DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4201), putative

Species:

Leishmania mexicana

UniProt:

E9APS7_LEIMU

TriTrypDb:

LmxM.14.0820

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005856	cytoskeleton	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9APS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APS7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.680
CLV_NRD_NRD_1	174	176	PF00675	0.629
CLV_NRD_NRD_1	181	183	PF00675	0.596
CLV_NRD_NRD_1	235	237	PF00675	0.582
CLV_NRD_NRD_1	267	269	PF00675	0.762
CLV_NRD_NRD_1	297	299	PF00675	0.534
CLV_NRD_NRD_1	330	332	PF00675	0.326
CLV_NRD_NRD_1	462	464	PF00675	0.292
CLV_NRD_NRD_1	480	482	PF00675	0.511
CLV_NRD_NRD_1	499	501	PF00675	0.464
CLV_NRD_NRD_1	531	533	PF00675	0.658
CLV_PCSK_FUR_1	328	332	PF00082	0.362
CLV_PCSK_FUR_1	393	397	PF00082	0.353
CLV_PCSK_KEX2_1	103	105	PF00082	0.680
CLV_PCSK_KEX2_1	174	176	PF00082	0.628
CLV_PCSK_KEX2_1	180	182	PF00082	0.606
CLV_PCSK_KEX2_1	234	236	PF00082	0.564
CLV_PCSK_KEX2_1	267	269	PF00082	0.776
CLV_PCSK_KEX2_1	297	299	PF00082	0.480
CLV_PCSK_KEX2_1	330	332	PF00082	0.334
CLV_PCSK_KEX2_1	395	397	PF00082	0.334
CLV_PCSK_KEX2_1	480	482	PF00082	0.578
CLV_PCSK_KEX2_1	496	498	PF00082	0.491
CLV_PCSK_KEX2_1	531	533	PF00082	0.643
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.353
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.610
CLV_PCSK_PC7_1	177	183	PF00082	0.712
CLV_PCSK_PC7_1	293	299	PF00082	0.484
CLV_PCSK_PC7_1	476	482	PF00082	0.594
CLV_PCSK_SKI1_1	196	200	PF00082	0.556
CLV_PCSK_SKI1_1	213	217	PF00082	0.478
CLV_PCSK_SKI1_1	248	252	PF00082	0.520
CLV_PCSK_SKI1_1	275	279	PF00082	0.716
CLV_PCSK_SKI1_1	396	400	PF00082	0.334
CLV_PCSK_SKI1_1	425	429	PF00082	0.284
CLV_PCSK_SKI1_1	456	460	PF00082	0.362
CLV_Separin_Metazoa	249	253	PF03568	0.574
CLV_Separin_Metazoa	290	294	PF03568	0.578
DEG_Nend_UBRbox_2	1	3	PF02207	0.743
DOC_MAPK_gen_1	234	241	PF00069	0.493
DOC_MAPK_MEF2A_6	234	243	PF00069	0.515
DOC_MAPK_NFAT4_5	236	244	PF00069	0.536
DOC_USP7_MATH_1	109	113	PF00917	0.668
DOC_USP7_MATH_1	126	130	PF00917	0.579
DOC_USP7_MATH_1	15	19	PF00917	0.752
DOC_USP7_MATH_1	261	265	PF00917	0.698
DOC_USP7_MATH_1	513	517	PF00917	0.720
DOC_USP7_MATH_1	520	524	PF00917	0.719
DOC_USP7_MATH_1	53	57	PF00917	0.441
DOC_USP7_MATH_1	547	551	PF00917	0.730
DOC_USP7_MATH_1	569	573	PF00917	0.764
DOC_USP7_UBL2_3	395	399	PF12436	0.562
DOC_WW_Pin1_4	132	137	PF00397	0.722
LIG_14-3-3_CanoR_1	174	180	PF00244	0.663
LIG_14-3-3_CanoR_1	181	185	PF00244	0.600
LIG_14-3-3_CanoR_1	297	306	PF00244	0.530
LIG_14-3-3_CanoR_1	486	493	PF00244	0.618
LIG_14-3-3_CanoR_1	500	507	PF00244	0.560
LIG_Actin_WH2_2	237	254	PF00022	0.553
LIG_CaM_IQ_9	417	432	PF13499	0.530
LIG_EH_1	268	272	PF12763	0.462
LIG_FHA_1	108	114	PF00498	0.602
LIG_FHA_1	138	144	PF00498	0.658
LIG_FHA_1	202	208	PF00498	0.573
LIG_FHA_1	369	375	PF00498	0.495
LIG_FHA_1	502	508	PF00498	0.743
LIG_FHA_1	566	572	PF00498	0.586
LIG_FHA_1	88	94	PF00498	0.552
LIG_FHA_2	226	232	PF00498	0.381
LIG_FHA_2	284	290	PF00498	0.621
LIG_LIR_Gen_1	188	198	PF02991	0.509
LIG_LIR_Gen_1	335	345	PF02991	0.486
LIG_LIR_Gen_1	40	50	PF02991	0.548
LIG_LIR_Nem_3	116	121	PF02991	0.452
LIG_LIR_Nem_3	188	193	PF02991	0.522
LIG_LIR_Nem_3	335	340	PF02991	0.482
LIG_LIR_Nem_3	40	45	PF02991	0.560
LIG_PCNA_yPIPBox_3	43	52	PF02747	0.594
LIG_RPA_C_Fungi	520	532	PF08784	0.584
LIG_SH2_GRB2like	492	495	PF00017	0.716
LIG_SH2_NCK_1	50	54	PF00017	0.572
LIG_SH2_STAP1	50	54	PF00017	0.578
LIG_SH2_STAT3	444	447	PF00017	0.335
LIG_SH2_STAT5	294	297	PF00017	0.511
LIG_SH2_STAT5	305	308	PF00017	0.277
LIG_SH2_STAT5	404	407	PF00017	0.335
LIG_SH2_STAT5	492	495	PF00017	0.660
LIG_SH2_STAT5	50	53	PF00017	0.481
LIG_SH3_3	433	439	PF00018	0.355
LIG_SH3_3	541	547	PF00018	0.718
LIG_TRAF2_1	209	212	PF00917	0.595
LIG_TRAF2_1	228	231	PF00917	0.319
LIG_TRAF2_1	431	434	PF00917	0.447
LIG_TRAF2_1	537	540	PF00917	0.510
LIG_TRAF2_1	85	88	PF00917	0.627
LIG_WRC_WIRS_1	46	51	PF05994	0.577
LIG_WW_2	544	547	PF00397	0.481
MOD_CK1_1	151	157	PF00069	0.651
MOD_CK1_1	25	31	PF00069	0.762
MOD_CK1_1	3	9	PF00069	0.710
MOD_CK1_1	370	376	PF00069	0.335
MOD_CK1_1	389	395	PF00069	0.335
MOD_CK1_1	48	54	PF00069	0.569
MOD_CK1_1	499	505	PF00069	0.704
MOD_CK1_1	523	529	PF00069	0.762
MOD_CK2_1	111	117	PF00069	0.644
MOD_CK2_1	225	231	PF00069	0.399
MOD_CK2_1	284	290	PF00069	0.619
MOD_CK2_1	397	403	PF00069	0.378
MOD_CK2_1	547	553	PF00069	0.783
MOD_Cter_Amidation	172	175	PF01082	0.773
MOD_GlcNHglycan	127	131	PF01048	0.651
MOD_GlcNHglycan	15	18	PF01048	0.704
MOD_GlcNHglycan	157	160	PF01048	0.683
MOD_GlcNHglycan	167	170	PF01048	0.637
MOD_GlcNHglycan	24	27	PF01048	0.594
MOD_GlcNHglycan	280	283	PF01048	0.673
MOD_GlcNHglycan	30	33	PF01048	0.654
MOD_GlcNHglycan	352	355	PF01048	0.188
MOD_GlcNHglycan	487	490	PF01048	0.590
MOD_GlcNHglycan	509	512	PF01048	0.762
MOD_GlcNHglycan	522	525	PF01048	0.714
MOD_GlcNHglycan	55	58	PF01048	0.643
MOD_GlcNHglycan	555	559	PF01048	0.813
MOD_GlcNHglycan	82	86	PF01048	0.618
MOD_GSK3_1	107	114	PF00069	0.476
MOD_GSK3_1	128	135	PF00069	0.691
MOD_GSK3_1	151	158	PF00069	0.696
MOD_GSK3_1	165	172	PF00069	0.680
MOD_GSK3_1	24	31	PF00069	0.728
MOD_GSK3_1	271	278	PF00069	0.458
MOD_GSK3_1	297	304	PF00069	0.615
MOD_GSK3_1	366	373	PF00069	0.335
MOD_GSK3_1	399	406	PF00069	0.428
MOD_GSK3_1	41	48	PF00069	0.597
MOD_GSK3_1	421	428	PF00069	0.285
MOD_GSK3_1	496	503	PF00069	0.610
MOD_GSK3_1	5	12	PF00069	0.721
MOD_GSK3_1	507	514	PF00069	0.601
MOD_GSK3_1	565	572	PF00069	0.580
MOD_NEK2_1	162	167	PF00069	0.617
MOD_NEK2_1	271	276	PF00069	0.606
MOD_NEK2_1	277	282	PF00069	0.645
MOD_NEK2_1	366	371	PF00069	0.335
MOD_NEK2_1	45	50	PF00069	0.575
MOD_NEK2_1	567	572	PF00069	0.502
MOD_NEK2_2	261	266	PF00069	0.484
MOD_PIKK_1	151	157	PF00454	0.552
MOD_PIKK_1	298	304	PF00454	0.540
MOD_PIKK_1	514	520	PF00454	0.685
MOD_PK_1	180	186	PF00069	0.449
MOD_PKA_1	180	186	PF00069	0.707
MOD_PKA_1	275	281	PF00069	0.664
MOD_PKA_1	297	303	PF00069	0.567
MOD_PKA_1	496	502	PF00069	0.696
MOD_PKA_2	155	161	PF00069	0.707
MOD_PKA_2	180	186	PF00069	0.638
MOD_PKA_2	271	277	PF00069	0.455
MOD_PKA_2	297	303	PF00069	0.567
MOD_PKA_2	485	491	PF00069	0.584
MOD_PKA_2	496	502	PF00069	0.628
MOD_PKA_2	505	511	PF00069	0.655
MOD_PKB_1	22	30	PF00069	0.672
MOD_Plk_1	137	143	PF00069	0.730
MOD_Plk_1	148	154	PF00069	0.665
MOD_Plk_1	261	267	PF00069	0.484
MOD_Plk_1	3	9	PF00069	0.468
MOD_Plk_1	389	395	PF00069	0.376
MOD_Plk_1	547	553	PF00069	0.731
MOD_Plk_1	81	87	PF00069	0.612
MOD_Plk_2-3	548	554	PF00069	0.737
MOD_Plk_4	137	143	PF00069	0.698
MOD_Plk_4	301	307	PF00069	0.402
MOD_Plk_4	41	47	PF00069	0.648
MOD_ProDKin_1	132	138	PF00069	0.723
MOD_SUMO_for_1	394	397	PF00179	0.434
MOD_SUMO_for_1	439	442	PF00179	0.349
MOD_SUMO_rev_2	188	198	PF00179	0.619
MOD_SUMO_rev_2	257	261	PF00179	0.592
MOD_SUMO_rev_2	343	352	PF00179	0.384
MOD_SUMO_rev_2	353	360	PF00179	0.288
MOD_SUMO_rev_2	362	369	PF00179	0.186
MOD_SUMO_rev_2	418	427	PF00179	0.360
TRG_DiLeu_BaEn_4	88	94	PF01217	0.544
TRG_ER_diArg_1	103	105	PF00400	0.713
TRG_ER_diArg_1	174	177	PF00400	0.645
TRG_ER_diArg_1	179	182	PF00400	0.639
TRG_ER_diArg_1	233	236	PF00400	0.558
TRG_ER_diArg_1	327	330	PF00400	0.355
TRG_ER_diArg_1	480	482	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.766

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T9	Leptomonas seymouri	59%	100%
A0A1X0NNL2	Trypanosomatidae	40%	100%
A0A3Q8IIC4	Leishmania donovani	88%	99%
A0A422N1M9	Trypanosoma rangeli	40%	100%
A4H7N6	Leishmania braziliensis	75%	100%
A4HW26	Leishmania infantum	89%	99%
C9ZT07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QFQ1	Leishmania major	89%	100%
V5BEA4	Trypanosoma cruzi	41%	100%