AA_permease domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APV0_LEIMU

TriTrypDb:

LmxM.14.1045

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9APV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.560
DEG_Nend_UBRbox_2	1	3	PF02207	0.736
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.759
DOC_MAPK_DCC_7	98	106	PF00069	0.759
DOC_PP1_RVXF_1	155	162	PF00149	0.360
DOC_PP4_FxxP_1	16	19	PF00568	0.704
DOC_PP4_FxxP_1	21	24	PF00568	0.363
DOC_USP7_MATH_1	184	188	PF00917	0.721
DOC_USP7_MATH_1	197	201	PF00917	0.702
DOC_WW_Pin1_4	86	91	PF00397	0.719
LIG_BRCT_BRCA1_1	12	16	PF00533	0.696
LIG_BRCT_BRCA1_1	122	126	PF00533	0.391
LIG_FHA_1	127	133	PF00498	0.491
LIG_FHA_1	174	180	PF00498	0.454
LIG_FHA_1	18	24	PF00498	0.525
LIG_FHA_1	183	189	PF00498	0.749
LIG_FHA_1	64	70	PF00498	0.339
LIG_FHA_1	79	85	PF00498	0.644
LIG_LIR_Apic_2	13	19	PF02991	0.650
LIG_LIR_Apic_2	193	199	PF02991	0.737
LIG_LIR_Apic_2	20	24	PF02991	0.268
LIG_LIR_Gen_1	64	72	PF02991	0.460
LIG_LIR_Gen_1	9	19	PF02991	0.712
LIG_LIR_LC3C_4	129	132	PF02991	0.491
LIG_LIR_Nem_3	162	168	PF02991	0.359
LIG_LIR_Nem_3	64	68	PF02991	0.422
LIG_LIR_Nem_3	9	15	PF02991	0.678
LIG_PCNA_PIPBox_1	152	161	PF02747	0.545
LIG_PCNA_yPIPBox_3	152	166	PF02747	0.397
LIG_Pex14_2	12	16	PF04695	0.685
LIG_Pex14_2	21	25	PF04695	0.364
LIG_Pex14_2	59	63	PF04695	0.203
LIG_PTB_Apo_2	144	151	PF02174	0.485
LIG_PTB_Phospho_1	144	150	PF10480	0.397
LIG_SH2_CRK	122	126	PF00017	0.438
LIG_SH2_NCK_1	122	126	PF00017	0.426
LIG_SH2_STAP1	122	126	PF00017	0.422
LIG_SH2_STAT5	158	161	PF00017	0.417
LIG_SH2_STAT5	178	181	PF00017	0.347
LIG_SH2_STAT5	37	40	PF00017	0.491
LIG_SH3_3	185	191	PF00018	0.734
LIG_Sin3_3	49	56	PF02671	0.279
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.265
LIG_SUMO_SIM_par_1	128	134	PF11976	0.429
LIG_TYR_ITIM	120	125	PF00017	0.438
LIG_WRC_WIRS_1	62	67	PF05994	0.410
MOD_CDK_SPxxK_3	86	93	PF00069	0.735
MOD_CK1_1	192	198	PF00069	0.746
MOD_CK1_1	26	32	PF00069	0.491
MOD_CK1_1	75	81	PF00069	0.737
MOD_CK2_1	39	45	PF00069	0.513
MOD_GlcNHglycan	47	50	PF01048	0.758
MOD_GSK3_1	23	30	PF00069	0.279
MOD_GSK3_1	6	13	PF00069	0.750
MOD_GSK3_1	70	77	PF00069	0.599
MOD_GSK3_1	92	99	PF00069	0.660
MOD_N-GLC_1	45	50	PF02516	0.747
MOD_N-GLC_1	75	80	PF02516	0.440
MOD_NEK2_1	159	164	PF00069	0.415
MOD_NEK2_1	39	44	PF00069	0.488
MOD_NEK2_1	63	68	PF00069	0.366
MOD_NEK2_1	74	79	PF00069	0.655
MOD_NEK2_1	92	97	PF00069	0.569
MOD_PIKK_1	10	16	PF00454	0.698
MOD_PIKK_1	182	188	PF00454	0.660
MOD_PIKK_1	75	81	PF00454	0.749
MOD_PKA_2	17	23	PF00069	0.560
MOD_Plk_1	39	45	PF00069	0.501
MOD_Plk_1	75	81	PF00069	0.643
MOD_Plk_4	102	108	PF00069	0.691
MOD_Plk_4	120	126	PF00069	0.224
MOD_Plk_4	184	190	PF00069	0.688
MOD_Plk_4	39	45	PF00069	0.455
MOD_Plk_4	92	98	PF00069	0.679
MOD_ProDKin_1	86	92	PF00069	0.720
TRG_ENDOCYTIC_2	122	125	PF00928	0.433
TRG_ENDOCYTIC_2	150	153	PF00928	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I195	Leptomonas seymouri	66%	100%
A0A0S4IKP2	Bodo saltans	30%	96%
A0A0S4JKJ4	Bodo saltans	26%	90%
A0A3Q8I8V9	Leishmania donovani	91%	100%
A4H7Q8	Leishmania braziliensis	80%	100%
E9ACR4	Leishmania major	88%	100%
E9AGL4	Leishmania infantum	91%	100%