Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APS5_LEIMU

TriTrypDb:

LmxM.14.0800

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.521
CLV_NRD_NRD_1	202	204	PF00675	0.695
CLV_PCSK_KEX2_1	105	107	PF00082	0.518
CLV_PCSK_KEX2_1	442	444	PF00082	0.655
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.518
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.645
CLV_PCSK_SKI1_1	149	153	PF00082	0.637
CLV_PCSK_SKI1_1	159	163	PF00082	0.637
CLV_PCSK_SKI1_1	399	403	PF00082	0.469
CLV_PCSK_SKI1_1	45	49	PF00082	0.660
CLV_PCSK_SKI1_1	90	94	PF00082	0.520
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DEG_SCF_FBW7_1	233	240	PF00400	0.632
DEG_SPOP_SBC_1	312	316	PF00917	0.536
DOC_CDC14_PxL_1	189	197	PF14671	0.636
DOC_CKS1_1	207	212	PF01111	0.551
DOC_CKS1_1	338	343	PF01111	0.608
DOC_MAPK_MEF2A_6	72	81	PF00069	0.603
DOC_PP2B_LxvP_1	67	70	PF13499	0.648
DOC_USP7_MATH_1	210	214	PF00917	0.601
DOC_USP7_MATH_1	221	225	PF00917	0.622
DOC_USP7_MATH_1	237	241	PF00917	0.596
DOC_USP7_MATH_1	260	264	PF00917	0.622
DOC_USP7_MATH_1	280	284	PF00917	0.476
DOC_USP7_MATH_1	295	299	PF00917	0.597
DOC_USP7_MATH_1	313	317	PF00917	0.641
DOC_USP7_MATH_1	324	328	PF00917	0.622
DOC_USP7_MATH_1	367	371	PF00917	0.619
DOC_USP7_MATH_1	37	41	PF00917	0.678
DOC_USP7_MATH_1	390	394	PF00917	0.632
DOC_USP7_MATH_1	430	434	PF00917	0.660
DOC_USP7_MATH_2	237	243	PF00917	0.607
DOC_USP7_UBL2_3	16	20	PF12436	0.584
DOC_USP7_UBL2_3	438	442	PF12436	0.620
DOC_USP7_UBL2_3	9	13	PF12436	0.541
DOC_WW_Pin1_4	137	142	PF00397	0.722
DOC_WW_Pin1_4	206	211	PF00397	0.654
DOC_WW_Pin1_4	233	238	PF00397	0.668
DOC_WW_Pin1_4	241	246	PF00397	0.674
DOC_WW_Pin1_4	273	278	PF00397	0.728
DOC_WW_Pin1_4	337	342	PF00397	0.663
DOC_WW_Pin1_4	62	67	PF00397	0.613
LIG_14-3-3_CanoR_1	203	210	PF00244	0.597
LIG_14-3-3_CanoR_1	311	321	PF00244	0.489
LIG_14-3-3_CanoR_1	350	359	PF00244	0.650
LIG_14-3-3_CanoR_1	38	47	PF00244	0.730
LIG_14-3-3_CanoR_1	90	96	PF00244	0.569
LIG_BRCT_BRCA1_1	176	180	PF00533	0.629
LIG_BRCT_BRCA1_1	81	85	PF00533	0.489
LIG_FHA_1	160	166	PF00498	0.586
LIG_FHA_1	182	188	PF00498	0.648
LIG_FHA_2	192	198	PF00498	0.601
LIG_FHA_2	234	240	PF00498	0.640
LIG_LIR_Apic_2	254	260	PF02991	0.612
LIG_LIR_Apic_2	300	305	PF02991	0.697
LIG_LIR_Apic_2	307	313	PF02991	0.635
LIG_LIR_Apic_2	319	324	PF02991	0.660
LIG_LIR_Apic_2	357	362	PF02991	0.682
LIG_LIR_Apic_2	409	414	PF02991	0.691
LIG_LIR_Apic_2	434	440	PF02991	0.672
LIG_LIR_Gen_1	94	100	PF02991	0.511
LIG_LIR_Nem_3	94	98	PF02991	0.515
LIG_MYND_3	192	196	PF01753	0.575
LIG_PTAP_UEV_1	325	330	PF05743	0.601
LIG_SH2_CRK	302	306	PF00017	0.532
LIG_SH2_CRK	310	314	PF00017	0.572
LIG_SH2_CRK	321	325	PF00017	0.548
LIG_SH2_CRK	336	340	PF00017	0.555
LIG_SH2_CRK	349	353	PF00017	0.612
LIG_SH2_CRK	374	378	PF00017	0.748
LIG_SH2_CRK	385	389	PF00017	0.677
LIG_SH2_CRK	411	415	PF00017	0.684
LIG_SH2_CRK	425	429	PF00017	0.644
LIG_SH2_CRK	437	441	PF00017	0.600
LIG_SH2_PTP2	257	260	PF00017	0.644
LIG_SH2_SRC	257	260	PF00017	0.644
LIG_SH2_STAT5	257	260	PF00017	0.644
LIG_SH3_3	298	304	PF00018	0.612
LIG_SH3_3	317	323	PF00018	0.595
LIG_SH3_3	335	341	PF00018	0.546
LIG_SH3_3	358	364	PF00018	0.517
LIG_SH3_3	370	376	PF00018	0.443
LIG_SH3_3	381	387	PF00018	0.572
LIG_SH3_3	433	439	PF00018	0.620
LIG_SH3_3	71	77	PF00018	0.625
LIG_SH3_4	438	445	PF00018	0.631
LIG_SUMO_SIM_par_1	77	82	PF11976	0.484
LIG_TRAF2_1	118	121	PF00917	0.576
LIG_TRAF2_1	194	197	PF00917	0.579
LIG_TRAF2_1	236	239	PF00917	0.592
LIG_WRC_WIRS_1	3	8	PF05994	0.386
LIG_WRPW_2	398	401	PF00400	0.467
MOD_CDK_SPK_2	141	146	PF00069	0.668
MOD_CK1_1	101	107	PF00069	0.440
MOD_CK1_1	140	146	PF00069	0.723
MOD_CK1_1	206	212	PF00069	0.669
MOD_CK1_1	240	246	PF00069	0.709
MOD_CK1_1	261	267	PF00069	0.662
MOD_CK1_1	275	281	PF00069	0.730
MOD_CK1_1	327	333	PF00069	0.767
MOD_CK1_1	389	395	PF00069	0.581
MOD_CK1_1	407	413	PF00069	0.509
MOD_CK1_1	418	424	PF00069	0.561
MOD_CK1_1	55	61	PF00069	0.665
MOD_CK1_1	91	97	PF00069	0.588
MOD_CK2_1	141	147	PF00069	0.676
MOD_CK2_1	191	197	PF00069	0.602
MOD_CK2_1	233	239	PF00069	0.637
MOD_CK2_1	313	319	PF00069	0.660
MOD_CK2_1	351	357	PF00069	0.640
MOD_CK2_1	438	444	PF00069	0.585
MOD_Cter_Amidation	18	21	PF01082	0.482
MOD_GlcNHglycan	21	24	PF01048	0.771
MOD_GlcNHglycan	230	233	PF01048	0.673
MOD_GlcNHglycan	246	249	PF01048	0.717
MOD_GlcNHglycan	263	266	PF01048	0.604
MOD_GlcNHglycan	282	285	PF01048	0.744
MOD_GlcNHglycan	287	290	PF01048	0.657
MOD_GlcNHglycan	295	298	PF01048	0.667
MOD_GlcNHglycan	315	318	PF01048	0.666
MOD_GlcNHglycan	326	329	PF01048	0.633
MOD_GlcNHglycan	330	333	PF01048	0.662
MOD_GlcNHglycan	369	372	PF01048	0.644
MOD_GlcNHglycan	378	381	PF01048	0.730
MOD_GlcNHglycan	388	391	PF01048	0.635
MOD_GlcNHglycan	406	409	PF01048	0.611
MOD_GlcNHglycan	417	420	PF01048	0.628
MOD_GlcNHglycan	428	431	PF01048	0.609
MOD_GlcNHglycan	56	60	PF01048	0.775
MOD_GlcNHglycan	90	93	PF01048	0.556
MOD_GSK3_1	137	144	PF00069	0.695
MOD_GSK3_1	181	188	PF00069	0.756
MOD_GSK3_1	191	198	PF00069	0.642
MOD_GSK3_1	206	213	PF00069	0.575
MOD_GSK3_1	233	240	PF00069	0.719
MOD_GSK3_1	263	270	PF00069	0.671
MOD_GSK3_1	271	278	PF00069	0.734
MOD_GSK3_1	280	287	PF00069	0.627
MOD_GSK3_1	293	300	PF00069	0.588
MOD_GSK3_1	324	331	PF00069	0.726
MOD_GSK3_1	363	370	PF00069	0.620
MOD_GSK3_1	386	393	PF00069	0.696
MOD_GSK3_1	426	433	PF00069	0.706
MOD_GSK3_1	45	52	PF00069	0.688
MOD_GSK3_1	84	91	PF00069	0.587
MOD_N-GLC_1	159	164	PF02516	0.640
MOD_NEK2_1	195	200	PF00069	0.647
MOD_NEK2_1	267	272	PF00069	0.636
MOD_NEK2_1	401	406	PF00069	0.534
MOD_NEK2_1	85	90	PF00069	0.699
MOD_NEK2_2	297	302	PF00069	0.464
MOD_PIKK_1	181	187	PF00454	0.648
MOD_PIKK_1	203	209	PF00454	0.705
MOD_PIKK_1	210	216	PF00454	0.632
MOD_PIKK_1	221	227	PF00454	0.514
MOD_PIKK_1	98	104	PF00454	0.497
MOD_PKA_1	12	18	PF00069	0.650
MOD_PKA_1	203	209	PF00069	0.705
MOD_PKA_2	280	286	PF00069	0.631
MOD_PKA_2	37	43	PF00069	0.775
MOD_Plk_1	195	201	PF00069	0.649
MOD_Plk_1	70	76	PF00069	0.629
MOD_Plk_4	2	8	PF00069	0.387
MOD_Plk_4	246	252	PF00069	0.484
MOD_ProDKin_1	137	143	PF00069	0.720
MOD_ProDKin_1	206	212	PF00069	0.653
MOD_ProDKin_1	233	239	PF00069	0.667
MOD_ProDKin_1	241	247	PF00069	0.673
MOD_ProDKin_1	273	279	PF00069	0.728
MOD_ProDKin_1	337	343	PF00069	0.662
MOD_ProDKin_1	62	68	PF00069	0.610
MOD_SUMO_for_1	118	121	PF00179	0.528
MOD_SUMO_rev_2	120	130	PF00179	0.599
MOD_SUMO_rev_2	142	151	PF00179	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE22	Leptomonas seymouri	42%	100%
A0A1X0NNK6	Trypanosomatidae	31%	93%
A0A3S7WT08	Leishmania donovani	84%	100%
A4H7N5	Leishmania braziliensis	68%	94%
A4HW24	Leishmania infantum	84%	100%
Q4QFQ3	Leishmania major	86%	96%