Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APU5_LEIMU

TriTrypDb:

LmxM.14.1000

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9APU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.625
CLV_NRD_NRD_1	243	245	PF00675	0.618
CLV_NRD_NRD_1	27	29	PF00675	0.396
CLV_NRD_NRD_1	378	380	PF00675	0.556
CLV_NRD_NRD_1	395	397	PF00675	0.309
CLV_NRD_NRD_1	90	92	PF00675	0.464
CLV_PCSK_KEX2_1	11	13	PF00082	0.641
CLV_PCSK_KEX2_1	243	245	PF00082	0.613
CLV_PCSK_KEX2_1	26	28	PF00082	0.405
CLV_PCSK_KEX2_1	378	380	PF00082	0.556
CLV_PCSK_KEX2_1	395	397	PF00082	0.309
CLV_PCSK_SKI1_1	265	269	PF00082	0.454
CLV_PCSK_SKI1_1	351	355	PF00082	0.464
CLV_PCSK_SKI1_1	74	78	PF00082	0.482
CLV_PCSK_SKI1_1	92	96	PF00082	0.342
DEG_APCC_DBOX_1	350	358	PF00400	0.632
DEG_SPOP_SBC_1	43	47	PF00917	0.671
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.672
DOC_MAPK_gen_1	138	146	PF00069	0.612
DOC_MAPK_gen_1	208	216	PF00069	0.667
DOC_MAPK_gen_1	349	357	PF00069	0.622
DOC_MAPK_MEF2A_6	192	200	PF00069	0.238
DOC_MAPK_MEF2A_6	324	332	PF00069	0.425
DOC_PP2B_LxvP_1	168	171	PF13499	0.359
DOC_PP2B_LxvP_1	355	358	PF13499	0.509
DOC_USP7_MATH_1	160	164	PF00917	0.637
DOC_USP7_MATH_1	220	224	PF00917	0.670
DOC_USP7_MATH_1	43	47	PF00917	0.796
DOC_USP7_MATH_1	65	69	PF00917	0.714
DOC_USP7_MATH_1	97	101	PF00917	0.783
DOC_WW_Pin1_4	106	111	PF00397	0.845
DOC_WW_Pin1_4	171	176	PF00397	0.389
DOC_WW_Pin1_4	227	232	PF00397	0.708
DOC_WW_Pin1_4	370	375	PF00397	0.784
LIG_14-3-3_CanoR_1	116	123	PF00244	0.592
LIG_14-3-3_CanoR_1	208	218	PF00244	0.669
LIG_14-3-3_CanoR_1	247	255	PF00244	0.627
LIG_14-3-3_CanoR_1	26	33	PF00244	0.770
LIG_14-3-3_CanoR_1	279	284	PF00244	0.693
LIG_14-3-3_CanoR_1	96	104	PF00244	0.722
LIG_Actin_WH2_2	193	210	PF00022	0.501
LIG_BIR_II_1	1	5	PF00653	0.814
LIG_BRCT_BRCA1_1	67	71	PF00533	0.558
LIG_Clathr_ClatBox_1	77	81	PF01394	0.671
LIG_FHA_1	191	197	PF00498	0.300
LIG_FHA_1	211	217	PF00498	0.579
LIG_FHA_1	410	416	PF00498	0.530
LIG_FHA_1	52	58	PF00498	0.752
LIG_FHA_2	148	154	PF00498	0.316
LIG_FHA_2	47	53	PF00498	0.763
LIG_GBD_Chelix_1	194	202	PF00786	0.238
LIG_Integrin_RGD_1	13	15	PF01839	0.502
LIG_LIR_Nem_3	117	123	PF02991	0.729
LIG_LIR_Nem_3	252	258	PF02991	0.697
LIG_LIR_Nem_3	421	425	PF02991	0.472
LIG_NRBOX	327	333	PF00104	0.452
LIG_PCNA_yPIPBox_3	260	268	PF02747	0.531
LIG_PTAP_UEV_1	425	430	PF05743	0.526
LIG_RPA_C_Fungi	187	199	PF08784	0.238
LIG_SH2_GRB2like	383	386	PF00017	0.522
LIG_SH2_NCK_1	248	252	PF00017	0.657
LIG_SH2_SRC	383	386	PF00017	0.522
LIG_SH2_STAT5	248	251	PF00017	0.575
LIG_SH3_1	167	173	PF00018	0.529
LIG_SH3_3	167	173	PF00018	0.577
LIG_SH3_3	223	229	PF00018	0.757
LIG_SH3_3	286	292	PF00018	0.557
LIG_SH3_3	423	429	PF00018	0.723
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.483
LIG_SUMO_SIM_par_1	191	197	PF11976	0.296
LIG_WRC_WIRS_1	148	153	PF05994	0.530
LIG_WRC_WIRS_1	419	424	PF05994	0.568
LIG_WW_2	170	173	PF00397	0.450
MOD_CK1_1	111	117	PF00069	0.560
MOD_CK1_1	174	180	PF00069	0.585
MOD_CK1_1	2	8	PF00069	0.530
MOD_CK1_1	201	207	PF00069	0.602
MOD_CK1_1	46	52	PF00069	0.633
MOD_CK1_1	63	69	PF00069	0.372
MOD_CK2_1	147	153	PF00069	0.530
MOD_CK2_1	247	253	PF00069	0.662
MOD_GlcNHglycan	1	4	PF01048	0.780
MOD_GlcNHglycan	117	120	PF01048	0.650
MOD_GlcNHglycan	176	179	PF01048	0.547
MOD_GlcNHglycan	249	252	PF01048	0.663
MOD_GlcNHglycan	311	314	PF01048	0.376
MOD_GlcNHglycan	431	434	PF01048	0.573
MOD_GlcNHglycan	54	57	PF01048	0.647
MOD_GlcNHglycan	67	70	PF01048	0.475
MOD_GSK3_1	108	115	PF00069	0.633
MOD_GSK3_1	190	197	PF00069	0.530
MOD_GSK3_1	275	282	PF00069	0.518
MOD_GSK3_1	309	316	PF00069	0.324
MOD_GSK3_1	42	49	PF00069	0.644
MOD_GSK3_1	63	70	PF00069	0.549
MOD_GSK3_1	92	99	PF00069	0.616
MOD_N-GLC_1	303	308	PF02516	0.316
MOD_NEK2_1	190	195	PF00069	0.456
MOD_NEK2_1	198	203	PF00069	0.390
MOD_NEK2_1	219	224	PF00069	0.590
MOD_NEK2_1	285	290	PF00069	0.506
MOD_NEK2_1	410	415	PF00069	0.369
MOD_NEK2_1	418	423	PF00069	0.511
MOD_NEK2_1	60	65	PF00069	0.678
MOD_PIKK_1	108	114	PF00454	0.517
MOD_PKA_1	26	32	PF00069	0.727
MOD_PKA_2	115	121	PF00069	0.489
MOD_PKA_2	210	216	PF00069	0.576
MOD_PKA_2	246	252	PF00069	0.611
MOD_PKA_2	26	32	PF00069	0.727
MOD_PKA_2	95	101	PF00069	0.630
MOD_PKB_1	26	34	PF00069	0.433
MOD_Plk_1	29	35	PF00069	0.584
MOD_Plk_4	147	153	PF00069	0.530
MOD_Plk_4	194	200	PF00069	0.460
MOD_Plk_4	313	319	PF00069	0.307
MOD_Plk_4	411	417	PF00069	0.530
MOD_Plk_4	67	73	PF00069	0.535
MOD_ProDKin_1	106	112	PF00069	0.822
MOD_ProDKin_1	171	177	PF00069	0.462
MOD_ProDKin_1	227	233	PF00069	0.633
MOD_ProDKin_1	370	376	PF00069	0.733
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.638
TRG_ER_diArg_1	10	13	PF00400	0.818
TRG_ER_diArg_1	26	28	PF00400	0.470
TRG_ER_diArg_1	348	351	PF00400	0.571
TRG_ER_diArg_1	394	396	PF00400	0.366
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9V0	Leishmania donovani	86%	100%
A4H7Q3	Leishmania braziliensis	73%	100%
A4HW42	Leishmania infantum	86%	100%
Q4QFN5	Leishmania major	85%	100%