LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania mexicana
UniProt:
E9APR2_LEIMU
TriTrypDb:
LmxM.14.0670
Length:
294

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 28
NetGPI no yes: 0, no: 28
Cellular components
Term Name Level Count
GO:0016020 membrane 2 27
GO:0110165 cellular anatomical entity 1 28
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9APR2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APR2

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 29
GO:0006629 lipid metabolic process 3 29
GO:0006631 fatty acid metabolic process 4 29
GO:0006633 fatty acid biosynthetic process 5 29
GO:0008152 metabolic process 1 29
GO:0008610 lipid biosynthetic process 4 29
GO:0009058 biosynthetic process 2 29
GO:0009987 cellular process 1 29
GO:0016053 organic acid biosynthetic process 4 29
GO:0019752 carboxylic acid metabolic process 5 29
GO:0032787 monocarboxylic acid metabolic process 6 29
GO:0043436 oxoacid metabolic process 4 29
GO:0044237 cellular metabolic process 2 29
GO:0044238 primary metabolic process 2 29
GO:0044249 cellular biosynthetic process 3 29
GO:0044255 cellular lipid metabolic process 3 29
GO:0044281 small molecule metabolic process 2 29
GO:0044283 small molecule biosynthetic process 3 29
GO:0046394 carboxylic acid biosynthetic process 5 29
GO:0071704 organic substance metabolic process 2 29
GO:0072330 monocarboxylic acid biosynthetic process 6 29
GO:1901576 organic substance biosynthetic process 3 29
GO:0000038 very long-chain fatty acid metabolic process 5 2
GO:0006643 membrane lipid metabolic process 4 2
GO:0006665 sphingolipid metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0019367 fatty acid elongation, saturated fatty acid 7 2
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 2
GO:0030148 sphingolipid biosynthetic process 5 2
GO:0030497 fatty acid elongation 6 2
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 2
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 2
GO:0042761 very long-chain fatty acid biosynthetic process 6 2
GO:0046467 membrane lipid biosynthetic process 4 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901566 organonitrogen compound biosynthetic process 4 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 29
GO:0004312 fatty acid synthase activity 5 29
GO:0009922 fatty acid elongase activity 6 29
GO:0016740 transferase activity 2 29
GO:0016746 acyltransferase activity 3 29
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 29
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 29

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 59 61 PF00082 0.259
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.224
CLV_PCSK_SKI1_1 203 207 PF00082 0.329
CLV_PCSK_SKI1_1 43 47 PF00082 0.289
CLV_PCSK_SKI1_1 59 63 PF00082 0.328
DEG_SPOP_SBC_1 172 176 PF00917 0.118
DOC_AGCK_PIF_1 165 170 PF00069 0.142
DOC_CDC14_PxL_1 131 139 PF14671 0.214
DOC_CDC14_PxL_1 90 98 PF14671 0.297
DOC_CYCLIN_yCln2_LP_2 205 211 PF00134 0.478
DOC_USP7_MATH_1 121 125 PF00917 0.159
DOC_USP7_MATH_1 284 288 PF00917 0.660
DOC_USP7_MATH_1 290 294 PF00917 0.677
DOC_USP7_UBL2_3 102 106 PF12436 0.148
DOC_WW_Pin1_4 117 122 PF00397 0.244
DOC_WW_Pin1_4 147 152 PF00397 0.486
DOC_WW_Pin1_4 46 51 PF00397 0.364
LIG_14-3-3_CanoR_1 71 75 PF00244 0.485
LIG_Actin_WH2_2 90 108 PF00022 0.354
LIG_APCC_ABBA_1 1 6 PF00400 0.373
LIG_APCC_ABBA_1 269 274 PF00400 0.343
LIG_EH1_1 157 165 PF00400 0.273
LIG_FHA_1 138 144 PF00498 0.262
LIG_FHA_1 174 180 PF00498 0.258
LIG_FHA_2 106 112 PF00498 0.252
LIG_GBD_Chelix_1 137 145 PF00786 0.359
LIG_LIR_Apic_2 115 121 PF02991 0.262
LIG_LIR_Gen_1 124 131 PF02991 0.340
LIG_LIR_Gen_1 189 199 PF02991 0.339
LIG_LIR_Gen_1 267 276 PF02991 0.287
LIG_LIR_Gen_1 66 76 PF02991 0.449
LIG_LIR_Nem_3 139 145 PF02991 0.285
LIG_LIR_Nem_3 189 195 PF02991 0.296
LIG_LIR_Nem_3 22 26 PF02991 0.350
LIG_LIR_Nem_3 228 232 PF02991 0.323
LIG_LIR_Nem_3 267 271 PF02991 0.268
LIG_LIR_Nem_3 66 72 PF02991 0.443
LIG_Pex14_1 125 129 PF04695 0.233
LIG_PTB_Apo_2 17 24 PF02174 0.305
LIG_PTB_Phospho_1 17 23 PF10480 0.305
LIG_SH2_CRK 118 122 PF00017 0.257
LIG_SH2_GRB2like 18 21 PF00017 0.320
LIG_SH2_GRB2like 276 279 PF00017 0.417
LIG_SH2_GRB2like 7 10 PF00017 0.364
LIG_SH2_NCK_1 18 22 PF00017 0.159
LIG_SH2_SRC 18 21 PF00017 0.301
LIG_SH2_SRC 276 279 PF00017 0.200
LIG_SH2_SRC 7 10 PF00017 0.366
LIG_SH2_STAP1 23 27 PF00017 0.417
LIG_SH2_STAP1 230 234 PF00017 0.338
LIG_SH2_STAT5 118 121 PF00017 0.229
LIG_SH2_STAT5 194 197 PF00017 0.301
LIG_SH2_STAT5 26 29 PF00017 0.234
LIG_SH2_STAT5 265 268 PF00017 0.283
LIG_SH2_STAT5 270 273 PF00017 0.280
LIG_SH2_STAT5 276 279 PF00017 0.278
LIG_SH2_STAT5 280 283 PF00017 0.429
LIG_SH2_STAT5 31 34 PF00017 0.252
LIG_SH2_STAT5 7 10 PF00017 0.317
LIG_SH3_3 205 211 PF00018 0.434
LIG_SH3_3 231 237 PF00018 0.277
LIG_SH3_3 88 94 PF00018 0.278
LIG_TRAF2_1 3 6 PF00917 0.455
LIG_TYR_ITIM 266 271 PF00017 0.289
LIG_UBA3_1 128 133 PF00899 0.313
LIG_UBA3_1 96 102 PF00899 0.263
MOD_CDK_SPK_2 117 122 PF00069 0.174
MOD_CK1_1 171 177 PF00069 0.148
MOD_CK1_1 82 88 PF00069 0.264
MOD_CK2_1 105 111 PF00069 0.291
MOD_Cter_Amidation 57 60 PF01082 0.316
MOD_GlcNHglycan 255 258 PF01048 0.464
MOD_GlcNHglycan 286 289 PF01048 0.476
MOD_GlcNHglycan 81 84 PF01048 0.317
MOD_GSK3_1 117 124 PF00069 0.277
MOD_GSK3_1 168 175 PF00069 0.341
MOD_GSK3_1 286 293 PF00069 0.610
MOD_NEK2_1 105 110 PF00069 0.220
MOD_NEK2_1 116 121 PF00069 0.207
MOD_NEK2_1 129 134 PF00069 0.282
MOD_NEK2_1 137 142 PF00069 0.298
MOD_NEK2_1 168 173 PF00069 0.276
MOD_NEK2_1 186 191 PF00069 0.247
MOD_NEK2_1 264 269 PF00069 0.287
MOD_NEK2_1 70 75 PF00069 0.459
MOD_NEK2_1 79 84 PF00069 0.287
MOD_NEK2_1 96 101 PF00069 0.253
MOD_PKA_2 121 127 PF00069 0.279
MOD_PKA_2 70 76 PF00069 0.485
MOD_Plk_4 121 127 PF00069 0.264
MOD_Plk_4 137 143 PF00069 0.217
MOD_Plk_4 158 164 PF00069 0.287
MOD_Plk_4 186 192 PF00069 0.261
MOD_Plk_4 225 231 PF00069 0.264
MOD_Plk_4 264 270 PF00069 0.262
MOD_Plk_4 276 282 PF00069 0.262
MOD_Plk_4 70 76 PF00069 0.444
MOD_ProDKin_1 117 123 PF00069 0.244
MOD_ProDKin_1 147 153 PF00069 0.486
MOD_ProDKin_1 46 52 PF00069 0.364
TRG_DiLeu_BaLyEn_6 208 213 PF01217 0.474
TRG_ENDOCYTIC_2 157 160 PF00928 0.277
TRG_ENDOCYTIC_2 18 21 PF00928 0.253
TRG_ENDOCYTIC_2 192 195 PF00928 0.293
TRG_ENDOCYTIC_2 26 29 PF00928 0.263
TRG_ENDOCYTIC_2 268 271 PF00928 0.262
TRG_ENDOCYTIC_2 31 34 PF00928 0.255
TRG_ER_diLys_1 291 294 PF00400 0.633
TRG_NLS_MonoExtC_3 146 151 PF00514 0.534
TRG_NLS_MonoExtC_3 58 63 PF00514 0.465
TRG_NLS_MonoExtN_4 56 63 PF00514 0.318

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 37% 98%
A0A0N0P7D1 Leptomonas seymouri 32% 88%
A0A0N0P7D6 Leptomonas seymouri 32% 100%
A0A0N0P7R2 Leptomonas seymouri 41% 96%
A0A0N1I9H5 Leptomonas seymouri 36% 100%
A0A0N1IIZ8 Leptomonas seymouri 27% 96%
A0A0N1ILQ4 Leptomonas seymouri 76% 100%
A0A0N1IM10 Leptomonas seymouri 33% 100%
A0A0N1PDR8 Leptomonas seymouri 36% 100%
A0A0N1PFE8 Leptomonas seymouri 38% 100%
A0A0S4IS29 Bodo saltans 41% 100%
A0A0S4IVJ6 Bodo saltans 35% 92%
A0A0S4IVS6 Bodo saltans 41% 100%
A0A0S4IW98 Bodo saltans 35% 93%
A0A0S4J4C4 Bodo saltans 22% 100%
A0A1X0NNK7 Trypanosomatidae 40% 100%
A0A1X0NNL0 Trypanosomatidae 39% 97%
A0A1X0NNM4 Trypanosomatidae 48% 100%
A0A1X0NNM5 Trypanosomatidae 37% 95%
A0A1X0NP89 Trypanosomatidae 29% 92%
A0A1X0NUJ4 Trypanosomatidae 28% 81%
A0A3Q8I9U9 Leishmania donovani 31% 90%
A0A3Q8I9X8 Leishmania donovani 33% 88%
A0A3Q8IC05 Leishmania donovani 38% 96%
A0A3Q8IIA9 Leishmania donovani 36% 100%
A0A3R7KG78 Trypanosoma rangeli 39% 100%
A0A3R7MJR2 Trypanosoma rangeli 48% 100%
A0A3R7NSQ3 Trypanosoma rangeli 41% 100%
A0A3S5H6R7 Leishmania donovani 35% 100%
A0A3S5H6R8 Leishmania donovani 96% 100%
A0A3S7WSY8 Leishmania donovani 36% 100%
A0A3S7WSZ1 Leishmania donovani 35% 98%
A0A3S7WT03 Leishmania donovani 35% 98%
A0A3S7WT05 Leishmania donovani 25% 96%
A0A3S7WT16 Leishmania donovani 34% 91%
A0A422NNP1 Trypanosoma rangeli 36% 98%
A0JNC4 Bos taurus 28% 100%
A1L3X0 Homo sapiens 29% 100%
A4H7M1 Leishmania braziliensis 25% 96%
A4H7M2 Leishmania braziliensis 36% 99%
A4H7M3 Leishmania braziliensis 36% 98%
A4H7M4 Leishmania braziliensis 34% 99%
A4H7M5 Leishmania braziliensis 85% 100%
A4H7M6 Leishmania braziliensis 40% 100%
A4H7M7 Leishmania braziliensis 34% 100%
A4H7M8 Leishmania braziliensis 32% 77%
A4H7N0 Leishmania braziliensis 38% 100%
A4HW06 Leishmania infantum 25% 96%
A4HW07 Leishmania infantum 36% 100%
A4HW08 Leishmania infantum 35% 100%
A4HW09 Leishmania infantum 36% 100%
A4HW10 Leishmania infantum 95% 100%
A4HW12 Leishmania infantum 34% 88%
A4HW13 Leishmania infantum 31% 90%
A4HW14 Leishmania infantum 33% 91%
A4HW18 Leishmania infantum 38% 97%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 98%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 96%
D4A612 Rattus norvegicus 25% 100%
D4ADY9 Rattus norvegicus 29% 100%
E9AGL0 Leishmania infantum 34% 98%
E9AGL2 Leishmania infantum 38% 98%
E9APQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 99%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 98%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 98%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 88%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 90%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 91%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 98%
G5EEE5 Caenorhabditis elegans 30% 100%
O35949 Mus musculus 33% 100%
P25358 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 85%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 95%
P40319 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 85%
P49191 Caenorhabditis elegans 31% 92%
Q03574 Caenorhabditis elegans 31% 100%
Q20300 Caenorhabditis elegans 32% 100%
Q20303 Caenorhabditis elegans 33% 100%
Q4QFQ9 Leishmania major 39% 100%
Q4QFR3 Leishmania major 32% 100%
Q4QFR4 Leishmania major 30% 100%
Q4QFR5 Leishmania major 34% 100%
Q4QFR6 Leishmania major 35% 96%
Q4QFR7 Leishmania major 93% 100%
Q4QFR8 Leishmania major 35% 96%
Q4QFR9 Leishmania major 36% 100%
Q4QFS0 Leishmania major 37% 97%
Q4QFS1 Leishmania major 23% 100%
Q54TC9 Dictyostelium discoideum 31% 100%
Q5ZJR8 Gallus gallus 33% 100%
Q6PC64 Danio rerio 38% 100%
Q7LKX0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 81%
Q920L5 Mus musculus 37% 100%
Q9D2Y9 Mus musculus 29% 100%
Q9EQC4 Mus musculus 27% 94%
Q9GZR5 Homo sapiens 26% 94%
Q9H5J4 Homo sapiens 37% 100%
Q9HB03 Homo sapiens 32% 100%
Q9NXB9 Homo sapiens 26% 99%
Q9UTF7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 88%
Q9VV87 Drosophila melanogaster 32% 93%
Q9XVQ9 Caenorhabditis elegans 34% 100%
V5BE99 Trypanosoma cruzi 39% 100%
V5BIX9 Trypanosoma cruzi 46% 100%
V5BND3 Trypanosoma cruzi 40% 98%
V5DF68 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS