LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania mexicana
UniProt:
E9APR8_LEIMU
TriTrypDb:
LmxM.14.0730 *
Length:
385

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 68
NetGPI no yes: 0, no: 69
Cellular components
Term Name Level Count
GO:0016020 membrane 2 60
GO:0110165 cellular anatomical entity 1 63
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

E9APR8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APR8

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 70
GO:0006629 lipid metabolic process 3 70
GO:0006631 fatty acid metabolic process 4 70
GO:0006633 fatty acid biosynthetic process 5 70
GO:0008152 metabolic process 1 70
GO:0008610 lipid biosynthetic process 4 70
GO:0009058 biosynthetic process 2 70
GO:0009987 cellular process 1 70
GO:0016053 organic acid biosynthetic process 4 70
GO:0019752 carboxylic acid metabolic process 5 70
GO:0032787 monocarboxylic acid metabolic process 6 70
GO:0043436 oxoacid metabolic process 4 70
GO:0044237 cellular metabolic process 2 70
GO:0044238 primary metabolic process 2 70
GO:0044249 cellular biosynthetic process 3 70
GO:0044255 cellular lipid metabolic process 3 70
GO:0044281 small molecule metabolic process 2 70
GO:0044283 small molecule biosynthetic process 3 70
GO:0046394 carboxylic acid biosynthetic process 5 70
GO:0071704 organic substance metabolic process 2 70
GO:0072330 monocarboxylic acid biosynthetic process 6 70
GO:1901576 organic substance biosynthetic process 3 70
GO:0000038 very long-chain fatty acid metabolic process 5 10
GO:0006643 membrane lipid metabolic process 4 10
GO:0006665 sphingolipid metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0019367 fatty acid elongation, saturated fatty acid 7 10
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 10
GO:0030148 sphingolipid biosynthetic process 5 10
GO:0030497 fatty acid elongation 6 10
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 10
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 10
GO:0042761 very long-chain fatty acid biosynthetic process 6 10
GO:0046467 membrane lipid biosynthetic process 4 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901566 organonitrogen compound biosynthetic process 4 10
GO:0001676 long-chain fatty acid metabolic process 5 2
GO:0042759 long-chain fatty acid biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 70
GO:0004312 fatty acid synthase activity 5 70
GO:0009922 fatty acid elongase activity 6 70
GO:0016740 transferase activity 2 70
GO:0016746 acyltransferase activity 3 70
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 70
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 70

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 108 110 PF00675 0.373
CLV_NRD_NRD_1 183 185 PF00675 0.320
CLV_NRD_NRD_1 238 240 PF00675 0.279
CLV_NRD_NRD_1 54 56 PF00675 0.322
CLV_PCSK_KEX2_1 108 110 PF00082 0.372
CLV_PCSK_KEX2_1 357 359 PF00082 0.310
CLV_PCSK_KEX2_1 376 378 PF00082 0.437
CLV_PCSK_KEX2_1 54 56 PF00082 0.326
CLV_PCSK_PC1ET2_1 357 359 PF00082 0.313
CLV_PCSK_PC1ET2_1 376 378 PF00082 0.463
CLV_PCSK_SKI1_1 24 28 PF00082 0.644
DOC_CKS1_1 12 17 PF01111 0.242
DOC_CKS1_1 169 174 PF01111 0.476
DOC_CYCLIN_RxL_1 348 356 PF00134 0.350
DOC_CYCLIN_yClb5_NLxxxL_5 65 74 PF00134 0.366
DOC_MAPK_MEF2A_6 243 251 PF00069 0.492
DOC_MAPK_RevD_3 40 55 PF00069 0.189
DOC_PP1_RVXF_1 183 190 PF00149 0.467
DOC_USP7_MATH_1 209 213 PF00917 0.332
DOC_USP7_MATH_1 308 312 PF00917 0.208
DOC_USP7_UBL2_3 95 99 PF12436 0.155
DOC_WW_Pin1_4 11 16 PF00397 0.401
DOC_WW_Pin1_4 123 128 PF00397 0.357
DOC_WW_Pin1_4 168 173 PF00397 0.476
DOC_WW_Pin1_4 369 374 PF00397 0.615
LIG_14-3-3_CanoR_1 142 147 PF00244 0.244
LIG_14-3-3_CanoR_1 159 169 PF00244 0.225
LIG_14-3-3_CanoR_1 184 190 PF00244 0.529
LIG_14-3-3_CanoR_1 368 373 PF00244 0.582
LIG_Actin_WH2_2 226 241 PF00022 0.441
LIG_BIR_II_1 1 5 PF00653 0.310
LIG_BIR_III_2 28 32 PF00653 0.171
LIG_BRCT_BRCA1_1 109 113 PF00533 0.167
LIG_BRCT_BRCA1_1 318 322 PF00533 0.215
LIG_CORNRBOX 40 48 PF00104 0.151
LIG_deltaCOP1_diTrp_1 6 11 PF00928 0.463
LIG_eIF4E_1 228 234 PF01652 0.373
LIG_FHA_1 145 151 PF00498 0.336
LIG_FHA_1 169 175 PF00498 0.323
LIG_FHA_1 35 41 PF00498 0.226
LIG_FHA_1 376 382 PF00498 0.688
LIG_FHA_1 60 66 PF00498 0.554
LIG_FHA_1 88 94 PF00498 0.287
LIG_FHA_2 143 149 PF00498 0.294
LIG_GBD_Chelix_1 196 204 PF00786 0.205
LIG_GBD_Chelix_1 70 78 PF00786 0.183
LIG_KLC1_Yacidic_2 352 356 PF13176 0.405
LIG_LIR_Apic_2 152 158 PF02991 0.273
LIG_LIR_Gen_1 100 107 PF02991 0.150
LIG_LIR_Gen_1 163 174 PF02991 0.338
LIG_LIR_Gen_1 176 187 PF02991 0.310
LIG_LIR_Gen_1 198 209 PF02991 0.448
LIG_LIR_Gen_1 225 234 PF02991 0.421
LIG_LIR_Gen_1 264 273 PF02991 0.393
LIG_LIR_Gen_1 341 350 PF02991 0.316
LIG_LIR_Gen_1 80 88 PF02991 0.327
LIG_LIR_Nem_3 100 105 PF02991 0.159
LIG_LIR_Nem_3 163 169 PF02991 0.310
LIG_LIR_Nem_3 176 182 PF02991 0.327
LIG_LIR_Nem_3 198 204 PF02991 0.396
LIG_LIR_Nem_3 225 231 PF02991 0.320
LIG_LIR_Nem_3 264 269 PF02991 0.337
LIG_LIR_Nem_3 280 285 PF02991 0.257
LIG_LIR_Nem_3 291 297 PF02991 0.175
LIG_LIR_Nem_3 32 36 PF02991 0.362
LIG_LIR_Nem_3 341 345 PF02991 0.296
LIG_LIR_Nem_3 80 84 PF02991 0.388
LIG_Pex14_1 203 207 PF04695 0.451
LIG_Pex14_2 222 226 PF04695 0.435
LIG_Pex14_2 346 350 PF04695 0.328
LIG_Pex14_2 88 92 PF04695 0.331
LIG_PTB_Apo_2 117 124 PF02174 0.171
LIG_PTB_Apo_2 289 296 PF02174 0.175
LIG_PTB_Phospho_1 117 123 PF10480 0.171
LIG_PTB_Phospho_1 289 295 PF10480 0.184
LIG_REV1ctd_RIR_1 280 288 PF16727 0.190
LIG_SH2_CRK 102 106 PF00017 0.341
LIG_SH2_CRK 155 159 PF00017 0.294
LIG_SH2_CRK 162 166 PF00017 0.370
LIG_SH2_CRK 342 346 PF00017 0.231
LIG_SH2_CRK 36 40 PF00017 0.352
LIG_SH2_CRK 81 85 PF00017 0.305
LIG_SH2_PTP2 201 204 PF00017 0.467
LIG_SH2_PTP2 262 265 PF00017 0.464
LIG_SH2_SRC 123 126 PF00017 0.347
LIG_SH2_SRC 41 44 PF00017 0.461
LIG_SH2_STAP1 146 150 PF00017 0.243
LIG_SH2_STAP1 162 166 PF00017 0.255
LIG_SH2_STAP1 36 40 PF00017 0.387
LIG_SH2_STAP1 5 9 PF00017 0.286
LIG_SH2_STAT3 146 149 PF00017 0.177
LIG_SH2_STAT5 146 149 PF00017 0.270
LIG_SH2_STAT5 162 165 PF00017 0.298
LIG_SH2_STAT5 168 171 PF00017 0.336
LIG_SH2_STAT5 201 204 PF00017 0.353
LIG_SH2_STAT5 221 224 PF00017 0.279
LIG_SH2_STAT5 228 231 PF00017 0.330
LIG_SH2_STAT5 262 265 PF00017 0.339
LIG_SH2_STAT5 266 269 PF00017 0.325
LIG_SH2_STAT5 297 300 PF00017 0.202
LIG_SH2_STAT5 342 345 PF00017 0.317
LIG_SH2_STAT5 354 357 PF00017 0.462
LIG_SH2_STAT5 36 39 PF00017 0.315
LIG_SH2_STAT5 41 44 PF00017 0.315
LIG_SH2_STAT5 63 66 PF00017 0.580
LIG_SH3_3 241 247 PF00018 0.454
LIG_SH3_3 28 34 PF00018 0.369
LIG_SUMO_SIM_anti_2 73 80 PF11976 0.189
LIG_TRFH_1 271 275 PF08558 0.210
LIG_TYR_ITIM 39 44 PF00017 0.275
LIG_UBA3_1 165 170 PF00899 0.378
LIG_UBA3_1 178 185 PF00899 0.336
LIG_UBA3_1 235 240 PF00899 0.399
LIG_UBA3_1 345 351 PF00899 0.323
LIG_UBA3_1 87 95 PF00899 0.315
LIG_WRC_WIRS_1 223 228 PF05994 0.218
MOD_CDK_SPxxK_3 369 376 PF00069 0.662
MOD_CK1_1 302 308 PF00069 0.207
MOD_CK1_1 327 333 PF00069 0.318
MOD_CK1_1 73 79 PF00069 0.380
MOD_GlcNHglycan 21 24 PF01048 0.543
MOD_GlcNHglycan 211 214 PF01048 0.469
MOD_GlcNHglycan 48 51 PF01048 0.349
MOD_GSK3_1 103 110 PF00069 0.348
MOD_GSK3_1 14 21 PF00069 0.426
MOD_GSK3_1 299 306 PF00069 0.392
MOD_GSK3_1 73 80 PF00069 0.340
MOD_GSK3_1 93 100 PF00069 0.288
MOD_NEK2_1 131 136 PF00069 0.274
MOD_NEK2_1 174 179 PF00069 0.336
MOD_NEK2_1 18 23 PF00069 0.414
MOD_NEK2_1 222 227 PF00069 0.345
MOD_NEK2_1 238 243 PF00069 0.525
MOD_NEK2_1 261 266 PF00069 0.358
MOD_NEK2_1 338 343 PF00069 0.305
MOD_NEK2_1 46 51 PF00069 0.327
MOD_NEK2_1 59 64 PF00069 0.502
MOD_NEK2_1 70 75 PF00069 0.336
MOD_NEK2_1 87 92 PF00069 0.253
MOD_NEK2_1 97 102 PF00069 0.325
MOD_NEK2_2 103 108 PF00069 0.359
MOD_OFUCOSY 325 331 PF10250 0.396
MOD_PKA_1 108 114 PF00069 0.150
MOD_PKA_2 107 113 PF00069 0.344
MOD_PKA_2 141 147 PF00069 0.251
MOD_PKA_2 238 244 PF00069 0.419
MOD_PKA_2 308 314 PF00069 0.157
MOD_Plk_1 360 366 PF00069 0.694
MOD_Plk_1 59 65 PF00069 0.474
MOD_Plk_1 93 99 PF00069 0.299
MOD_Plk_4 174 180 PF00069 0.290
MOD_Plk_4 185 191 PF00069 0.468
MOD_Plk_4 203 209 PF00069 0.295
MOD_Plk_4 222 228 PF00069 0.275
MOD_Plk_4 261 267 PF00069 0.307
MOD_Plk_4 277 283 PF00069 0.277
MOD_Plk_4 299 305 PF00069 0.207
MOD_Plk_4 360 366 PF00069 0.680
MOD_Plk_4 70 76 PF00069 0.331
MOD_Plk_4 87 93 PF00069 0.255
MOD_ProDKin_1 11 17 PF00069 0.404
MOD_ProDKin_1 123 129 PF00069 0.357
MOD_ProDKin_1 168 174 PF00069 0.476
MOD_ProDKin_1 369 375 PF00069 0.615
TRG_ENDOCYTIC_2 102 105 PF00928 0.326
TRG_ENDOCYTIC_2 162 165 PF00928 0.263
TRG_ENDOCYTIC_2 193 196 PF00928 0.344
TRG_ENDOCYTIC_2 201 204 PF00928 0.358
TRG_ENDOCYTIC_2 207 210 PF00928 0.303
TRG_ENDOCYTIC_2 230 233 PF00928 0.319
TRG_ENDOCYTIC_2 262 265 PF00928 0.375
TRG_ENDOCYTIC_2 266 269 PF00928 0.354
TRG_ENDOCYTIC_2 342 345 PF00928 0.302
TRG_ENDOCYTIC_2 36 39 PF00928 0.316
TRG_ENDOCYTIC_2 41 44 PF00928 0.311
TRG_ENDOCYTIC_2 81 84 PF00928 0.342
TRG_ER_diArg_1 107 109 PF00400 0.164

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 34% 100%
A0A0N0P7D1 Leptomonas seymouri 29% 100%
A0A0N0P7D6 Leptomonas seymouri 27% 100%
A0A0N0P7R2 Leptomonas seymouri 32% 100%
A0A0N1HZJ8 Leptomonas seymouri 30% 100%
A0A0N1I9H5 Leptomonas seymouri 30% 100%
A0A0N1PDR8 Leptomonas seymouri 30% 100%
A0A0S4IS29 Bodo saltans 31% 100%
A0A0S4IVS6 Bodo saltans 29% 100%
A0A0S4IW98 Bodo saltans 30% 100%
A0A1X0NNK7 Trypanosomatidae 32% 100%
A0A1X0NNM4 Trypanosomatidae 27% 100%
A0A1X0NNM5 Trypanosomatidae 31% 100%
A0A1X0NP89 Trypanosomatidae 32% 100%
A0A3Q8I8T7 Leishmania donovani 90% 98%
A0A3Q8I9T2 Leishmania donovani 67% 100%
A0A3Q8I9U9 Leishmania donovani 32% 100%
A0A3Q8I9X8 Leishmania donovani 30% 100%
A0A3Q8IC05 Leishmania donovani 35% 100%
A0A3Q8ID51 Leishmania donovani 67% 97%
A0A3Q8IIA9 Leishmania donovani 28% 100%
A0A3R7KG78 Trypanosoma rangeli 33% 100%
A0A3S7WSY8 Leishmania donovani 28% 100%
A0A3S7WSZ1 Leishmania donovani 32% 100%
A0A3S7WT03 Leishmania donovani 31% 100%
A0A3S7WT16 Leishmania donovani 30% 100%
A0A422NNP1 Trypanosoma rangeli 28% 100%
A4H7M2 Leishmania braziliensis 29% 100%
A4H7M4 Leishmania braziliensis 27% 100%
A4H7M6 Leishmania braziliensis 31% 81%
A4H7M7 Leishmania braziliensis 29% 93%
A4H7M8 Leishmania braziliensis 62% 100%
A4H7M9 Leishmania braziliensis 78% 100%
A4H7N0 Leishmania braziliensis 36% 78%
A4HW07 Leishmania infantum 28% 100%
A4HW09 Leishmania infantum 28% 100%
A4HW12 Leishmania infantum 31% 100%
A4HW13 Leishmania infantum 32% 100%
A4HW14 Leishmania infantum 30% 100%
A4HW15 Leishmania infantum 67% 100%
A4HW16 Leishmania infantum 66% 100%
A4HW17 Leishmania infantum 88% 98%
A4HW18 Leishmania infantum 35% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
E9AGL0 Leishmania infantum 31% 100%
E9AGL2 Leishmania infantum 32% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 88%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 88%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 91%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 90%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 97%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
Q20300 Caenorhabditis elegans 26% 100%
Q4QFQ9 Leishmania major 34% 81%
Q4QFR0 Leishmania major 87% 100%
Q4QFR1 Leishmania major 67% 100%
Q4QFR2 Leishmania major 68% 100%
Q4QFR3 Leishmania major 30% 97%
Q4QFR4 Leishmania major 29% 91%
Q4QFR5 Leishmania major 31% 100%
Q4QFR6 Leishmania major 32% 88%
Q4QFR8 Leishmania major 28% 100%
Q4QFS0 Leishmania major 28% 100%
Q9VV87 Drosophila melanogaster 25% 100%
Q9XVQ9 Caenorhabditis elegans 26% 100%
V5BE99 Trypanosoma cruzi 33% 100%
V5BND3 Trypanosoma cruzi 33% 100%
V5DF68 Trypanosoma cruzi 28% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS