Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 1, no: 70 |
| NetGPI | no | yes: 0, no: 71 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 65 |
| GO:0110165 | cellular anatomical entity | 1 | 67 |
| GO:0005737 | cytoplasm | 2 | 2 |
Related structures:
AlphaFold database: E9APR6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 72 |
| GO:0006629 | lipid metabolic process | 3 | 72 |
| GO:0006631 | fatty acid metabolic process | 4 | 72 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 72 |
| GO:0008152 | metabolic process | 1 | 72 |
| GO:0008610 | lipid biosynthetic process | 4 | 72 |
| GO:0009058 | biosynthetic process | 2 | 72 |
| GO:0009987 | cellular process | 1 | 72 |
| GO:0016053 | organic acid biosynthetic process | 4 | 72 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 72 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 72 |
| GO:0043436 | oxoacid metabolic process | 4 | 72 |
| GO:0044237 | cellular metabolic process | 2 | 72 |
| GO:0044238 | primary metabolic process | 2 | 72 |
| GO:0044249 | cellular biosynthetic process | 3 | 72 |
| GO:0044255 | cellular lipid metabolic process | 3 | 72 |
| GO:0044281 | small molecule metabolic process | 2 | 72 |
| GO:0044283 | small molecule biosynthetic process | 3 | 72 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 72 |
| GO:0071704 | organic substance metabolic process | 2 | 72 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 72 |
| GO:1901576 | organic substance biosynthetic process | 3 | 72 |
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 7 |
| GO:0006643 | membrane lipid metabolic process | 4 | 7 |
| GO:0006665 | sphingolipid metabolic process | 4 | 7 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 7 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 7 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 7 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 7 |
| GO:0030497 | fatty acid elongation | 6 | 7 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 7 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 7 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 7 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 7 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 7 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 7 |
| GO:0001676 | long-chain fatty acid metabolic process | 5 | 1 |
| GO:0042759 | long-chain fatty acid biosynthetic process | 6 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 72 |
| GO:0004312 | fatty acid synthase activity | 5 | 72 |
| GO:0009922 | fatty acid elongase activity | 6 | 72 |
| GO:0016740 | transferase activity | 2 | 72 |
| GO:0016746 | acyltransferase activity | 3 | 72 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 72 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 72 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 239 | 241 | PF00675 | 0.268 |
| CLV_NRD_NRD_1 | 319 | 321 | PF00675 | 0.438 |
| CLV_PCSK_FUR_1 | 316 | 320 | PF00082 | 0.436 |
| CLV_PCSK_KEX2_1 | 312 | 314 | PF00082 | 0.285 |
| CLV_PCSK_KEX2_1 | 318 | 320 | PF00082 | 0.417 |
| CLV_PCSK_PC1ET2_1 | 312 | 314 | PF00082 | 0.284 |
| CLV_PCSK_SKI1_1 | 110 | 114 | PF00082 | 0.502 |
| CLV_PCSK_SKI1_1 | 152 | 156 | PF00082 | 0.450 |
| DEG_Nend_UBRbox_2 | 1 | 3 | PF02207 | 0.488 |
| DOC_CKS1_1 | 49 | 54 | PF01111 | 0.200 |
| DOC_MAPK_RevD_3 | 299 | 313 | PF00069 | 0.263 |
| DOC_USP7_MATH_1 | 206 | 210 | PF00917 | 0.417 |
| DOC_USP7_MATH_1 | 245 | 249 | PF00917 | 0.517 |
| DOC_USP7_MATH_1 | 4 | 8 | PF00917 | 0.327 |
| DOC_WW_Pin1_4 | 16 | 21 | PF00397 | 0.469 |
| DOC_WW_Pin1_4 | 45 | 50 | PF00397 | 0.259 |
| LIG_14-3-3_CanoR_1 | 110 | 115 | PF00244 | 0.328 |
| LIG_14-3-3_CanoR_1 | 244 | 250 | PF00244 | 0.515 |
| LIG_14-3-3_CanoR_1 | 270 | 276 | PF00244 | 0.305 |
| LIG_APCC_ABBA_1 | 301 | 306 | PF00400 | 0.362 |
| LIG_BRCT_BRCA1_1 | 169 | 173 | PF00533 | 0.253 |
| LIG_BRCT_BRCA1_1 | 22 | 26 | PF00533 | 0.244 |
| LIG_BRCT_BRCA1_1 | 284 | 288 | PF00533 | 0.344 |
| LIG_CSL_BTD_1 | 17 | 20 | PF09270 | 0.359 |
| LIG_EH_1 | 23 | 27 | PF12763 | 0.258 |
| LIG_EH1_1 | 216 | 224 | PF00400 | 0.305 |
| LIG_eIF4E_1 | 103 | 109 | PF01652 | 0.336 |
| LIG_FHA_1 | 164 | 170 | PF00498 | 0.316 |
| LIG_FHA_1 | 176 | 182 | PF00498 | 0.293 |
| LIG_FHA_1 | 266 | 272 | PF00498 | 0.313 |
| LIG_FHA_1 | 3 | 9 | PF00498 | 0.427 |
| LIG_FHA_1 | 49 | 55 | PF00498 | 0.211 |
| LIG_FHA_2 | 111 | 117 | PF00498 | 0.333 |
| LIG_FHA_2 | 127 | 133 | PF00498 | 0.326 |
| LIG_LIR_Gen_1 | 170 | 181 | PF02991 | 0.315 |
| LIG_LIR_Gen_1 | 295 | 304 | PF02991 | 0.311 |
| LIG_LIR_Nem_3 | 160 | 165 | PF02991 | 0.302 |
| LIG_LIR_Nem_3 | 177 | 183 | PF02991 | 0.315 |
| LIG_LIR_Nem_3 | 226 | 232 | PF02991 | 0.325 |
| LIG_LIR_Nem_3 | 285 | 291 | PF02991 | 0.304 |
| LIG_LIR_Nem_3 | 295 | 299 | PF02991 | 0.291 |
| LIG_MYND_1 | 120 | 124 | PF01753 | 0.305 |
| LIG_MYND_1 | 80 | 84 | PF01753 | 0.359 |
| LIG_Pex14_1 | 163 | 167 | PF04695 | 0.225 |
| LIG_Pex14_1 | 28 | 32 | PF04695 | 0.412 |
| LIG_Pex14_1 | 89 | 93 | PF04695 | 0.371 |
| LIG_Pex14_2 | 300 | 304 | PF04695 | 0.312 |
| LIG_PTB_Apo_2 | 87 | 94 | PF02174 | 0.360 |
| LIG_SH2_CRK | 103 | 107 | PF00017 | 0.308 |
| LIG_SH2_GRB2like | 149 | 152 | PF00017 | 0.223 |
| LIG_SH2_PTP2 | 296 | 299 | PF00017 | 0.350 |
| LIG_SH2_STAP1 | 267 | 271 | PF00017 | 0.337 |
| LIG_SH2_STAT5 | 103 | 106 | PF00017 | 0.298 |
| LIG_SH2_STAT5 | 229 | 232 | PF00017 | 0.327 |
| LIG_SH2_STAT5 | 267 | 270 | PF00017 | 0.322 |
| LIG_SH2_STAT5 | 272 | 275 | PF00017 | 0.271 |
| LIG_SH2_STAT5 | 293 | 296 | PF00017 | 0.308 |
| LIG_SH2_STAT5 | 308 | 311 | PF00017 | 0.459 |
| LIG_SH2_STAT5 | 32 | 35 | PF00017 | 0.307 |
| LIG_SH2_STAT5 | 59 | 62 | PF00017 | 0.303 |
| LIG_SH3_3 | 270 | 276 | PF00018 | 0.164 |
| LIG_SH3_3 | 46 | 52 | PF00018 | 0.342 |
| LIG_SUMO_SIM_anti_2 | 248 | 254 | PF11976 | 0.541 |
| LIG_SUMO_SIM_anti_2 | 51 | 57 | PF11976 | 0.225 |
| LIG_TYR_ITIM | 294 | 299 | PF00017 | 0.314 |
| LIG_WRC_WIRS_1 | 164 | 169 | PF05994 | 0.271 |
| MOD_CK1_1 | 209 | 215 | PF00069 | 0.232 |
| MOD_CK1_1 | 248 | 254 | PF00069 | 0.513 |
| MOD_CK1_1 | 282 | 288 | PF00069 | 0.315 |
| MOD_CK1_1 | 3 | 9 | PF00069 | 0.320 |
| MOD_CK1_1 | 48 | 54 | PF00069 | 0.318 |
| MOD_CK1_1 | 94 | 100 | PF00069 | 0.348 |
| MOD_CK2_1 | 112 | 118 | PF00069 | 0.213 |
| MOD_CK2_1 | 126 | 132 | PF00069 | 0.175 |
| MOD_GlcNHglycan | 2 | 5 | PF01048 | 0.529 |
| MOD_GlcNHglycan | 208 | 211 | PF01048 | 0.459 |
| MOD_GlcNHglycan | 280 | 284 | PF01048 | 0.472 |
| MOD_GSK3_1 | 16 | 23 | PF00069 | 0.448 |
| MOD_GSK3_1 | 163 | 170 | PF00069 | 0.358 |
| MOD_GSK3_1 | 2 | 9 | PF00069 | 0.472 |
| MOD_GSK3_1 | 278 | 285 | PF00069 | 0.275 |
| MOD_GSK3_1 | 91 | 98 | PF00069 | 0.349 |
| MOD_N-GLC_1 | 167 | 172 | PF02516 | 0.344 |
| MOD_NEK2_1 | 143 | 148 | PF00069 | 0.266 |
| MOD_NEK2_1 | 167 | 172 | PF00069 | 0.308 |
| MOD_NEK2_1 | 175 | 180 | PF00069 | 0.342 |
| MOD_NEK2_1 | 223 | 228 | PF00069 | 0.317 |
| MOD_NEK2_1 | 266 | 271 | PF00069 | 0.344 |
| MOD_NEK2_1 | 292 | 297 | PF00069 | 0.309 |
| MOD_NEK2_1 | 91 | 96 | PF00069 | 0.321 |
| MOD_PKA_1 | 319 | 325 | PF00069 | 0.591 |
| MOD_PKA_2 | 127 | 133 | PF00069 | 0.333 |
| MOD_PKA_2 | 319 | 325 | PF00069 | 0.650 |
| MOD_Plk_4 | 175 | 181 | PF00069 | 0.280 |
| MOD_Plk_4 | 195 | 201 | PF00069 | 0.312 |
| MOD_Plk_4 | 223 | 229 | PF00069 | 0.279 |
| MOD_Plk_4 | 245 | 251 | PF00069 | 0.463 |
| MOD_Plk_4 | 287 | 293 | PF00069 | 0.279 |
| MOD_ProDKin_1 | 16 | 22 | PF00069 | 0.463 |
| MOD_ProDKin_1 | 45 | 51 | PF00069 | 0.259 |
| MOD_SUMO_rev_2 | 317 | 325 | PF00179 | 0.713 |
| TRG_DiLeu_BaLyEn_6 | 49 | 54 | PF01217 | 0.373 |
| TRG_DiLeu_BaLyEn_6 | 69 | 74 | PF01217 | 0.532 |
| TRG_ENDOCYTIC_2 | 231 | 234 | PF00928 | 0.321 |
| TRG_ENDOCYTIC_2 | 296 | 299 | PF00928 | 0.294 |
| TRG_ENDOCYTIC_2 | 59 | 62 | PF00928 | 0.304 |
| TRG_ER_diArg_1 | 318 | 320 | PF00400 | 0.680 |
| TRG_Pf-PMV_PEXEL_1 | 152 | 156 | PF00026 | 0.581 |
| TRG_Pf-PMV_PEXEL_1 | 72 | 76 | PF00026 | 0.207 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P5E5 | Leptomonas seymouri | 38% | 100% |
| A0A0N0P7D1 | Leptomonas seymouri | 39% | 97% |
| A0A0N0P7D6 | Leptomonas seymouri | 28% | 100% |
| A0A0N0P7R2 | Leptomonas seymouri | 44% | 100% |
| A0A0N1HZJ8 | Leptomonas seymouri | 61% | 100% |
| A0A0N1I9H5 | Leptomonas seymouri | 31% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 25% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 35% | 100% |
| A0A0S4IS29 | Bodo saltans | 38% | 100% |
| A0A0S4IVJ6 | Bodo saltans | 29% | 100% |
| A0A0S4IVS6 | Bodo saltans | 37% | 100% |
| A0A0S4IW98 | Bodo saltans | 39% | 100% |
| A0A1X0NNK7 | Trypanosomatidae | 38% | 100% |
| A0A1X0NNL0 | Trypanosomatidae | 30% | 100% |
| A0A1X0NNM4 | Trypanosomatidae | 32% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 43% | 100% |
| A0A1X0NP89 | Trypanosomatidae | 40% | 100% |
| A0A3Q8I8T7 | Leishmania donovani | 31% | 83% |
| A0A3Q8I9T2 | Leishmania donovani | 30% | 87% |
| A0A3Q8I9U9 | Leishmania donovani | 93% | 100% |
| A0A3Q8I9X8 | Leishmania donovani | 39% | 97% |
| A0A3Q8ID51 | Leishmania donovani | 30% | 82% |
| A0A3Q8IIA9 | Leishmania donovani | 29% | 100% |
| A0A3R7KG78 | Trypanosoma rangeli | 37% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7NSQ3 | Trypanosoma rangeli | 34% | 100% |
| A0A3S5H5M3 | Leishmania donovani | 28% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 28% | 100% |
| A0A3S5H6R8 | Leishmania donovani | 31% | 100% |
| A0A3S7WSY8 | Leishmania donovani | 31% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 40% | 100% |
| A0A3S7WT03 | Leishmania donovani | 44% | 100% |
| A0A3S7WT16 | Leishmania donovani | 38% | 100% |
| A0A422NNP1 | Trypanosoma rangeli | 40% | 100% |
| A4H7M1 | Leishmania braziliensis | 21% | 96% |
| A4H7M2 | Leishmania braziliensis | 31% | 100% |
| A4H7M3 | Leishmania braziliensis | 28% | 92% |
| A4H7M4 | Leishmania braziliensis | 30% | 98% |
| A4H7M5 | Leishmania braziliensis | 32% | 99% |
| A4H7M6 | Leishmania braziliensis | 40% | 100% |
| A4H7M7 | Leishmania braziliensis | 39% | 100% |
| A4H7M8 | Leishmania braziliensis | 30% | 100% |
| A4H7M9 | Leishmania braziliensis | 29% | 100% |
| A4H7N0 | Leishmania braziliensis | 37% | 100% |
| A4HSN8 | Leishmania infantum | 28% | 100% |
| A4HW07 | Leishmania infantum | 31% | 100% |
| A4HW08 | Leishmania infantum | 28% | 100% |
| A4HW09 | Leishmania infantum | 29% | 100% |
| A4HW10 | Leishmania infantum | 31% | 100% |
| A4HW12 | Leishmania infantum | 37% | 97% |
| A4HW13 | Leishmania infantum | 93% | 100% |
| A4HW14 | Leishmania infantum | 39% | 100% |
| A4HW15 | Leishmania infantum | 30% | 87% |
| A4HW16 | Leishmania infantum | 30% | 87% |
| A4HW17 | Leishmania infantum | 31% | 83% |
| A4HW18 | Leishmania infantum | 36% | 100% |
| C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 41% | 100% |
| C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 100% |
| C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
| E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 100% |
| E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 100% |
| E9AGL0 | Leishmania infantum | 44% | 100% |
| E9AGL2 | Leishmania infantum | 40% | 100% |
| E9AKM3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 93% |
| E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 99% |
| E9APR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 93% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 43% | 100% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 43% | 100% |
| E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 84% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
| P49191 | Caenorhabditis elegans | 29% | 100% |
| Q20300 | Caenorhabditis elegans | 26% | 100% |
| Q4QFR0 | Leishmania major | 29% | 100% |
| Q4QFR1 | Leishmania major | 29% | 100% |
| Q4QFR2 | Leishmania major | 30% | 100% |
| Q4QFR3 | Leishmania major | 40% | 100% |
| Q4QFR4 | Leishmania major | 93% | 100% |
| Q4QFR5 | Leishmania major | 39% | 100% |
| Q4QFR6 | Leishmania major | 40% | 100% |
| Q4QFR7 | Leishmania major | 31% | 95% |
| Q4QFR8 | Leishmania major | 29% | 99% |
| Q4QFR9 | Leishmania major | 28% | 93% |
| Q4QFS0 | Leishmania major | 31% | 95% |
| Q4QJ85 | Leishmania major | 28% | 100% |
| Q4R516 | Macaca fascicularis | 24% | 100% |
| Q5M8U1 | Xenopus tropicalis | 23% | 100% |
| Q5RFL5 | Pongo abelii | 24% | 100% |
| Q5ZJR8 | Gallus gallus | 29% | 100% |
| Q6PC64 | Danio rerio | 27% | 100% |
| Q7LKX0 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 27% | 89% |
| Q920L5 | Mus musculus | 28% | 100% |
| Q920L6 | Rattus norvegicus | 28% | 100% |
| Q9H5J4 | Homo sapiens | 28% | 100% |
| Q9NYP7 | Homo sapiens | 24% | 100% |
| Q9VV87 | Drosophila melanogaster | 29% | 100% |
| Q9XVQ9 | Caenorhabditis elegans | 28% | 100% |
| V5BE99 | Trypanosoma cruzi | 37% | 100% |
| V5BIX9 | Trypanosoma cruzi | 35% | 100% |
| V5BND3 | Trypanosoma cruzi | 40% | 100% |
| V5DF68 | Trypanosoma cruzi | 31% | 100% |