Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 35 |
NetGPI | no | yes: 0, no: 35 |
Term | Name | Level | Count |
---|---|---|---|
GO:0016020 | membrane | 2 | 33 |
GO:0110165 | cellular anatomical entity | 1 | 34 |
GO:0005737 | cytoplasm | 2 | 1 |
Related structures:
AlphaFold database: E9APR9
Term | Name | Level | Count |
---|---|---|---|
GO:0006082 | organic acid metabolic process | 3 | 36 |
GO:0006629 | lipid metabolic process | 3 | 36 |
GO:0006631 | fatty acid metabolic process | 4 | 36 |
GO:0006633 | fatty acid biosynthetic process | 5 | 36 |
GO:0008152 | metabolic process | 1 | 36 |
GO:0008610 | lipid biosynthetic process | 4 | 36 |
GO:0009058 | biosynthetic process | 2 | 36 |
GO:0009987 | cellular process | 1 | 36 |
GO:0016053 | organic acid biosynthetic process | 4 | 36 |
GO:0019752 | carboxylic acid metabolic process | 5 | 36 |
GO:0032787 | monocarboxylic acid metabolic process | 6 | 36 |
GO:0043436 | oxoacid metabolic process | 4 | 36 |
GO:0044237 | cellular metabolic process | 2 | 36 |
GO:0044238 | primary metabolic process | 2 | 36 |
GO:0044249 | cellular biosynthetic process | 3 | 36 |
GO:0044255 | cellular lipid metabolic process | 3 | 36 |
GO:0044281 | small molecule metabolic process | 2 | 36 |
GO:0044283 | small molecule biosynthetic process | 3 | 36 |
GO:0046394 | carboxylic acid biosynthetic process | 5 | 36 |
GO:0071704 | organic substance metabolic process | 2 | 36 |
GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 36 |
GO:1901576 | organic substance biosynthetic process | 3 | 36 |
GO:0000038 | very long-chain fatty acid metabolic process | 5 | 3 |
GO:0006643 | membrane lipid metabolic process | 4 | 3 |
GO:0006665 | sphingolipid metabolic process | 4 | 3 |
GO:0006807 | nitrogen compound metabolic process | 2 | 3 |
GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 3 |
GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 3 |
GO:0030148 | sphingolipid biosynthetic process | 5 | 3 |
GO:0030497 | fatty acid elongation | 6 | 3 |
GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 3 |
GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 3 |
GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 3 |
GO:0046467 | membrane lipid biosynthetic process | 4 | 3 |
GO:1901564 | organonitrogen compound metabolic process | 3 | 3 |
GO:1901566 | organonitrogen compound biosynthetic process | 4 | 3 |
Term | Name | Level | Count |
---|---|---|---|
GO:0003824 | catalytic activity | 1 | 36 |
GO:0004312 | fatty acid synthase activity | 5 | 36 |
GO:0009922 | fatty acid elongase activity | 6 | 36 |
GO:0016740 | transferase activity | 2 | 36 |
GO:0016746 | acyltransferase activity | 3 | 36 |
GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 36 |
GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 36 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_NRD_NRD_1 | 191 | 193 | PF00675 | 0.257 |
CLV_NRD_NRD_1 | 269 | 271 | PF00675 | 0.472 |
CLV_PCSK_KEX2_1 | 271 | 273 | PF00082 | 0.451 |
CLV_PCSK_PC1ET2_1 | 271 | 273 | PF00082 | 0.465 |
CLV_PCSK_SKI1_1 | 263 | 267 | PF00082 | 0.199 |
DEG_ODPH_VHL_1 | 198 | 210 | PF01847 | 0.395 |
DOC_MAPK_gen_1 | 137 | 143 | PF00069 | 0.433 |
DOC_MAPK_MEF2A_6 | 236 | 244 | PF00069 | 0.215 |
DOC_PP1_RVXF_1 | 136 | 143 | PF00149 | 0.445 |
DOC_PP4_FxxP_1 | 194 | 197 | PF00568 | 0.352 |
DOC_PP4_FxxP_1 | 47 | 50 | PF00568 | 0.334 |
DOC_WW_Pin1_4 | 271 | 276 | PF00397 | 0.617 |
LIG_Actin_RPEL_3 | 189 | 208 | PF02755 | 0.472 |
LIG_AP2alpha_1 | 28 | 32 | PF02296 | 0.352 |
LIG_APCC_ABBA_1 | 34 | 39 | PF00400 | 0.363 |
LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.342 |
LIG_BIR_III_3 | 1 | 5 | PF00653 | 0.424 |
LIG_eIF4E_1 | 157 | 163 | PF01652 | 0.385 |
LIG_eIF4E_1 | 59 | 65 | PF01652 | 0.516 |
LIG_FHA_1 | 111 | 117 | PF00498 | 0.240 |
LIG_FHA_1 | 128 | 134 | PF00498 | 0.278 |
LIG_FHA_1 | 148 | 154 | PF00498 | 0.294 |
LIG_FHA_1 | 212 | 218 | PF00498 | 0.311 |
LIG_FHA_1 | 252 | 258 | PF00498 | 0.426 |
LIG_FHA_1 | 78 | 84 | PF00498 | 0.365 |
LIG_FHA_1 | 98 | 104 | PF00498 | 0.331 |
LIG_FHA_2 | 24 | 30 | PF00498 | 0.238 |
LIG_LIR_Gen_1 | 126 | 135 | PF02991 | 0.279 |
LIG_LIR_Gen_1 | 247 | 257 | PF02991 | 0.277 |
LIG_LIR_Gen_1 | 29 | 40 | PF02991 | 0.287 |
LIG_LIR_Gen_1 | 73 | 81 | PF02991 | 0.263 |
LIG_LIR_Nem_3 | 111 | 117 | PF02991 | 0.243 |
LIG_LIR_Nem_3 | 126 | 131 | PF02991 | 0.297 |
LIG_LIR_Nem_3 | 152 | 157 | PF02991 | 0.332 |
LIG_LIR_Nem_3 | 178 | 184 | PF02991 | 0.293 |
LIG_LIR_Nem_3 | 220 | 226 | PF02991 | 0.293 |
LIG_LIR_Nem_3 | 247 | 252 | PF02991 | 0.276 |
LIG_LIR_Nem_3 | 25 | 31 | PF02991 | 0.295 |
LIG_LIR_Nem_3 | 254 | 259 | PF02991 | 0.271 |
LIG_LIR_Nem_3 | 39 | 45 | PF02991 | 0.221 |
LIG_LIR_Nem_3 | 73 | 77 | PF02991 | 0.336 |
LIG_NRBOX | 5 | 11 | PF00104 | 0.270 |
LIG_Pex14_1 | 115 | 119 | PF04695 | 0.199 |
LIG_Pex14_1 | 156 | 160 | PF04695 | 0.209 |
LIG_Pex14_2 | 128 | 132 | PF04695 | 0.429 |
LIG_Pex14_2 | 252 | 256 | PF04695 | 0.299 |
LIG_Pex14_2 | 28 | 32 | PF04695 | 0.280 |
LIG_Rb_pABgroove_1 | 122 | 130 | PF01858 | 0.195 |
LIG_SH2_CRK | 160 | 164 | PF00017 | 0.323 |
LIG_SH2_CRK | 223 | 227 | PF00017 | 0.304 |
LIG_SH2_NCK_1 | 160 | 164 | PF00017 | 0.170 |
LIG_SH2_PTP2 | 42 | 45 | PF00017 | 0.332 |
LIG_SH2_STAP1 | 160 | 164 | PF00017 | 0.264 |
LIG_SH2_STAP1 | 219 | 223 | PF00017 | 0.311 |
LIG_SH2_STAP1 | 37 | 41 | PF00017 | 0.343 |
LIG_SH2_STAT5 | 102 | 105 | PF00017 | 0.279 |
LIG_SH2_STAT5 | 160 | 163 | PF00017 | 0.250 |
LIG_SH2_STAT5 | 181 | 184 | PF00017 | 0.307 |
LIG_SH2_STAT5 | 219 | 222 | PF00017 | 0.299 |
LIG_SH2_STAT5 | 225 | 228 | PF00017 | 0.251 |
LIG_SH2_STAT5 | 248 | 251 | PF00017 | 0.292 |
LIG_SH2_STAT5 | 31 | 34 | PF00017 | 0.242 |
LIG_SH2_STAT5 | 42 | 45 | PF00017 | 0.280 |
LIG_SH2_STAT5 | 63 | 66 | PF00017 | 0.516 |
LIG_SH3_3 | 194 | 200 | PF00018 | 0.424 |
LIG_SUMO_SIM_anti_2 | 214 | 220 | PF11976 | 0.362 |
LIG_SUMO_SIM_par_1 | 214 | 220 | PF11976 | 0.250 |
LIG_TRAF2_1 | 90 | 93 | PF00917 | 0.170 |
LIG_TYR_ITIM | 35 | 40 | PF00017 | 0.232 |
LIG_UBA3_1 | 116 | 123 | PF00899 | 0.347 |
LIG_UBA3_1 | 255 | 263 | PF00899 | 0.311 |
LIG_UBA3_1 | 44 | 51 | PF00899 | 0.316 |
LIG_WRC_WIRS_1 | 218 | 223 | PF05994 | 0.347 |
MOD_CK1_1 | 73 | 79 | PF00069 | 0.323 |
MOD_CK2_1 | 87 | 93 | PF00069 | 0.316 |
MOD_GlcNHglycan | 164 | 167 | PF01048 | 0.444 |
MOD_GSK3_1 | 158 | 165 | PF00069 | 0.274 |
MOD_GSK3_1 | 73 | 80 | PF00069 | 0.321 |
MOD_NEK2_1 | 119 | 124 | PF00069 | 0.303 |
MOD_NEK2_1 | 127 | 132 | PF00069 | 0.300 |
MOD_NEK2_1 | 133 | 138 | PF00069 | 0.290 |
MOD_NEK2_1 | 149 | 154 | PF00069 | 0.222 |
MOD_NEK2_1 | 162 | 167 | PF00069 | 0.242 |
MOD_NEK2_1 | 185 | 190 | PF00069 | 0.375 |
MOD_NEK2_1 | 244 | 249 | PF00069 | 0.273 |
MOD_NEK2_1 | 251 | 256 | PF00069 | 0.269 |
MOD_NEK2_1 | 70 | 75 | PF00069 | 0.311 |
MOD_NEK2_1 | 77 | 82 | PF00069 | 0.301 |
MOD_NEK2_1 | 96 | 101 | PF00069 | 0.207 |
MOD_NEK2_2 | 97 | 102 | PF00069 | 0.278 |
MOD_PIKK_1 | 14 | 20 | PF00454 | 0.287 |
MOD_Plk_1 | 110 | 116 | PF00069 | 0.212 |
MOD_Plk_1 | 97 | 103 | PF00069 | 0.235 |
MOD_Plk_4 | 110 | 116 | PF00069 | 0.235 |
MOD_Plk_4 | 127 | 133 | PF00069 | 0.210 |
MOD_Plk_4 | 149 | 155 | PF00069 | 0.306 |
MOD_Plk_4 | 158 | 164 | PF00069 | 0.294 |
MOD_Plk_4 | 175 | 181 | PF00069 | 0.266 |
MOD_Plk_4 | 211 | 217 | PF00069 | 0.260 |
MOD_Plk_4 | 23 | 29 | PF00069 | 0.317 |
MOD_Plk_4 | 244 | 250 | PF00069 | 0.278 |
MOD_Plk_4 | 251 | 257 | PF00069 | 0.280 |
MOD_Plk_4 | 70 | 76 | PF00069 | 0.329 |
MOD_ProDKin_1 | 271 | 277 | PF00069 | 0.618 |
TRG_ENDOCYTIC_2 | 146 | 149 | PF00928 | 0.304 |
TRG_ENDOCYTIC_2 | 160 | 163 | PF00928 | 0.274 |
TRG_ENDOCYTIC_2 | 183 | 186 | PF00928 | 0.290 |
TRG_ENDOCYTIC_2 | 223 | 226 | PF00928 | 0.297 |
TRG_ENDOCYTIC_2 | 248 | 251 | PF00928 | 0.270 |
TRG_ENDOCYTIC_2 | 31 | 34 | PF00928 | 0.243 |
TRG_ENDOCYTIC_2 | 37 | 40 | PF00928 | 0.283 |
TRG_ENDOCYTIC_2 | 42 | 45 | PF00928 | 0.288 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0C5PHQ7 | Tachysurus fulvidraco | 27% | 100% |
A0A0N0P5E5 | Leptomonas seymouri | 68% | 100% |
A0A0N0P7D1 | Leptomonas seymouri | 39% | 90% |
A0A0N0P7D6 | Leptomonas seymouri | 31% | 100% |
A0A0N0P7R2 | Leptomonas seymouri | 44% | 99% |
A0A0N1HZJ8 | Leptomonas seymouri | 35% | 93% |
A0A0N1I9H5 | Leptomonas seymouri | 32% | 100% |
A0A0N1ILQ4 | Leptomonas seymouri | 39% | 100% |
A0A0N1IM10 | Leptomonas seymouri | 29% | 100% |
A0A0N1PDR8 | Leptomonas seymouri | 49% | 100% |
A0A0S4IS29 | Bodo saltans | 47% | 100% |
A0A0S4IVJ6 | Bodo saltans | 34% | 95% |
A0A0S4IVS6 | Bodo saltans | 43% | 100% |
A0A0S4IW98 | Bodo saltans | 43% | 95% |
A0A0S4J4C4 | Bodo saltans | 28% | 100% |
A0A0S4JH58 | Bodo saltans | 27% | 100% |
A0A1X0NNK7 | Trypanosomatidae | 54% | 100% |
A0A1X0NNM4 | Trypanosomatidae | 39% | 100% |
A0A1X0NNM5 | Trypanosomatidae | 40% | 98% |
A0A1X0NP89 | Trypanosomatidae | 35% | 94% |
A0A1X0NUJ4 | Trypanosomatidae | 29% | 83% |
A0A3Q8I8T7 | Leishmania donovani | 36% | 77% |
A0A3Q8I9T2 | Leishmania donovani | 36% | 80% |
A0A3Q8I9U9 | Leishmania donovani | 36% | 92% |
A0A3Q8I9X8 | Leishmania donovani | 40% | 90% |
A0A3Q8IC05 | Leishmania donovani | 92% | 99% |
A0A3Q8ID51 | Leishmania donovani | 33% | 76% |
A0A3Q8IIA9 | Leishmania donovani | 31% | 100% |
A0A3R7KG78 | Trypanosoma rangeli | 57% | 100% |
A0A3R7MJR2 | Trypanosoma rangeli | 40% | 100% |
A0A3R7NSQ3 | Trypanosoma rangeli | 38% | 100% |
A0A3S5H5M3 | Leishmania donovani | 34% | 100% |
A0A3S5H6R7 | Leishmania donovani | 33% | 100% |
A0A3S5H6R8 | Leishmania donovani | 37% | 100% |
A0A3S7WSY8 | Leishmania donovani | 31% | 100% |
A0A3S7WSZ1 | Leishmania donovani | 40% | 100% |
A0A3S7WT03 | Leishmania donovani | 42% | 100% |
A0A3S7WT16 | Leishmania donovani | 36% | 93% |
A0A422NNP1 | Trypanosoma rangeli | 46% | 100% |
A0A422NYI1 | Trypanosoma rangeli | 27% | 100% |
A0JNC4 | Bos taurus | 30% | 100% |
A4H4G1 | Leishmania braziliensis | 35% | 100% |
A4H7M2 | Leishmania braziliensis | 34% | 100% |
A4H7M3 | Leishmania braziliensis | 32% | 100% |
A4H7M4 | Leishmania braziliensis | 31% | 99% |
A4H7M5 | Leishmania braziliensis | 33% | 100% |
A4H7M6 | Leishmania braziliensis | 41% | 100% |
A4H7M7 | Leishmania braziliensis | 36% | 100% |
A4H7M8 | Leishmania braziliensis | 33% | 100% |
A4H7M9 | Leishmania braziliensis | 34% | 100% |
A4H7N0 | Leishmania braziliensis | 74% | 100% |
A4HSN8 | Leishmania infantum | 34% | 100% |
A4HW07 | Leishmania infantum | 31% | 100% |
A4HW08 | Leishmania infantum | 33% | 100% |
A4HW09 | Leishmania infantum | 31% | 100% |
A4HW10 | Leishmania infantum | 37% | 100% |
A4HW12 | Leishmania infantum | 40% | 90% |
A4HW13 | Leishmania infantum | 36% | 92% |
A4HW14 | Leishmania infantum | 36% | 93% |
A4HW15 | Leishmania infantum | 36% | 80% |
A4HW16 | Leishmania infantum | 33% | 80% |
A4HW17 | Leishmania infantum | 36% | 77% |
A4HW18 | Leishmania infantum | 92% | 99% |
B4QVX4 | Drosophila simulans | 29% | 100% |
C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 40% | 100% |
C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 40% | 100% |
C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 37% | 98% |
D4A612 | Rattus norvegicus | 28% | 100% |
D4ADY9 | Rattus norvegicus | 32% | 100% |
E8NHR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 38% | 100% |
E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
E9AGL0 | Leishmania infantum | 42% | 100% |
E9AGL2 | Leishmania infantum | 40% | 100% |
E9AKM3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
E9APR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 100% |
E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 100% |
E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 100% |
E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
E9B2P1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 79% |
G5EEE5 | Caenorhabditis elegans | 29% | 100% |
O35949 | Mus musculus | 34% | 100% |
P25358 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 28% | 87% |
P39540 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 25% | 97% |
P40319 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 30% | 87% |
P49191 | Caenorhabditis elegans | 36% | 94% |
Q20300 | Caenorhabditis elegans | 32% | 100% |
Q20303 | Caenorhabditis elegans | 33% | 100% |
Q2KJD9 | Bos taurus | 32% | 100% |
Q32NI8 | Xenopus laevis | 27% | 100% |
Q3S8M4 | Macaca mulatta | 28% | 96% |
Q4Q5G6 | Leishmania major | 28% | 79% |
Q4QFQ9 | Leishmania major | 91% | 100% |
Q4QFR0 | Leishmania major | 35% | 100% |
Q4QFR1 | Leishmania major | 32% | 100% |
Q4QFR2 | Leishmania major | 36% | 100% |
Q4QFR3 | Leishmania major | 35% | 100% |
Q4QFR4 | Leishmania major | 34% | 100% |
Q4QFR5 | Leishmania major | 40% | 100% |
Q4QFR6 | Leishmania major | 41% | 100% |
Q4QFR7 | Leishmania major | 37% | 100% |
Q4QFR8 | Leishmania major | 32% | 100% |
Q4QFR9 | Leishmania major | 32% | 100% |
Q4QFS0 | Leishmania major | 31% | 100% |
Q4QJ85 | Leishmania major | 34% | 100% |
Q4R516 | Macaca fascicularis | 30% | 100% |
Q5M8U1 | Xenopus tropicalis | 27% | 100% |
Q5RFL5 | Pongo abelii | 31% | 100% |
Q5ZJR8 | Gallus gallus | 39% | 100% |
Q6PC64 | Danio rerio | 37% | 100% |
Q8BHI7 | Mus musculus | 31% | 100% |
Q920L5 | Mus musculus | 37% | 100% |
Q920L6 | Rattus norvegicus | 37% | 100% |
Q920L7 | Rattus norvegicus | 31% | 100% |
Q95K73 | Macaca fascicularis | 28% | 96% |
Q9BW60 | Homo sapiens | 30% | 100% |
Q9D2Y9 | Mus musculus | 32% | 100% |
Q9EQC4 | Mus musculus | 27% | 96% |
Q9GZR5 | Homo sapiens | 27% | 96% |
Q9H5J4 | Homo sapiens | 35% | 100% |
Q9HB03 | Homo sapiens | 30% | 100% |
Q9JLJ4 | Mus musculus | 28% | 100% |
Q9JLJ5 | Mus musculus | 30% | 100% |
Q9NXB9 | Homo sapiens | 28% | 100% |
Q9NYP7 | Homo sapiens | 30% | 100% |
Q9UTF7 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 29% | 90% |
Q9VH58 | Drosophila melanogaster | 29% | 100% |
Q9VHX7 | Drosophila melanogaster | 26% | 91% |
Q9VV87 | Drosophila melanogaster | 36% | 95% |
Q9XVQ9 | Caenorhabditis elegans | 36% | 100% |
V5BE99 | Trypanosoma cruzi | 54% | 100% |
V5BIX9 | Trypanosoma cruzi | 40% | 100% |
V5BND3 | Trypanosoma cruzi | 44% | 100% |
V5DF68 | Trypanosoma cruzi | 38% | 100% |