Guanine nucleotide-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania mexicana

UniProt:

E9APS1_LEIMU

TriTrypDb:

LmxM.14.0760

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APS1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.328
CLV_C14_Caspase3-7	6	10	PF00656	0.730
CLV_NRD_NRD_1	305	307	PF00675	0.508
CLV_PCSK_KEX2_1	305	307	PF00082	0.508
CLV_PCSK_SKI1_1	272	276	PF00082	0.349
DEG_Nend_UBRbox_2	1	3	PF02207	0.655
DOC_ANK_TNKS_1	23	30	PF00023	0.614
DOC_ANK_TNKS_1	342	349	PF00023	0.638
DOC_MAPK_MEF2A_6	216	224	PF00069	0.340
DOC_PIKK_1	5	13	PF02985	0.500
DOC_PP1_RVXF_1	225	231	PF00149	0.195
DOC_PP2B_LxvP_1	202	205	PF13499	0.329
DOC_PP2B_LxvP_1	91	94	PF13499	0.582
DOC_PP2B_PxIxI_1	136	142	PF00149	0.195
DOC_USP7_MATH_1	236	240	PF00917	0.369
DOC_USP7_MATH_1	329	333	PF00917	0.651
DOC_USP7_MATH_1	351	355	PF00917	0.645
DOC_USP7_MATH_1	370	374	PF00917	0.622
DOC_USP7_MATH_1	408	412	PF00917	0.581
DOC_USP7_MATH_1	45	49	PF00917	0.514
DOC_USP7_MATH_1	52	56	PF00917	0.704
DOC_WW_Pin1_4	368	373	PF00397	0.632
DOC_WW_Pin1_4	397	402	PF00397	0.670
DOC_WW_Pin1_4	404	409	PF00397	0.721
DOC_WW_Pin1_4	41	46	PF00397	0.611
DOC_WW_Pin1_4	68	73	PF00397	0.648
LIG_14-3-3_CanoR_1	24	32	PF00244	0.642
LIG_14-3-3_CanoR_1	254	261	PF00244	0.376
LIG_14-3-3_CanoR_1	379	389	PF00244	0.647
LIG_14-3-3_CanoR_1	73	83	PF00244	0.553
LIG_14-3-3_CanoR_1	99	107	PF00244	0.347
LIG_BRCT_BRCA1_1	178	182	PF00533	0.300
LIG_FHA_1	104	110	PF00498	0.359
LIG_FHA_1	136	142	PF00498	0.305
LIG_FHA_1	156	162	PF00498	0.231
LIG_FHA_1	23	29	PF00498	0.521
LIG_FHA_1	264	270	PF00498	0.374
LIG_FHA_1	277	283	PF00498	0.272
LIG_FHA_1	386	392	PF00498	0.729
LIG_FHA_2	194	200	PF00498	0.291
LIG_LIR_Gen_1	276	285	PF02991	0.302
LIG_LIR_Nem_3	106	110	PF02991	0.324
LIG_LIR_Nem_3	130	134	PF02991	0.195
LIG_LIR_Nem_3	276	281	PF02991	0.302
LIG_MYND_1	133	137	PF01753	0.195
LIG_PTB_Apo_2	177	184	PF02174	0.360
LIG_PTB_Phospho_1	177	183	PF10480	0.360
LIG_SH2_CRK	107	111	PF00017	0.300
LIG_SH2_CRK	131	135	PF00017	0.195
LIG_SH2_NCK_1	40	44	PF00017	0.464
LIG_SH2_SRC	131	134	PF00017	0.328
LIG_SH2_STAT5	126	129	PF00017	0.360
LIG_SH2_STAT5	367	370	PF00017	0.737
LIG_SH3_3	130	136	PF00018	0.360
LIG_SH3_3	145	151	PF00018	0.360
LIG_SH3_3	374	380	PF00018	0.616
LIG_SH3_3	39	45	PF00018	0.546
LIG_SH3_3	66	72	PF00018	0.647
LIG_SUMO_SIM_par_1	108	114	PF11976	0.300
LIG_SUMO_SIM_par_1	281	286	PF11976	0.360
LIG_TRAF2_1	169	172	PF00917	0.300
LIG_TRAF2_1	247	250	PF00917	0.195
MOD_CDK_SPK_2	68	73	PF00069	0.627
MOD_CK1_1	18	24	PF00069	0.675
MOD_CK1_1	200	206	PF00069	0.341
MOD_CK1_1	267	273	PF00069	0.360
MOD_CK1_1	309	315	PF00069	0.728
MOD_CK1_1	34	40	PF00069	0.603
MOD_CK1_1	353	359	PF00069	0.669
MOD_CK1_1	365	371	PF00069	0.581
MOD_CK1_1	397	403	PF00069	0.508
MOD_CK1_1	55	61	PF00069	0.702
MOD_CK1_1	78	84	PF00069	0.655
MOD_CK2_1	193	199	PF00069	0.267
MOD_CK2_1	312	318	PF00069	0.618
MOD_GlcNHglycan	151	154	PF01048	0.336
MOD_GlcNHglycan	238	241	PF01048	0.349
MOD_GlcNHglycan	25	28	PF01048	0.541
MOD_GlcNHglycan	266	269	PF01048	0.300
MOD_GlcNHglycan	299	302	PF01048	0.631
MOD_GlcNHglycan	311	314	PF01048	0.739
MOD_GlcNHglycan	337	340	PF01048	0.579
MOD_GlcNHglycan	364	367	PF01048	0.655
MOD_GlcNHglycan	372	375	PF01048	0.702
MOD_GlcNHglycan	410	413	PF01048	0.555
MOD_GlcNHglycan	65	68	PF01048	0.626
MOD_GlcNHglycan	77	80	PF01048	0.660
MOD_GlcNHglycan	94	97	PF01048	0.579
MOD_GSK3_1	18	25	PF00069	0.586
MOD_GSK3_1	193	200	PF00069	0.247
MOD_GSK3_1	263	270	PF00069	0.376
MOD_GSK3_1	295	302	PF00069	0.560
MOD_GSK3_1	30	37	PF00069	0.650
MOD_GSK3_1	305	312	PF00069	0.594
MOD_GSK3_1	329	336	PF00069	0.676
MOD_GSK3_1	349	356	PF00069	0.752
MOD_GSK3_1	358	365	PF00069	0.527
MOD_GSK3_1	393	400	PF00069	0.716
MOD_GSK3_1	404	411	PF00069	0.573
MOD_GSK3_1	41	48	PF00069	0.594
MOD_GSK3_1	51	58	PF00069	0.583
MOD_GSK3_1	74	81	PF00069	0.683
MOD_N-GLC_1	295	300	PF02516	0.462
MOD_N-GLC_1	333	338	PF02516	0.624
MOD_NEK2_1	103	108	PF00069	0.523
MOD_NEK2_1	165	170	PF00069	0.391
MOD_NEK2_1	264	269	PF00069	0.316
MOD_NEK2_1	299	304	PF00069	0.527
MOD_NEK2_1	75	80	PF00069	0.680
MOD_NEK2_1	84	89	PF00069	0.643
MOD_PIKK_1	209	215	PF00454	0.427
MOD_PKA_1	305	311	PF00069	0.464
MOD_PKA_2	23	29	PF00069	0.675
MOD_PKA_2	253	259	PF00069	0.376
MOD_PKA_2	305	311	PF00069	0.584
MOD_PKA_2	75	81	PF00069	0.526
MOD_PKA_2	98	104	PF00069	0.390
MOD_Plk_1	295	301	PF00069	0.413
MOD_Plk_4	118	124	PF00069	0.195
MOD_Plk_4	157	163	PF00069	0.394
MOD_Plk_4	197	203	PF00069	0.360
MOD_Plk_4	31	37	PF00069	0.585
MOD_ProDKin_1	368	374	PF00069	0.631
MOD_ProDKin_1	397	403	PF00069	0.669
MOD_ProDKin_1	404	410	PF00069	0.721
MOD_ProDKin_1	41	47	PF00069	0.613
MOD_ProDKin_1	68	74	PF00069	0.647
TRG_ENDOCYTIC_2	107	110	PF00928	0.247
TRG_ENDOCYTIC_2	131	134	PF00928	0.195

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL4	Leptomonas seymouri	49%	100%
A0A1X0NQ87	Trypanosomatidae	40%	100%
A0A3S7WT13	Leishmania donovani	84%	100%
A4HW20	Leishmania infantum	84%	100%
E9AI46	Leishmania braziliensis	64%	100%
Q4QFQ7	Leishmania major	84%	100%