Putative immunodominant antigen (Tc40 antigen-like)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tc40 antigen-like

Species:

Leishmania mexicana

UniProt:

E9APT8_LEIMU

TriTrypDb:

LmxM.14.0930

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	597	601	PF00656	0.587
CLV_C14_Caspase3-7	843	847	PF00656	0.422
CLV_NRD_NRD_1	495	497	PF00675	0.611
CLV_NRD_NRD_1	50	52	PF00675	0.460
CLV_NRD_NRD_1	621	623	PF00675	0.645
CLV_NRD_NRD_1	668	670	PF00675	0.573
CLV_NRD_NRD_1	848	850	PF00675	0.577
CLV_PCSK_KEX2_1	495	497	PF00082	0.611
CLV_PCSK_KEX2_1	50	52	PF00082	0.437
CLV_PCSK_KEX2_1	620	622	PF00082	0.639
CLV_PCSK_KEX2_1	848	850	PF00082	0.585
CLV_PCSK_SKI1_1	16	20	PF00082	0.533
CLV_PCSK_SKI1_1	290	294	PF00082	0.493
CLV_PCSK_SKI1_1	350	354	PF00082	0.479
CLV_PCSK_SKI1_1	385	389	PF00082	0.655
CLV_PCSK_SKI1_1	467	471	PF00082	0.604
CLV_PCSK_SKI1_1	506	510	PF00082	0.564
CLV_PCSK_SKI1_1	616	620	PF00082	0.553
CLV_PCSK_SKI1_1	63	67	PF00082	0.517
CLV_PCSK_SKI1_1	731	735	PF00082	0.561
CLV_PCSK_SKI1_1	782	786	PF00082	0.443
CLV_PCSK_SKI1_1	820	824	PF00082	0.663
CLV_PCSK_SKI1_1	848	852	PF00082	0.550
CLV_Separin_Metazoa	617	621	PF03568	0.629
DEG_APCC_DBOX_1	690	698	PF00400	0.550
DEG_APCC_DBOX_1	847	855	PF00400	0.532
DEG_SPOP_SBC_1	260	264	PF00917	0.657
DEG_SPOP_SBC_1	431	435	PF00917	0.584
DOC_CKS1_1	513	518	PF01111	0.536
DOC_CKS1_1	628	633	PF01111	0.604
DOC_MAPK_gen_1	48	55	PF00069	0.437
DOC_PP1_RVXF_1	75	82	PF00149	0.518
DOC_PP2B_LxvP_1	575	578	PF13499	0.610
DOC_PP4_FxxP_1	141	144	PF00568	0.532
DOC_PP4_FxxP_1	403	406	PF00568	0.673
DOC_USP7_MATH_1	2	6	PF00917	0.642
DOC_USP7_MATH_1	209	213	PF00917	0.467
DOC_USP7_MATH_1	260	264	PF00917	0.611
DOC_USP7_MATH_1	268	272	PF00917	0.402
DOC_USP7_MATH_1	374	378	PF00917	0.728
DOC_USP7_MATH_1	417	421	PF00917	0.703
DOC_USP7_MATH_1	429	433	PF00917	0.633
DOC_USP7_MATH_1	436	440	PF00917	0.703
DOC_USP7_MATH_1	462	466	PF00917	0.605
DOC_USP7_MATH_1	558	562	PF00917	0.729
DOC_USP7_MATH_1	566	570	PF00917	0.617
DOC_USP7_MATH_1	578	582	PF00917	0.361
DOC_USP7_MATH_1	606	610	PF00917	0.579
DOC_USP7_MATH_1	659	663	PF00917	0.539
DOC_USP7_MATH_1	700	704	PF00917	0.647
DOC_USP7_MATH_1	87	91	PF00917	0.404
DOC_USP7_UBL2_3	124	128	PF12436	0.440
DOC_USP7_UBL2_3	16	20	PF12436	0.586
DOC_USP7_UBL2_3	819	823	PF12436	0.564
DOC_USP7_UBL2_3	852	856	PF12436	0.461
DOC_WW_Pin1_4	224	229	PF00397	0.481
DOC_WW_Pin1_4	375	380	PF00397	0.709
DOC_WW_Pin1_4	398	403	PF00397	0.653
DOC_WW_Pin1_4	432	437	PF00397	0.773
DOC_WW_Pin1_4	438	443	PF00397	0.791
DOC_WW_Pin1_4	512	517	PF00397	0.571
DOC_WW_Pin1_4	627	632	PF00397	0.608
DOC_WW_Pin1_4	68	73	PF00397	0.528
DOC_WW_Pin1_4	716	721	PF00397	0.607
LIG_14-3-3_CanoR_1	120	124	PF00244	0.447
LIG_14-3-3_CanoR_1	197	207	PF00244	0.517
LIG_14-3-3_CanoR_1	223	228	PF00244	0.530
LIG_14-3-3_CanoR_1	290	295	PF00244	0.503
LIG_14-3-3_CanoR_1	339	344	PF00244	0.495
LIG_14-3-3_CanoR_1	350	355	PF00244	0.500
LIG_14-3-3_CanoR_1	397	402	PF00244	0.715
LIG_14-3-3_CanoR_1	562	570	PF00244	0.645
LIG_14-3-3_CanoR_1	656	662	PF00244	0.623
LIG_14-3-3_CanoR_1	669	679	PF00244	0.591
LIG_14-3-3_CanoR_1	737	745	PF00244	0.574
LIG_14-3-3_CanoR_1	760	766	PF00244	0.588
LIG_Actin_WH2_2	480	497	PF00022	0.678
LIG_Actin_WH2_2	683	700	PF00022	0.548
LIG_APCC_ABBA_1	23	28	PF00400	0.497
LIG_APCC_ABBA_1	307	312	PF00400	0.410
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	347	351	PF00533	0.593
LIG_BRCT_BRCA1_1	38	42	PF00533	0.455
LIG_BRCT_BRCA1_1	399	403	PF00533	0.571
LIG_BRCT_BRCA1_1	563	567	PF00533	0.596
LIG_BRCT_BRCA1_1	803	807	PF00533	0.463
LIG_BRCT_BRCA1_1	90	94	PF00533	0.443
LIG_eIF4E_1	570	576	PF01652	0.620
LIG_FHA_1	156	162	PF00498	0.462
LIG_FHA_1	171	177	PF00498	0.402
LIG_FHA_1	351	357	PF00498	0.524
LIG_FHA_1	386	392	PF00498	0.618
LIG_FHA_1	399	405	PF00498	0.615
LIG_FHA_1	507	513	PF00498	0.533
LIG_FHA_1	586	592	PF00498	0.601
LIG_FHA_1	674	680	PF00498	0.638
LIG_FHA_1	7	13	PF00498	0.385
LIG_FHA_2	328	334	PF00498	0.448
LIG_FHA_2	595	601	PF00498	0.624
LIG_FHA_2	631	637	PF00498	0.544
LIG_FHA_2	722	728	PF00498	0.579
LIG_FHA_2	793	799	PF00498	0.548
LIG_GBD_Chelix_1	802	810	PF00786	0.452
LIG_Integrin_RGD_1	322	324	PF01839	0.502
LIG_LIR_Apic_2	400	406	PF02991	0.679
LIG_LIR_Gen_1	137	145	PF02991	0.467
LIG_LIR_Gen_1	204	214	PF02991	0.458
LIG_LIR_Gen_1	348	359	PF02991	0.508
LIG_LIR_Gen_1	743	751	PF02991	0.489
LIG_LIR_Gen_1	75	86	PF02991	0.539
LIG_LIR_Gen_1	777	787	PF02991	0.528
LIG_LIR_Gen_1	804	814	PF02991	0.476
LIG_LIR_Gen_1	92	101	PF02991	0.414
LIG_LIR_Nem_3	137	141	PF02991	0.483
LIG_LIR_Nem_3	204	210	PF02991	0.466
LIG_LIR_Nem_3	291	297	PF02991	0.507
LIG_LIR_Nem_3	348	354	PF02991	0.580
LIG_LIR_Nem_3	39	45	PF02991	0.426
LIG_LIR_Nem_3	564	570	PF02991	0.549
LIG_LIR_Nem_3	75	81	PF02991	0.450
LIG_LIR_Nem_3	777	783	PF02991	0.535
LIG_LIR_Nem_3	804	810	PF02991	0.460
LIG_LIR_Nem_3	92	98	PF02991	0.406
LIG_LYPXL_SIV_4	462	470	PF13949	0.670
LIG_NRBOX	571	577	PF00104	0.616
LIG_Pex14_1	641	645	PF04695	0.552
LIG_Pex14_1	97	101	PF04695	0.583
LIG_Pex14_2	203	207	PF04695	0.536
LIG_SH2_NCK_1	422	426	PF00017	0.646
LIG_SH2_PTP2	95	98	PF00017	0.418
LIG_SH2_STAP1	171	175	PF00017	0.541
LIG_SH2_STAT5	126	129	PF00017	0.367
LIG_SH2_STAT5	45	48	PF00017	0.423
LIG_SH2_STAT5	645	648	PF00017	0.583
LIG_SH2_STAT5	732	735	PF00017	0.465
LIG_SH2_STAT5	744	747	PF00017	0.425
LIG_SH2_STAT5	95	98	PF00017	0.553
LIG_SH3_3	280	286	PF00018	0.591
LIG_SH3_3	388	394	PF00018	0.604
LIG_SH3_3	411	417	PF00018	0.730
LIG_SH3_3	548	554	PF00018	0.710
LIG_SH3_4	124	131	PF00018	0.503
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.343
LIG_SUMO_SIM_anti_2	509	515	PF11976	0.462
LIG_SUMO_SIM_par_1	261	271	PF11976	0.538
LIG_SUMO_SIM_par_1	352	357	PF11976	0.491
LIG_SUMO_SIM_par_1	509	515	PF11976	0.525
LIG_SxIP_EBH_1	406	416	PF03271	0.724
LIG_TRAF2_1	626	629	PF00917	0.562
LIG_TRAF2_1	663	666	PF00917	0.591
LIG_TRAF2_1	683	686	PF00917	0.542
LIG_UBA3_1	151	157	PF00899	0.498
LIG_UBA3_1	266	274	PF00899	0.325
LIG_WRC_WIRS_1	135	140	PF05994	0.480
LIG_WRC_WIRS_1	289	294	PF05994	0.466
LIG_WRC_WIRS_1	802	807	PF05994	0.460
MOD_CDK_SPK_2	627	632	PF00069	0.608
MOD_CDK_SPxxK_3	438	445	PF00069	0.606
MOD_CK1_1	169	175	PF00069	0.573
MOD_CK1_1	181	187	PF00069	0.470
MOD_CK1_1	195	201	PF00069	0.374
MOD_CK1_1	212	218	PF00069	0.455
MOD_CK1_1	270	276	PF00069	0.535
MOD_CK1_1	375	381	PF00069	0.756
MOD_CK1_1	398	404	PF00069	0.755
MOD_CK1_1	407	413	PF00069	0.504
MOD_CK1_1	430	436	PF00069	0.720
MOD_CK1_1	449	455	PF00069	0.712
MOD_CK1_1	465	471	PF00069	0.508
MOD_CK1_1	5	11	PF00069	0.515
MOD_CK1_1	561	567	PF00069	0.601
MOD_CK1_1	721	727	PF00069	0.542
MOD_CK1_1	88	94	PF00069	0.434
MOD_CK2_1	171	177	PF00069	0.600
MOD_CK2_1	228	234	PF00069	0.450
MOD_CK2_1	630	636	PF00069	0.630
MOD_CK2_1	659	665	PF00069	0.535
MOD_CK2_1	721	727	PF00069	0.586
MOD_CK2_1	768	774	PF00069	0.540
MOD_CK2_1	792	798	PF00069	0.527
MOD_GlcNHglycan	180	183	PF01048	0.656
MOD_GlcNHglycan	203	206	PF01048	0.463
MOD_GlcNHglycan	230	233	PF01048	0.549
MOD_GlcNHglycan	263	266	PF01048	0.564
MOD_GlcNHglycan	374	377	PF01048	0.678
MOD_GlcNHglycan	380	383	PF01048	0.716
MOD_GlcNHglycan	429	432	PF01048	0.726
MOD_GlcNHglycan	438	441	PF01048	0.700
MOD_GlcNHglycan	442	445	PF01048	0.577
MOD_GlcNHglycan	448	451	PF01048	0.716
MOD_GlcNHglycan	460	463	PF01048	0.678
MOD_GlcNHglycan	464	467	PF01048	0.741
MOD_GlcNHglycan	484	487	PF01048	0.580
MOD_GlcNHglycan	542	545	PF01048	0.690
MOD_GlcNHglycan	661	664	PF01048	0.593
MOD_GlcNHglycan	680	683	PF01048	0.500
MOD_GlcNHglycan	702	705	PF01048	0.622
MOD_GlcNHglycan	87	90	PF01048	0.445
MOD_GSK3_1	14	21	PF00069	0.605
MOD_GSK3_1	162	169	PF00069	0.419
MOD_GSK3_1	191	198	PF00069	0.564
MOD_GSK3_1	199	206	PF00069	0.470
MOD_GSK3_1	2	9	PF00069	0.586
MOD_GSK3_1	208	215	PF00069	0.337
MOD_GSK3_1	218	225	PF00069	0.403
MOD_GSK3_1	239	246	PF00069	0.535
MOD_GSK3_1	296	303	PF00069	0.386
MOD_GSK3_1	346	353	PF00069	0.559
MOD_GSK3_1	368	375	PF00069	0.615
MOD_GSK3_1	404	411	PF00069	0.690
MOD_GSK3_1	427	434	PF00069	0.647
MOD_GSK3_1	436	443	PF00069	0.646
MOD_GSK3_1	458	465	PF00069	0.700
MOD_GSK3_1	471	478	PF00069	0.661
MOD_GSK3_1	538	545	PF00069	0.557
MOD_GSK3_1	578	585	PF00069	0.672
MOD_GSK3_1	721	728	PF00069	0.508
MOD_GSK3_1	736	743	PF00069	0.489
MOD_GSK3_1	768	775	PF00069	0.549
MOD_GSK3_1	85	92	PF00069	0.478
MOD_N-GLC_1	223	228	PF02516	0.530
MOD_N-GLC_1	369	374	PF02516	0.584
MOD_N-GLC_1	398	403	PF02516	0.728
MOD_N-GLC_1	471	476	PF02516	0.623
MOD_N-GLC_1	5	10	PF02516	0.509
MOD_N-GLC_1	506	511	PF02516	0.569
MOD_N-GLC_1	607	612	PF02516	0.508
MOD_N-GLC_1	657	662	PF02516	0.538
MOD_N-GLC_1	709	714	PF02516	0.512
MOD_NEK2_1	162	167	PF00069	0.426
MOD_NEK2_1	199	204	PF00069	0.489
MOD_NEK2_1	218	223	PF00069	0.579
MOD_NEK2_1	243	248	PF00069	0.546
MOD_NEK2_1	267	272	PF00069	0.512
MOD_NEK2_1	288	293	PF00069	0.411
MOD_NEK2_1	300	305	PF00069	0.513
MOD_NEK2_1	327	332	PF00069	0.493
MOD_NEK2_1	482	487	PF00069	0.674
MOD_NEK2_1	538	543	PF00069	0.632
MOD_NEK2_1	607	612	PF00069	0.604
MOD_NEK2_1	650	655	PF00069	0.582
MOD_NEK2_1	657	662	PF00069	0.597
MOD_NEK2_1	854	859	PF00069	0.623
MOD_NEK2_2	119	124	PF00069	0.536
MOD_PIKK_1	506	512	PF00454	0.570
MOD_PIKK_1	673	679	PF00454	0.674
MOD_PIKK_1	736	742	PF00454	0.583
MOD_PIKK_1	782	788	PF00454	0.576
MOD_PK_1	339	345	PF00069	0.547
MOD_PKA_2	119	125	PF00069	0.447
MOD_PKA_2	222	228	PF00069	0.581
MOD_PKA_2	338	344	PF00069	0.511
MOD_PKA_2	561	567	PF00069	0.653
MOD_PKA_2	591	597	PF00069	0.612
MOD_PKA_2	736	742	PF00069	0.482
MOD_PKA_2	759	765	PF00069	0.590
MOD_Plk_1	192	198	PF00069	0.597
MOD_Plk_1	327	333	PF00069	0.571
MOD_Plk_1	346	352	PF00069	0.597
MOD_Plk_1	471	477	PF00069	0.603
MOD_Plk_1	506	512	PF00069	0.551
MOD_Plk_1	607	613	PF00069	0.509
MOD_Plk_1	657	663	PF00069	0.561
MOD_Plk_1	776	782	PF00069	0.546
MOD_Plk_2-3	759	765	PF00069	0.649
MOD_Plk_2-3	808	814	PF00069	0.440
MOD_Plk_4	14	20	PF00069	0.625
MOD_Plk_4	171	177	PF00069	0.573
MOD_Plk_4	203	209	PF00069	0.560
MOD_Plk_4	239	245	PF00069	0.511
MOD_Plk_4	296	302	PF00069	0.416
MOD_Plk_4	327	333	PF00069	0.519
MOD_Plk_4	350	356	PF00069	0.476
MOD_Plk_4	404	410	PF00069	0.709
MOD_Plk_4	721	727	PF00069	0.506
MOD_Plk_4	740	746	PF00069	0.520
MOD_Plk_4	776	782	PF00069	0.542
MOD_Plk_4	801	807	PF00069	0.469
MOD_ProDKin_1	224	230	PF00069	0.473
MOD_ProDKin_1	375	381	PF00069	0.709
MOD_ProDKin_1	398	404	PF00069	0.653
MOD_ProDKin_1	432	438	PF00069	0.774
MOD_ProDKin_1	512	518	PF00069	0.572
MOD_ProDKin_1	627	633	PF00069	0.604
MOD_ProDKin_1	68	74	PF00069	0.525
MOD_ProDKin_1	716	722	PF00069	0.598
MOD_SUMO_for_1	26	29	PF00179	0.574
MOD_SUMO_rev_2	172	181	PF00179	0.509
MOD_SUMO_rev_2	312	317	PF00179	0.389
TRG_DiLeu_BaEn_1	163	168	PF01217	0.465
TRG_DiLeu_BaEn_2	37	43	PF01217	0.503
TRG_DiLeu_BaEn_4	666	672	PF01217	0.495
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.501
TRG_ENDOCYTIC_2	126	129	PF00928	0.367
TRG_ENDOCYTIC_2	744	747	PF00928	0.479
TRG_ENDOCYTIC_2	95	98	PF00928	0.418
TRG_ER_diArg_1	494	496	PF00400	0.639
TRG_ER_diArg_1	619	622	PF00400	0.641
TRG_ER_diArg_1	848	850	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	849	853	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P333	Leptomonas seymouri	70%	99%
A0A0S4JBI5	Bodo saltans	28%	100%
A0A3R7NEG9	Trypanosoma rangeli	32%	94%
A0A3S5H6S3	Leishmania donovani	94%	100%
A4H7P6	Leishmania braziliensis	84%	98%
A4HW35	Leishmania infantum	94%	100%
C9ZSY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
Q4QFP2	Leishmania major	93%	100%