Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APS2_LEIMU

TriTrypDb:

LmxM.14.0770

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9APS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.508
CLV_NRD_NRD_1	123	125	PF00675	0.752
CLV_NRD_NRD_1	17	19	PF00675	0.670
CLV_NRD_NRD_1	178	180	PF00675	0.667
CLV_NRD_NRD_1	195	197	PF00675	0.728
CLV_NRD_NRD_1	264	266	PF00675	0.807
CLV_NRD_NRD_1	275	277	PF00675	0.648
CLV_NRD_NRD_1	330	332	PF00675	0.769
CLV_NRD_NRD_1	359	361	PF00675	0.706
CLV_NRD_NRD_1	88	90	PF00675	0.781
CLV_PCSK_FUR_1	121	125	PF00082	0.738
CLV_PCSK_KEX2_1	123	125	PF00082	0.752
CLV_PCSK_KEX2_1	17	19	PF00082	0.670
CLV_PCSK_KEX2_1	180	182	PF00082	0.778
CLV_PCSK_KEX2_1	264	266	PF00082	0.807
CLV_PCSK_KEX2_1	275	277	PF00082	0.648
CLV_PCSK_KEX2_1	330	332	PF00082	0.769
CLV_PCSK_KEX2_1	358	360	PF00082	0.714
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.769
CLV_PCSK_SKI1_1	345	349	PF00082	0.754
CLV_PCSK_SKI1_1	370	374	PF00082	0.714
CLV_PCSK_SKI1_1	75	79	PF00082	0.760
CLV_Separin_Metazoa	217	221	PF03568	0.533
DEG_APCC_DBOX_1	219	227	PF00400	0.606
DEG_SPOP_SBC_1	190	194	PF00917	0.581
DEG_SPOP_SBC_1	3	7	PF00917	0.620
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.454
DOC_MAPK_gen_1	14	24	PF00069	0.638
DOC_MAPK_gen_1	381	389	PF00069	0.493
DOC_MAPK_MEF2A_6	17	26	PF00069	0.477
DOC_MAPK_RevD_3	167	181	PF00069	0.518
DOC_MAPK_RevD_3	316	331	PF00069	0.414
DOC_PP2B_LxvP_1	35	38	PF13499	0.655
DOC_PP2B_PxIxI_1	315	321	PF00149	0.566
DOC_USP7_MATH_1	190	194	PF00917	0.540
DOC_USP7_MATH_1	222	226	PF00917	0.471
DOC_USP7_MATH_1	260	264	PF00917	0.566
DOC_USP7_MATH_1	338	342	PF00917	0.533
DOC_USP7_MATH_1	39	43	PF00917	0.669
DOC_USP7_MATH_1	409	413	PF00917	0.513
DOC_WW_Pin1_4	138	143	PF00397	0.635
DOC_WW_Pin1_4	154	159	PF00397	0.459
DOC_WW_Pin1_4	251	256	PF00397	0.542
DOC_WW_Pin1_4	345	350	PF00397	0.413
LIG_14-3-3_CanoR_1	164	170	PF00244	0.533
LIG_14-3-3_CanoR_1	181	191	PF00244	0.565
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_BIR_III_2	215	219	PF00653	0.415
LIG_FHA_2	129	135	PF00498	0.588
LIG_FHA_2	210	216	PF00498	0.493
LIG_FHA_2	349	355	PF00498	0.562
LIG_FHA_2	55	61	PF00498	0.646
LIG_GBD_Chelix_1	29	37	PF00786	0.550
LIG_LIR_Nem_3	98	104	PF02991	0.492
LIG_PDZ_Class_2	421	426	PF00595	0.411
LIG_Pex14_2	422	426	PF04695	0.389
LIG_SH2_NCK_1	213	217	PF00017	0.491
LIG_SH2_STAT5	102	105	PF00017	0.537
LIG_SH2_STAT5	182	185	PF00017	0.428
LIG_SH2_STAT5	213	216	PF00017	0.423
LIG_SH3_3	114	120	PF00018	0.482
LIG_SH3_3	166	172	PF00018	0.535
LIG_SH3_3	216	222	PF00018	0.527
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.488
LIG_SUMO_SIM_par_1	316	322	PF11976	0.565
LIG_TRAF2_1	131	134	PF00917	0.596
LIG_TRAF2_1	376	379	PF00917	0.509
LIG_WW_3	217	221	PF00397	0.693
MOD_CDC14_SPxK_1	141	144	PF00782	0.534
MOD_CDK_SPxK_1	138	144	PF00069	0.541
MOD_CDK_SPxxK_3	251	258	PF00069	0.628
MOD_CK1_1	140	146	PF00069	0.707
MOD_CK1_1	263	269	PF00069	0.789
MOD_CK1_1	366	372	PF00069	0.512
MOD_CK1_1	42	48	PF00069	0.691
MOD_CK1_1	9	15	PF00069	0.577
MOD_CK2_1	128	134	PF00069	0.751
MOD_CK2_1	211	217	PF00069	0.518
MOD_CK2_1	348	354	PF00069	0.679
MOD_CK2_1	54	60	PF00069	0.714
MOD_Cter_Amidation	113	116	PF01082	0.738
MOD_GlcNHglycan	18	21	PF01048	0.551
MOD_GlcNHglycan	269	272	PF01048	0.766
MOD_GlcNHglycan	340	343	PF01048	0.688
MOD_GlcNHglycan	402	405	PF01048	0.689
MOD_GlcNHglycan	42	45	PF01048	0.714
MOD_GlcNHglycan	65	68	PF01048	0.783
MOD_GlcNHglycan	70	73	PF01048	0.719
MOD_GlcNHglycan	8	11	PF01048	0.609
MOD_GlcNHglycan	82	85	PF01048	0.520
MOD_GSK3_1	128	135	PF00069	0.549
MOD_GSK3_1	2	9	PF00069	0.620
MOD_GSK3_1	256	263	PF00069	0.809
MOD_GSK3_1	343	350	PF00069	0.715
MOD_GSK3_1	396	403	PF00069	0.716
MOD_GSK3_1	409	416	PF00069	0.349
MOD_GSK3_1	59	66	PF00069	0.763
MOD_NEK2_1	413	418	PF00069	0.416
MOD_NEK2_2	165	170	PF00069	0.672
MOD_NEK2_2	222	227	PF00069	0.644
MOD_NEK2_2	409	414	PF00069	0.513
MOD_PKA_2	16	22	PF00069	0.521
MOD_PKA_2	263	269	PF00069	0.726
MOD_PKA_2	329	335	PF00069	0.720
MOD_PKA_2	366	372	PF00069	0.734
MOD_PKB_1	265	273	PF00069	0.697
MOD_Plk_1	132	138	PF00069	0.763
MOD_Plk_4	409	415	PF00069	0.424
MOD_ProDKin_1	138	144	PF00069	0.818
MOD_ProDKin_1	154	160	PF00069	0.571
MOD_ProDKin_1	251	257	PF00069	0.688
MOD_ProDKin_1	345	351	PF00069	0.506
MOD_SUMO_rev_2	107	117	PF00179	0.793
MOD_SUMO_rev_2	341	347	PF00179	0.695
MOD_SUMO_rev_2	366	372	PF00179	0.660
TRG_ER_diArg_1	120	123	PF00400	0.674
TRG_ER_diArg_1	178	181	PF00400	0.530
TRG_ER_diArg_1	264	267	PF00400	0.703
TRG_ER_diArg_1	357	360	PF00400	0.639
TRG_NLS_Bipartite_1	179	200	PF00514	0.741

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I683	Leptomonas seymouri	31%	100%
A0A3S7WT04	Leishmania donovani	81%	100%
A4H7N2	Leishmania braziliensis	53%	94%
A4HW21	Leishmania infantum	80%	100%
Q4QFQ6	Leishmania major	80%	100%