Protein phosphatase 2C-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania mexicana

UniProt:

E9APT5_LEIMU

TriTrypDb:

LmxM.14.0900

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APT5

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	473	477	PF00656	0.827
CLV_C14_Caspase3-7	495	499	PF00656	0.733
CLV_C14_Caspase3-7	763	767	PF00656	0.213
CLV_NRD_NRD_1	100	102	PF00675	0.749
CLV_NRD_NRD_1	194	196	PF00675	0.676
CLV_NRD_NRD_1	2	4	PF00675	0.621
CLV_NRD_NRD_1	216	218	PF00675	0.754
CLV_NRD_NRD_1	411	413	PF00675	0.778
CLV_NRD_NRD_1	438	440	PF00675	0.573
CLV_NRD_NRD_1	5	7	PF00675	0.620
CLV_NRD_NRD_1	600	602	PF00675	0.457
CLV_NRD_NRD_1	663	665	PF00675	0.404
CLV_NRD_NRD_1	728	730	PF00675	0.336
CLV_NRD_NRD_1	949	951	PF00675	0.699
CLV_PCSK_FUR_1	661	665	PF00082	0.315
CLV_PCSK_FUR_1	98	102	PF00082	0.612
CLV_PCSK_KEX2_1	100	102	PF00082	0.749
CLV_PCSK_KEX2_1	112	114	PF00082	0.565
CLV_PCSK_KEX2_1	194	196	PF00082	0.640
CLV_PCSK_KEX2_1	216	218	PF00082	0.776
CLV_PCSK_KEX2_1	411	413	PF00082	0.778
CLV_PCSK_KEX2_1	452	454	PF00082	0.586
CLV_PCSK_KEX2_1	600	602	PF00082	0.457
CLV_PCSK_KEX2_1	661	663	PF00082	0.336
CLV_PCSK_KEX2_1	728	730	PF00082	0.336
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.614
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.536
CLV_PCSK_SKI1_1	245	249	PF00082	0.740
CLV_PCSK_SKI1_1	309	313	PF00082	0.671
CLV_PCSK_SKI1_1	412	416	PF00082	0.670
CLV_PCSK_SKI1_1	548	552	PF00082	0.549
CLV_PCSK_SKI1_1	637	641	PF00082	0.336
CLV_PCSK_SKI1_1	703	707	PF00082	0.336
CLV_PCSK_SKI1_1	729	733	PF00082	0.336
CLV_PCSK_SKI1_1	849	853	PF00082	0.336
CLV_PCSK_SKI1_1	962	966	PF00082	0.594
DEG_Nend_Nbox_1	1	3	PF02207	0.753
DEG_SPOP_SBC_1	316	320	PF00917	0.770
DEG_SPOP_SBC_1	69	73	PF00917	0.531
DOC_MAPK_DCC_7	505	513	PF00069	0.711
DOC_MAPK_gen_1	529	537	PF00069	0.482
DOC_MAPK_gen_1	728	739	PF00069	0.336
DOC_MAPK_MEF2A_6	505	513	PF00069	0.711
DOC_PP2B_LxvP_1	312	315	PF13499	0.663
DOC_PP4_FxxP_1	66	69	PF00568	0.678
DOC_USP7_MATH_1	13	17	PF00917	0.602
DOC_USP7_MATH_1	171	175	PF00917	0.647
DOC_USP7_MATH_1	232	236	PF00917	0.734
DOC_USP7_MATH_1	271	275	PF00917	0.681
DOC_USP7_MATH_1	285	289	PF00917	0.544
DOC_USP7_MATH_1	316	320	PF00917	0.773
DOC_USP7_MATH_1	370	374	PF00917	0.692
DOC_USP7_MATH_1	381	385	PF00917	0.584
DOC_USP7_MATH_1	494	498	PF00917	0.707
DOC_USP7_MATH_1	793	797	PF00917	0.435
DOC_USP7_MATH_1	949	953	PF00917	0.625
DOC_WW_Pin1_4	137	142	PF00397	0.643
DOC_WW_Pin1_4	219	224	PF00397	0.555
DOC_WW_Pin1_4	23	28	PF00397	0.573
DOC_WW_Pin1_4	265	270	PF00397	0.740
DOC_WW_Pin1_4	324	329	PF00397	0.651
DOC_WW_Pin1_4	357	362	PF00397	0.663
DOC_WW_Pin1_4	366	371	PF00397	0.650
DOC_WW_Pin1_4	38	43	PF00397	0.671
DOC_WW_Pin1_4	451	456	PF00397	0.717
DOC_WW_Pin1_4	65	70	PF00397	0.799
DOC_WW_Pin1_4	761	766	PF00397	0.387
DOC_WW_Pin1_4	791	796	PF00397	0.417
DOC_WW_Pin1_4	852	857	PF00397	0.336
DOC_WW_Pin1_4	920	925	PF00397	0.508
LIG_14-3-3_CanoR_1	163	169	PF00244	0.640
LIG_14-3-3_CanoR_1	208	212	PF00244	0.677
LIG_14-3-3_CanoR_1	216	224	PF00244	0.605
LIG_14-3-3_CanoR_1	233	238	PF00244	0.636
LIG_14-3-3_CanoR_1	272	276	PF00244	0.518
LIG_14-3-3_CanoR_1	290	294	PF00244	0.484
LIG_14-3-3_CanoR_1	936	942	PF00244	0.572
LIG_14-3-3_CanoR_1	950	954	PF00244	0.693
LIG_Actin_WH2_2	240	257	PF00022	0.740
LIG_BIR_III_2	503	507	PF00653	0.537
LIG_BIR_III_4	766	770	PF00653	0.304
LIG_BRCT_BRCA1_1	773	777	PF00533	0.457
LIG_FHA_1	138	144	PF00498	0.692
LIG_FHA_1	160	166	PF00498	0.630
LIG_FHA_1	208	214	PF00498	0.735
LIG_FHA_1	361	367	PF00498	0.703
LIG_FHA_1	403	409	PF00498	0.770
LIG_FHA_1	482	488	PF00498	0.613
LIG_FHA_1	549	555	PF00498	0.467
LIG_FHA_1	843	849	PF00498	0.336
LIG_FHA_1	853	859	PF00498	0.336
LIG_FHA_2	238	244	PF00498	0.747
LIG_FHA_2	301	307	PF00498	0.530
LIG_FHA_2	567	573	PF00498	0.336
LIG_FHA_2	633	639	PF00498	0.336
LIG_Integrin_isoDGR_2	214	216	PF01839	0.600
LIG_Integrin_isoDGR_2	402	404	PF01839	0.709
LIG_Integrin_isoDGR_2	968	970	PF01839	0.615
LIG_LIR_Apic_2	65	69	PF02991	0.615
LIG_LIR_Gen_1	572	583	PF02991	0.336
LIG_LIR_Gen_1	825	835	PF02991	0.336
LIG_LIR_LC3C_4	162	166	PF02991	0.631
LIG_LIR_Nem_3	572	578	PF02991	0.336
LIG_LIR_Nem_3	638	643	PF02991	0.336
LIG_LIR_Nem_3	776	782	PF02991	0.213
LIG_LIR_Nem_3	825	830	PF02991	0.336
LIG_LIR_Nem_3	833	839	PF02991	0.336
LIG_LIR_Nem_3	850	854	PF02991	0.336
LIG_MYND_1	141	145	PF01753	0.747
LIG_MYND_1	249	253	PF01753	0.629
LIG_Pex14_1	609	613	PF04695	0.336
LIG_Pex14_2	755	759	PF04695	0.336
LIG_Pex14_2	847	851	PF04695	0.336
LIG_SH2_GRB2like	157	160	PF00017	0.640
LIG_SH2_GRB2like	444	447	PF00017	0.574
LIG_SH2_SRC	444	447	PF00017	0.516
LIG_SH2_SRC	59	62	PF00017	0.571
LIG_SH2_STAP1	209	213	PF00017	0.672
LIG_SH2_STAP1	54	58	PF00017	0.569
LIG_SH2_STAT5	157	160	PF00017	0.678
LIG_SH2_STAT5	190	193	PF00017	0.758
LIG_SH2_STAT5	209	212	PF00017	0.685
LIG_SH2_STAT5	613	616	PF00017	0.336
LIG_SH2_STAT5	695	698	PF00017	0.336
LIG_SH2_STAT5	854	857	PF00017	0.336
LIG_SH3_3	139	145	PF00018	0.683
LIG_SH3_3	163	169	PF00018	0.640
LIG_SH3_3	503	509	PF00018	0.771
LIG_SH3_3	510	516	PF00018	0.742
LIG_SH3_3	55	61	PF00018	0.582
LIG_SH3_3	855	861	PF00018	0.336
LIG_SH3_3	918	924	PF00018	0.482
LIG_SUMO_SIM_anti_2	589	595	PF11976	0.457
LIG_SUMO_SIM_anti_2	898	904	PF11976	0.354
LIG_SUMO_SIM_par_1	589	595	PF11976	0.457
LIG_SUMO_SIM_par_1	744	749	PF11976	0.336
LIG_SxIP_EBH_1	315	329	PF03271	0.770
LIG_TRAF2_1	768	771	PF00917	0.396
LIG_TRAF2_1	840	843	PF00917	0.336
LIG_UBA3_1	639	646	PF00899	0.336
MOD_CDC14_SPxK_1	26	29	PF00782	0.578
MOD_CDK_SPK_2	324	329	PF00069	0.762
MOD_CDK_SPxK_1	23	29	PF00069	0.577
MOD_CDK_SPxxK_3	265	272	PF00069	0.759
MOD_CDK_SPxxK_3	357	364	PF00069	0.614
MOD_CK1_1	134	140	PF00069	0.810
MOD_CK1_1	188	194	PF00069	0.607
MOD_CK1_1	219	225	PF00069	0.530
MOD_CK1_1	288	294	PF00069	0.621
MOD_CK1_1	324	330	PF00069	0.662
MOD_CK1_1	360	366	PF00069	0.670
MOD_CK1_1	369	375	PF00069	0.644
MOD_CK1_1	384	390	PF00069	0.533
MOD_CK1_1	489	495	PF00069	0.740
MOD_CK1_1	546	552	PF00069	0.566
MOD_CK1_1	62	68	PF00069	0.631
MOD_CK1_1	70	76	PF00069	0.729
MOD_CK1_1	787	793	PF00069	0.304
MOD_CK1_1	794	800	PF00069	0.346
MOD_CK1_1	932	938	PF00069	0.672
MOD_CK1_1	944	950	PF00069	0.609
MOD_CK1_1	952	958	PF00069	0.694
MOD_CK2_1	300	306	PF00069	0.531
MOD_CK2_1	38	44	PF00069	0.521
MOD_CK2_1	384	390	PF00069	0.641
MOD_CK2_1	489	495	PF00069	0.759
MOD_CK2_1	632	638	PF00069	0.336
MOD_CK2_1	837	843	PF00069	0.336
MOD_CK2_1	952	958	PF00069	0.578
MOD_Cter_Amidation	214	217	PF01082	0.677
MOD_Cter_Amidation	4	7	PF01082	0.683
MOD_Cter_Amidation	598	601	PF01082	0.457
MOD_Cter_Amidation	659	662	PF01082	0.336
MOD_DYRK1A_RPxSP_1	920	924	PF00069	0.507
MOD_GlcNHglycan	15	18	PF01048	0.598
MOD_GlcNHglycan	191	194	PF01048	0.534
MOD_GlcNHglycan	224	227	PF01048	0.659
MOD_GlcNHglycan	312	315	PF01048	0.670
MOD_GlcNHglycan	372	375	PF01048	0.673
MOD_GlcNHglycan	381	384	PF01048	0.576
MOD_GlcNHglycan	386	389	PF01048	0.542
MOD_GlcNHglycan	445	449	PF01048	0.659
MOD_GlcNHglycan	491	494	PF01048	0.783
MOD_GlcNHglycan	524	528	PF01048	0.717
MOD_GlcNHglycan	545	548	PF01048	0.570
MOD_GlcNHglycan	559	562	PF01048	0.336
MOD_GlcNHglycan	658	661	PF01048	0.338
MOD_GlcNHglycan	675	678	PF01048	0.276
MOD_GlcNHglycan	72	75	PF01048	0.718
MOD_GlcNHglycan	786	790	PF01048	0.342
MOD_GlcNHglycan	80	83	PF01048	0.572
MOD_GlcNHglycan	823	827	PF01048	0.336
MOD_GlcNHglycan	864	867	PF01048	0.336
MOD_GlcNHglycan	92	95	PF01048	0.499
MOD_GlcNHglycan	943	946	PF01048	0.783
MOD_GSK3_1	108	115	PF00069	0.543
MOD_GSK3_1	117	124	PF00069	0.679
MOD_GSK3_1	185	192	PF00069	0.572
MOD_GSK3_1	21	28	PF00069	0.602
MOD_GSK3_1	218	225	PF00069	0.665
MOD_GSK3_1	233	240	PF00069	0.569
MOD_GSK3_1	261	268	PF00069	0.595
MOD_GSK3_1	285	292	PF00069	0.720
MOD_GSK3_1	317	324	PF00069	0.756
MOD_GSK3_1	343	350	PF00069	0.831
MOD_GSK3_1	366	373	PF00069	0.698
MOD_GSK3_1	38	45	PF00069	0.717
MOD_GSK3_1	384	391	PF00069	0.516
MOD_GSK3_1	494	501	PF00069	0.725
MOD_GSK3_1	511	518	PF00069	0.803
MOD_GSK3_1	542	549	PF00069	0.560
MOD_GSK3_1	628	635	PF00069	0.336
MOD_GSK3_1	65	72	PF00069	0.641
MOD_GSK3_1	675	682	PF00069	0.457
MOD_GSK3_1	709	716	PF00069	0.336
MOD_GSK3_1	787	794	PF00069	0.405
MOD_GSK3_1	862	869	PF00069	0.457
MOD_GSK3_1	90	97	PF00069	0.574
MOD_GSK3_1	937	944	PF00069	0.642
MOD_N-GLC_1	108	113	PF02516	0.600
MOD_N-GLC_1	294	299	PF02516	0.779
MOD_N-GLC_1	578	583	PF02516	0.315
MOD_N-GLC_1	62	67	PF02516	0.643
MOD_N-GLC_1	656	661	PF02516	0.396
MOD_N-GLC_1	784	789	PF02516	0.309
MOD_N-GLC_1	898	903	PF02516	0.355
MOD_N-GLC_1	932	937	PF02516	0.516
MOD_N-GLC_2	881	883	PF02516	0.336
MOD_NEK2_1	108	113	PF00069	0.620
MOD_NEK2_1	289	294	PF00069	0.513
MOD_NEK2_1	389	394	PF00069	0.524
MOD_NEK2_1	434	439	PF00069	0.638
MOD_NEK2_1	480	485	PF00069	0.627
MOD_NEK2_1	486	491	PF00069	0.644
MOD_NEK2_1	578	583	PF00069	0.315
MOD_NEK2_1	628	633	PF00069	0.336
MOD_NEK2_1	746	751	PF00069	0.336
MOD_NEK2_1	773	778	PF00069	0.231
MOD_NEK2_1	808	813	PF00069	0.336
MOD_NEK2_1	941	946	PF00069	0.782
MOD_NEK2_1	957	962	PF00069	0.471
MOD_NEK2_2	285	290	PF00069	0.692
MOD_NEK2_2	294	299	PF00069	0.619
MOD_NEK2_2	54	59	PF00069	0.571
MOD_PIKK_1	481	487	PF00454	0.690
MOD_PK_1	101	107	PF00069	0.682
MOD_PK_1	404	410	PF00069	0.525
MOD_PKA_1	112	118	PF00069	0.574
MOD_PKA_1	216	222	PF00069	0.744
MOD_PKA_2	112	118	PF00069	0.601
MOD_PKA_2	207	213	PF00069	0.709
MOD_PKA_2	216	222	PF00069	0.676
MOD_PKA_2	232	238	PF00069	0.676
MOD_PKA_2	271	277	PF00069	0.763
MOD_PKA_2	289	295	PF00069	0.496
MOD_PKA_2	343	349	PF00069	0.774
MOD_PKA_2	566	572	PF00069	0.316
MOD_PKA_2	78	84	PF00069	0.653
MOD_PKA_2	893	899	PF00069	0.336
MOD_PKA_2	949	955	PF00069	0.679
MOD_PKB_1	231	239	PF00069	0.634
MOD_PKB_1	521	529	PF00069	0.680
MOD_Plk_1	159	165	PF00069	0.676
MOD_Plk_1	261	267	PF00069	0.536
MOD_Plk_1	54	60	PF00069	0.611
MOD_Plk_1	578	584	PF00069	0.315
MOD_Plk_1	62	68	PF00069	0.579
MOD_Plk_1	822	828	PF00069	0.336
MOD_Plk_1	898	904	PF00069	0.354
MOD_Plk_2-3	893	899	PF00069	0.336
MOD_Plk_4	153	159	PF00069	0.691
MOD_Plk_4	294	300	PF00069	0.776
MOD_Plk_4	317	323	PF00069	0.775
MOD_Plk_4	54	60	PF00069	0.607
MOD_Plk_4	586	592	PF00069	0.336
MOD_Plk_4	62	68	PF00069	0.569
MOD_Plk_4	628	634	PF00069	0.336
MOD_Plk_4	680	686	PF00069	0.336
MOD_Plk_4	898	904	PF00069	0.354
MOD_Plk_4	952	958	PF00069	0.658
MOD_ProDKin_1	137	143	PF00069	0.644
MOD_ProDKin_1	219	225	PF00069	0.558
MOD_ProDKin_1	23	29	PF00069	0.577
MOD_ProDKin_1	265	271	PF00069	0.737
MOD_ProDKin_1	324	330	PF00069	0.650
MOD_ProDKin_1	357	363	PF00069	0.662
MOD_ProDKin_1	366	372	PF00069	0.648
MOD_ProDKin_1	38	44	PF00069	0.670
MOD_ProDKin_1	451	457	PF00069	0.719
MOD_ProDKin_1	65	71	PF00069	0.799
MOD_ProDKin_1	761	767	PF00069	0.387
MOD_ProDKin_1	791	797	PF00069	0.417
MOD_ProDKin_1	852	858	PF00069	0.336
MOD_ProDKin_1	920	926	PF00069	0.511
MOD_SUMO_rev_2	242	247	PF00179	0.738
MOD_SUMO_rev_2	716	721	PF00179	0.336
MOD_SUMO_rev_2	754	759	PF00179	0.336
MOD_SUMO_rev_2	764	774	PF00179	0.336
TRG_DiLeu_BaEn_1	160	165	PF01217	0.630
TRG_DiLeu_BaEn_3	842	848	PF01217	0.336
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.614
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.779
TRG_ER_diArg_1	249	252	PF00400	0.626
TRG_ER_diArg_1	520	523	PF00400	0.633
TRG_ER_diArg_1	600	602	PF00400	0.457
TRG_ER_diArg_1	661	664	PF00400	0.336
TRG_ER_diArg_1	728	730	PF00400	0.336
TRG_ER_diArg_1	98	101	PF00400	0.669
TRG_ER_FFAT_2	186	196	PF00635	0.532
TRG_NLS_MonoExtC_3	2	7	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.738
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	750	754	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L7	Leptomonas seymouri	50%	93%
A0A3Q8ID61	Leishmania donovani	90%	100%
A4H7P3	Leishmania braziliensis	70%	96%
A4HW33	Leishmania infantum	90%	100%
Q4QFP5	Leishmania major	90%	100%