Na_H_Exchanger domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sodium/hydrogen exchanger, putative

Species:

Leishmania mexicana

UniProt:

E9APU3_LEIMU

TriTrypDb:

LmxM.14.0980

Length:

636

Annotations

LeishMANIAdb annotations

Homologous to animal Na+ / H+ exchangers.. Interestingly most heavily expanded in Strigomonas species and the non-parazitic Bodo saltans

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

E9APU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APU3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	15
GO:0005451	obsolete monoatomic cation:proton antiporter activity	5	15
GO:0008324	monoatomic cation transmembrane transporter activity	4	15
GO:0015075	monoatomic ion transmembrane transporter activity	3	15
GO:0015078	proton transmembrane transporter activity	5	15
GO:0015291	secondary active transmembrane transporter activity	4	15
GO:0015297	antiporter activity	5	15
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	15
GO:0015299	obsolete solute:proton antiporter activity	6	15
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	15
GO:0022804	active transmembrane transporter activity	3	15
GO:0022853	active monoatomic ion transmembrane transporter activity	4	15
GO:0022857	transmembrane transporter activity	2	15
GO:0022890	inorganic cation transmembrane transporter activity	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.358
CLV_PCSK_KEX2_1	73	75	PF00082	0.357
CLV_PCSK_SKI1_1	154	158	PF00082	0.526
CLV_PCSK_SKI1_1	162	166	PF00082	0.508
CLV_PCSK_SKI1_1	430	434	PF00082	0.510
CLV_PCSK_SKI1_1	435	439	PF00082	0.490
CLV_PCSK_SKI1_1	544	548	PF00082	0.406
DOC_ANK_TNKS_1	46	53	PF00023	0.476
DOC_CDC14_PxL_1	131	139	PF14671	0.357
DOC_MAPK_DCC_7	130	140	PF00069	0.477
DOC_MAPK_gen_1	468	475	PF00069	0.518
DOC_MAPK_HePTP_8	82	94	PF00069	0.365
DOC_MAPK_MEF2A_6	170	177	PF00069	0.304
DOC_MAPK_MEF2A_6	292	299	PF00069	0.278
DOC_MAPK_MEF2A_6	468	475	PF00069	0.505
DOC_MAPK_MEF2A_6	612	620	PF00069	0.545
DOC_MAPK_MEF2A_6	63	70	PF00069	0.548
DOC_MAPK_MEF2A_6	78	86	PF00069	0.403
DOC_PP1_RVXF_1	433	439	PF00149	0.142
DOC_PP1_RVXF_1	83	89	PF00149	0.406
DOC_PP2B_LxvP_1	132	135	PF13499	0.317
DOC_PP4_FxxP_1	591	594	PF00568	0.570
DOC_SPAK_OSR1_1	452	456	PF12202	0.428
DOC_USP7_MATH_1	483	487	PF00917	0.467
DOC_USP7_MATH_1	604	608	PF00917	0.779
DOC_USP7_UBL2_3	183	187	PF12436	0.524
DOC_USP7_UBL2_3	426	430	PF12436	0.342
DOC_USP7_UBL2_3	544	548	PF12436	0.634
DOC_WW_Pin1_4	236	241	PF00397	0.306
LIG_14-3-3_CanoR_1	452	458	PF00244	0.341
LIG_14-3-3_CanoR_1	541	547	PF00244	0.622
LIG_BRCT_BRCA1_1	38	42	PF00533	0.584
LIG_BRCT_BRCA1_1	587	591	PF00533	0.565
LIG_deltaCOP1_diTrp_1	53	62	PF00928	0.584
LIG_eIF4E_1	110	116	PF01652	0.305
LIG_FHA_1	155	161	PF00498	0.238
LIG_FHA_1	172	178	PF00498	0.361
LIG_FHA_1	194	200	PF00498	0.496
LIG_FHA_1	454	460	PF00498	0.341
LIG_FHA_1	570	576	PF00498	0.728
LIG_FHA_1	619	625	PF00498	0.690
LIG_FHA_2	510	516	PF00498	0.313
LIG_FHA_2	580	586	PF00498	0.743
LIG_GBD_Chelix_1	119	127	PF00786	0.428
LIG_GBD_Chelix_1	490	498	PF00786	0.428
LIG_LIR_Apic_2	39	44	PF02991	0.533
LIG_LIR_Apic_2	588	594	PF02991	0.731
LIG_LIR_Gen_1	29	36	PF02991	0.568
LIG_LIR_Gen_1	347	358	PF02991	0.314
LIG_LIR_Gen_1	405	414	PF02991	0.458
LIG_LIR_Gen_1	524	535	PF02991	0.373
LIG_LIR_Nem_3	29	34	PF02991	0.569
LIG_LIR_Nem_3	347	353	PF02991	0.322
LIG_LIR_Nem_3	356	361	PF02991	0.297
LIG_LIR_Nem_3	405	409	PF02991	0.466
LIG_LIR_Nem_3	410	414	PF02991	0.330
LIG_LIR_Nem_3	524	530	PF02991	0.373
LIG_LIR_Nem_3	615	620	PF02991	0.612
LIG_Pex14_1	278	282	PF04695	0.306
LIG_Pex14_2	433	437	PF04695	0.235
LIG_Pex14_2	453	457	PF04695	0.109
LIG_PTB_Apo_2	213	220	PF02174	0.344
LIG_PTB_Apo_2	331	338	PF02174	0.467
LIG_PTB_Apo_2	431	438	PF02174	0.249
LIG_PTB_Phospho_1	331	337	PF10480	0.467
LIG_REV1ctd_RIR_1	360	370	PF16727	0.428
LIG_SH2_CRK	31	35	PF00017	0.564
LIG_SH2_CRK	358	362	PF00017	0.421
LIG_SH2_GRB2like	516	519	PF00017	0.295
LIG_SH2_NCK_1	358	362	PF00017	0.428
LIG_SH2_STAP1	358	362	PF00017	0.353
LIG_SH2_STAP1	516	520	PF00017	0.274
LIG_SH2_STAT5	110	113	PF00017	0.242
LIG_SH2_STAT5	155	158	PF00017	0.241
LIG_SH2_STAT5	17	20	PF00017	0.610
LIG_SH2_STAT5	249	252	PF00017	0.344
LIG_SH2_STAT5	320	323	PF00017	0.298
LIG_SH2_STAT5	337	340	PF00017	0.440
LIG_SH2_STAT5	36	39	PF00017	0.584
LIG_SH2_STAT5	477	480	PF00017	0.489
LIG_SH2_STAT5	527	530	PF00017	0.317
LIG_SH3_3	108	114	PF00018	0.259
LIG_SH3_3	239	245	PF00018	0.295
LIG_SH3_3	411	417	PF00018	0.401
LIG_SH3_3	613	619	PF00018	0.542
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.361
LIG_SUMO_SIM_par_1	115	121	PF11976	0.377
LIG_TRAF2_1	556	559	PF00917	0.637
LIG_TRFH_1	31	35	PF08558	0.478
LIG_UBA3_1	283	292	PF00899	0.379
LIG_UBA3_1	317	326	PF00899	0.268
LIG_UBA3_1	419	426	PF00899	0.345
LIG_UBA3_1	498	506	PF00899	0.449
MOD_CK1_1	236	242	PF00069	0.328
MOD_CK1_1	509	515	PF00069	0.410
MOD_CK1_1	562	568	PF00069	0.721
MOD_CK1_1	605	611	PF00069	0.650
MOD_CK2_1	42	48	PF00069	0.533
MOD_CK2_1	509	515	PF00069	0.383
MOD_CK2_1	579	585	PF00069	0.747
MOD_Cter_Amidation	71	74	PF01082	0.489
MOD_GlcNHglycan	120	123	PF01048	0.330
MOD_GlcNHglycan	266	269	PF01048	0.319
MOD_GlcNHglycan	380	383	PF01048	0.354
MOD_GlcNHglycan	462	465	PF01048	0.361
MOD_GlcNHglycan	481	484	PF01048	0.302
MOD_GlcNHglycan	523	526	PF01048	0.394
MOD_GlcNHglycan	561	564	PF01048	0.732
MOD_GlcNHglycan	566	569	PF01048	0.685
MOD_GlcNHglycan	597	600	PF01048	0.744
MOD_GlcNHglycan	604	607	PF01048	0.685
MOD_GSK3_1	260	267	PF00069	0.310
MOD_GSK3_1	479	486	PF00069	0.310
MOD_GSK3_1	558	565	PF00069	0.675
MOD_N-GLC_1	585	590	PF02516	0.744
MOD_N-GLC_2	343	345	PF02516	0.435
MOD_NEK2_1	165	170	PF00069	0.420
MOD_NEK2_1	171	176	PF00069	0.257
MOD_NEK2_1	198	203	PF00069	0.383
MOD_NEK2_1	233	238	PF00069	0.337
MOD_NEK2_1	264	269	PF00069	0.293
MOD_NEK2_1	380	385	PF00069	0.317
MOD_NEK2_1	419	424	PF00069	0.348
MOD_NEK2_1	445	450	PF00069	0.265
MOD_NEK2_1	453	458	PF00069	0.170
MOD_PIKK_1	585	591	PF00454	0.731
MOD_PK_1	73	79	PF00069	0.523
MOD_PKA_1	73	79	PF00069	0.523
MOD_PKA_2	451	457	PF00069	0.445
MOD_PKA_2	559	565	PF00069	0.716
MOD_PKA_2	73	79	PF00069	0.476
MOD_Plk_1	506	512	PF00069	0.295
MOD_Plk_1	579	585	PF00069	0.735
MOD_Plk_4	171	177	PF00069	0.312
MOD_Plk_4	209	215	PF00069	0.419
MOD_Plk_4	233	239	PF00069	0.323
MOD_Plk_4	244	250	PF00069	0.291
MOD_Plk_4	260	266	PF00069	0.201
MOD_Plk_4	29	35	PF00069	0.476
MOD_Plk_4	402	408	PF00069	0.335
MOD_Plk_4	453	459	PF00069	0.351
MOD_Plk_4	542	548	PF00069	0.414
MOD_ProDKin_1	236	242	PF00069	0.306
MOD_SUMO_for_1	325	328	PF00179	0.330
MOD_SUMO_for_1	556	559	PF00179	0.540
TRG_ENDOCYTIC_2	31	34	PF00928	0.458
TRG_ENDOCYTIC_2	358	361	PF00928	0.379
TRG_ENDOCYTIC_2	527	530	PF00928	0.312
TRG_ER_diArg_1	73	75	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H5	Leptomonas seymouri	33%	70%
A0A0N1I1I3	Leptomonas seymouri	80%	78%
A0A0S4IUH4	Bodo saltans	41%	92%
A0A0S4IYS7	Bodo saltans	46%	99%
A0A0S4J2L9	Bodo saltans	50%	98%
A0A1X0NSQ8	Trypanosomatidae	66%	89%
A0A1X0P4B5	Trypanosomatidae	29%	79%
A0A3Q8I9W9	Leishmania donovani	92%	98%
A0A3R7NWD7	Trypanosoma rangeli	27%	84%
A0A422N0A8	Trypanosoma rangeli	57%	94%
A4HW40	Leishmania infantum	92%	98%
A4IHB9	Xenopus tropicalis	28%	100%
C9ZP87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0A5M2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	79%
E9AI47	Leishmania braziliensis	85%	100%
Q4QFN7	Leishmania major	90%	100%
Q4R7S2	Macaca fascicularis	24%	100%
Q4ZJI4	Homo sapiens	24%	100%
Q5BKR2	Mus musculus	26%	100%
Q5R6B8	Pongo abelii	24%	100%
Q86UD5	Homo sapiens	24%	100%
V5BES3	Trypanosoma cruzi	62%	94%
V5BN48	Trypanosoma cruzi	28%	79%