Ribosomal_L16 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein L16p/L10e, putative

Species:

Leishmania mexicana

UniProt:

E9APU0_LEIMU

TriTrypDb:

LmxM.14.0950

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	10
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

E9APU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APU0

PDB structure(s): 7aih_H , 7ane_H

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003735	structural constituent of ribosome	2	10
GO:0005198	structural molecule activity	1	10
GO:0005488	binding	1	10
GO:0019843	rRNA binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.232
CLV_NRD_NRD_1	29	31	PF00675	0.547
CLV_NRD_NRD_1	73	75	PF00675	0.232
CLV_PCSK_KEX2_1	131	133	PF00082	0.232
CLV_PCSK_KEX2_1	73	75	PF00082	0.232
CLV_PCSK_SKI1_1	46	50	PF00082	0.264
DEG_Nend_UBRbox_3	1	3	PF02207	0.669
DOC_CYCLIN_RxL_1	43	53	PF00134	0.318
DOC_USP7_MATH_1	104	108	PF00917	0.485
DOC_USP7_MATH_1	127	131	PF00917	0.453
DOC_USP7_MATH_1	76	80	PF00917	0.521
DOC_WW_Pin1_4	94	99	PF00397	0.445
LIG_14-3-3_CanoR_1	7	12	PF00244	0.631
LIG_APCC_ABBA_1	82	87	PF00400	0.450
LIG_FHA_1	115	121	PF00498	0.432
LIG_FHA_1	151	157	PF00498	0.432
LIG_FHA_2	84	90	PF00498	0.432
LIG_LIR_Gen_1	86	94	PF02991	0.432
LIG_LIR_Nem_3	162	167	PF02991	0.375
LIG_LIR_Nem_3	53	59	PF02991	0.438
LIG_LIR_Nem_3	86	91	PF02991	0.432
LIG_Pex14_2	112	116	PF04695	0.432
LIG_SH2_CRK	15	19	PF00017	0.440
LIG_SH2_PTP2	17	20	PF00017	0.415
LIG_SH2_SRC	17	20	PF00017	0.437
LIG_SH2_STAT5	17	20	PF00017	0.437
LIG_SUMO_SIM_anti_2	41	46	PF11976	0.457
MOD_CDK_SPxxK_3	94	101	PF00069	0.432
MOD_CK1_1	97	103	PF00069	0.432
MOD_CK2_1	59	65	PF00069	0.432
MOD_CK2_1	83	89	PF00069	0.432
MOD_GlcNHglycan	3	6	PF01048	0.640
MOD_GSK3_1	123	130	PF00069	0.475
MOD_GSK3_1	76	83	PF00069	0.524
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	123	128	PF00069	0.460
MOD_NEK2_1	80	85	PF00069	0.450
MOD_PIKK_1	57	63	PF00454	0.432
MOD_PKA_2	6	12	PF00069	0.598
MOD_PKA_2	76	82	PF00069	0.513
MOD_Plk_1	123	129	PF00069	0.467
MOD_Plk_4	7	13	PF00069	0.531
MOD_ProDKin_1	94	100	PF00069	0.445
TRG_ENDOCYTIC_2	15	18	PF00928	0.454
TRG_ENDOCYTIC_2	164	167	PF00928	0.382
TRG_ENDOCYTIC_2	88	91	PF00928	0.432
TRG_ER_diArg_1	131	133	PF00400	0.432
TRG_ER_diArg_1	157	160	PF00400	0.482
TRG_ER_diArg_1	72	74	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P481	Leptomonas seymouri	91%	100%
A0A1X0NNV3	Trypanosomatidae	86%	100%
A0A3R7M6C9	Trypanosoma rangeli	83%	100%
A0A3S7WT29	Leishmania donovani	98%	100%
A0K3N2	Burkholderia cenocepacia (strain HI2424)	30%	100%
A1QZS1	Borrelia turicatae (strain 91E135)	29%	100%
A1TJ14	Acidovorax citrulli (strain AAC00-1)	34%	100%
A1V896	Burkholderia mallei (strain SAVP1)	31%	100%
A1VIQ7	Polaromonas naphthalenivorans (strain CJ2)	35%	100%
A1W2R4	Acidovorax sp. (strain JS42)	34%	100%
A1WHD2	Verminephrobacter eiseniae (strain EF01-2)	34%	100%
A2S7I3	Burkholderia mallei (strain NCTC 10229)	31%	100%
A2SLF0	Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)	34%	100%
A3MRW1	Burkholderia mallei (strain NCTC 10247)	31%	100%
A3NEH2	Burkholderia pseudomallei (strain 668)	31%	100%
A3P0A6	Burkholderia pseudomallei (strain 1106a)	31%	100%
A3PGL8	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	35%	100%
A3Q989	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	29%	100%
A4H7P8	Leishmania braziliensis	96%	100%
A4HW37	Leishmania infantum	99%	100%
A4J118	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	28%	100%
A4JAP7	Burkholderia vietnamiensis (strain G4 / LMG 22486)	30%	100%
A4SUW8	Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)	32%	100%
A4WVK1	Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)	35%	100%
A5CCK5	Orientia tsutsugamushi (strain Boryong)	33%	100%
A5IM90	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	32%	100%
A5WCJ7	Psychrobacter sp. (strain PRwf-1)	30%	100%
A7HBM5	Anaeromyxobacter sp. (strain Fw109-5)	31%	100%
A8GYY3	Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)	30%	100%
A9ADK0	Burkholderia multivorans (strain ATCC 17616 / 249)	30%	100%
A9BPS5	Delftia acidovorans (strain DSM 14801 / SPH-1)	34%	100%
A9IIY9	Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)	33%	100%
B0T2C9	Caulobacter sp. (strain K31)	34%	100%
B0TM05	Shewanella halifaxensis (strain HAW-EB4)	30%	100%
B1JU29	Burkholderia cenocepacia (strain MC0-3)	30%	100%
B1LBN3	Thermotoga sp. (strain RQ2)	32%	100%
B1XSQ8	Polynucleobacter necessarius subsp. necessarius (strain STIR1)	32%	100%
B1Y8I0	Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)	33%	100%
B1YRD7	Burkholderia ambifaria (strain MC40-6)	30%	100%
B2S0I8	Borrelia hermsii (strain HS1 / DAH)	30%	100%
B3CT12	Orientia tsutsugamushi (strain Ikeda)	36%	100%
B3QZZ8	Phytoplasma mali (strain AT)	30%	100%
B4E5C7	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	30%	100%
B4UBA6	Anaeromyxobacter sp. (strain K)	32%	100%
B5ELY6	Acidithiobacillus ferrooxidans (strain ATCC 53993 / BNL-5-31)	34%	100%
B5RM43	Borrelia duttonii (strain Ly)	29%	100%
B5RPI9	Borrelia recurrentis (strain A1)	30%	100%
B7J250	Borreliella burgdorferi (strain ZS7)	28%	100%
B7J474	Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455)	34%	100%
B8GV51	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	31%	100%
B8J867	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	32%	100%
B9KL98	Cereibacter sphaeroides (strain KD131 / KCTC 12085)	35%	100%
B9MB80	Acidovorax ebreus (strain TPSY)	34%	100%
C5CP46	Variovorax paradoxus (strain S110)	34%	100%
C9ZSY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
O51438	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	28%	100%
P38509	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	31%	100%
P46173	Buchnera aphidicola subsp. Acyrthosiphon kondoi	31%	100%
P60489	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	28%	100%
Q089P7	Shewanella frigidimarina (strain NCIMB 400)	29%	100%
Q0BJ39	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	30%	100%
Q0SN22	Borreliella afzelii (strain PKo)	28%	100%
Q0SQF1	Clostridium perfringens (strain SM101 / Type A)	32%	100%
Q0TMQ3	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	32%	100%
Q12GW4	Polaromonas sp. (strain JS666 / ATCC BAA-500)	34%	100%
Q1BRV5	Burkholderia cenocepacia (strain AU 1054)	30%	100%
Q1D768	Myxococcus xanthus (strain DK1622)	28%	100%
Q21RW5	Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)	34%	100%
Q2IJ83	Anaeromyxobacter dehalogenans (strain 2CP-C)	32%	100%
Q2L2B8	Bordetella avium (strain 197N)	33%	100%
Q2SU34	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	31%	100%
Q39KG0	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	30%	100%
Q3J5R5	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	35%	100%
Q3JMS0	Burkholderia pseudomallei (strain 1710b)	31%	100%
Q4QFP0	Leishmania major	99%	100%
Q62GL2	Burkholderia mallei (strain ATCC 23344)	31%	100%
Q63Q18	Burkholderia pseudomallei (strain K96243)	31%	100%
Q661D5	Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)	28%	100%
Q6F7R9	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	30%	100%
Q72I11	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	29%	100%
Q7VQE1	Blochmannia floridanus	30%	100%
Q7VTC6	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	33%	100%
Q7W2E9	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	33%	100%
Q7WRB8	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	33%	100%
Q83FZ3	Tropheryma whipplei (strain Twist)	27%	100%
Q83I71	Tropheryma whipplei (strain TW08/27)	27%	100%
Q890P5	Clostridium tetani (strain Massachusetts / E88)	32%	100%
Q8K957	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	34%	100%
Q8XHT0	Clostridium perfringens (strain 13 / Type A)	32%	100%