Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 48 |
| NetGPI | no | yes: 0, no: 48 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 44 |
| GO:0110165 | cellular anatomical entity | 1 | 46 |
| GO:0005737 | cytoplasm | 2 | 2 |
Related structures:
AlphaFold database: E9APR7
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 49 |
| GO:0006629 | lipid metabolic process | 3 | 49 |
| GO:0006631 | fatty acid metabolic process | 4 | 49 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 49 |
| GO:0008152 | metabolic process | 1 | 49 |
| GO:0008610 | lipid biosynthetic process | 4 | 49 |
| GO:0009058 | biosynthetic process | 2 | 49 |
| GO:0009987 | cellular process | 1 | 49 |
| GO:0016053 | organic acid biosynthetic process | 4 | 49 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 49 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 49 |
| GO:0043436 | oxoacid metabolic process | 4 | 49 |
| GO:0044237 | cellular metabolic process | 2 | 49 |
| GO:0044238 | primary metabolic process | 2 | 49 |
| GO:0044249 | cellular biosynthetic process | 3 | 49 |
| GO:0044255 | cellular lipid metabolic process | 3 | 49 |
| GO:0044281 | small molecule metabolic process | 2 | 49 |
| GO:0044283 | small molecule biosynthetic process | 3 | 49 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 49 |
| GO:0071704 | organic substance metabolic process | 2 | 49 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 49 |
| GO:1901576 | organic substance biosynthetic process | 3 | 49 |
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 5 |
| GO:0006643 | membrane lipid metabolic process | 4 | 5 |
| GO:0006665 | sphingolipid metabolic process | 4 | 5 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 5 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 5 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 5 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 5 |
| GO:0030497 | fatty acid elongation | 6 | 5 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 5 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 5 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 5 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 5 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 5 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 5 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 49 |
| GO:0004312 | fatty acid synthase activity | 5 | 49 |
| GO:0009922 | fatty acid elongase activity | 6 | 49 |
| GO:0016740 | transferase activity | 2 | 49 |
| GO:0016746 | acyltransferase activity | 3 | 49 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 49 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 49 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 123 | 127 | PF00656 | 0.374 |
| CLV_NRD_NRD_1 | 112 | 114 | PF00675 | 0.369 |
| CLV_NRD_NRD_1 | 147 | 149 | PF00675 | 0.369 |
| CLV_NRD_NRD_1 | 230 | 232 | PF00675 | 0.273 |
| CLV_PCSK_KEX2_1 | 112 | 114 | PF00082 | 0.369 |
| CLV_PCSK_KEX2_1 | 147 | 149 | PF00082 | 0.369 |
| CLV_PCSK_SKI1_1 | 277 | 281 | PF00082 | 0.462 |
| CLV_PCSK_SKI1_1 | 297 | 301 | PF00082 | 0.169 |
| DEG_Nend_UBRbox_2 | 1 | 3 | PF02207 | 0.307 |
| DOC_CDC14_PxL_1 | 78 | 86 | PF14671 | 0.273 |
| DOC_MAPK_gen_1 | 176 | 182 | PF00069 | 0.453 |
| DOC_MAPK_MEF2A_6 | 235 | 243 | PF00069 | 0.443 |
| DOC_PP1_RVXF_1 | 175 | 182 | PF00149 | 0.463 |
| DOC_PP2B_LxvP_1 | 236 | 239 | PF13499 | 0.338 |
| DOC_USP7_MATH_1 | 306 | 310 | PF00917 | 0.629 |
| DOC_WW_Pin1_4 | 105 | 110 | PF00397 | 0.371 |
| LIG_14-3-3_CanoR_1 | 102 | 108 | PF00244 | 0.314 |
| LIG_Actin_WH2_2 | 89 | 104 | PF00022 | 0.306 |
| LIG_APCC_ABBA_1 | 138 | 143 | PF00400 | 0.169 |
| LIG_BRCT_BRCA1_1 | 290 | 294 | PF00533 | 0.306 |
| LIG_BRCT_BRCA1_1 | 45 | 49 | PF00533 | 0.199 |
| LIG_BRCT_BRCA1_2 | 45 | 51 | PF00533 | 0.199 |
| LIG_EH1_1 | 185 | 193 | PF00400 | 0.330 |
| LIG_EH1_1 | 212 | 220 | PF00400 | 0.303 |
| LIG_FHA_1 | 167 | 173 | PF00498 | 0.288 |
| LIG_FHA_1 | 187 | 193 | PF00498 | 0.287 |
| LIG_FHA_1 | 3 | 9 | PF00498 | 0.379 |
| LIG_FHA_1 | 308 | 314 | PF00498 | 0.660 |
| LIG_FHA_1 | 58 | 64 | PF00498 | 0.529 |
| LIG_GBD_Chelix_1 | 33 | 41 | PF00786 | 0.309 |
| LIG_GBD_Chelix_1 | 63 | 71 | PF00786 | 0.396 |
| LIG_LIR_Gen_1 | 242 | 251 | PF02991 | 0.380 |
| LIG_LIR_Gen_1 | 285 | 294 | PF02991 | 0.310 |
| LIG_LIR_Gen_1 | 35 | 45 | PF02991 | 0.319 |
| LIG_LIR_Gen_1 | 62 | 72 | PF02991 | 0.299 |
| LIG_LIR_Nem_3 | 217 | 223 | PF02991 | 0.324 |
| LIG_LIR_Nem_3 | 242 | 246 | PF02991 | 0.319 |
| LIG_LIR_Nem_3 | 285 | 289 | PF02991 | 0.293 |
| LIG_LIR_Nem_3 | 318 | 322 | PF02991 | 0.529 |
| LIG_LIR_Nem_3 | 35 | 41 | PF02991 | 0.273 |
| LIG_LIR_Nem_3 | 62 | 68 | PF02991 | 0.297 |
| LIG_LIR_Nem_3 | 70 | 75 | PF02991 | 0.329 |
| LIG_NRBOX | 36 | 42 | PF00104 | 0.199 |
| LIG_PCNA_PIPBox_1 | 1 | 10 | PF02747 | 0.386 |
| LIG_Pex14_2 | 290 | 294 | PF04695 | 0.313 |
| LIG_PTB_Apo_2 | 313 | 320 | PF02174 | 0.673 |
| LIG_PTB_Phospho_1 | 313 | 319 | PF10480 | 0.669 |
| LIG_SH2_CRK | 79 | 83 | PF00017 | 0.309 |
| LIG_SH2_NCK_1 | 85 | 89 | PF00017 | 0.345 |
| LIG_SH2_PTP2 | 233 | 236 | PF00017 | 0.533 |
| LIG_SH2_PTP2 | 286 | 289 | PF00017 | 0.348 |
| LIG_SH2_STAT3 | 261 | 264 | PF00017 | 0.339 |
| LIG_SH2_STAT5 | 103 | 106 | PF00017 | 0.381 |
| LIG_SH2_STAT5 | 193 | 196 | PF00017 | 0.332 |
| LIG_SH2_STAT5 | 220 | 223 | PF00017 | 0.327 |
| LIG_SH2_STAT5 | 233 | 236 | PF00017 | 0.473 |
| LIG_SH2_STAT5 | 258 | 261 | PF00017 | 0.331 |
| LIG_SH2_STAT5 | 283 | 286 | PF00017 | 0.299 |
| LIG_SH2_STAT5 | 298 | 301 | PF00017 | 0.453 |
| LIG_SH2_STAT5 | 38 | 41 | PF00017 | 0.295 |
| LIG_SH2_STAT5 | 79 | 82 | PF00017 | 0.330 |
| LIG_SH3_3 | 113 | 119 | PF00018 | 0.355 |
| LIG_SH3_3 | 12 | 18 | PF00018 | 0.387 |
| LIG_SH3_3 | 85 | 91 | PF00018 | 0.309 |
| LIG_SUMO_SIM_anti_2 | 60 | 65 | PF11976 | 0.338 |
| LIG_SUMO_SIM_par_1 | 67 | 73 | PF11976 | 0.305 |
| LIG_TYR_ITIM | 284 | 289 | PF00017 | 0.328 |
| LIG_Vh1_VBS_1 | 30 | 48 | PF01044 | 0.183 |
| LIG_WRC_WIRS_1 | 240 | 245 | PF05994 | 0.389 |
| LIG_WRC_WIRS_1 | 71 | 76 | PF05994 | 0.393 |
| MOD_CDK_SPxxK_3 | 105 | 112 | PF00069 | 0.169 |
| MOD_CK1_1 | 133 | 139 | PF00069 | 0.264 |
| MOD_CK1_1 | 200 | 206 | PF00069 | 0.254 |
| MOD_CK1_1 | 70 | 76 | PF00069 | 0.358 |
| MOD_CK2_1 | 91 | 97 | PF00069 | 0.350 |
| MOD_CMANNOS | 195 | 198 | PF00535 | 0.199 |
| MOD_GlcNHglycan | 150 | 153 | PF01048 | 0.466 |
| MOD_GlcNHglycan | 203 | 206 | PF01048 | 0.465 |
| MOD_GlcNHglycan | 304 | 307 | PF01048 | 0.488 |
| MOD_GlcNHglycan | 93 | 96 | PF01048 | 0.461 |
| MOD_GSK3_1 | 126 | 133 | PF00069 | 0.260 |
| MOD_GSK3_1 | 197 | 204 | PF00069 | 0.318 |
| MOD_GSK3_1 | 302 | 309 | PF00069 | 0.620 |
| MOD_N-GLC_1 | 148 | 153 | PF02516 | 0.513 |
| MOD_NEK2_1 | 134 | 139 | PF00069 | 0.247 |
| MOD_NEK2_1 | 158 | 163 | PF00069 | 0.318 |
| MOD_NEK2_1 | 166 | 171 | PF00069 | 0.320 |
| MOD_NEK2_1 | 199 | 204 | PF00069 | 0.266 |
| MOD_NEK2_1 | 282 | 287 | PF00069 | 0.311 |
| MOD_NEK2_1 | 293 | 298 | PF00069 | 0.295 |
| MOD_NEK2_1 | 67 | 72 | PF00069 | 0.321 |
| MOD_PK_1 | 59 | 65 | PF00069 | 0.338 |
| MOD_PKA_1 | 300 | 306 | PF00069 | 0.460 |
| MOD_PKA_2 | 130 | 136 | PF00069 | 0.269 |
| MOD_PKA_2 | 271 | 277 | PF00069 | 0.246 |
| MOD_Plk_1 | 134 | 140 | PF00069 | 0.277 |
| MOD_Plk_4 | 186 | 192 | PF00069 | 0.321 |
| MOD_Plk_4 | 214 | 220 | PF00069 | 0.294 |
| MOD_Plk_4 | 250 | 256 | PF00069 | 0.286 |
| MOD_Plk_4 | 282 | 288 | PF00069 | 0.305 |
| MOD_Plk_4 | 45 | 51 | PF00069 | 0.288 |
| MOD_Plk_4 | 67 | 73 | PF00069 | 0.326 |
| MOD_ProDKin_1 | 105 | 111 | PF00069 | 0.371 |
| TRG_DiLeu_BaLyEn_6 | 236 | 241 | PF01217 | 0.458 |
| TRG_ENDOCYTIC_2 | 185 | 188 | PF00928 | 0.309 |
| TRG_ENDOCYTIC_2 | 222 | 225 | PF00928 | 0.309 |
| TRG_ENDOCYTIC_2 | 233 | 236 | PF00928 | 0.456 |
| TRG_ENDOCYTIC_2 | 286 | 289 | PF00928 | 0.300 |
| TRG_ENDOCYTIC_2 | 38 | 41 | PF00928 | 0.295 |
| TRG_ENDOCYTIC_2 | 78 | 81 | PF00928 | 0.313 |
| TRG_ENDOCYTIC_2 | 85 | 88 | PF00928 | 0.263 |
| TRG_ER_diArg_1 | 111 | 113 | PF00400 | 0.169 |
| TRG_ER_diArg_1 | 146 | 148 | PF00400 | 0.169 |
| TRG_ER_diArg_1 | 294 | 297 | PF00400 | 0.425 |
| TRG_ER_diLys_1 | 320 | 323 | PF00400 | 0.629 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0C5PHQ7 | Tachysurus fulvidraco | 23% | 100% |
| A0A0N0P5E5 | Leptomonas seymouri | 36% | 100% |
| A0A0N0P7D1 | Leptomonas seymouri | 48% | 97% |
| A0A0N0P7D6 | Leptomonas seymouri | 27% | 100% |
| A0A0N0P7R2 | Leptomonas seymouri | 44% | 100% |
| A0A0N1HZJ8 | Leptomonas seymouri | 37% | 100% |
| A0A0N1I9H5 | Leptomonas seymouri | 28% | 100% |
| A0A0N1ILQ4 | Leptomonas seymouri | 34% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 26% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 34% | 100% |
| A0A0S4IS29 | Bodo saltans | 41% | 100% |
| A0A0S4IVJ6 | Bodo saltans | 32% | 100% |
| A0A0S4IVS6 | Bodo saltans | 38% | 100% |
| A0A0S4IW98 | Bodo saltans | 40% | 100% |
| A0A1X0NNK7 | Trypanosomatidae | 38% | 100% |
| A0A1X0NNL0 | Trypanosomatidae | 36% | 100% |
| A0A1X0NNM4 | Trypanosomatidae | 32% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 48% | 100% |
| A0A1X0NP89 | Trypanosomatidae | 39% | 100% |
| A0A3Q8I8T7 | Leishmania donovani | 30% | 82% |
| A0A3Q8I9T2 | Leishmania donovani | 28% | 86% |
| A0A3Q8I9U9 | Leishmania donovani | 39% | 99% |
| A0A3Q8I9X8 | Leishmania donovani | 50% | 96% |
| A0A3Q8IC05 | Leishmania donovani | 36% | 100% |
| A0A3Q8ID51 | Leishmania donovani | 28% | 81% |
| A0A3Q8IIA9 | Leishmania donovani | 29% | 100% |
| A0A3R7KG78 | Trypanosoma rangeli | 40% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7NSQ3 | Trypanosoma rangeli | 32% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 28% | 100% |
| A0A3S5H6R8 | Leishmania donovani | 32% | 100% |
| A0A3S7WSY8 | Leishmania donovani | 29% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 44% | 100% |
| A0A3S7WT03 | Leishmania donovani | 46% | 100% |
| A0A3S7WT16 | Leishmania donovani | 91% | 100% |
| A0A422NNP1 | Trypanosoma rangeli | 45% | 100% |
| A1L3X0 | Homo sapiens | 28% | 100% |
| A4H7M2 | Leishmania braziliensis | 29% | 95% |
| A4H7M3 | Leishmania braziliensis | 28% | 89% |
| A4H7M4 | Leishmania braziliensis | 29% | 95% |
| A4H7M5 | Leishmania braziliensis | 33% | 100% |
| A4H7M6 | Leishmania braziliensis | 45% | 100% |
| A4H7M7 | Leishmania braziliensis | 76% | 100% |
| A4H7M8 | Leishmania braziliensis | 29% | 99% |
| A4H7M9 | Leishmania braziliensis | 32% | 100% |
| A4H7N0 | Leishmania braziliensis | 36% | 92% |
| A4HW07 | Leishmania infantum | 29% | 100% |
| A4HW08 | Leishmania infantum | 28% | 100% |
| A4HW09 | Leishmania infantum | 29% | 100% |
| A4HW10 | Leishmania infantum | 32% | 100% |
| A4HW12 | Leishmania infantum | 50% | 96% |
| A4HW13 | Leishmania infantum | 39% | 99% |
| A4HW14 | Leishmania infantum | 91% | 100% |
| A4HW15 | Leishmania infantum | 28% | 86% |
| A4HW16 | Leishmania infantum | 28% | 86% |
| A4HW17 | Leishmania infantum | 30% | 82% |
| A4HW18 | Leishmania infantum | 36% | 100% |
| C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 43% | 100% |
| C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
| C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 31% | 100% |
| D4ADY9 | Rattus norvegicus | 26% | 100% |
| E8NHR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
| E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |
| E9AGL0 | Leishmania infantum | 46% | 100% |
| E9AGL2 | Leishmania infantum | 44% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 94% |
| E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 86% |
| E9APR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 45% | 100% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 46% | 100% |
| E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 49% | 100% |
| E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 84% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
| G5EEE5 | Caenorhabditis elegans | 28% | 100% |
| O35949 | Mus musculus | 31% | 100% |
| P49191 | Caenorhabditis elegans | 33% | 100% |
| Q03574 | Caenorhabditis elegans | 27% | 100% |
| Q20300 | Caenorhabditis elegans | 27% | 100% |
| Q4QFQ9 | Leishmania major | 36% | 96% |
| Q4QFR0 | Leishmania major | 30% | 100% |
| Q4QFR1 | Leishmania major | 28% | 100% |
| Q4QFR2 | Leishmania major | 28% | 100% |
| Q4QFR3 | Leishmania major | 88% | 100% |
| Q4QFR4 | Leishmania major | 38% | 100% |
| Q4QFR5 | Leishmania major | 50% | 100% |
| Q4QFR6 | Leishmania major | 47% | 100% |
| Q4QFR7 | Leishmania major | 32% | 100% |
| Q4QFR8 | Leishmania major | 29% | 91% |
| Q4QFR9 | Leishmania major | 28% | 91% |
| Q4QFS0 | Leishmania major | 28% | 96% |
| Q5ZJR8 | Gallus gallus | 30% | 100% |
| Q6PC64 | Danio rerio | 31% | 100% |
| Q86JM5 | Dictyostelium discoideum | 30% | 100% |
| Q920L5 | Mus musculus | 28% | 100% |
| Q920L6 | Rattus norvegicus | 28% | 100% |
| Q9D2Y9 | Mus musculus | 27% | 100% |
| Q9H5J4 | Homo sapiens | 28% | 100% |
| Q9HB03 | Homo sapiens | 31% | 100% |
| Q9VV87 | Drosophila melanogaster | 32% | 100% |
| Q9XVQ9 | Caenorhabditis elegans | 27% | 100% |
| V5BE99 | Trypanosoma cruzi | 40% | 100% |
| V5BIX9 | Trypanosoma cruzi | 35% | 100% |
| V5BND3 | Trypanosoma cruzi | 47% | 100% |
| V5DF68 | Trypanosoma cruzi | 36% | 100% |