LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania mexicana
UniProt:
E9APQ9_LEIMU
TriTrypDb:
LmxM.14.0640
Length:
375

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 45
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 1, no: 31
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0016020 membrane 2 29
GO:0110165 cellular anatomical entity 1 30
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9APQ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APQ9

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 33
GO:0006629 lipid metabolic process 3 33
GO:0006631 fatty acid metabolic process 4 33
GO:0006633 fatty acid biosynthetic process 5 33
GO:0008152 metabolic process 1 33
GO:0008610 lipid biosynthetic process 4 33
GO:0009058 biosynthetic process 2 33
GO:0009987 cellular process 1 33
GO:0016053 organic acid biosynthetic process 4 33
GO:0019752 carboxylic acid metabolic process 5 33
GO:0032787 monocarboxylic acid metabolic process 6 33
GO:0043436 oxoacid metabolic process 4 33
GO:0044237 cellular metabolic process 2 33
GO:0044238 primary metabolic process 2 33
GO:0044249 cellular biosynthetic process 3 33
GO:0044255 cellular lipid metabolic process 3 33
GO:0044281 small molecule metabolic process 2 33
GO:0044283 small molecule biosynthetic process 3 33
GO:0046394 carboxylic acid biosynthetic process 5 33
GO:0071704 organic substance metabolic process 2 33
GO:0072330 monocarboxylic acid biosynthetic process 6 33
GO:1901576 organic substance biosynthetic process 3 33
GO:0000038 very long-chain fatty acid metabolic process 5 4
GO:0001676 long-chain fatty acid metabolic process 5 3
GO:0006643 membrane lipid metabolic process 4 4
GO:0006665 sphingolipid metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0019367 fatty acid elongation, saturated fatty acid 7 4
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 4
GO:0030148 sphingolipid biosynthetic process 5 4
GO:0030497 fatty acid elongation 6 4
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 4
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 4
GO:0042759 long-chain fatty acid biosynthetic process 6 3
GO:0042761 very long-chain fatty acid biosynthetic process 6 4
GO:0046467 membrane lipid biosynthetic process 4 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 33
GO:0004312 fatty acid synthase activity 5 33
GO:0009922 fatty acid elongase activity 6 33
GO:0016740 transferase activity 2 33
GO:0016746 acyltransferase activity 3 33
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 33
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 33

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 359 361 PF00675 0.286
CLV_NRD_NRD_1 367 369 PF00675 0.484
CLV_NRD_NRD_1 58 60 PF00675 0.512
CLV_NRD_NRD_1 73 75 PF00675 0.477
CLV_NRD_NRD_1 85 87 PF00675 0.462
CLV_NRD_NRD_1 92 94 PF00675 0.465
CLV_PCSK_KEX2_1 367 369 PF00082 0.455
CLV_PCSK_KEX2_1 373 375 PF00082 0.534
CLV_PCSK_KEX2_1 73 75 PF00082 0.482
CLV_PCSK_KEX2_1 85 87 PF00082 0.462
CLV_PCSK_KEX2_1 92 94 PF00082 0.465
CLV_PCSK_PC1ET2_1 373 375 PF00082 0.554
CLV_PCSK_SKI1_1 286 290 PF00082 0.339
CLV_PCSK_SKI1_1 316 320 PF00082 0.529
DEG_Nend_UBRbox_1 1 4 PF02207 0.382
DOC_AGCK_PIF_1 247 252 PF00069 0.413
DOC_CYCLIN_RxL_1 57 68 PF00134 0.311
DOC_CYCLIN_yCln2_LP_2 287 293 PF00134 0.532
DOC_CYCLIN_yCln2_LP_2 75 81 PF00134 0.257
DOC_MAPK_gen_1 285 295 PF00069 0.420
DOC_MAPK_gen_1 59 66 PF00069 0.312
DOC_MAPK_MEF2A_6 2 9 PF00069 0.374
DOC_MAPK_MEF2A_6 289 297 PF00069 0.453
DOC_MAPK_MEF2A_6 335 342 PF00069 0.298
DOC_MAPK_MEF2A_6 59 66 PF00069 0.312
DOC_MAPK_NFAT4_5 59 67 PF00069 0.310
DOC_PP1_RVXF_1 202 208 PF00149 0.321
DOC_PP1_RVXF_1 230 236 PF00149 0.517
DOC_PP1_RVXF_1 71 78 PF00149 0.277
DOC_PP2B_LxvP_1 19 22 PF13499 0.373
DOC_PP4_FxxP_1 135 138 PF00568 0.332
DOC_PP4_FxxP_1 15 18 PF00568 0.371
DOC_USP7_MATH_1 327 331 PF00917 0.216
DOC_USP7_MATH_1 369 373 PF00917 0.715
DOC_USP7_UBL2_3 285 289 PF12436 0.486
DOC_WW_Pin1_4 321 326 PF00397 0.164
DOC_WW_Pin1_4 367 372 PF00397 0.660
LIG_14-3-3_CanoR_1 33 37 PF00244 0.322
LIG_14-3-3_CanoR_1 48 56 PF00244 0.303
LIG_14-3-3_CanoR_1 73 78 PF00244 0.272
LIG_Actin_WH2_2 159 176 PF00022 0.440
LIG_APCC_ABBA_1 345 350 PF00400 0.382
LIG_BRCT_BRCA1_1 348 352 PF00533 0.284
LIG_BRCT_BRCA1_2 348 354 PF00533 0.367
LIG_EH1_1 266 274 PF00400 0.345
LIG_EVH1_1 17 21 PF00568 0.367
LIG_FHA_1 200 206 PF00498 0.225
LIG_FHA_1 221 227 PF00498 0.310
LIG_FHA_1 241 247 PF00498 0.265
LIG_FHA_1 299 305 PF00498 0.417
LIG_FHA_1 334 340 PF00498 0.412
LIG_FHA_1 65 71 PF00498 0.303
LIG_FHA_2 192 198 PF00498 0.281
LIG_FHA_2 63 69 PF00498 0.308
LIG_FHA_2 89 95 PF00498 0.425
LIG_HCF-1_HBM_1 104 107 PF13415 0.248
LIG_LIR_Gen_1 222 233 PF02991 0.473
LIG_LIR_Gen_1 237 247 PF02991 0.406
LIG_LIR_Gen_1 271 282 PF02991 0.355
LIG_LIR_Gen_1 43 54 PF02991 0.310
LIG_LIR_Nem_3 165 170 PF02991 0.296
LIG_LIR_Nem_3 237 242 PF02991 0.331
LIG_LIR_Nem_3 244 250 PF02991 0.300
LIG_LIR_Nem_3 271 277 PF02991 0.317
LIG_LIR_Nem_3 281 287 PF02991 0.463
LIG_LIR_Nem_3 43 49 PF02991 0.314
LIG_LIR_Nem_3 53 58 PF02991 0.308
LIG_LIR_Nem_3 76 82 PF02991 0.254
LIG_PCNA_yPIPBox_3 113 126 PF02747 0.146
LIG_PCNA_yPIPBox_3 59 70 PF02747 0.309
LIG_Pex14_1 98 102 PF04695 0.368
LIG_Pex14_2 235 239 PF04695 0.383
LIG_Pex14_2 348 352 PF04695 0.274
LIG_PTAP_UEV_1 21 26 PF05743 0.385
LIG_REV1ctd_RIR_1 53 64 PF16727 0.312
LIG_SH2_PTP2 294 297 PF00017 0.333
LIG_SH2_PTP2 356 359 PF00017 0.548
LIG_SH2_STAP1 201 205 PF00017 0.247
LIG_SH2_STAP1 274 278 PF00017 0.224
LIG_SH2_STAT3 250 253 PF00017 0.321
LIG_SH2_STAT5 125 128 PF00017 0.298
LIG_SH2_STAT5 130 133 PF00017 0.299
LIG_SH2_STAT5 201 204 PF00017 0.287
LIG_SH2_STAT5 245 248 PF00017 0.295
LIG_SH2_STAT5 267 270 PF00017 0.362
LIG_SH2_STAT5 274 277 PF00017 0.302
LIG_SH2_STAT5 294 297 PF00017 0.424
LIG_SH2_STAT5 312 315 PF00017 0.265
LIG_SH2_STAT5 341 344 PF00017 0.314
LIG_SH2_STAT5 346 349 PF00017 0.299
LIG_SH2_STAT5 356 359 PF00017 0.431
LIG_SH2_STAT5 82 85 PF00017 0.323
LIG_SH3_3 15 21 PF00018 0.371
LIG_SH3_3 172 178 PF00018 0.348
LIG_SH3_3 22 28 PF00018 0.393
LIG_SH3_3 319 325 PF00018 0.199
LIG_SH3_3 363 369 PF00018 0.611
LIG_UBA3_1 140 148 PF00899 0.488
LIG_UBA3_1 211 216 PF00899 0.329
LIG_UBA3_1 347 354 PF00899 0.309
LIG_WRC_WIRS_1 192 197 PF05994 0.302
MOD_CDC14_SPxK_1 370 373 PF00782 0.715
MOD_CDK_SPxK_1 367 373 PF00069 0.690
MOD_CDK_SPxxK_3 367 374 PF00069 0.718
MOD_CK1_1 165 171 PF00069 0.249
MOD_CK1_1 50 56 PF00069 0.306
MOD_CK2_1 191 197 PF00069 0.308
MOD_CMANNOS 157 160 PF00535 0.397
MOD_GlcNHglycan 22 25 PF01048 0.513
MOD_GlcNHglycan 228 231 PF01048 0.307
MOD_GlcNHglycan 309 312 PF01048 0.365
MOD_GlcNHglycan 331 334 PF01048 0.528
MOD_GlcNHglycan 49 52 PF01048 0.504
MOD_GSK3_1 268 275 PF00069 0.435
MOD_GSK3_1 316 323 PF00069 0.261
MOD_GSK3_1 329 336 PF00069 0.296
MOD_NEK2_1 133 138 PF00069 0.304
MOD_NEK2_1 162 167 PF00069 0.292
MOD_NEK2_1 188 193 PF00069 0.258
MOD_NEK2_1 200 205 PF00069 0.227
MOD_NEK2_1 212 217 PF00069 0.312
MOD_NEK2_1 220 225 PF00069 0.321
MOD_NEK2_1 226 231 PF00069 0.455
MOD_NEK2_1 268 273 PF00069 0.299
MOD_NEK2_1 293 298 PF00069 0.485
MOD_NEK2_1 307 312 PF00069 0.272
MOD_NEK2_1 62 67 PF00069 0.310
MOD_PIKK_1 298 304 PF00454 0.369
MOD_PIKK_1 32 38 PF00454 0.322
MOD_PIKK_1 333 339 PF00454 0.375
MOD_PKA_1 316 322 PF00069 0.140
MOD_PKA_1 73 79 PF00069 0.270
MOD_PKA_1 86 92 PF00069 0.257
MOD_PKA_2 32 38 PF00069 0.322
MOD_PKA_2 47 53 PF00069 0.302
MOD_PKA_2 73 79 PF00069 0.270
MOD_Plk_4 162 168 PF00069 0.245
MOD_Plk_4 220 226 PF00069 0.302
MOD_Plk_4 234 240 PF00069 0.292
MOD_Plk_4 241 247 PF00069 0.283
MOD_Plk_4 254 260 PF00069 0.193
MOD_Plk_4 268 274 PF00069 0.271
MOD_Plk_4 50 56 PF00069 0.306
MOD_ProDKin_1 321 327 PF00069 0.164
MOD_ProDKin_1 367 373 PF00069 0.661
TRG_DiLeu_BaLyEn_6 175 180 PF01217 0.435
TRG_ENDOCYTIC_2 130 133 PF00928 0.293
TRG_ENDOCYTIC_2 170 173 PF00928 0.372
TRG_ENDOCYTIC_2 274 277 PF00928 0.327
TRG_ENDOCYTIC_2 294 297 PF00928 0.133
TRG_ER_diArg_1 366 368 PF00400 0.752
TRG_ER_diArg_1 72 74 PF00400 0.290
TRG_NES_CRM1_1 337 350 PF08389 0.433
TRG_Pf-PMV_PEXEL_1 181 186 PF00026 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 33% 100%
A0A0N0P7D1 Leptomonas seymouri 32% 100%
A0A0N0P7D6 Leptomonas seymouri 44% 100%
A0A0N1HZJ8 Leptomonas seymouri 29% 100%
A0A0N1I9H5 Leptomonas seymouri 72% 100%
A0A0N1ILQ4 Leptomonas seymouri 38% 100%
A0A0N1IM10 Leptomonas seymouri 50% 100%
A0A0N1PDR8 Leptomonas seymouri 32% 100%
A0A0S4IS29 Bodo saltans 35% 100%
A0A0S4IVJ6 Bodo saltans 29% 100%
A0A0S4IVS6 Bodo saltans 32% 100%
A0A0S4IW98 Bodo saltans 34% 100%
A0A0S4J4C4 Bodo saltans 24% 100%
A0A1X0NNK7 Trypanosomatidae 33% 100%
A0A1X0NNL0 Trypanosomatidae 45% 100%
A0A1X0NNM4 Trypanosomatidae 40% 100%
A0A1X0NNM5 Trypanosomatidae 30% 100%
A0A3Q8I8T7 Leishmania donovani 28% 96%
A0A3Q8I9T2 Leishmania donovani 31% 100%
A0A3Q8I9U9 Leishmania donovani 31% 100%
A0A3Q8I9X8 Leishmania donovani 32% 100%
A0A3Q8IC05 Leishmania donovani 30% 100%
A0A3Q8ID51 Leishmania donovani 30% 94%
A0A3Q8IIA9 Leishmania donovani 61% 100%
A0A3R7KG78 Trypanosoma rangeli 29% 100%
A0A3R7MJR2 Trypanosoma rangeli 41% 100%
A0A3R7NSQ3 Trypanosoma rangeli 47% 100%
A0A3S5H6R7 Leishmania donovani 53% 100%
A0A3S5H6R8 Leishmania donovani 35% 100%
A0A3S7WSY8 Leishmania donovani 92% 100%
A0A3S7WSZ1 Leishmania donovani 32% 100%
A0A3S7WT03 Leishmania donovani 32% 100%
A0A3S7WT16 Leishmania donovani 30% 100%
A0A422NNP1 Trypanosoma rangeli 30% 100%
A4H7M2 Leishmania braziliensis 82% 100%
A4H7M3 Leishmania braziliensis 54% 100%
A4H7M4 Leishmania braziliensis 59% 100%
A4H7M5 Leishmania braziliensis 35% 100%
A4H7M6 Leishmania braziliensis 31% 100%
A4H7M7 Leishmania braziliensis 31% 100%
A4H7M8 Leishmania braziliensis 31% 100%
A4H7M9 Leishmania braziliensis 29% 92%
A4H7N0 Leishmania braziliensis 34% 100%
A4HW07 Leishmania infantum 92% 100%
A4HW08 Leishmania infantum 53% 100%
A4HW09 Leishmania infantum 61% 100%
A4HW10 Leishmania infantum 35% 100%
A4HW12 Leishmania infantum 32% 100%
A4HW13 Leishmania infantum 31% 100%
A4HW14 Leishmania infantum 30% 100%
A4HW15 Leishmania infantum 31% 100%
A4HW16 Leishmania infantum 30% 100%
A4HW17 Leishmania infantum 29% 96%
A4HW18 Leishmania infantum 31% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AGL0 Leishmania infantum 32% 100%
E9AGL2 Leishmania infantum 32% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 97%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
G5EEE5 Caenorhabditis elegans 27% 100%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
Q4QFQ9 Leishmania major 31% 100%
Q4QFR0 Leishmania major 28% 100%
Q4QFR2 Leishmania major 31% 100%
Q4QFR3 Leishmania major 30% 100%
Q4QFR4 Leishmania major 31% 100%
Q4QFR5 Leishmania major 32% 100%
Q4QFR6 Leishmania major 34% 100%
Q4QFR7 Leishmania major 37% 99%
Q4QFR8 Leishmania major 59% 100%
Q4QFR9 Leishmania major 53% 100%
Q4QFS0 Leishmania major 92% 100%
Q5ZJR8 Gallus gallus 34% 100%
Q6PC64 Danio rerio 34% 100%
Q920L5 Mus musculus 35% 100%
Q9H5J4 Homo sapiens 34% 100%
Q9VV87 Drosophila melanogaster 32% 100%
V5BE99 Trypanosoma cruzi 30% 100%
V5BIX9 Trypanosoma cruzi 41% 100%
V5BND3 Trypanosoma cruzi 31% 100%
V5DF68 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS