DUF202 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF202), putative

Species:

Leishmania mexicana

UniProt:

E9APU9_LEIMU

TriTrypDb:

LmxM.14.1040

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

E9APU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APU9

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	50	52	PF00082	0.443
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.443
CLV_PCSK_SKI1_1	41	45	PF00082	0.477
CLV_PCSK_SKI1_1	61	65	PF00082	0.282
CLV_PCSK_SKI1_1	68	72	PF00082	0.282
CLV_Separin_Metazoa	131	135	PF03568	0.619
DEG_APCC_DBOX_1	67	75	PF00400	0.482
DEG_Nend_UBRbox_2	1	3	PF02207	0.719
DOC_MAPK_MEF2A_6	139	148	PF00069	0.482
DOC_MAPK_MEF2A_6	72	80	PF00069	0.335

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA80	Leptomonas seymouri	92%	100%
A0A0S4IYL4	Bodo saltans	68%	96%
A0A1X0NNJ4	Trypanosomatidae	79%	100%
A0A3S7WT40	Leishmania donovani	98%	100%
A0A422MQN2	Trypanosoma rangeli	74%	100%
A4H7Q7	Leishmania braziliensis	94%	100%
A4HW46	Leishmania infantum	98%	100%
C9ZSX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
Q4QFN1	Leishmania major	98%	100%

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