Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania mexicana

UniProt:

E9APR0_LEIMU

TriTrypDb:

LmxM.14.0650

Length:

285

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 29
NetGPI	no	yes: 0, no: 30

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	28

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Expansion

Sequence features

E9APR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APR0

Function

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Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	4
GO:0001676	long-chain fatty acid metabolic process	5	3
GO:0006082	organic acid metabolic process	3	31
GO:0006629	lipid metabolic process	3	31
GO:0006631	fatty acid metabolic process	4	31
GO:0006633	fatty acid biosynthetic process	5	31
GO:0006643	membrane lipid metabolic process	4	4
GO:0006665	sphingolipid metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	31

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	31
GO:0004312	fatty acid synthase activity	5	31
GO:0009922	fatty acid elongase activity	6	31
GO:0016740	transferase activity	2	31
GO:0016746	acyltransferase activity	3	31
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	31
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	31

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	229	233	PF00082	0.526
CLV_PCSK_SKI1_1	279	283	PF00082	0.197
DEG_Nend_UBRbox_3	1	3	PF02207	0.359
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.522
DOC_MAPK_MEF2A_6	201	209	PF00069	0.456
DOC_PP1_RVXF_1	142	148	PF00149	0.543
DOC_PP2B_LxvP_1	50	53	PF13499	0.522
DOC_PP4_FxxP_1	40	43	PF00568	0.316
DOC_USP7_MATH_1	56	60	PF00917	0.360

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	32%	95%
A0A0N0P7D1	Leptomonas seymouri	31%	85%
A0A0N0P7D6	Leptomonas seymouri	43%	99%
A0A0N0P7R2	Leptomonas seymouri	33%	93%
A0A0N1HZJ8	Leptomonas seymouri	27%	88%
A0A0N1I9H5	Leptomonas seymouri	50%	100%
A0A0N1IIZ8	Leptomonas seymouri	26%	93%
A0A0N1ILQ4	Leptomonas seymouri	36%	97%
A0A0N1IM10	Leptomonas seymouri	85%	100%
A0A0N1PDR8	Leptomonas seymouri	27%	100%

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