LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania mexicana
UniProt:
E9APR1_LEIMU
TriTrypDb:
LmxM.14.0660
Length:
284

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 45
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 29
NetGPI no yes: 0, no: 30
Cellular components
Term Name Level Count
GO:0016020 membrane 2 28
GO:0110165 cellular anatomical entity 1 29
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9APR1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APR1

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 31
GO:0006629 lipid metabolic process 3 31
GO:0006631 fatty acid metabolic process 4 31
GO:0006633 fatty acid biosynthetic process 5 31
GO:0008152 metabolic process 1 31
GO:0008610 lipid biosynthetic process 4 31
GO:0009058 biosynthetic process 2 31
GO:0009987 cellular process 1 31
GO:0016053 organic acid biosynthetic process 4 31
GO:0019752 carboxylic acid metabolic process 5 31
GO:0032787 monocarboxylic acid metabolic process 6 31
GO:0043436 oxoacid metabolic process 4 31
GO:0044237 cellular metabolic process 2 31
GO:0044238 primary metabolic process 2 31
GO:0044249 cellular biosynthetic process 3 31
GO:0044255 cellular lipid metabolic process 3 31
GO:0044281 small molecule metabolic process 2 31
GO:0044283 small molecule biosynthetic process 3 31
GO:0046394 carboxylic acid biosynthetic process 5 31
GO:0071704 organic substance metabolic process 2 31
GO:0072330 monocarboxylic acid biosynthetic process 6 31
GO:1901576 organic substance biosynthetic process 3 31
GO:0000038 very long-chain fatty acid metabolic process 5 3
GO:0001676 long-chain fatty acid metabolic process 5 3
GO:0006643 membrane lipid metabolic process 4 3
GO:0006665 sphingolipid metabolic process 4 3
GO:0006807 nitrogen compound metabolic process 2 3
GO:0019367 fatty acid elongation, saturated fatty acid 7 3
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 3
GO:0030148 sphingolipid biosynthetic process 5 3
GO:0030497 fatty acid elongation 6 3
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 3
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 3
GO:0042759 long-chain fatty acid biosynthetic process 6 3
GO:0042761 very long-chain fatty acid biosynthetic process 6 3
GO:0046467 membrane lipid biosynthetic process 4 3
GO:1901564 organonitrogen compound metabolic process 3 3
GO:1901566 organonitrogen compound biosynthetic process 4 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 31
GO:0004312 fatty acid synthase activity 5 31
GO:0009922 fatty acid elongase activity 6 31
GO:0016740 transferase activity 2 31
GO:0016746 acyltransferase activity 3 31
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 31
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 31

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 2 6 PF00656 0.253
CLV_NRD_NRD_1 137 139 PF00675 0.320
CLV_NRD_NRD_1 265 267 PF00675 0.284
CLV_PCSK_KEX2_1 137 139 PF00082 0.283
CLV_PCSK_KEX2_1 265 267 PF00082 0.213
CLV_PCSK_KEX2_1 282 284 PF00082 0.510
CLV_PCSK_PC1ET2_1 137 139 PF00082 0.320
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.537
CLV_PCSK_SKI1_1 193 197 PF00082 0.360
CLV_PCSK_SKI1_1 57 61 PF00082 0.309
CLV_PCSK_SKI1_1 95 99 PF00082 0.436
DEG_Nend_UBRbox_2 1 3 PF02207 0.361
DOC_CYCLIN_yCln2_LP_2 194 200 PF00134 0.529
DOC_MAPK_gen_1 192 202 PF00069 0.420
DOC_MAPK_MEF2A_6 196 204 PF00069 0.459
DOC_MAPK_MEF2A_6 41 48 PF00069 0.458
DOC_PP4_FxxP_1 40 43 PF00568 0.321
DOC_USP7_MATH_1 269 273 PF00917 0.706
DOC_USP7_UBL2_3 192 196 PF12436 0.471
DOC_USP7_UBL2_3 225 229 PF12436 0.175
LIG_AP2alpha_1 126 130 PF02296 0.397
LIG_APCC_ABBA_1 250 255 PF00400 0.394
LIG_BRCT_BRCA1_1 253 257 PF00533 0.283
LIG_BRCT_BRCA1_2 253 259 PF00533 0.367
LIG_EH1_1 173 181 PF00400 0.345
LIG_eIF4E_1 79 85 PF01652 0.214
LIG_FHA_1 127 133 PF00498 0.307
LIG_FHA_1 148 154 PF00498 0.258
LIG_FHA_1 206 212 PF00498 0.397
LIG_FHA_1 233 239 PF00498 0.341
LIG_FHA_1 54 60 PF00498 0.513
LIG_LIR_Apic_2 37 43 PF02991 0.369
LIG_LIR_Gen_1 144 154 PF02991 0.359
LIG_LIR_Gen_1 163 174 PF02991 0.216
LIG_LIR_Gen_1 178 189 PF02991 0.379
LIG_LIR_Gen_1 217 226 PF02991 0.409
LIG_LIR_Nem_3 128 133 PF02991 0.453
LIG_LIR_Nem_3 144 149 PF02991 0.326
LIG_LIR_Nem_3 163 169 PF02991 0.203
LIG_LIR_Nem_3 178 184 PF02991 0.314
LIG_LIR_Nem_3 188 194 PF02991 0.455
LIG_LIR_Nem_3 217 223 PF02991 0.326
LIG_LIR_Nem_3 74 79 PF02991 0.295
LIG_PCNA_PIPBox_1 1 10 PF02747 0.381
LIG_Pex14_2 126 130 PF04695 0.386
LIG_Pex14_2 142 146 PF04695 0.366
LIG_Pex14_2 152 156 PF04695 0.345
LIG_Pex14_2 216 220 PF04695 0.214
LIG_Pex14_2 253 257 PF04695 0.280
LIG_SH2_CRK 79 83 PF00017 0.287
LIG_SH2_PTP2 201 204 PF00017 0.333
LIG_SH2_PTP2 261 264 PF00017 0.520
LIG_SH2_SRC 7 10 PF00017 0.343
LIG_SH2_STAP1 154 158 PF00017 0.354
LIG_SH2_STAP1 181 185 PF00017 0.403
LIG_SH2_STAT5 107 110 PF00017 0.276
LIG_SH2_STAT5 174 177 PF00017 0.358
LIG_SH2_STAT5 181 184 PF00017 0.302
LIG_SH2_STAT5 201 204 PF00017 0.419
LIG_SH2_STAT5 215 218 PF00017 0.296
LIG_SH2_STAT5 246 249 PF00017 0.319
LIG_SH2_STAT5 251 254 PF00017 0.303
LIG_SH2_STAT5 261 264 PF00017 0.432
LIG_SH2_STAT5 30 33 PF00017 0.290
LIG_SH2_STAT5 35 38 PF00017 0.296
LIG_SH2_STAT5 7 10 PF00017 0.324
LIG_SUMO_SIM_par_1 42 47 PF11976 0.400
LIG_UBA3_1 117 122 PF00899 0.320
LIG_UBA3_1 252 259 PF00899 0.308
LIG_WRC_WIRS_1 215 220 PF05994 0.365
LIG_WRC_WIRS_1 35 40 PF05994 0.363
MOD_CK1_1 219 225 PF00069 0.293
MOD_CMANNOS 63 66 PF00535 0.377
MOD_Cter_Amidation 135 138 PF01082 0.283
MOD_Cter_Amidation 279 282 PF01082 0.474
MOD_GlcNHglycan 271 274 PF01048 0.362
MOD_GSK3_1 175 182 PF00069 0.388
MOD_GSK3_1 269 276 PF00069 0.632
MOD_N-GLC_1 231 236 PF02516 0.531
MOD_NEK2_1 118 123 PF00069 0.303
MOD_NEK2_1 126 131 PF00069 0.317
MOD_NEK2_1 175 180 PF00069 0.293
MOD_NEK2_1 200 205 PF00069 0.485
MOD_NEK2_1 214 219 PF00069 0.284
MOD_NEK2_1 61 66 PF00069 0.470
MOD_NEK2_2 71 76 PF00069 0.395
MOD_PIKK_1 205 211 PF00454 0.369
MOD_Plk_4 126 132 PF00069 0.310
MOD_Plk_4 141 147 PF00069 0.279
MOD_Plk_4 161 167 PF00069 0.191
MOD_Plk_4 175 181 PF00069 0.265
MOD_Plk_4 34 40 PF00069 0.291
MOD_SUMO_rev_2 222 230 PF00179 0.138
TRG_DiLeu_BaLyEn_6 40 45 PF01217 0.141
TRG_DiLeu_BaLyEn_6 54 59 PF01217 0.505
TRG_ENDOCYTIC_2 154 157 PF00928 0.320
TRG_ENDOCYTIC_2 181 184 PF00928 0.325
TRG_ENDOCYTIC_2 201 204 PF00928 0.131
TRG_ENDOCYTIC_2 215 218 PF00928 0.336
TRG_ENDOCYTIC_2 35 38 PF00928 0.290
TRG_ENDOCYTIC_2 79 82 PF00928 0.334
TRG_ER_diArg_1 264 266 PF00400 0.514
TRG_ER_diLys_1 281 284 PF00400 0.642
TRG_NES_CRM1_1 242 255 PF08389 0.432
TRG_NLS_MonoExtC_3 136 141 PF00514 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 30% 95%
A0A0N0P7D1 Leptomonas seymouri 33% 85%
A0A0N0P7D6 Leptomonas seymouri 41% 98%
A0A0N0P7R2 Leptomonas seymouri 39% 93%
A0A0N1HZJ8 Leptomonas seymouri 28% 88%
A0A0N1I9H5 Leptomonas seymouri 56% 100%
A0A0N1ILQ4 Leptomonas seymouri 36% 97%
A0A0N1IM10 Leptomonas seymouri 46% 99%
A0A0N1PDR8 Leptomonas seymouri 32% 100%
A0A0N1PFE8 Leptomonas seymouri 83% 100%
A0A0S4IS29 Bodo saltans 36% 100%
A0A0S4IVJ6 Bodo saltans 33% 89%
A0A0S4IVS6 Bodo saltans 32% 100%
A0A0S4IW98 Bodo saltans 35% 90%
A0A0S4JH58 Bodo saltans 25% 95%
A0A1X0NNK7 Trypanosomatidae 31% 100%
A0A1X0NNL0 Trypanosomatidae 41% 94%
A0A1X0NNM4 Trypanosomatidae 38% 99%
A0A1X0NNM5 Trypanosomatidae 31% 92%
A0A1X0NP89 Trypanosomatidae 27% 89%
A0A3Q8I9T2 Leishmania donovani 31% 76%
A0A3Q8I9U9 Leishmania donovani 29% 87%
A0A3Q8I9X8 Leishmania donovani 36% 85%
A0A3Q8IC05 Leishmania donovani 31% 93%
A0A3Q8ID51 Leishmania donovani 29% 72%
A0A3Q8IIA9 Leishmania donovani 95% 100%
A0A3R7KG78 Trypanosoma rangeli 29% 100%
A0A3R7MJR2 Trypanosoma rangeli 37% 100%
A0A3R7NSQ3 Trypanosoma rangeli 44% 99%
A0A3S5H6R7 Leishmania donovani 49% 100%
A0A3S5H6R8 Leishmania donovani 37% 97%
A0A3S7WSY8 Leishmania donovani 57% 100%
A0A3S7WSZ1 Leishmania donovani 33% 95%
A0A3S7WT03 Leishmania donovani 35% 95%
A0A3S7WT05 Leishmania donovani 22% 93%
A0A3S7WT16 Leishmania donovani 29% 88%
A0A422NNP1 Trypanosoma rangeli 29% 95%
A4H7M1 Leishmania braziliensis 26% 93%
A4H7M2 Leishmania braziliensis 58% 100%
A4H7M3 Leishmania braziliensis 49% 99%
A4H7M4 Leishmania braziliensis 88% 100%
A4H7M5 Leishmania braziliensis 33% 100%
A4H7M6 Leishmania braziliensis 34% 98%
A4H7M7 Leishmania braziliensis 30% 100%
A4H7M9 Leishmania braziliensis 29% 70%
A4H7N0 Leishmania braziliensis 31% 100%
A4HW06 Leishmania infantum 23% 93%
A4HW07 Leishmania infantum 57% 100%
A4HW08 Leishmania infantum 49% 100%
A4HW09 Leishmania infantum 95% 100%
A4HW10 Leishmania infantum 37% 97%
A4HW12 Leishmania infantum 36% 85%
A4HW13 Leishmania infantum 29% 87%
A4HW14 Leishmania infantum 29% 88%
A4HW15 Leishmania infantum 31% 76%
A4HW16 Leishmania infantum 29% 76%
A4HW18 Leishmania infantum 31% 94%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 94%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 93%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AGL0 Leishmania infantum 34% 95%
E9AGL2 Leishmania infantum 33% 95%
E9APQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 93%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 99%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 97%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 95%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 95%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 85%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 87%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 88%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 74%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 94%
G5EEE5 Caenorhabditis elegans 31% 99%
O35949 Mus musculus 34% 100%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 92%
P49191 Caenorhabditis elegans 31% 89%
Q32NI8 Xenopus laevis 26% 96%
Q4QFQ9 Leishmania major 30% 100%
Q4QFR1 Leishmania major 29% 100%
Q4QFR3 Leishmania major 29% 98%
Q4QFR4 Leishmania major 28% 100%
Q4QFR5 Leishmania major 35% 100%
Q4QFR6 Leishmania major 34% 100%
Q4QFR7 Leishmania major 36% 100%
Q4QFR8 Leishmania major 94% 100%
Q4QFR9 Leishmania major 47% 99%
Q4QFS0 Leishmania major 59% 100%
Q4QFS1 Leishmania major 21% 97%
Q5M8U1 Xenopus tropicalis 26% 96%
Q5ZJR8 Gallus gallus 36% 100%
Q6PC64 Danio rerio 34% 100%
Q920L5 Mus musculus 33% 100%
Q920L6 Rattus norvegicus 35% 100%
Q9H5J4 Homo sapiens 33% 100%
Q9HB03 Homo sapiens 33% 100%
Q9VV87 Drosophila melanogaster 31% 90%
Q9XVQ9 Caenorhabditis elegans 33% 100%
V5BE99 Trypanosoma cruzi 33% 99%
V5BIX9 Trypanosoma cruzi 39% 100%
V5BND3 Trypanosoma cruzi 30% 95%
V5DF68 Trypanosoma cruzi 41% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS