Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 18 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 55 |
| NetGPI | no | yes: 0, no: 55 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 49 |
| GO:0110165 | cellular anatomical entity | 1 | 51 |
| GO:0005737 | cytoplasm | 2 | 2 |
Related structures:
AlphaFold database: E9APR5
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 56 |
| GO:0006629 | lipid metabolic process | 3 | 56 |
| GO:0006631 | fatty acid metabolic process | 4 | 56 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 56 |
| GO:0008152 | metabolic process | 1 | 56 |
| GO:0008610 | lipid biosynthetic process | 4 | 56 |
| GO:0009058 | biosynthetic process | 2 | 56 |
| GO:0009987 | cellular process | 1 | 56 |
| GO:0016053 | organic acid biosynthetic process | 4 | 56 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 56 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 56 |
| GO:0043436 | oxoacid metabolic process | 4 | 56 |
| GO:0044237 | cellular metabolic process | 2 | 56 |
| GO:0044238 | primary metabolic process | 2 | 56 |
| GO:0044249 | cellular biosynthetic process | 3 | 56 |
| GO:0044255 | cellular lipid metabolic process | 3 | 56 |
| GO:0044281 | small molecule metabolic process | 2 | 56 |
| GO:0044283 | small molecule biosynthetic process | 3 | 56 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 56 |
| GO:0071704 | organic substance metabolic process | 2 | 56 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 56 |
| GO:1901576 | organic substance biosynthetic process | 3 | 56 |
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 7 |
| GO:0006643 | membrane lipid metabolic process | 4 | 7 |
| GO:0006665 | sphingolipid metabolic process | 4 | 7 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 7 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 7 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 7 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 7 |
| GO:0030497 | fatty acid elongation | 6 | 7 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 7 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 7 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 7 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 7 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 7 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 7 |
| GO:0001676 | long-chain fatty acid metabolic process | 5 | 1 |
| GO:0042759 | long-chain fatty acid biosynthetic process | 6 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 56 |
| GO:0004312 | fatty acid synthase activity | 5 | 56 |
| GO:0009922 | fatty acid elongase activity | 6 | 56 |
| GO:0016740 | transferase activity | 2 | 56 |
| GO:0016746 | acyltransferase activity | 3 | 56 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 56 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 56 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 202 | 204 | PF00675 | 0.260 |
| CLV_NRD_NRD_1 | 290 | 292 | PF00675 | 0.444 |
| CLV_NRD_NRD_1 | 333 | 335 | PF00675 | 0.469 |
| CLV_PCSK_KEX2_1 | 290 | 292 | PF00082 | 0.432 |
| CLV_PCSK_KEX2_1 | 332 | 334 | PF00082 | 0.496 |
| CLV_PCSK_PC1ET2_1 | 290 | 292 | PF00082 | 0.420 |
| CLV_PCSK_PC1ET2_1 | 332 | 334 | PF00082 | 0.496 |
| CLV_PCSK_PC7_1 | 286 | 292 | PF00082 | 0.429 |
| CLV_PCSK_SKI1_1 | 292 | 296 | PF00082 | 0.507 |
| CLV_PCSK_SKI1_1 | 82 | 86 | PF00082 | 0.506 |
| DEG_APCC_DBOX_1 | 290 | 298 | PF00400 | 0.484 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.384 |
| DOC_CYCLIN_RxL_1 | 79 | 88 | PF00134 | 0.276 |
| DOC_CYCLIN_yClb5_NLxxxL_5 | 54 | 63 | PF00134 | 0.473 |
| DOC_MAPK_gen_1 | 148 | 154 | PF00069 | 0.444 |
| DOC_MAPK_gen_1 | 290 | 297 | PF00069 | 0.589 |
| DOC_PP1_RVXF_1 | 147 | 154 | PF00149 | 0.450 |
| DOC_PP2B_LxvP_1 | 24 | 27 | PF13499 | 0.325 |
| DOC_PP2B_LxvP_1 | 39 | 42 | PF13499 | 0.258 |
| DOC_USP7_MATH_1 | 208 | 212 | PF00917 | 0.524 |
| LIG_14-3-3_CanoR_1 | 207 | 213 | PF00244 | 0.523 |
| LIG_APCC_ABBA_1 | 223 | 228 | PF00400 | 0.206 |
| LIG_BIR_III_2 | 315 | 319 | PF00653 | 0.549 |
| LIG_BRCT_BRCA1_1 | 263 | 267 | PF00533 | 0.309 |
| LIG_Clathr_ClatBox_1 | 84 | 88 | PF01394 | 0.137 |
| LIG_EH1_1 | 157 | 165 | PF00400 | 0.320 |
| LIG_EH1_1 | 184 | 192 | PF00400 | 0.308 |
| LIG_FHA_1 | 139 | 145 | PF00498 | 0.293 |
| LIG_FHA_1 | 159 | 165 | PF00498 | 0.286 |
| LIG_GBD_Chelix_1 | 29 | 37 | PF00786 | 0.285 |
| LIG_Integrin_RGD_1 | 12 | 14 | PF01839 | 0.589 |
| LIG_LIR_Gen_1 | 140 | 151 | PF02991 | 0.289 |
| LIG_LIR_Gen_1 | 214 | 223 | PF02991 | 0.370 |
| LIG_LIR_Gen_1 | 257 | 268 | PF02991 | 0.296 |
| LIG_LIR_Gen_1 | 3 | 11 | PF02991 | 0.319 |
| LIG_LIR_Gen_1 | 31 | 42 | PF02991 | 0.305 |
| LIG_LIR_Nem_3 | 140 | 146 | PF02991 | 0.305 |
| LIG_LIR_Nem_3 | 189 | 195 | PF02991 | 0.319 |
| LIG_LIR_Nem_3 | 199 | 205 | PF02991 | 0.464 |
| LIG_LIR_Nem_3 | 214 | 218 | PF02991 | 0.316 |
| LIG_LIR_Nem_3 | 228 | 233 | PF02991 | 0.306 |
| LIG_LIR_Nem_3 | 257 | 263 | PF02991 | 0.285 |
| LIG_LIR_Nem_3 | 3 | 8 | PF02991 | 0.303 |
| LIG_LIR_Nem_3 | 71 | 77 | PF02991 | 0.325 |
| LIG_LIR_Nem_3 | 79 | 84 | PF02991 | 0.282 |
| LIG_Pex14_2 | 126 | 130 | PF04695 | 0.398 |
| LIG_Pex14_2 | 263 | 267 | PF04695 | 0.305 |
| LIG_Pex14_2 | 81 | 85 | PF04695 | 0.318 |
| LIG_SH2_PTP2 | 205 | 208 | PF00017 | 0.525 |
| LIG_SH2_STAP1 | 170 | 174 | PF00017 | 0.299 |
| LIG_SH2_STAP1 | 256 | 260 | PF00017 | 0.220 |
| LIG_SH2_STAP1 | 268 | 272 | PF00017 | 0.471 |
| LIG_SH2_STAT5 | 165 | 168 | PF00017 | 0.309 |
| LIG_SH2_STAT5 | 192 | 195 | PF00017 | 0.324 |
| LIG_SH2_STAT5 | 205 | 208 | PF00017 | 0.468 |
| LIG_SH2_STAT5 | 230 | 233 | PF00017 | 0.314 |
| LIG_SH2_STAT5 | 236 | 239 | PF00017 | 0.261 |
| LIG_SH2_STAT5 | 256 | 259 | PF00017 | 0.303 |
| LIG_SH2_STAT5 | 271 | 274 | PF00017 | 0.449 |
| LIG_SH2_STAT5 | 34 | 37 | PF00017 | 0.290 |
| LIG_SH2_STAT5 | 40 | 43 | PF00017 | 0.299 |
| LIG_SH2_STAT5 | 7 | 10 | PF00017 | 0.341 |
| LIG_SH2_STAT5 | 75 | 78 | PF00017 | 0.311 |
| LIG_SUMO_SIM_anti_2 | 28 | 34 | PF11976 | 0.272 |
| LIG_UBA3_1 | 129 | 134 | PF00899 | 0.332 |
| LIG_WRC_WIRS_1 | 2 | 7 | PF05994 | 0.464 |
| LIG_WRC_WIRS_1 | 212 | 217 | PF05994 | 0.384 |
| MOD_CK1_1 | 211 | 217 | PF00069 | 0.514 |
| MOD_CK1_1 | 244 | 250 | PF00069 | 0.302 |
| MOD_CK1_1 | 270 | 276 | PF00069 | 0.435 |
| MOD_CK1_1 | 28 | 34 | PF00069 | 0.389 |
| MOD_CK1_1 | 284 | 290 | PF00069 | 0.621 |
| MOD_CK1_1 | 308 | 314 | PF00069 | 0.760 |
| MOD_CK1_1 | 66 | 72 | PF00069 | 0.331 |
| MOD_Cter_Amidation | 274 | 277 | PF01082 | 0.204 |
| MOD_GlcNHglycan | 174 | 177 | PF01048 | 0.450 |
| MOD_GlcNHglycan | 237 | 240 | PF01048 | 0.394 |
| MOD_GlcNHglycan | 273 | 276 | PF01048 | 0.335 |
| MOD_GlcNHglycan | 282 | 286 | PF01048 | 0.498 |
| MOD_GlcNHglycan | 70 | 73 | PF01048 | 0.305 |
| MOD_GSK3_1 | 267 | 274 | PF00069 | 0.389 |
| MOD_N-GLC_1 | 244 | 249 | PF02516 | 0.452 |
| MOD_N-GLC_1 | 92 | 97 | PF02516 | 0.539 |
| MOD_NEK2_1 | 1 | 6 | PF00069 | 0.389 |
| MOD_NEK2_1 | 130 | 135 | PF00069 | 0.312 |
| MOD_NEK2_1 | 138 | 143 | PF00069 | 0.323 |
| MOD_NEK2_1 | 172 | 177 | PF00069 | 0.266 |
| MOD_NEK2_1 | 196 | 201 | PF00069 | 0.359 |
| MOD_NEK2_1 | 235 | 240 | PF00069 | 0.269 |
| MOD_NEK2_1 | 254 | 259 | PF00069 | 0.299 |
| MOD_NEK2_1 | 267 | 272 | PF00069 | 0.282 |
| MOD_NEK2_1 | 63 | 68 | PF00069 | 0.313 |
| MOD_NEK2_1 | 87 | 92 | PF00069 | 0.279 |
| MOD_Plk_1 | 308 | 314 | PF00069 | 0.540 |
| MOD_Plk_1 | 87 | 93 | PF00069 | 0.315 |
| MOD_Plk_2-3 | 305 | 311 | PF00069 | 0.536 |
| MOD_Plk_4 | 159 | 165 | PF00069 | 0.311 |
| MOD_Plk_4 | 186 | 192 | PF00069 | 0.290 |
| MOD_Plk_4 | 208 | 214 | PF00069 | 0.468 |
| MOD_Plk_4 | 228 | 234 | PF00069 | 0.285 |
| MOD_Plk_4 | 25 | 31 | PF00069 | 0.335 |
| MOD_Plk_4 | 255 | 261 | PF00069 | 0.294 |
| MOD_Plk_4 | 267 | 273 | PF00069 | 0.288 |
| MOD_Plk_4 | 63 | 69 | PF00069 | 0.307 |
| MOD_Plk_4 | 80 | 86 | PF00069 | 0.215 |
| MOD_Plk_4 | 97 | 103 | PF00069 | 0.248 |
| TRG_AP2beta_CARGO_1 | 3 | 12 | PF09066 | 0.225 |
| TRG_DiLeu_BaLyEn_6 | 290 | 295 | PF01217 | 0.516 |
| TRG_ENDOCYTIC_2 | 107 | 110 | PF00928 | 0.277 |
| TRG_ENDOCYTIC_2 | 157 | 160 | PF00928 | 0.311 |
| TRG_ENDOCYTIC_2 | 192 | 195 | PF00928 | 0.309 |
| TRG_ENDOCYTIC_2 | 259 | 262 | PF00928 | 0.288 |
| TRG_ENDOCYTIC_2 | 34 | 37 | PF00928 | 0.295 |
| TRG_ENDOCYTIC_2 | 74 | 77 | PF00928 | 0.322 |
| TRG_ER_diArg_1 | 291 | 294 | PF00400 | 0.521 |
| TRG_NES_CRM1_1 | 217 | 228 | PF08389 | 0.233 |
| TRG_NLS_Bipartite_1 | 276 | 295 | PF00514 | 0.667 |
| TRG_NLS_MonoCore_2 | 289 | 294 | PF00514 | 0.699 |
| TRG_NLS_MonoExtN_4 | 290 | 295 | PF00514 | 0.726 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0C5PHQ7 | Tachysurus fulvidraco | 23% | 100% |
| A0A0N0P5E5 | Leptomonas seymouri | 40% | 100% |
| A0A0N0P7D1 | Leptomonas seymouri | 64% | 100% |
| A0A0N0P7D6 | Leptomonas seymouri | 32% | 100% |
| A0A0N0P7R2 | Leptomonas seymouri | 60% | 100% |
| A0A0N1HZJ8 | Leptomonas seymouri | 38% | 100% |
| A0A0N1I9H5 | Leptomonas seymouri | 33% | 100% |
| A0A0N1ILQ4 | Leptomonas seymouri | 40% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 31% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 39% | 100% |
| A0A0S4IS29 | Bodo saltans | 47% | 100% |
| A0A0S4IVJ6 | Bodo saltans | 36% | 100% |
| A0A0S4IVS6 | Bodo saltans | 40% | 100% |
| A0A0S4IW98 | Bodo saltans | 47% | 100% |
| A0A1X0NNK7 | Trypanosomatidae | 45% | 100% |
| A0A1X0NNL0 | Trypanosomatidae | 34% | 100% |
| A0A1X0NNM4 | Trypanosomatidae | 35% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 52% | 100% |
| A0A1X0NP89 | Trypanosomatidae | 40% | 100% |
| A0A3Q8I8T7 | Leishmania donovani | 32% | 85% |
| A0A3Q8I9T2 | Leishmania donovani | 31% | 89% |
| A0A3Q8I9U9 | Leishmania donovani | 41% | 100% |
| A0A3Q8I9X8 | Leishmania donovani | 90% | 100% |
| A0A3Q8IC05 | Leishmania donovani | 40% | 100% |
| A0A3Q8ID51 | Leishmania donovani | 31% | 84% |
| A0A3Q8IIA9 | Leishmania donovani | 36% | 100% |
| A0A3Q8IT78 | Leishmania donovani | 25% | 88% |
| A0A3R7KG78 | Trypanosoma rangeli | 48% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 37% | 100% |
| A0A3R7NSQ3 | Trypanosoma rangeli | 38% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 32% | 100% |
| A0A3S5H6R8 | Leishmania donovani | 34% | 100% |
| A0A3S7WSY8 | Leishmania donovani | 34% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 61% | 100% |
| A0A3S7WT03 | Leishmania donovani | 65% | 100% |
| A0A3S7WT16 | Leishmania donovani | 48% | 100% |
| A0A422NNP1 | Trypanosoma rangeli | 51% | 100% |
| A0JNC4 | Bos taurus | 28% | 100% |
| A1L3X0 | Homo sapiens | 29% | 100% |
| A4H4G1 | Leishmania braziliensis | 26% | 100% |
| A4H7M2 | Leishmania braziliensis | 34% | 95% |
| A4H7M3 | Leishmania braziliensis | 32% | 100% |
| A4H7M4 | Leishmania braziliensis | 35% | 97% |
| A4H7M5 | Leishmania braziliensis | 33% | 95% |
| A4H7M6 | Leishmania braziliensis | 59% | 100% |
| A4H7M7 | Leishmania braziliensis | 45% | 100% |
| A4H7M8 | Leishmania braziliensis | 30% | 100% |
| A4H7M9 | Leishmania braziliensis | 31% | 100% |
| A4H7N0 | Leishmania braziliensis | 44% | 100% |
| A4HKA3 | Leishmania braziliensis | 26% | 100% |
| A4HW07 | Leishmania infantum | 34% | 100% |
| A4HW08 | Leishmania infantum | 32% | 100% |
| A4HW09 | Leishmania infantum | 36% | 100% |
| A4HW10 | Leishmania infantum | 34% | 100% |
| A4HW12 | Leishmania infantum | 90% | 100% |
| A4HW13 | Leishmania infantum | 41% | 100% |
| A4HW14 | Leishmania infantum | 50% | 100% |
| A4HW15 | Leishmania infantum | 31% | 89% |
| A4HW16 | Leishmania infantum | 32% | 90% |
| A4HW17 | Leishmania infantum | 32% | 85% |
| A4HW18 | Leishmania infantum | 41% | 100% |
| A4I7T3 | Leishmania infantum | 25% | 88% |
| C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 48% | 100% |
| C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 100% |
| C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 37% | 100% |
| D4ADY9 | Rattus norvegicus | 27% | 100% |
| E8NHR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
| E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| E9AGL0 | Leishmania infantum | 65% | 100% |
| E9AGL2 | Leishmania infantum | 61% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 100% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 98% |
| E9APR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 95% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 68% | 100% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 69% | 100% |
| E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 49% | 100% |
| E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 87% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| G5EEE5 | Caenorhabditis elegans | 32% | 100% |
| O35949 | Mus musculus | 33% | 100% |
| P49191 | Caenorhabditis elegans | 34% | 100% |
| Q03574 | Caenorhabditis elegans | 32% | 100% |
| Q20300 | Caenorhabditis elegans | 30% | 100% |
| Q20303 | Caenorhabditis elegans | 35% | 100% |
| Q32NI8 | Xenopus laevis | 26% | 100% |
| Q4QFQ9 | Leishmania major | 38% | 95% |
| Q4QFR0 | Leishmania major | 31% | 100% |
| Q4QFR1 | Leishmania major | 31% | 100% |
| Q4QFR2 | Leishmania major | 32% | 100% |
| Q4QFR3 | Leishmania major | 50% | 100% |
| Q4QFR4 | Leishmania major | 40% | 100% |
| Q4QFR5 | Leishmania major | 87% | 100% |
| Q4QFR6 | Leishmania major | 63% | 99% |
| Q4QFR7 | Leishmania major | 37% | 100% |
| Q4QFR8 | Leishmania major | 36% | 97% |
| Q4QFR9 | Leishmania major | 32% | 100% |
| Q4QFS0 | Leishmania major | 33% | 94% |
| Q4QJ85 | Leishmania major | 28% | 100% |
| Q5M8U1 | Xenopus tropicalis | 24% | 100% |
| Q5ZJR8 | Gallus gallus | 33% | 100% |
| Q6PC64 | Danio rerio | 34% | 100% |
| Q7LKX0 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 24% | 92% |
| Q920L5 | Mus musculus | 32% | 100% |
| Q920L6 | Rattus norvegicus | 32% | 100% |
| Q9BW60 | Homo sapiens | 26% | 100% |
| Q9EQC4 | Mus musculus | 29% | 100% |
| Q9H5J4 | Homo sapiens | 32% | 100% |
| Q9HB03 | Homo sapiens | 32% | 100% |
| Q9JLJ5 | Mus musculus | 28% | 100% |
| Q9UTF7 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 26% | 100% |
| Q9VV87 | Drosophila melanogaster | 32% | 100% |
| Q9XVQ9 | Caenorhabditis elegans | 31% | 100% |
| V5BE99 | Trypanosoma cruzi | 45% | 100% |
| V5BIX9 | Trypanosoma cruzi | 37% | 100% |
| V5BND3 | Trypanosoma cruzi | 51% | 100% |
| V5DF68 | Trypanosoma cruzi | 37% | 100% |