Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APT9_LEIMU

TriTrypDb:

LmxM.14.0940

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.613
CLV_C14_Caspase3-7	355	359	PF00656	0.617
CLV_NRD_NRD_1	278	280	PF00675	0.546
CLV_NRD_NRD_1	375	377	PF00675	0.590
CLV_NRD_NRD_1	473	475	PF00675	0.656
CLV_NRD_NRD_1	480	482	PF00675	0.644
CLV_PCSK_FUR_1	478	482	PF00082	0.681
CLV_PCSK_KEX2_1	278	280	PF00082	0.546
CLV_PCSK_KEX2_1	375	377	PF00082	0.590
CLV_PCSK_KEX2_1	477	479	PF00082	0.678
CLV_PCSK_KEX2_1	480	482	PF00082	0.656
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.678
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DEG_SCF_FBW7_1	335	342	PF00400	0.548
DEG_SCF_FBW7_1	64	71	PF00400	0.664
DEG_SPOP_SBC_1	207	211	PF00917	0.610
DEG_SPOP_SBC_1	524	528	PF00917	0.551
DOC_CKS1_1	308	313	PF01111	0.641
DOC_CKS1_1	336	341	PF01111	0.619
DOC_CKS1_1	657	662	PF01111	0.602
DOC_MAPK_MEF2A_6	406	413	PF00069	0.593
DOC_PP2B_LxvP_1	281	284	PF13499	0.547
DOC_PP2B_LxvP_1	466	469	PF13499	0.647
DOC_PP2B_LxvP_1	500	503	PF13499	0.645
DOC_PP2B_LxvP_1	728	731	PF13499	0.631
DOC_PP2B_PxIxI_1	59	65	PF00149	0.631
DOC_PP4_FxxP_1	308	311	PF00568	0.577
DOC_PP4_FxxP_1	657	660	PF00568	0.598
DOC_PP4_MxPP_1	796	799	PF00568	0.599
DOC_USP7_MATH_1	206	210	PF00917	0.605
DOC_USP7_MATH_1	321	325	PF00917	0.746
DOC_USP7_MATH_1	339	343	PF00917	0.624
DOC_USP7_MATH_1	4	8	PF00917	0.604
DOC_USP7_MATH_1	407	411	PF00917	0.666
DOC_USP7_MATH_1	415	419	PF00917	0.639
DOC_USP7_MATH_1	429	433	PF00917	0.643
DOC_USP7_MATH_1	493	497	PF00917	0.712
DOC_USP7_MATH_1	524	528	PF00917	0.636
DOC_USP7_MATH_1	555	559	PF00917	0.621
DOC_USP7_MATH_1	567	571	PF00917	0.682
DOC_USP7_MATH_1	604	608	PF00917	0.630
DOC_USP7_MATH_1	770	774	PF00917	0.633
DOC_WW_Pin1_4	128	133	PF00397	0.712
DOC_WW_Pin1_4	179	184	PF00397	0.645
DOC_WW_Pin1_4	244	249	PF00397	0.581
DOC_WW_Pin1_4	284	289	PF00397	0.669
DOC_WW_Pin1_4	293	298	PF00397	0.591
DOC_WW_Pin1_4	303	308	PF00397	0.510
DOC_WW_Pin1_4	335	340	PF00397	0.764
DOC_WW_Pin1_4	42	47	PF00397	0.584
DOC_WW_Pin1_4	600	605	PF00397	0.609
DOC_WW_Pin1_4	64	69	PF00397	0.664
DOC_WW_Pin1_4	656	661	PF00397	0.590
DOC_WW_Pin1_4	721	726	PF00397	0.599
LIG_14-3-3_CanoR_1	149	158	PF00244	0.597
LIG_14-3-3_CanoR_1	234	240	PF00244	0.586
LIG_14-3-3_CanoR_1	745	751	PF00244	0.510
LIG_14-3-3_CanoR_1	781	787	PF00244	0.527
LIG_Actin_WH2_2	601	617	PF00022	0.640
LIG_BIR_III_4	221	225	PF00653	0.517
LIG_BRCT_BRCA1_1	25	29	PF00533	0.561
LIG_BRCT_BRCA1_1	526	530	PF00533	0.699
LIG_EVH1_1	500	504	PF00568	0.641
LIG_FHA_1	106	112	PF00498	0.614
LIG_FHA_1	209	215	PF00498	0.616
LIG_FHA_1	223	229	PF00498	0.614
LIG_FHA_1	265	271	PF00498	0.592
LIG_FHA_1	32	38	PF00498	0.606
LIG_FHA_1	68	74	PF00498	0.650
LIG_IBAR_NPY_1	59	61	PF08397	0.645
LIG_LIR_Apic_2	174	180	PF02991	0.623
LIG_LIR_Apic_2	306	311	PF02991	0.577
LIG_LIR_Apic_2	40	46	PF02991	0.508
LIG_LIR_Apic_2	496	502	PF02991	0.663
LIG_LIR_Gen_1	152	163	PF02991	0.646
LIG_LIR_Gen_1	233	244	PF02991	0.671
LIG_LIR_Gen_1	531	542	PF02991	0.539
LIG_LIR_Gen_1	694	705	PF02991	0.687
LIG_LIR_Nem_3	233	239	PF02991	0.761
LIG_LIR_Nem_3	527	533	PF02991	0.726
LIG_LIR_Nem_3	694	700	PF02991	0.701
LIG_MYND_1	163	167	PF01753	0.594
LIG_MYND_2	162	166	PF01753	0.498
LIG_PALB2_WD40_1	692	700	PF16756	0.416
LIG_Pex14_1	695	699	PF04695	0.547
LIG_Pex14_2	697	701	PF04695	0.550
LIG_PROFILIN_1	501	507	PF00235	0.607
LIG_SH2_CRK	292	296	PF00017	0.600
LIG_SH2_CRK	43	47	PF00017	0.643
LIG_SH2_CRK	534	538	PF00017	0.530
LIG_SH2_CRK	541	545	PF00017	0.537
LIG_SH2_PTP2	61	64	PF00017	0.662
LIG_SH2_SRC	119	122	PF00017	0.596
LIG_SH2_SRC	177	180	PF00017	0.630
LIG_SH2_SRC	499	502	PF00017	0.657
LIG_SH2_SRC	595	598	PF00017	0.500
LIG_SH2_STAP1	534	538	PF00017	0.530
LIG_SH2_STAP1	541	545	PF00017	0.537
LIG_SH2_STAT3	350	353	PF00017	0.632
LIG_SH2_STAT3	441	444	PF00017	0.655
LIG_SH2_STAT5	119	122	PF00017	0.532
LIG_SH2_STAT5	177	180	PF00017	0.630
LIG_SH2_STAT5	197	200	PF00017	0.561
LIG_SH2_STAT5	499	502	PF00017	0.657
LIG_SH2_STAT5	595	598	PF00017	0.500
LIG_SH2_STAT5	61	64	PF00017	0.831
LIG_SH2_STAT5	620	623	PF00017	0.629
LIG_SH2_STAT5	699	702	PF00017	0.552
LIG_SH2_STAT5	807	810	PF00017	0.538
LIG_SH3_1	177	183	PF00018	0.636
LIG_SH3_1	498	504	PF00018	0.652
LIG_SH3_2	288	293	PF14604	0.533
LIG_SH3_2	797	802	PF14604	0.502
LIG_SH3_3	177	183	PF00018	0.636
LIG_SH3_3	285	291	PF00018	0.656
LIG_SH3_3	294	300	PF00018	0.599
LIG_SH3_3	345	351	PF00018	0.569
LIG_SH3_3	423	429	PF00018	0.650
LIG_SH3_3	498	504	PF00018	0.694
LIG_SH3_3	505	511	PF00018	0.716
LIG_SH3_3	633	639	PF00018	0.638
LIG_SH3_3	713	719	PF00018	0.545
LIG_SH3_3	747	753	PF00018	0.504
LIG_SH3_3	794	800	PF00018	0.564
LIG_SH3_CIN85_PxpxPR_1	507	512	PF14604	0.548
LIG_SH3_CIN85_PxpxPR_1	797	802	PF14604	0.502
LIG_SUMO_SIM_anti_2	609	614	PF11976	0.469
LIG_SUMO_SIM_par_1	209	218	PF11976	0.524
LIG_SUMO_SIM_par_1	550	556	PF11976	0.480
LIG_TRAF2_1	250	253	PF00917	0.536
LIG_WW_1	311	314	PF00397	0.636
LIG_WW_1	804	807	PF00397	0.600
LIG_WW_3	310	314	PF00397	0.572
LIG_WW_3	799	803	PF00397	0.501
MOD_CDC14_SPxK_1	287	290	PF00782	0.661
MOD_CDC14_SPxK_1	296	299	PF00782	0.589
MOD_CDC14_SPxK_1	724	727	PF00782	0.542
MOD_CDK_SPxK_1	284	290	PF00069	0.668
MOD_CDK_SPxK_1	293	299	PF00069	0.592
MOD_CDK_SPxK_1	307	313	PF00069	0.518
MOD_CDK_SPxK_1	721	727	PF00069	0.538
MOD_CK1_1	123	129	PF00069	0.663
MOD_CK1_1	213	219	PF00069	0.565
MOD_CK1_1	262	268	PF00069	0.626
MOD_CK1_1	306	312	PF00069	0.559
MOD_CK1_1	324	330	PF00069	0.715
MOD_CK1_1	341	347	PF00069	0.634
MOD_CK1_1	379	385	PF00069	0.694
MOD_CK1_1	45	51	PF00069	0.744
MOD_CK1_1	5	11	PF00069	0.632
MOD_CK1_1	525	531	PF00069	0.670
MOD_CK1_1	54	60	PF00069	0.582
MOD_CK1_1	600	606	PF00069	0.565
MOD_CK1_1	623	629	PF00069	0.572
MOD_CK2_1	328	334	PF00069	0.642
MOD_GlcNHglycan	108	111	PF01048	0.688
MOD_GlcNHglycan	144	147	PF01048	0.733
MOD_GlcNHglycan	221	225	PF01048	0.538
MOD_GlcNHglycan	25	28	PF01048	0.660
MOD_GlcNHglycan	362	365	PF01048	0.627
MOD_GlcNHglycan	387	390	PF01048	0.693
MOD_GlcNHglycan	4	7	PF01048	0.630
MOD_GlcNHglycan	422	425	PF01048	0.770
MOD_GlcNHglycan	435	438	PF01048	0.592
MOD_GlcNHglycan	527	530	PF01048	0.513
MOD_GlcNHglycan	53	56	PF01048	0.579
MOD_GlcNHglycan	588	591	PF01048	0.547
MOD_GlcNHglycan	597	600	PF01048	0.724
MOD_GlcNHglycan	623	626	PF01048	0.742
MOD_GlcNHglycan	627	630	PF01048	0.675
MOD_GlcNHglycan	683	686	PF01048	0.546
MOD_GlcNHglycan	734	737	PF01048	0.603
MOD_GlcNHglycan	76	79	PF01048	0.620
MOD_GlcNHglycan	767	770	PF01048	0.618
MOD_GlcNHglycan	772	775	PF01048	0.602
MOD_GlcNHglycan	82	85	PF01048	0.655
MOD_GSK3_1	123	130	PF00069	0.699
MOD_GSK3_1	206	213	PF00069	0.619
MOD_GSK3_1	220	227	PF00069	0.611
MOD_GSK3_1	230	237	PF00069	0.732
MOD_GSK3_1	260	267	PF00069	0.808
MOD_GSK3_1	303	310	PF00069	0.654
MOD_GSK3_1	324	331	PF00069	0.724
MOD_GSK3_1	33	40	PF00069	0.745
MOD_GSK3_1	334	341	PF00069	0.675
MOD_GSK3_1	416	423	PF00069	0.747
MOD_GSK3_1	429	436	PF00069	0.719
MOD_GSK3_1	45	52	PF00069	0.647
MOD_GSK3_1	5	12	PF00069	0.634
MOD_GSK3_1	595	602	PF00069	0.626
MOD_GSK3_1	604	611	PF00069	0.541
MOD_GSK3_1	621	628	PF00069	0.589
MOD_GSK3_1	64	71	PF00069	0.664
MOD_GSK3_1	726	733	PF00069	0.633
MOD_N-GLC_1	142	147	PF02516	0.576
MOD_N-GLC_1	49	54	PF02516	0.660
MOD_NEK2_1	2	7	PF00069	0.629
MOD_NEK2_1	266	271	PF00069	0.657
MOD_NEK2_1	322	327	PF00069	0.653
MOD_NEK2_1	37	42	PF00069	0.598
MOD_NEK2_1	621	626	PF00069	0.631
MOD_NEK2_1	755	760	PF00069	0.602
MOD_NEK2_1	9	14	PF00069	0.592
MOD_NEK2_2	493	498	PF00069	0.666
MOD_PIKK_1	322	328	PF00454	0.656
MOD_PIKK_1	376	382	PF00454	0.615
MOD_PIKK_1	662	668	PF00454	0.616
MOD_PIKK_1	9	15	PF00454	0.648
MOD_PKA_2	123	129	PF00069	0.731
MOD_PKA_2	141	147	PF00069	0.576
MOD_PKA_2	726	732	PF00069	0.543
MOD_PKA_2	744	750	PF00069	0.491
MOD_PKA_2	782	788	PF00069	0.525
MOD_PKA_2	9	15	PF00069	0.648
MOD_Plk_1	49	55	PF00069	0.635
MOD_Plk_1	68	74	PF00069	0.668
MOD_Plk_4	608	614	PF00069	0.601
MOD_Plk_4	68	74	PF00069	0.629
MOD_Plk_4	691	697	PF00069	0.664
MOD_Plk_4	782	788	PF00069	0.564
MOD_ProDKin_1	128	134	PF00069	0.715
MOD_ProDKin_1	179	185	PF00069	0.645
MOD_ProDKin_1	244	250	PF00069	0.581
MOD_ProDKin_1	284	290	PF00069	0.668
MOD_ProDKin_1	293	299	PF00069	0.592
MOD_ProDKin_1	303	309	PF00069	0.509
MOD_ProDKin_1	335	341	PF00069	0.763
MOD_ProDKin_1	42	48	PF00069	0.584
MOD_ProDKin_1	600	606	PF00069	0.608
MOD_ProDKin_1	64	70	PF00069	0.664
MOD_ProDKin_1	656	662	PF00069	0.594
MOD_ProDKin_1	721	727	PF00069	0.603
MOD_SUMO_rev_2	418	423	PF00179	0.555
MOD_SUMO_rev_2	578	588	PF00179	0.601
TRG_DiLeu_BaEn_4	461	467	PF01217	0.556
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.533
TRG_ENDOCYTIC_2	155	158	PF00928	0.656
TRG_ENDOCYTIC_2	292	295	PF00928	0.601
TRG_ENDOCYTIC_2	533	536	PF00928	0.535
TRG_ENDOCYTIC_2	541	544	PF00928	0.536
TRG_ENDOCYTIC_2	61	64	PF00928	0.831
TRG_ENDOCYTIC_2	807	810	PF00928	0.499
TRG_ER_diArg_1	277	279	PF00400	0.521
TRG_ER_diArg_1	375	377	PF00400	0.593
TRG_ER_diArg_1	478	481	PF00400	0.678
TRG_NLS_MonoCore_2	473	478	PF00514	0.663
TRG_NLS_MonoCore_2	482	487	PF00514	0.615
TRG_NLS_MonoExtC_3	473	478	PF00514	0.672
TRG_NLS_MonoExtN_4	474	481	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	375	380	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IID6	Leishmania donovani	74%	95%
A4H7P7	Leishmania braziliensis	56%	99%
A4HW36	Leishmania infantum	75%	93%
Q4QFP1	Leishmania major	73%	100%