LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania mexicana
UniProt:
E9APR0_LEIMU
TriTrypDb:
LmxM.14.0650
Length:
285

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 36
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 29
NetGPI no yes: 0, no: 30
Cellular components
Term Name Level Count
GO:0016020 membrane 2 27
GO:0110165 cellular anatomical entity 1 28
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9APR0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APR0

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 31
GO:0006629 lipid metabolic process 3 31
GO:0006631 fatty acid metabolic process 4 31
GO:0006633 fatty acid biosynthetic process 5 31
GO:0008152 metabolic process 1 31
GO:0008610 lipid biosynthetic process 4 31
GO:0009058 biosynthetic process 2 31
GO:0009987 cellular process 1 31
GO:0016053 organic acid biosynthetic process 4 31
GO:0019752 carboxylic acid metabolic process 5 31
GO:0032787 monocarboxylic acid metabolic process 6 31
GO:0043436 oxoacid metabolic process 4 31
GO:0044237 cellular metabolic process 2 31
GO:0044238 primary metabolic process 2 31
GO:0044249 cellular biosynthetic process 3 31
GO:0044255 cellular lipid metabolic process 3 31
GO:0044281 small molecule metabolic process 2 31
GO:0044283 small molecule biosynthetic process 3 31
GO:0046394 carboxylic acid biosynthetic process 5 31
GO:0071704 organic substance metabolic process 2 31
GO:0072330 monocarboxylic acid biosynthetic process 6 31
GO:1901576 organic substance biosynthetic process 3 31
GO:0000038 very long-chain fatty acid metabolic process 5 4
GO:0001676 long-chain fatty acid metabolic process 5 3
GO:0006643 membrane lipid metabolic process 4 4
GO:0006665 sphingolipid metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0019367 fatty acid elongation, saturated fatty acid 7 4
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 4
GO:0030148 sphingolipid biosynthetic process 5 4
GO:0030497 fatty acid elongation 6 4
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 4
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 4
GO:0042759 long-chain fatty acid biosynthetic process 6 3
GO:0042761 very long-chain fatty acid biosynthetic process 6 4
GO:0046467 membrane lipid biosynthetic process 4 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 31
GO:0004312 fatty acid synthase activity 5 31
GO:0009922 fatty acid elongase activity 6 31
GO:0016740 transferase activity 2 31
GO:0016746 acyltransferase activity 3 31
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 31
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 31

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 229 233 PF00082 0.526
CLV_PCSK_SKI1_1 279 283 PF00082 0.197
DEG_Nend_UBRbox_3 1 3 PF02207 0.359
DOC_CYCLIN_yCln2_LP_2 199 205 PF00134 0.545
DOC_CYCLIN_yCln2_LP_2 50 56 PF00134 0.522
DOC_MAPK_MEF2A_6 201 209 PF00069 0.456
DOC_PP1_RVXF_1 142 148 PF00149 0.543
DOC_PP2B_LxvP_1 50 53 PF13499 0.522
DOC_PP4_FxxP_1 40 43 PF00568 0.316
DOC_USP7_MATH_1 56 60 PF00917 0.360
DOC_USP7_UBL2_3 44 48 PF12436 0.455
LIG_14-3-3_CanoR_1 146 151 PF00244 0.466
LIG_AP2alpha_1 132 136 PF02296 0.395
LIG_APCC_ABBA_1 264 269 PF00400 0.377
LIG_EH1_1 178 186 PF00400 0.356
LIG_FHA_1 112 118 PF00498 0.214
LIG_FHA_1 133 139 PF00498 0.461
LIG_FHA_1 250 256 PF00498 0.340
LIG_FHA_1 259 265 PF00498 0.398
LIG_FHA_1 66 72 PF00498 0.504
LIG_FHA_1 82 88 PF00498 0.233
LIG_FHA_1 95 101 PF00498 0.264
LIG_LIR_Apic_2 37 43 PF02991 0.365
LIG_LIR_Gen_1 134 145 PF02991 0.490
LIG_LIR_Gen_1 154 164 PF02991 0.366
LIG_LIR_Gen_1 261 271 PF02991 0.285
LIG_LIR_Gen_1 47 56 PF02991 0.484
LIG_LIR_Nem_3 134 140 PF02991 0.458
LIG_LIR_Nem_3 154 160 PF02991 0.311
LIG_LIR_Nem_3 183 189 PF02991 0.321
LIG_LIR_Nem_3 193 199 PF02991 0.458
LIG_LIR_Nem_3 261 266 PF02991 0.277
LIG_LIR_Nem_3 47 52 PF02991 0.492
LIG_LIR_Nem_3 77 82 PF02991 0.301
LIG_Pex14_2 132 136 PF04695 0.394
LIG_Pex14_2 147 151 PF04695 0.371
LIG_Pex14_2 157 161 PF04695 0.341
LIG_Pex14_2 263 267 PF04695 0.293
LIG_SH2_GRB2like 49 52 PF00017 0.522
LIG_SH2_PTP2 159 162 PF00017 0.321
LIG_SH2_PTP2 30 33 PF00017 0.222
LIG_SH2_SRC 224 227 PF00017 0.373
LIG_SH2_STAP1 113 117 PF00017 0.248
LIG_SH2_STAP1 260 264 PF00017 0.265
LIG_SH2_STAT5 113 116 PF00017 0.274
LIG_SH2_STAT5 159 162 PF00017 0.304
LIG_SH2_STAT5 179 182 PF00017 0.343
LIG_SH2_STAT5 186 189 PF00017 0.310
LIG_SH2_STAT5 206 209 PF00017 0.419
LIG_SH2_STAT5 224 227 PF00017 0.276
LIG_SH2_STAT5 230 233 PF00017 0.270
LIG_SH2_STAT5 260 263 PF00017 0.324
LIG_SH2_STAT5 265 268 PF00017 0.306
LIG_SH2_STAT5 30 33 PF00017 0.297
LIG_SH2_STAT5 35 38 PF00017 0.305
LIG_SH2_STAT5 49 52 PF00017 0.416
LIG_SH3_3 84 90 PF00018 0.356
LIG_UBA3_1 123 128 PF00899 0.317
LIG_UBA3_1 91 96 PF00899 0.324
LIG_WRC_WIRS_1 104 109 PF05994 0.295
LIG_WRC_WIRS_1 35 40 PF05994 0.359
MOD_CK1_1 163 169 PF00069 0.214
MOD_CK1_1 246 252 PF00069 0.305
MOD_CMANNOS 69 72 PF00535 0.373
MOD_GlcNHglycan 221 224 PF01048 0.385
MOD_GlcNHglycan 245 248 PF01048 0.533
MOD_GlcNHglycan 58 61 PF01048 0.213
MOD_GlcNHglycan 76 79 PF01048 0.360
MOD_GSK3_1 163 170 PF00069 0.300
MOD_GSK3_1 241 248 PF00069 0.312
MOD_N-GLC_1 65 70 PF02516 0.308
MOD_NEK2_1 100 105 PF00069 0.253
MOD_NEK2_1 124 129 PF00069 0.317
MOD_NEK2_1 132 137 PF00069 0.326
MOD_NEK2_1 140 145 PF00069 0.455
MOD_NEK2_1 151 156 PF00069 0.134
MOD_NEK2_1 180 185 PF00069 0.300
MOD_NEK2_1 205 210 PF00069 0.496
MOD_NEK2_1 219 224 PF00069 0.275
MOD_NEK2_1 241 246 PF00069 0.248
MOD_NEK2_1 81 86 PF00069 0.304
MOD_Plk_1 65 71 PF00069 0.490
MOD_Plk_4 132 138 PF00069 0.305
MOD_Plk_4 146 152 PF00069 0.447
MOD_Plk_4 167 173 PF00069 0.287
MOD_Plk_4 180 186 PF00069 0.274
TRG_DiLeu_BaLyEn_6 87 92 PF01217 0.433
TRG_ENDOCYTIC_2 159 162 PF00928 0.324
TRG_ENDOCYTIC_2 186 189 PF00928 0.329
TRG_ENDOCYTIC_2 206 209 PF00928 0.134
TRG_ENDOCYTIC_2 260 263 PF00928 0.275
TRG_ENDOCYTIC_2 30 33 PF00928 0.296
TRG_ENDOCYTIC_2 35 38 PF00928 0.296
TRG_ENDOCYTIC_2 49 52 PF00928 0.455
TRG_ER_diArg_1 276 279 PF00400 0.538
TRG_ER_diLys_1 282 285 PF00400 0.679

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 32% 95%
A0A0N0P7D1 Leptomonas seymouri 31% 85%
A0A0N0P7D6 Leptomonas seymouri 43% 99%
A0A0N0P7R2 Leptomonas seymouri 33% 93%
A0A0N1HZJ8 Leptomonas seymouri 27% 88%
A0A0N1I9H5 Leptomonas seymouri 50% 100%
A0A0N1IIZ8 Leptomonas seymouri 26% 93%
A0A0N1ILQ4 Leptomonas seymouri 36% 97%
A0A0N1IM10 Leptomonas seymouri 85% 100%
A0A0N1PDR8 Leptomonas seymouri 27% 100%
A0A0N1PFE8 Leptomonas seymouri 51% 100%
A0A0S4IS29 Bodo saltans 34% 100%
A0A0S4IVJ6 Bodo saltans 28% 90%
A0A0S4IVS6 Bodo saltans 34% 100%
A0A0S4IW98 Bodo saltans 34% 90%
A0A1X0NNK7 Trypanosomatidae 33% 100%
A0A1X0NNL0 Trypanosomatidae 38% 94%
A0A1X0NNM4 Trypanosomatidae 39% 100%
A0A1X0NNM5 Trypanosomatidae 29% 93%
A0A1X0NP89 Trypanosomatidae 26% 89%
A0A3Q8I8T7 Leishmania donovani 27% 73%
A0A3Q8I9T2 Leishmania donovani 29% 76%
A0A3Q8I9U9 Leishmania donovani 27% 87%
A0A3Q8I9X8 Leishmania donovani 32% 85%
A0A3Q8IC05 Leishmania donovani 32% 93%
A0A3Q8ID51 Leishmania donovani 29% 72%
A0A3Q8IIA9 Leishmania donovani 49% 100%
A0A3R7KG78 Trypanosoma rangeli 33% 100%
A0A3R7MJR2 Trypanosoma rangeli 40% 100%
A0A3R7NSQ3 Trypanosoma rangeli 39% 99%
A0A3S5H6R7 Leishmania donovani 98% 100%
A0A3S5H6R8 Leishmania donovani 35% 97%
A0A3S7WSY8 Leishmania donovani 53% 100%
A0A3S7WSZ1 Leishmania donovani 30% 95%
A0A3S7WT03 Leishmania donovani 29% 95%
A0A3S7WT05 Leishmania donovani 23% 93%
A0A3S7WT16 Leishmania donovani 29% 89%
A0A422NNP1 Trypanosoma rangeli 29% 95%
A4H7M1 Leishmania braziliensis 24% 93%
A4H7M2 Leishmania braziliensis 54% 100%
A4H7M3 Leishmania braziliensis 95% 100%
A4H7M4 Leishmania braziliensis 47% 99%
A4H7M5 Leishmania braziliensis 35% 100%
A4H7M6 Leishmania braziliensis 29% 100%
A4H7M7 Leishmania braziliensis 31% 100%
A4H7M8 Leishmania braziliensis 28% 100%
A4H7M9 Leishmania braziliensis 28% 100%
A4H7N0 Leishmania braziliensis 34% 100%
A4HW06 Leishmania infantum 23% 93%
A4HW07 Leishmania infantum 53% 100%
A4HW08 Leishmania infantum 98% 100%
A4HW09 Leishmania infantum 49% 100%
A4HW10 Leishmania infantum 35% 97%
A4HW12 Leishmania infantum 33% 85%
A4HW13 Leishmania infantum 28% 87%
A4HW14 Leishmania infantum 29% 88%
A4HW15 Leishmania infantum 29% 76%
A4HW16 Leishmania infantum 30% 76%
A4HW17 Leishmania infantum 27% 73%
A4HW18 Leishmania infantum 32% 94%
B4QVX4 Drosophila simulans 26% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 95%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 93%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AGL0 Leishmania infantum 29% 95%
E9AGL2 Leishmania infantum 31% 95%
E9APQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 97%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 95%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 95%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 85%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 88%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 88%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 95%
G5EEE5 Caenorhabditis elegans 25% 99%
O35949 Mus musculus 30% 100%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 92%
P40319 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 83%
P49191 Caenorhabditis elegans 27% 89%
Q20300 Caenorhabditis elegans 30% 100%
Q20303 Caenorhabditis elegans 30% 100%
Q4QFQ9 Leishmania major 32% 100%
Q4QFR0 Leishmania major 29% 100%
Q4QFR1 Leishmania major 28% 100%
Q4QFR2 Leishmania major 31% 100%
Q4QFR3 Leishmania major 29% 100%
Q4QFR4 Leishmania major 28% 100%
Q4QFR5 Leishmania major 33% 100%
Q4QFR6 Leishmania major 29% 100%
Q4QFR7 Leishmania major 36% 100%
Q4QFR8 Leishmania major 48% 99%
Q4QFR9 Leishmania major 99% 100%
Q4QFS0 Leishmania major 54% 98%
Q4QFS1 Leishmania major 23% 100%
Q5ZJR8 Gallus gallus 35% 100%
Q6PC64 Danio rerio 33% 100%
Q920L5 Mus musculus 35% 100%
Q920L6 Rattus norvegicus 35% 100%
Q9H5J4 Homo sapiens 34% 100%
Q9HB03 Homo sapiens 30% 100%
Q9VH58 Drosophila melanogaster 26% 100%
Q9VV87 Drosophila melanogaster 31% 90%
Q9XVQ9 Caenorhabditis elegans 27% 100%
V5BE99 Trypanosoma cruzi 30% 99%
V5BIX9 Trypanosoma cruzi 40% 100%
V5BND3 Trypanosoma cruzi 27% 95%
V5DF68 Trypanosoma cruzi 39% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS