_PKA_2	890	896	PF00069	0.447
MOD_PKA_2	9	15	PF00069	0.637
MOD_PKB_1	657	665	PF00069	0.447
MOD_PKB_1	9	17	PF00069	0.687
MOD_Plk_1	138	144	PF00069	0.556
MOD_Plk_1	37	43	PF00069	0.739
MOD_Plk_1	380	386	PF00069	0.680
MOD_Plk_1	589	595	PF00069	0.335
MOD_Plk_2-3	165	171	PF00069	0.773
MOD_Plk_2-3	491	497	PF00069	0.711
MOD_Plk_2-3	875	881	PF00069	0.289
MOD_Plk_4	454	460	PF00069	0.453
MOD_Plk_4	597	603	PF00069	0.334
MOD_Plk_4	633	639	PF00069	0.398
MOD_Plk_4	667	673	PF00069	0.447
MOD_Plk_4	711	717	PF00069	0.335
MOD_Plk_4	857	863	PF00069	0.360
MOD_ProDKin_1	277	283	PF00069	0.798
MOD_ProDKin_1	386	392	PF00069	0.580
MOD_ProDKin_1	770	776	PF00069	0.447
MOD_ProDKin_1	823	829	PF00069	0.335
MOD_ProDKin_1	95	101	PF00069	0.756
MOD_SUMO_for_1	682	685	PF00179	0.335
MOD_SUMO_rev_2	271	280	PF00179	0.782
MOD_SUMO_rev_2	41	47	PF00179	0.770
MOD_SUMO_rev_2	446	451	PF00179	0.495
MOD_SUMO_rev_2	646	651	PF00179	0.402
TRG_DiLeu_BaEn_1	624	629	PF01217	0.335
TRG_DiLeu_BaEn_2	684	690	PF01217	0.335
TRG_DiLeu_BaEn_3	874	880	PF01217	0.402
TRG_DiLeu_BaEn_4	819	825	PF01217	0.447
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.335
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.335
TRG_ENDOCYTIC_2	21	24	PF00928	0.593
TRG_ENDOCYTIC_2	221	224	PF00928	0.623
TRG_ENDOCYTIC_2	238	241	PF00928	0.596
TRG_ENDOCYTIC_2	370	373	PF00928	0.708
TRG_ENDOCYTIC_2	391	394	PF00928	0.669
TRG_ENDOCYTIC_2	463	466	PF00928	0.391
TRG_ENDOCYTIC_2	574	577	PF00928	0.388
TRG_ENDOCYTIC_2	652	655	PF00928	0.335
TRG_ENDOCYTIC_2	825	828	PF00928	0.350
TRG_ENDOCYTIC_2	859	862	PF00928	0.335
TRG_ER_diArg_1	253	255	PF00400	0.702
TRG_ER_diArg_1	412	415	PF00400	0.584
TRG_ER_diArg_1	656	659	PF00400	0.336
TRG_ER_diArg_1	776	778	PF00400	0.355
TRG_ER_diArg_1	9	11	PF00400	0.653
TRG_NES_CRM1_1	667	681	PF08389	0.335
TRG_NES_CRM1_1	875	887	PF08389	0.447
TRG_NLS_MonoExtN_4	112	119	PF00514	0.634
TRG_NLS_MonoExtN_4	566	572	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	334	339	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G9	Leptomonas seymouri	73%	88%
A0A1X0NNI0	Trypanosomatidae	51%	100%
A0A3Q8IIF0	Leishmania donovani	92%	87%
A0A422MWR8	Trypanosoma rangeli	47%	100%
A4H7R1	Leishmania braziliensis	78%	100%
A4HW49	Leishmania infantum	92%	100%
C9ZSX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q4QFM8	Leishmania major	92%	100%
V5AZ01	Trypanosoma cruzi	48%	100%