Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania mexicana

UniProt:

E9APR8_LEIMU

TriTrypDb:

LmxM.14.0730

Length:

385

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 68
NetGPI	no	yes: 0, no: 69

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	60
GO:0110165	cellular anatomical entity	1	63
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9APR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APR8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	70
GO:0006629	lipid metabolic process	3	70
GO:0006631	fatty acid metabolic process	4	70
GO:0006633	fatty acid biosynthetic process	5	70
GO:0008152	metabolic process	1	70
GO:0008610	lipid biosynthetic process	4	70
GO:0009058	biosynthetic process	2	70
GO:0009987	cellular process	1	70
GO:0016053	organic acid biosynthetic process	4	70
GO:0019752	carboxylic acid metabolic process	5	70
GO:0032787	monocarboxylic acid metabolic process	6	70
GO:0043436	oxoacid metabolic process	4	70
GO:0044237	cellular metabolic process	2	70
GO:0044238	primary metabolic process	2	70
GO:0044249	cellular biosynthetic process	3	70
GO:0044255	cellular lipid metabolic process	3	70
GO:0044281	small molecule metabolic process	2	70
GO:0044283	small molecule biosynthetic process	3	70
GO:0046394	carboxylic acid biosynthetic process	5	70
GO:0071704	organic substance metabolic process	2	70
GO:0072330	monocarboxylic acid biosynthetic process	6	70
GO:1901576	organic substance biosynthetic process	3	70
GO:0000038	very long-chain fatty acid metabolic process	5	10
GO:0006643	membrane lipid metabolic process	4	10
GO:0006665	sphingolipid metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0019367	fatty acid elongation, saturated fatty acid	7	10
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	10
GO:0030148	sphingolipid biosynthetic process	5	10
GO:0030497	fatty acid elongation	6	10
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	10
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	10
GO:0042761	very long-chain fatty acid biosynthetic process	6	10
GO:0046467	membrane lipid biosynthetic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:0001676	long-chain fatty acid metabolic process	5	2
GO:0042759	long-chain fatty acid biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	70
GO:0004312	fatty acid synthase activity	5	70
GO:0009922	fatty acid elongase activity	6	70
GO:0016740	transferase activity	2	70
GO:0016746	acyltransferase activity	3	70
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	70
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.373
CLV_NRD_NRD_1	183	185	PF00675	0.320
CLV_NRD_NRD_1	238	240	PF00675	0.279
CLV_NRD_NRD_1	54	56	PF00675	0.322
CLV_PCSK_KEX2_1	108	110	PF00082	0.372
CLV_PCSK_KEX2_1	357	359	PF00082	0.310
CLV_PCSK_KEX2_1	376	378	PF00082	0.437
CLV_PCSK_KEX2_1	54	56	PF00082	0.326
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.313
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.463
CLV_PCSK_SKI1_1	24	28	PF00082	0.644
DOC_CKS1_1	12	17	PF01111	0.242
DOC_CKS1_1	169	174	PF01111	0.476
DOC_CYCLIN_RxL_1	348	356	PF00134	0.350
DOC_CYCLIN_yClb5_NLxxxL_5	65	74	PF00134	0.366
DOC_MAPK_MEF2A_6	243	251	PF00069	0.492
DOC_MAPK_RevD_3	40	55	PF00069	0.189
DOC_PP1_RVXF_1	183	190	PF00149	0.467
DOC_USP7_MATH_1	209	213	PF00917	0.332
DOC_USP7_MATH_1	308	312	PF00917	0.208
DOC_USP7_UBL2_3	95	99	PF12436	0.155
DOC_WW_Pin1_4	11	16	PF00397	0.401
DOC_WW_Pin1_4	123	128	PF00397	0.357
DOC_WW_Pin1_4	168	173	PF00397	0.476
DOC_WW_Pin1_4	369	374	PF00397	0.615
LIG_14-3-3_CanoR_1	142	147	PF00244	0.244
LIG_14-3-3_CanoR_1	159	169	PF00244	0.225
LIG_14-3-3_CanoR_1	184	190	PF00244	0.529
LIG_14-3-3_CanoR_1	368	373	PF00244	0.582
LIG_Actin_WH2_2	226	241	PF00022	0.441
LIG_BIR_II_1	1	5	PF00653	0.310
LIG_BIR_III_2	28	32	PF00653	0.171
LIG_BRCT_BRCA1_1	109	113	PF00533	0.167
LIG_BRCT_BRCA1_1	318	322	PF00533	0.215
LIG_CORNRBOX	40	48	PF00104	0.151
LIG_deltaCOP1_diTrp_1	6	11	PF00928	0.463
LIG_eIF4E_1	228	234	PF01652	0.373
LIG_FHA_1	145	151	PF00498	0.336
LIG_FHA_1	169	175	PF00498	0.323
LIG_FHA_1	35	41	PF00498	0.226
LIG_FHA_1	376	382	PF00498	0.688
LIG_FHA_1	60	66	PF00498	0.554
LIG_FHA_1	88	94	PF00498	0.287
LIG_FHA_2	143	149	PF00498	0.294
LIG_GBD_Chelix_1	196	204	PF00786	0.205
LIG_GBD_Chelix_1	70	78	PF00786	0.183
LIG_KLC1_Yacidic_2	352	356	PF13176	0.405
LIG_LIR_Apic_2	152	158	PF02991	0.273
LIG_LIR_Gen_1	100	107	PF02991	0.150
LIG_LIR_Gen_1	163	174	PF02991	0.338
LIG_LIR_Gen_1	176	187	PF02991	0.310
LIG_LIR_Gen_1	198	209	PF02991	0.448
LIG_LIR_Gen_1	225	234	PF02991	0.421
LIG_LIR_Gen_1	264	273	PF02991	0.393
LIG_LIR_Gen_1	341	350	PF02991	0.316
LIG_LIR_Gen_1	80	88	PF02991	0.327
LIG_LIR_Nem_3	100	105	PF02991	0.159
LIG_LIR_Nem_3	163	169	PF02991	0.310
LIG_LIR_Nem_3	176	182	PF02991	0.327
LIG_LIR_Nem_3	198	204	PF02991	0.396
LIG_LIR_Nem_3	225	231	PF02991	0.320
LIG_LIR_Nem_3	264	269	PF02991	0.337
LIG_LIR_Nem_3	280	285	PF02991	0.257
LIG_LIR_Nem_3	291	297	PF02991	0.175
LIG_LIR_Nem_3	32	36	PF02991	0.362
LIG_LIR_Nem_3	341	345	PF02991	0.296
LIG_LIR_Nem_3	80	84	PF02991	0.388
LIG_Pex14_1	203	207	PF04695	0.451
LIG_Pex14_2	222	226	PF04695	0.435
LIG_Pex14_2	346	350	PF04695	0.328
LIG_Pex14_2	88	92	PF04695	0.331
LIG_PTB_Apo_2	117	124	PF02174	0.171
LIG_PTB_Apo_2	289	296	PF02174	0.175
LIG_PTB_Phospho_1	117	123	PF10480	0.171
LIG_PTB_Phospho_1	289	295	PF10480	0.184
LIG_REV1ctd_RIR_1	280	288	PF16727	0.190
LIG_SH2_CRK	102	106	PF00017	0.341
LIG_SH2_CRK	155	159	PF00017	0.294
LIG_SH2_CRK	162	166	PF00017	0.370
LIG_SH2_CRK	342	346	PF00017	0.231
LIG_SH2_CRK	36	40	PF00017	0.352
LIG_SH2_CRK	81	85	PF00017	0.305
LIG_SH2_PTP2	201	204	PF00017	0.467
LIG_SH2_PTP2	262	265	PF00017	0.464
LIG_SH2_SRC	123	126	PF00017	0.347
LIG_SH2_SRC	41	44	PF00017	0.461
LIG_SH2_STAP1	146	150	PF00017	0.243
LIG_SH2_STAP1	162	166	PF00017	0.255
LIG_SH2_STAP1	36	40	PF00017	0.387
LIG_SH2_STAP1	5	9	PF00017	0.286
LIG_SH2_STAT3	146	149	PF00017	0.177
LIG_SH2_STAT5	146	149	PF00017	0.270
LIG_SH2_STAT5	162	165	PF00017	0.298
LIG_SH2_STAT5	168	171	PF00017	0.336
LIG_SH2_STAT5	201	204	PF00017	0.353
LIG_SH2_STAT5	221	224	PF00017	0.279
LIG_SH2_STAT5	228	231	PF00017	0.330
LIG_SH2_STAT5	262	265	PF00017	0.339
LIG_SH2_STAT5	266	269	PF00017	0.325
LIG_SH2_STAT5	297	300	PF00017	0.202
LIG_SH2_STAT5	342	345	PF00017	0.317
LIG_SH2_STAT5	354	357	PF00017	0.462
LIG_SH2_STAT5	36	39	PF00017	0.315
LIG_SH2_STAT5	41	44	PF00017	0.315
LIG_SH2_STAT5	63	66	PF00017	0.580
LIG_SH3_3	241	247	PF00018	0.454
LIG_SH3_3	28	34	PF00018	0.369
LIG_SUMO_SIM_anti_2	73	80	PF11976	0.189
LIG_TRFH_1	271	275	PF08558	0.210
LIG_TYR_ITIM	39	44	PF00017	0.275
LIG_UBA3_1	165	170	PF00899	0.378
LIG_UBA3_1	178	185	PF00899	0.336
LIG_UBA3_1	235	240	PF00899	0.399
LIG_UBA3_1	345	351	PF00899	0.323
LIG_UBA3_1	87	95	PF00899	0.315
LIG_WRC_WIRS_1	223	228	PF05994	0.218
MOD_CDK_SPxxK_3	369	376	PF00069	0.662
MOD_CK1_1	302	308	PF00069	0.207
MOD_CK1_1	327	333	PF00069	0.318
MOD_CK1_1	73	79	PF00069	0.380
MOD_GlcNHglycan	21	24	PF01048	0.543
MOD_GlcNHglycan	211	214	PF01048	0.469
MOD_GlcNHglycan	48	51	PF01048	0.349
MOD_GSK3_1	103	110	PF00069	0.348
MOD_GSK3_1	14	21	PF00069	0.426
MOD_GSK3_1	299	306	PF00069	0.392
MOD_GSK3_1	73	80	PF00069	0.340
MOD_GSK3_1	93	100	PF00069	0.288
MOD_NEK2_1	131	136	PF00069	0.274
MOD_NEK2_1	174	179	PF00069	0.336
MOD_NEK2_1	18	23	PF00069	0.414
MOD_NEK2_1	222	227	PF00069	0.345
MOD_NEK2_1	238	243	PF00069	0.525
MOD_NEK2_1	261	266	PF00069	0.358
MOD_NEK2_1	338	343	PF00069	0.305
MOD_NEK2_1	46	51	PF00069	0.327
MOD_NEK2_1	59	64	PF00069	0.502
MOD_NEK2_1	70	75	PF00069	0.336
MOD_NEK2_1	87	92	PF00069	0.253
MOD_NEK2_1	97	102	PF00069	0.325
MOD_NEK2_2	103	108	PF00069	0.359
MOD_OFUCOSY	325	331	PF10250	0.396
MOD_PKA_1	108	114	PF00069	0.150
MOD_PKA_2	107	113	PF00069	0.344
MOD_PKA_2	141	147	PF00069	0.251
MOD_PKA_2	238	244	PF00069	0.419
MOD_PKA_2	308	314	PF00069	0.157
MOD_Plk_1	360	366	PF00069	0.694
MOD_Plk_1	59	65	PF00069	0.474
MOD_Plk_1	93	99	PF00069	0.299
MOD_Plk_4	174	180	PF00069	0.290
MOD_Plk_4	185	191	PF00069	0.468
MOD_Plk_4	203	209	PF00069	0.295
MOD_Plk_4	222	228	PF00069	0.275
MOD_Plk_4	261	267	PF00069	0.307
MOD_Plk_4	277	283	PF00069	0.277
MOD_Plk_4	299	305	PF00069	0.207
MOD_Plk_4	360	366	PF00069	0.680
MOD_Plk_4	70	76	PF00069	0.331
MOD_Plk_4	87	93	PF00069	0.255
MOD_ProDKin_1	11	17	PF00069	0.404
MOD_ProDKin_1	123	129	PF00069	0.357
MOD_ProDKin_1	168	174	PF00069	0.476
MOD_ProDKin_1	369	375	PF00069	0.615
TRG_ENDOCYTIC_2	102	105	PF00928	0.326
TRG_ENDOCYTIC_2	162	165	PF00928	0.263
TRG_ENDOCYTIC_2	193	196	PF00928	0.344
TRG_ENDOCYTIC_2	201	204	PF00928	0.358
TRG_ENDOCYTIC_2	207	210	PF00928	0.303
TRG_ENDOCYTIC_2	230	233	PF00928	0.319
TRG_ENDOCYTIC_2	262	265	PF00928	0.375
TRG_ENDOCYTIC_2	266	269	PF00928	0.354
TRG_ENDOCYTIC_2	342	345	PF00928	0.302
TRG_ENDOCYTIC_2	36	39	PF00928	0.316
TRG_ENDOCYTIC_2	41	44	PF00928	0.311
TRG_ENDOCYTIC_2	81	84	PF00928	0.342
TRG_ER_diArg_1	107	109	PF00400	0.164

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	34%	100%
A0A0N0P7D1	Leptomonas seymouri	29%	100%
A0A0N0P7D6	Leptomonas seymouri	27%	100%
A0A0N0P7R2	Leptomonas seymouri	32%	100%
A0A0N1HZJ8	Leptomonas seymouri	30%	100%
A0A0N1I9H5	Leptomonas seymouri	30%	100%
A0A0N1PDR8	Leptomonas seymouri	30%	100%
A0A0S4IS29	Bodo saltans	31%	100%
A0A0S4IVS6	Bodo saltans	29%	100%
A0A0S4IW98	Bodo saltans	30%	100%
A0A1X0NNK7	Trypanosomatidae	32%	100%
A0A1X0NNM4	Trypanosomatidae	27%	100%
A0A1X0NNM5	Trypanosomatidae	31%	100%
A0A1X0NP89	Trypanosomatidae	32%	100%
A0A3Q8I8T7	Leishmania donovani	90%	98%
A0A3Q8I9T2	Leishmania donovani	67%	100%
A0A3Q8I9U9	Leishmania donovani	32%	100%
A0A3Q8I9X8	Leishmania donovani	30%	100%
A0A3Q8IC05	Leishmania donovani	35%	100%
A0A3Q8ID51	Leishmania donovani	67%	97%
A0A3Q8IIA9	Leishmania donovani	28%	100%
A0A3R7KG78	Trypanosoma rangeli	33%	100%
A0A3S7WSY8	Leishmania donovani	28%	100%
A0A3S7WSZ1	Leishmania donovani	32%	100%
A0A3S7WT03	Leishmania donovani	31%	100%
A0A3S7WT16	Leishmania donovani	30%	100%
A0A422NNP1	Trypanosoma rangeli	28%	100%
A4H7M2	Leishmania braziliensis	29%	100%
A4H7M4	Leishmania braziliensis	27%	100%
A4H7M6	Leishmania braziliensis	31%	81%
A4H7M7	Leishmania braziliensis	29%	93%
A4H7M8	Leishmania braziliensis	62%	100%
A4H7M9	Leishmania braziliensis	78%	100%
A4H7N0	Leishmania braziliensis	36%	78%
A4HW07	Leishmania infantum	28%	100%
A4HW09	Leishmania infantum	28%	100%
A4HW12	Leishmania infantum	31%	100%
A4HW13	Leishmania infantum	32%	100%
A4HW14	Leishmania infantum	30%	100%
A4HW15	Leishmania infantum	67%	100%
A4HW16	Leishmania infantum	66%	100%
A4HW17	Leishmania infantum	88%	98%
A4HW18	Leishmania infantum	35%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
E9AGL0	Leishmania infantum	31%	100%
E9AGL2	Leishmania infantum	32%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	88%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	88%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	91%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	90%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	97%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q20300	Caenorhabditis elegans	26%	100%
Q4QFQ9	Leishmania major	34%	81%
Q4QFR0	Leishmania major	87%	100%
Q4QFR1	Leishmania major	67%	100%
Q4QFR2	Leishmania major	68%	100%
Q4QFR3	Leishmania major	30%	97%
Q4QFR4	Leishmania major	29%	91%
Q4QFR5	Leishmania major	31%	100%
Q4QFR6	Leishmania major	32%	88%
Q4QFR8	Leishmania major	28%	100%
Q4QFS0	Leishmania major	28%	100%
Q9VV87	Drosophila melanogaster	25%	100%
Q9XVQ9	Caenorhabditis elegans	26%	100%
V5BE99	Trypanosoma cruzi	33%	100%
V5BND3	Trypanosoma cruzi	33%	100%
V5DF68	Trypanosoma cruzi	28%	100%