Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APT3_LEIMU

TriTrypDb:

LmxM.14.0880

Length:

1084

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1037	1041	PF00656	0.655
CLV_C14_Caspase3-7	240	244	PF00656	0.465
CLV_C14_Caspase3-7	785	789	PF00656	0.775
CLV_C14_Caspase3-7	815	819	PF00656	0.614
CLV_MEL_PAP_1	348	354	PF00089	0.527
CLV_NRD_NRD_1	171	173	PF00675	0.671
CLV_NRD_NRD_1	182	184	PF00675	0.614
CLV_NRD_NRD_1	401	403	PF00675	0.580
CLV_NRD_NRD_1	435	437	PF00675	0.823
CLV_NRD_NRD_1	48	50	PF00675	0.784
CLV_NRD_NRD_1	580	582	PF00675	0.629
CLV_NRD_NRD_1	63	65	PF00675	0.529
CLV_NRD_NRD_1	756	758	PF00675	0.783
CLV_NRD_NRD_1	978	980	PF00675	0.644
CLV_PCSK_FUR_1	399	403	PF00082	0.382
CLV_PCSK_KEX2_1	171	173	PF00082	0.671
CLV_PCSK_KEX2_1	182	184	PF00082	0.614
CLV_PCSK_KEX2_1	401	403	PF00082	0.580
CLV_PCSK_KEX2_1	47	49	PF00082	0.705
CLV_PCSK_KEX2_1	580	582	PF00082	0.627
CLV_PCSK_KEX2_1	63	65	PF00082	0.625
CLV_PCSK_KEX2_1	741	743	PF00082	0.654
CLV_PCSK_KEX2_1	756	758	PF00082	0.724
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.722
CLV_PCSK_SKI1_1	1054	1058	PF00082	0.629
CLV_PCSK_SKI1_1	436	440	PF00082	0.551
CLV_PCSK_SKI1_1	472	476	PF00082	0.663
CLV_PCSK_SKI1_1	618	622	PF00082	0.611
CLV_PCSK_SKI1_1	64	68	PF00082	0.650
CLV_PCSK_SKI1_1	674	678	PF00082	0.537
CLV_PCSK_SKI1_1	744	748	PF00082	0.665
DEG_APCC_DBOX_1	580	588	PF00400	0.637
DEG_Nend_UBRbox_2	1	3	PF02207	0.699
DEG_SCF_TRCP1_1	537	542	PF00400	0.746
DEG_SPOP_SBC_1	121	125	PF00917	0.729
DEG_SPOP_SBC_1	140	144	PF00917	0.720
DEG_SPOP_SBC_1	185	189	PF00917	0.744
DEG_SPOP_SBC_1	938	942	PF00917	0.768
DOC_CKS1_1	565	570	PF01111	0.769
DOC_CKS1_1	932	937	PF01111	0.657
DOC_MAPK_DCC_7	229	239	PF00069	0.493
DOC_MAPK_gen_1	171	179	PF00069	0.679
DOC_MAPK_gen_1	671	681	PF00069	0.704
DOC_MAPK_gen_1	756	763	PF00069	0.832
DOC_MAPK_MEF2A_6	351	359	PF00069	0.632
DOC_PP2B_LxvP_1	1000	1003	PF13499	0.642
DOC_PP2B_LxvP_1	514	517	PF13499	0.701
DOC_PP2B_LxvP_1	543	546	PF13499	0.834
DOC_PP2B_LxvP_1	897	900	PF13499	0.671
DOC_PP2B_LxvP_1	965	968	PF13499	0.788
DOC_PP4_FxxP_1	352	355	PF00568	0.534
DOC_USP7_MATH_1	140	144	PF00917	0.720
DOC_USP7_MATH_1	184	188	PF00917	0.687
DOC_USP7_MATH_1	191	195	PF00917	0.553
DOC_USP7_MATH_1	267	271	PF00917	0.731
DOC_USP7_MATH_1	40	44	PF00917	0.647
DOC_USP7_MATH_1	408	412	PF00917	0.636
DOC_USP7_MATH_1	488	492	PF00917	0.708
DOC_USP7_MATH_1	551	555	PF00917	0.761
DOC_USP7_MATH_1	683	687	PF00917	0.505
DOC_USP7_MATH_1	723	727	PF00917	0.723
DOC_USP7_MATH_1	786	790	PF00917	0.679
DOC_USP7_MATH_1	847	851	PF00917	0.732
DOC_USP7_MATH_1	855	859	PF00917	0.614
DOC_USP7_MATH_1	865	869	PF00917	0.532
DOC_USP7_MATH_1	936	940	PF00917	0.765
DOC_USP7_MATH_1	957	961	PF00917	0.750
DOC_USP7_MATH_2	794	800	PF00917	0.612
DOC_WW_Pin1_4	111	116	PF00397	0.723
DOC_WW_Pin1_4	187	192	PF00397	0.661
DOC_WW_Pin1_4	308	313	PF00397	0.584
DOC_WW_Pin1_4	418	423	PF00397	0.797
DOC_WW_Pin1_4	512	517	PF00397	0.682
DOC_WW_Pin1_4	545	550	PF00397	0.737
DOC_WW_Pin1_4	564	569	PF00397	0.538
DOC_WW_Pin1_4	721	726	PF00397	0.728
DOC_WW_Pin1_4	835	840	PF00397	0.849
DOC_WW_Pin1_4	931	936	PF00397	0.704
LIG_14-3-3_CanoR_1	1043	1052	PF00244	0.534
LIG_14-3-3_CanoR_1	171	175	PF00244	0.478
LIG_14-3-3_CanoR_1	260	266	PF00244	0.622
LIG_14-3-3_CanoR_1	3	12	PF00244	0.675
LIG_14-3-3_CanoR_1	336	340	PF00244	0.648
LIG_14-3-3_CanoR_1	392	396	PF00244	0.514
LIG_14-3-3_CanoR_1	436	443	PF00244	0.696
LIG_14-3-3_CanoR_1	49	59	PF00244	0.655
LIG_14-3-3_CanoR_1	561	568	PF00244	0.765
LIG_14-3-3_CanoR_1	671	681	PF00244	0.645
LIG_14-3-3_CanoR_1	830	840	PF00244	0.760
LIG_14-3-3_CanoR_1	846	852	PF00244	0.715
LIG_14-3-3_CanoR_1	979	986	PF00244	0.588
LIG_14-3-3_CanoR_1	989	998	PF00244	0.581
LIG_Actin_WH2_2	1052	1069	PF00022	0.574
LIG_Actin_WH2_2	5	20	PF00022	0.514
LIG_Actin_WH2_2	872	890	PF00022	0.622
LIG_BRCT_BRCA1_1	312	316	PF00533	0.579
LIG_BRCT_BRCA1_1	333	337	PF00533	0.634
LIG_deltaCOP1_diTrp_1	360	364	PF00928	0.653
LIG_deltaCOP1_diTrp_1	930	937	PF00928	0.654
LIG_eIF4E_1	1046	1052	PF01652	0.581
LIG_EVH1_1	897	901	PF00568	0.678
LIG_FHA_1	1023	1029	PF00498	0.744
LIG_FHA_1	122	128	PF00498	0.729
LIG_FHA_1	260	266	PF00498	0.505
LIG_FHA_1	392	398	PF00498	0.520
LIG_FHA_1	540	546	PF00498	0.539
LIG_FHA_1	676	682	PF00498	0.634
LIG_FHA_1	875	881	PF00498	0.586
LIG_FHA_1	906	912	PF00498	0.825
LIG_FHA_1	981	987	PF00498	0.603
LIG_FHA_2	1055	1061	PF00498	0.612
LIG_FHA_2	278	284	PF00498	0.730
LIG_FHA_2	316	322	PF00498	0.571
LIG_FHA_2	440	446	PF00498	0.802
LIG_FHA_2	555	561	PF00498	0.790
LIG_FHA_2	651	657	PF00498	0.794
LIG_FHA_2	925	931	PF00498	0.806
LIG_FHA_2	969	975	PF00498	0.687
LIG_LIR_Apic_2	360	365	PF02991	0.626
LIG_LIR_Apic_2	930	935	PF02991	0.744
LIG_LIR_Gen_1	321	332	PF02991	0.528
LIG_LIR_Gen_1	389	398	PF02991	0.519
LIG_LIR_Gen_1	471	481	PF02991	0.771
LIG_LIR_Gen_1	866	876	PF02991	0.740
LIG_LIR_Gen_1	972	981	PF02991	0.640
LIG_LIR_Nem_3	173	177	PF02991	0.621
LIG_LIR_Nem_3	313	319	PF02991	0.529
LIG_LIR_Nem_3	321	327	PF02991	0.497
LIG_LIR_Nem_3	389	393	PF02991	0.510
LIG_LIR_Nem_3	469	473	PF02991	0.654
LIG_LIR_Nem_3	866	872	PF02991	0.614
LIG_LIR_Nem_3	972	978	PF02991	0.678
LIG_MYND_1	840	844	PF01753	0.564
LIG_NRBOX	583	589	PF00104	0.642
LIG_PCNA_PIPBox_1	617	626	PF02747	0.647
LIG_PCNA_yPIPBox_3	617	626	PF02747	0.644
LIG_Pex14_2	466	470	PF04695	0.647
LIG_RPA_C_Fungi	387	399	PF08784	0.528
LIG_SH2_CRK	324	328	PF00017	0.551
LIG_SH2_CRK	390	394	PF00017	0.469
LIG_SH2_CRK	473	477	PF00017	0.664
LIG_SH2_CRK	869	873	PF00017	0.640
LIG_SH2_CRK	975	979	PF00017	0.679
LIG_SH2_STAP1	324	328	PF00017	0.607
LIG_SH2_STAT3	344	347	PF00017	0.590
LIG_SH2_STAT5	1020	1023	PF00017	0.621
LIG_SH2_STAT5	1046	1049	PF00017	0.522
LIG_SH2_STAT5	344	347	PF00017	0.489
LIG_SH2_STAT5	605	608	PF00017	0.544
LIG_SH2_STAT5	875	878	PF00017	0.618
LIG_SH3_1	841	847	PF00018	0.567
LIG_SH3_3	1078	1084	PF00018	0.633
LIG_SH3_3	221	227	PF00018	0.668
LIG_SH3_3	325	331	PF00018	0.599
LIG_SH3_3	514	520	PF00018	0.725
LIG_SH3_3	543	549	PF00018	0.754
LIG_SH3_3	68	74	PF00018	0.667
LIG_SH3_3	834	840	PF00018	0.662
LIG_SH3_3	841	847	PF00018	0.620
LIG_SH3_3	895	901	PF00018	0.676
LIG_SH3_3	932	938	PF00018	0.674
LIG_SUMO_SIM_anti_2	506	512	PF11976	0.773
LIG_SUMO_SIM_par_1	175	180	PF11976	0.682
LIG_SUMO_SIM_par_1	355	360	PF11976	0.533
LIG_SUMO_SIM_par_1	998	1004	PF11976	0.739
LIG_TRAF2_1	285	288	PF00917	0.675
LIG_TRAF2_1	382	385	PF00917	0.652
LIG_TRAF2_1	557	560	PF00917	0.787
LIG_TRAF2_1	813	816	PF00917	0.742
LIG_TRAF2_1	910	913	PF00917	0.679
LIG_TRAF2_1	944	947	PF00917	0.777
LIG_TRAF2_1	971	974	PF00917	0.609
LIG_WRC_WIRS_1	316	321	PF05994	0.563
LIG_WRC_WIRS_1	467	472	PF05994	0.648
LIG_WW_3	671	675	PF00397	0.628
LIG_WW_3	728	732	PF00397	0.642
MOD_CDC14_SPxK_1	724	727	PF00782	0.833
MOD_CDC14_SPxK_1	838	841	PF00782	0.782
MOD_CDK_SPxK_1	721	727	PF00069	0.838
MOD_CDK_SPxK_1	835	841	PF00069	0.788
MOD_CDK_SPxxK_3	422	429	PF00069	0.717
MOD_CK1_1	1001	1007	PF00069	0.747
MOD_CK1_1	141	147	PF00069	0.688
MOD_CK1_1	158	164	PF00069	0.484
MOD_CK1_1	187	193	PF00069	0.671
MOD_CK1_1	21	27	PF00069	0.619
MOD_CK1_1	258	264	PF00069	0.585
MOD_CK1_1	270	276	PF00069	0.594
MOD_CK1_1	297	303	PF00069	0.494
MOD_CK1_1	308	314	PF00069	0.606
MOD_CK1_1	418	424	PF00069	0.751
MOD_CK1_1	425	431	PF00069	0.693
MOD_CK1_1	512	518	PF00069	0.717
MOD_CK1_1	523	529	PF00069	0.734
MOD_CK1_1	554	560	PF00069	0.660
MOD_CK1_1	662	668	PF00069	0.685
MOD_CK1_1	675	681	PF00069	0.705
MOD_CK1_1	789	795	PF00069	0.772
MOD_CK1_1	799	805	PF00069	0.832
MOD_CK1_1	858	864	PF00069	0.665
MOD_CK1_1	939	945	PF00069	0.664
MOD_CK1_1	960	966	PF00069	0.809
MOD_CK2_1	1054	1060	PF00069	0.614
MOD_CK2_1	277	283	PF00069	0.734
MOD_CK2_1	315	321	PF00069	0.521
MOD_CK2_1	379	385	PF00069	0.640
MOD_CK2_1	439	445	PF00069	0.835
MOD_CK2_1	523	529	PF00069	0.546
MOD_CK2_1	54	60	PF00069	0.699
MOD_CK2_1	554	560	PF00069	0.796
MOD_CK2_1	622	628	PF00069	0.378
MOD_CK2_1	75	81	PF00069	0.688
MOD_CK2_1	763	769	PF00069	0.703
MOD_CK2_1	799	805	PF00069	0.797
MOD_CK2_1	924	930	PF00069	0.806
MOD_CK2_1	968	974	PF00069	0.705
MOD_Cter_Amidation	434	437	PF01082	0.786
MOD_Cter_Amidation	45	48	PF01082	0.754
MOD_Cter_Amidation	754	757	PF01082	0.827
MOD_GlcNHglycan	1003	1006	PF01048	0.690
MOD_GlcNHglycan	1023	1028	PF01048	0.501
MOD_GlcNHglycan	107	110	PF01048	0.582
MOD_GlcNHglycan	124	127	PF01048	0.669
MOD_GlcNHglycan	144	147	PF01048	0.451
MOD_GlcNHglycan	161	164	PF01048	0.471
MOD_GlcNHglycan	193	196	PF01048	0.551
MOD_GlcNHglycan	249	252	PF01048	0.641
MOD_GlcNHglycan	269	272	PF01048	0.457
MOD_GlcNHglycan	299	302	PF01048	0.671
MOD_GlcNHglycan	307	310	PF01048	0.716
MOD_GlcNHglycan	447	450	PF01048	0.729
MOD_GlcNHglycan	526	529	PF01048	0.694
MOD_GlcNHglycan	537	540	PF01048	0.611
MOD_GlcNHglycan	674	677	PF01048	0.563
MOD_GlcNHglycan	711	714	PF01048	0.711
MOD_GlcNHglycan	731	734	PF01048	0.820
MOD_GlcNHglycan	744	747	PF01048	0.657
MOD_GlcNHglycan	765	768	PF01048	0.755
MOD_GlcNHglycan	790	794	PF01048	0.784
MOD_GlcNHglycan	798	801	PF01048	0.675
MOD_GlcNHglycan	83	86	PF01048	0.724
MOD_GlcNHglycan	941	944	PF01048	0.761
MOD_GSK3_1	107	114	PF00069	0.648
MOD_GSK3_1	122	129	PF00069	0.747
MOD_GSK3_1	138	145	PF00069	0.569
MOD_GSK3_1	155	162	PF00069	0.510
MOD_GSK3_1	185	192	PF00069	0.690
MOD_GSK3_1	255	262	PF00069	0.618
MOD_GSK3_1	267	274	PF00069	0.671
MOD_GSK3_1	282	289	PF00069	0.654
MOD_GSK3_1	300	307	PF00069	0.754
MOD_GSK3_1	315	322	PF00069	0.446
MOD_GSK3_1	331	338	PF00069	0.475
MOD_GSK3_1	418	425	PF00069	0.783
MOD_GSK3_1	453	460	PF00069	0.764
MOD_GSK3_1	50	57	PF00069	0.781
MOD_GSK3_1	505	512	PF00069	0.842
MOD_GSK3_1	519	526	PF00069	0.651
MOD_GSK3_1	535	542	PF00069	0.564
MOD_GSK3_1	560	567	PF00069	0.664
MOD_GSK3_1	659	666	PF00069	0.688
MOD_GSK3_1	736	743	PF00069	0.579
MOD_GSK3_1	77	84	PF00069	0.724
MOD_GSK3_1	792	799	PF00069	0.776
MOD_GSK3_1	8	15	PF00069	0.726
MOD_GSK3_1	831	838	PF00069	0.791
MOD_GSK3_1	957	964	PF00069	0.646
MOD_N-GLC_1	195	200	PF02516	0.722
MOD_N-GLC_1	50	55	PF02516	0.614
MOD_N-GLC_1	650	655	PF02516	0.548
MOD_N-GLC_1	961	966	PF02516	0.509
MOD_NEK2_1	107	112	PF00069	0.771
MOD_NEK2_1	122	127	PF00069	0.627
MOD_NEK2_1	247	252	PF00069	0.649
MOD_NEK2_1	256	261	PF00069	0.617
MOD_NEK2_1	417	422	PF00069	0.716
MOD_NEK2_1	475	480	PF00069	0.716
MOD_NEK2_1	659	664	PF00069	0.676
MOD_NEK2_1	808	813	PF00069	0.660
MOD_NEK2_2	339	344	PF00069	0.506
MOD_PIKK_1	1044	1050	PF00454	0.590
MOD_PIKK_1	18	24	PF00454	0.523
MOD_PIKK_1	222	228	PF00454	0.716
MOD_PIKK_1	408	414	PF00454	0.595
MOD_PIKK_1	488	494	PF00454	0.782
MOD_PIKK_1	50	56	PF00454	0.668
MOD_PIKK_1	509	515	PF00454	0.746
MOD_PIKK_1	736	742	PF00454	0.829
MOD_PIKK_1	832	838	PF00454	0.745
MOD_PIKK_1	855	861	PF00454	0.679
MOD_PIKK_1	957	963	PF00454	0.632
MOD_PKA_1	1067	1073	PF00069	0.669
MOD_PKA_1	436	442	PF00069	0.838
MOD_PKA_1	47	53	PF00069	0.732
MOD_PKA_1	979	985	PF00069	0.581
MOD_PKA_2	170	176	PF00069	0.475
MOD_PKA_2	2	8	PF00069	0.730
MOD_PKA_2	259	265	PF00069	0.655
MOD_PKA_2	335	341	PF00069	0.644
MOD_PKA_2	391	397	PF00069	0.579
MOD_PKA_2	428	434	PF00069	0.743
MOD_PKA_2	47	53	PF00069	0.814
MOD_PKA_2	560	566	PF00069	0.766
MOD_PKA_2	749	755	PF00069	0.543
MOD_PKA_2	831	837	PF00069	0.672
MOD_PKA_2	847	853	PF00069	0.816
MOD_PKA_2	923	929	PF00069	0.579
MOD_PKB_1	742	750	PF00069	0.727
MOD_PKB_1	830	838	PF00069	0.801
MOD_Plk_1	1023	1029	PF00069	0.643
MOD_Plk_1	195	201	PF00069	0.720
MOD_Plk_1	286	292	PF00069	0.745
MOD_Plk_1	439	445	PF00069	0.773
MOD_Plk_1	50	56	PF00069	0.497
MOD_Plk_1	808	814	PF00069	0.672
MOD_Plk_1	865	871	PF00069	0.759
MOD_Plk_1	961	967	PF00069	0.507
MOD_Plk_2-3	915	921	PF00069	0.756
MOD_Plk_4	1034	1040	PF00069	0.620
MOD_Plk_4	294	300	PF00069	0.714
MOD_Plk_4	505	511	PF00069	0.838
MOD_Plk_4	54	60	PF00069	0.699
MOD_Plk_4	8	14	PF00069	0.744
MOD_Plk_4	961	967	PF00069	0.507
MOD_ProDKin_1	111	117	PF00069	0.723
MOD_ProDKin_1	187	193	PF00069	0.661
MOD_ProDKin_1	308	314	PF00069	0.584
MOD_ProDKin_1	418	424	PF00069	0.800
MOD_ProDKin_1	512	518	PF00069	0.679
MOD_ProDKin_1	545	551	PF00069	0.736
MOD_ProDKin_1	564	570	PF00069	0.542
MOD_ProDKin_1	721	727	PF00069	0.729
MOD_ProDKin_1	835	841	PF00069	0.853
MOD_ProDKin_1	931	937	PF00069	0.706
TRG_DiLeu_BaEn_4	973	979	PF01217	0.613
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.619
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.419
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.679
TRG_ENDOCYTIC_2	324	327	PF00928	0.518
TRG_ENDOCYTIC_2	390	393	PF00928	0.517
TRG_ENDOCYTIC_2	473	476	PF00928	0.660
TRG_ENDOCYTIC_2	605	608	PF00928	0.544
TRG_ENDOCYTIC_2	869	872	PF00928	0.646
TRG_ENDOCYTIC_2	975	978	PF00928	0.680
TRG_ER_diArg_1	170	172	PF00400	0.674
TRG_ER_diArg_1	398	401	PF00400	0.631
TRG_ER_diArg_1	402	405	PF00400	0.577
TRG_ER_diArg_1	47	49	PF00400	0.799
TRG_ER_diArg_1	63	65	PF00400	0.514
TRG_NLS_Bipartite_1	741	761	PF00514	0.669
TRG_NLS_MonoExtN_4	756	761	PF00514	0.769
TRG_Pf-PMV_PEXEL_1	1019	1023	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ7	Leptomonas seymouri	37%	93%
A0A3S5H6S2	Leishmania donovani	86%	100%
A4H7P1	Leishmania braziliensis	71%	100%
A4HW31	Leishmania infantum	86%	100%
Q4QFP7	Leishmania major	86%	100%